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1. 发明授权

US07170078B2 Biochemical analysis data producing method and scanner used therefor 失效
标题翻译：生化分析数据生成方法和扫描仪用于此
公开(公告)号：US07170078B2
公开(公告)日：2007-01-30
申请号：US10141555
申请日：2002-05-09
申请人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/54373
摘要： A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.
摘要翻译：生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

2. 发明授权

US06815692B2 Radiation image storage panel 失效
标题翻译：辐射图像存储面板
公开(公告)号：US06815692B2
公开(公告)日：2004-11-09
申请号：US10347394
申请日：2003-01-21
申请人： Yasuo Iwabuchi , Keiko Neriishi
发明人： Yasuo Iwabuchi , Keiko Neriishi
IPC分类号： G21K400
CPC分类号： G03B42/02
摘要： A radiation image storage panel having a deposited phosphor layer, wherein the phosphor layer comprises an alkali metal halide stimulable phosphor containing a small amount of oxygen atom and is annealed after deposition has high-sensitivity and gives a reproduced radiation image of high quality.

3. 发明授权

US06746840B1 Micro array and analyzing method using the same 失效
标题翻译：微阵列和分析方法使用相同
公开(公告)号：US06746840B1
公开(公告)日：2004-06-08
申请号：US09624395
申请日：2000-07-24
申请人： Keiko Neriishi
发明人： Keiko Neriishi
IPC分类号： C12Q168
CPC分类号： G01N21/6452 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01J2219/00729 , B01L3/508 , C12Q1/6837 , C40B40/06
摘要： A micro array, which comprises a stimulable phosphor sheet, and multiple kinds of biomolecules arrayed and fixed on the stimulable phosphor sheet, is prepared. A biomolecule labeled with an energy generating substance is brought into contact with the micro array and is subjected to hybridization with a fixed biomolecule, which is among the multiple kinds of the biomolecules fixed on the stimulable phosphor sheet. The stimulable phosphor sheet is caused to store energy from the energy generating substance acting as the label of the labeled biomolecule having been hybridized with the fixed biomolecule. The stimulable phosphor sheet is then exposed to stimulating rays, a which cause it to emit light in proportion to the amount of energy stored thereon. The emitted light is photoelectrically detected, and the fixed biomolecule having been hybridized with the labeled biomolecule is thus detected.
摘要翻译：制备包含可刺激的荧光体片的微阵列和排列并固定在可刺激的荧光体片上的多种生物分子。用能量产生物质标记的生物分子与微阵列接触，并与固定在可刺激的荧光体片上的多种生物分子之间的固定生物分子进行杂交。使可刺激的荧光体片材存储来自作为已经与固定的生物分子杂交的标记的生物分子的标记的能量产生物质的能量。然后将可刺激的荧光体片暴露于刺激光线，使其与存储在其上的能量的量成比例地发光。所发射的光被光电检测，并且已经与标记的生物分子杂交的固定的生物分子被检测到。

4. 发明授权

US07141805B2 Radiation image storage panel 有权
标题翻译：辐射图像存储面板
公开(公告)号：US07141805B2
公开(公告)日：2006-11-28
申请号：US10751456
申请日：2004-01-06
申请人： Keiko Neriishi , Kiyoteru Miyake , Yasuo Iwabuchi
发明人： Keiko Neriishi , Kiyoteru Miyake , Yasuo Iwabuchi
IPC分类号： H05B33/00
CPC分类号： G21K4/00 , C09K11/7733
摘要： In a radiation image storage panel having a phosphor layer which is produced by gas phase deposition and composed of prismatic phosphors, the phosphor layer has a relative density higher or same on a lower side than or as on a upper side, and the prismatic phosphors have a diameter which is larger on a upper side than on a lower side.
摘要翻译：在具有通过气相沉积制成并由棱柱形荧光体构成的荧光体层的放射线图像存储面板中，荧光体层的相对密度在下侧比上侧高或相同，棱镜荧光体具有在上侧比在下侧大的直径。

5. 发明授权

US5877503A Radiation image storage panel 失效
标题翻译：辐射图像存储面板
公开(公告)号：US5877503A
公开(公告)日：1999-03-02
申请号：US545531
申请日：1995-10-19
申请人： Keiko Neriishi
发明人： Keiko Neriishi
IPC分类号： G21K4/00
CPC分类号： G21K4/00 , G21K2004/06 , G21K2004/08
摘要： An improvement of a radiation image storage panel comprising a stimulable phosphor layer which comprises stimulable phosphor particles, a binder and a colorant resides in that a weight ratio of binder to phosphor particles and concentration of coloring are varied along the depth of the phosphor layer in such manner that a mean value of a weight ratio of binder to phosphor particles within 1/4 of the depth of the phosphor layer from one surface thereof is larger than a mean value of a weight ratio of binder to phosphor particles between 1/4 and 3/4 of the depth of the phosphor layer, and a mean value of a weight ratio of colorant to phosphor particles within 1/4 of the depth of the phosphor layer from the surface is smaller than a mean value of the weight ratio of colorant to phosphor particles between 1/4 and 4/4 of the depth of the phosphor layer from the surface.
摘要翻译：包括可刺激的荧光体颗粒，粘合剂和着色剂的可激发的荧光体层的改进在于粘合剂与荧光体颗粒的重量比和着色浓度沿着荧光体层的深度在其中变化粘合剂与磷光体颗粒的重量比的平均值在+ E内，荧光体层的一个表面的深度的1/4 + EE比粘合剂与荧光体颗粒的重量比的平均值大荧光体层深度的+ E，fra 1/4 + EE和+ E，fra 3/4 + EE，以及着色剂与荧光体颗粒在+ E内的重量比的平均值，1/4 + 来自表面的荧光体层的深度的EE小于着色剂与磷光体颗粒在+ E，fra 1/4 + EE和+ E之间的重量比的平均值，fra 4/4 + EE的深度荧光层从表面。

6. 发明授权

US07220389B2 Biochemical analysis unit and method of producing thereof 失效
标题翻译：生化分析单元及其生产方法
公开(公告)号：US07220389B2
公开(公告)日：2007-05-22
申请号：US10147826
申请日：2002-05-20
申请人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
发明人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
IPC分类号： B01L11/00
CPC分类号： G01N23/04 , B01J2219/00317 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01L3/02 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/168 , C40B60/14 , G01N21/0303 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2201/0642
摘要： The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.
摘要翻译：生化分析装置具有底板和吸收区。吸收区被由屏蔽放射线和光的材料形成的基板包围。在吸收区域中应用和吸收的特定结合物质与被生物体标记的生物体衍生的物质结合，以产生放射线或光。底板防止特定的结合物质渗入另一个吸收区域。当进行放射线和光的数据分析时，产生放射线和光的图像而没有噪声。

7. 发明授权

US06861216B2 DNA detection device 失效
标题翻译： DNA检测装置
公开(公告)号：US06861216B2
公开(公告)日：2005-03-01
申请号：US09749410
申请日：2000-12-28
申请人： Keiko Neriishi , Yuichi Hosoi , Chiyuki Umemoto , Nobuhiko Ogura
发明人： Keiko Neriishi , Yuichi Hosoi , Chiyuki Umemoto , Nobuhiko Ogura
IPC分类号： G01N33/53 , C07H21/04 , C12M1/00 , C12M1/34 , C12N15/09 , C12P19/34 , C12Q1/68 , C40B40/06 , G01N33/566 , G01N37/00 , G01T1/29 , G21K4/00 , H03G5/00 , G08F15/00
CPC分类号： G01T1/2942 , B01J2219/00527 , B01J2219/00574 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q1/6837 , C40B40/06
摘要： A process for detecting a complementary DNA fragment is performed utilizing a DNA micro-array, a radiation image storage panel containing a stimulable phosphor, and a spacer sheet having plural openings.
摘要翻译：使用DNA微阵列，含有可刺激荧光体的放射线图像存储面板和具有多个开口的间隔片进行检测互补DNA片段的方法。

8. 发明申请

US20070184483A1 Biochemical analysis unit and method of producing thereof 审中-公开
公开(公告)号：US20070184483A1
公开(公告)日：2007-08-09
申请号：US11783163
申请日：2007-04-06
申请人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
发明人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N23/04 , B01J2219/00317 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01L3/02 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/168 , C40B60/14 , G01N21/0303 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2201/0642
摘要： The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.

9. 发明申请

US20060266958A1 BIOCHEMICAL ANALYSIS DATA PRODUCING METHOD AND SCANNER USED THEREFOR 失效
标题翻译：生物化学分析数据生成方法及其使用的扫描仪
公开(公告)号：US20060266958A1
公开(公告)日：2006-11-30
申请号：US10141555
申请日：2002-05-09
申请人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/54373
摘要： A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.
摘要翻译：生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

10. 发明授权

US07037446B2 Radiation image storage panel 失效
标题翻译：辐射图像存储面板
公开(公告)号：US07037446B2
公开(公告)日：2006-05-02
申请号：US10776622
申请日：2004-02-12
申请人： Yuji Isoda , Keiko Neriishi , Atsunori Takasu
发明人： Yuji Isoda , Keiko Neriishi , Atsunori Takasu
IPC分类号： G21K4/00
CPC分类号： G21K4/00 , C09K11/7733
摘要： In a radiation image storage panel composed of a phosphor layer produced by vapor phase deposition, the phosphor layer is composed of an europium activated cesium halide stimulable phosphor and exhibits an ultraviolet light-excited emission spectrum satisfying the condition of: 0
摘要翻译：在由通过气相沉积制造的荧光体层构成的放射线图像存储面板中，荧光体层由铕活化的卤化铯可激发的荧光体构成，表现出满足以下条件的紫外光激发发射光谱：公式描述=“在线公式”end =“lead”？> 0 其中 S（400-420）表示基于发光总量，在400〜420nm的范围内赋予发光峰值的发光成分的发光量的比例。

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