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1. 发明专利

JP2008247899A Transdermal administration device for bisoprolol 有权
标题翻译：双酚A的超导管理装置
公开(公告)号：JP2008247899A
公开(公告)日：2008-10-16
申请号：JP2008057691
申请日：2008-03-07
申请人： Nitto Denko Corp , Toa Eiyo Ltd , トーアエイヨー株式会社 , 日東電工株式会社
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , IWAO YOSHIHIRO , YUASA SHUICHIRO , MATSUOKA KENSUKE
IPC分类号： A61K31/138 , A61K9/70 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： PROBLEM TO BE SOLVED: To provide a transdermal administration device which shows a relieved skin irritation at the application, particularly at the peeling, and enables the continuous administration of a therapeutically or preventively effective amount of bisoprolol to a living body. SOLUTION: The transdermal administration device 10 for bisoprolol is equipped with a supporting medium 1 and a pressure-sensitive adhesive layer 2 which is layered on one surface of the supporting medium 1 and contains bisoprolol in the pressure-sensitive adhesive layer 2. The maximum speed of releasing bisoprolol within 24 hours immediately after the application to the skin is not higher than 30 μg/cm 2 /hour, and the speed of releasing bisoprolol at the point 24 hours after the application to the skin is not higher than 10 μg/cm 2 /hour. Thus, not only the skin irritation by bisoprolol is restrained, but also the possibility of side effects such as bradycardia or dizziness by excessive antihypertension are excluded, ensuring sufficient safety. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种透皮给药装置，其在使用时特别是在剥离时显示缓解的皮肤刺激，并且能够将生物体上治疗或预防有效量的比索洛尔连续给药。
解决方案：比索洛尔的透皮给药装置10配备有支撑介质1和压敏粘合剂层2，其在层压在支撑介质1的一个表面上并在压敏粘合剂层2中含有比索洛尔。施用于皮肤后24小时内释放比索洛尔的最大速度不高于30μg/ cm 2 / SP /小时，施用后24小时释放比索洛尔的速度皮肤不高于10μg/ cm 2 / SP /小时。因此，不仅抑制了比索洛尔的皮肤刺激，而且排除了通过过度抗高血压引起的心动过缓或眩晕等副作用的可能性，确保了足够的安全性。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2013199486A Percutaneous administration device of bisoprolol 有权
标题翻译：双氯酚的经皮给药装置
公开(公告)号：JP2013199486A
公开(公告)日：2013-10-03
申请号：JP2013119229
申请日：2013-06-05
申请人： Nitto Denko Corp , 日東電工株式会社 , Toa Eiyo Ltd , トーアエイヨー株式会社
发明人： IWAO YOSHIHIRO , MATSUOKA KENSUKE , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/32 , A61K47/34 , A61P9/06 , A61P9/10 , A61P9/12
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： PROBLEM TO BE SOLVED: To provide a percutaneous administration device reduced in skin stimulation when applied, in particular, when reapplied, and capable of administrating an amount of bisoprolol effective to therapy or prophylaxis continuously to a living organism.SOLUTION: A percutaneous administration device 10 for bisoprolol includes a support body 1 and a pressure-sensitive adhesive layer 2 laminated on one surface of the support body 1, and the bisoprolol is contained in the pressure-sensitive adhesive layer 2, the maximum value of bisoprolol releasing speed is 30 μg/cm/hour or less in the period from the time just after applied onto a skin up to the lapse of 24 hours, and the bisoprolol releasing speed is 10 μg/cm/hour or less in the period from the time just after applied onto the skin up to the lapse of 24 hours. The skin is thereby not only restrained from being stimulated by the bisoprolol, but also the risk of a side effect such as bradycardia and vertigo to be caused due to excessive depression is eliminated to secure sufficient safety.
摘要翻译：要解决的问题：提供一种经皮给药装置，特别是在应用时，特别是重新施用时，能够施用一定量的比索洛尔，有效治疗或预防生物体的皮肤刺激。解决方案：经皮给药装置10 对比索洛尔包括支撑体1和层叠在支撑体1的一个表面上的压敏粘合剂层2，并且比索洛尔包含在压敏粘合剂层2中，比索洛尔释放速度的最大值为30μg/ cm 3 /小时以下，在从施用到皮肤上直到24小时后的时间段内，比索洛尔释放速度在从施加到皮肤上起算之后的时间内为10μg/ cm 3 /小时以下皮肤长达24小时。因此，皮肤不仅可以抑制比索洛尔的刺激，而且消除由于过度抑郁引起的副作用（如心动过缓和眩晕）的风险，以确保足够的安全性。

3. 发明专利

JP2012158612A Adhesive preparation containing bisoprolol 有权
标题翻译：包含双酚的胶体制剂
公开(公告)号：JP2012158612A
公开(公告)日：2012-08-23
申请号：JP2012120476
申请日：2012-05-28
申请人： Nitto Denko Corp , Toa Eiyo Ltd , トーアエイヨー株式会社 , 日東電工株式会社
发明人： IWAO YOSHIHIRO , OKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： PROBLEM TO BE SOLVED: To provide an adhesive preparation which has a low irritation to the skin surface, is superior in stability of bisoprolol in the preparation and further is capable of continuously administrating an effective amount of bisoprolol for treatment or prevention to the living body.SOLUTION: The adhesive preparation 10 has a support 1 and an adhesive layer 2 which is layered on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and tackifiers. Thus, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and an effective amount of bisoprolol for treatment and prevention can be continuously administrated to the living body through the skin surface is provided.
摘要翻译：要解决的问题：为了提供对皮肤表面具有低刺激性的粘合剂，在制剂中比基索洛尔的稳定性优异，并且还能够连续施用有效量的比索洛尔用于治疗或预防活体。粘合剂制剂10具有层叠在载体1的一个表面上的载体1和粘合剂层2.粘合剂层2的特征在于含有比索洛尔，聚异丁烯，增粘剂和有机液体组分，其为与聚异丁烯和增粘剂相容。因此，可以提供在从皮肤表面去除时具有良好的皮肤粘附性，低皮肤刺激性和减轻的疼痛或粘合剂残留的粘合剂。此外，提供了粘贴剂中比索洛尔的稳定性优异的粘合剂制剂和用于治疗和预防的有效量的比索洛尔可以通过皮肤表面连续施用于生物体。版权所有（C）2012，JPO＆INPIT

4. 发明专利

DK1932523T3 Klæbende produkt indeholdende bisoprolol 未知
公开(公告)号：DK1932523T3
公开(公告)日：2011-11-14
申请号：DK06783221
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OOKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61P9/06 , A61P9/10 , A61P9/12

5. 发明专利

AT517618T 未知
公开(公告)号：AT517618T
公开(公告)日：2011-08-15
申请号：AT06783221
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OOKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61P9/06 , A61P9/10 , A61P9/12

6. 发明专利

AU2006288260B2 Adhesive preparation containing bisoprolol 未知
公开(公告)号：AU2006288260B2
公开(公告)日：2011-05-26
申请号：AU2006288260
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OHKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisprolol can be administered continuously into the living body through the skin surface.

7. 发明专利

BRPI0807662A2 未知
公开(公告)号：BRPI0807662A2
公开(公告)日：2014-06-10
申请号：BRPI0807662
申请日：2008-03-06
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , IWAO YOSHIHIRO , YUASA SHUICHIRO , MATSUOKA KENSUKE
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12 , A61P25/02
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 µg/cm 2 /hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 µg/cm 2 /hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.

8. 发明专利

NZ566494A Adhesive preparation containing bisoprolol 未知
公开(公告)号：NZ566494A
公开(公告)日：2010-10-29
申请号：NZ56649406
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OOKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： Disclosed is an adhesive pharmaceutical preparation containing bisoprolol, which comprises a support and an adhesive layer on one side of the support, wherein the adhesive layer contains bisoprolol, polyisobutylene, a tackifier, and an organic liquid ingredient compatible with polyisobutylene and the tackifier selected from a fatty acid alkyl ester, a long-chain alcohol selected from saturated or unsaturated alcohols having from 12 to 28 carbon atoms, or a combination thereof; and wherein the content of bisoprolol per the total weight of the adhesive layer is 0.5 to 5% by weight.

9. 发明专利

AU2006288260A1 Adhesive preparation containing bisoprolol 未知
公开(公告)号：AU2006288260A1
公开(公告)日：2007-03-15
申请号：AU2006288260
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OHKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisprolol can be administered continuously into the living body through the skin surface.

10. 发明专利

BRPI0615762A2 未知
公开(公告)号：BRPI0615762A2
公开(公告)日：2011-05-24
申请号：BRPI0615762
申请日：2006-09-07
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , OHKUBO KATSUYUKI , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12
摘要： An adhesive pharmaceutical preparation which has a less irritation to the skin surface, keeps excellent stability of bisoprolol in the preparation, and allows continuous administration of a pharmacologically effective amount of bisoprolol into the living body, is provided. The adhesive preparation 10 comprises a support 1, an adhesive layer 2 laminated on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, tackifier, and an organic liquid ingredient compatible to polyisobutylene and tackifier. Thus, an adhesive pharmaceutical preparation which has a good adhesiveness with less irritation to the skin and which gives almost no pain at peel-off or removal from the skin surface with leaving almost no paste, can be provided. In addition, bisoprolol is very stably maintained in the preparation and a pharmacologically effective amount of bisprolol can be administered continuously into the living body through the skin surface.

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