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1. 发明专利

JP2011195565A Patch preparation containing bisoprolol 有权
标题翻译：包含双酚的配方制剂
公开(公告)号：JP2011195565A
公开(公告)日：2011-10-06
申请号：JP2011014534
申请日：2011-01-26
申请人： Nitto Denko Corp , Toa Eiyo Ltd , トーアエイヨー株式会社 , 日東電工株式会社
发明人： IWAO YOSHIHIRO , MATSUOKA KENSUKE , AOYANAGI KAZUHIRO , HARIMA JUN , KONNO MASAKATSU
IPC分类号： A61K31/138 , A61K9/70 , A61K47/06 , A61K47/14 , A61P9/06 , A61P9/10 , A61P9/12
CPC分类号： A61K31/138 , A61F13/02 , A61F13/0253 , A61F13/0259 , A61F2013/00646 , A61K9/703 , A61K9/7053
摘要： PROBLEM TO BE SOLVED: To provide a patch preparation well restrained in the decrease of drug content by generation of oozing and protrusion of the component of self-adhesive layer from the exposed area of the self-adhesive layer of the patch preparation in storage and oozing of bisoprolol or its salts from the self-adhesive layer.SOLUTION: Each shape of the flat surfaces of the patch preparation, a support, a peeling liner and the self-adhesive layer are made rectangle and a salient is made on the surface of the support at the edge of the rectangle of the patch preparation. It is also possible to make a central part and a peripheral part on the patch preparation and the salient is made at the corners of the rectangle of the central part, and further it is possible to make a built-up articulated portion having a thickness of thinner than that at the salient of the patch preparation between the neighboring not less than two salients. When a back split is made on the peeling liner, it must not go through the salient at the corner of the rectangle.
摘要翻译：要解决的问题：为了提供在药物含量降低方面良好抑制的贴剂制剂，通过产生渗出并将自粘层的组分从储存和渗出的贴剂的自粘层的暴露区域突出的比索洛尔或其盐。解决方案：贴片制剂，支撑体，剥离衬垫和自粘层的平坦表面的每个形状被制成矩形，并且在表面上形成凸起支持在补丁准备的矩形的边缘。也可以在贴片制剂上形成中心部分和周边部分，并且在中心部分的矩形的角部形成突出部，并且还可以制成具有厚度的稀薄比贴片制剂的突出点之间相邻不少于两种。当在剥皮衬垫上进行背部分割时，不得通过矩形角落处的凸面。

2. 发明专利

JP2013199486A Percutaneous administration device of bisoprolol 有权
标题翻译：双氯酚的经皮给药装置
公开(公告)号：JP2013199486A
公开(公告)日：2013-10-03
申请号：JP2013119229
申请日：2013-06-05
申请人： Nitto Denko Corp , 日東電工株式会社 , Toa Eiyo Ltd , トーアエイヨー株式会社
发明人： IWAO YOSHIHIRO , MATSUOKA KENSUKE , OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO
IPC分类号： A61K31/138 , A61K9/70 , A61K47/32 , A61K47/34 , A61P9/06 , A61P9/10 , A61P9/12
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： PROBLEM TO BE SOLVED: To provide a percutaneous administration device reduced in skin stimulation when applied, in particular, when reapplied, and capable of administrating an amount of bisoprolol effective to therapy or prophylaxis continuously to a living organism.SOLUTION: A percutaneous administration device 10 for bisoprolol includes a support body 1 and a pressure-sensitive adhesive layer 2 laminated on one surface of the support body 1, and the bisoprolol is contained in the pressure-sensitive adhesive layer 2, the maximum value of bisoprolol releasing speed is 30 μg/cm/hour or less in the period from the time just after applied onto a skin up to the lapse of 24 hours, and the bisoprolol releasing speed is 10 μg/cm/hour or less in the period from the time just after applied onto the skin up to the lapse of 24 hours. The skin is thereby not only restrained from being stimulated by the bisoprolol, but also the risk of a side effect such as bradycardia and vertigo to be caused due to excessive depression is eliminated to secure sufficient safety.
摘要翻译：要解决的问题：提供一种经皮给药装置，特别是在应用时，特别是重新施用时，能够施用一定量的比索洛尔，有效治疗或预防生物体的皮肤刺激。解决方案：经皮给药装置10 对比索洛尔包括支撑体1和层叠在支撑体1的一个表面上的压敏粘合剂层2，并且比索洛尔包含在压敏粘合剂层2中，比索洛尔释放速度的最大值为30μg/ cm 3 /小时以下，在从施用到皮肤上直到24小时后的时间段内，比索洛尔释放速度在从施加到皮肤上起算之后的时间内为10μg/ cm 3 /小时以下皮肤长达24小时。因此，皮肤不仅可以抑制比索洛尔的刺激，而且消除由于过度抑郁引起的副作用（如心动过缓和眩晕）的风险，以确保足够的安全性。

3. 发明专利

JP2013022060A Packaging structure of adhesive skin patch 审中-公开
标题翻译：粘合皮肤包装的包装结构
公开(公告)号：JP2013022060A
公开(公告)日：2013-02-04
申请号：JP2011156771
申请日：2011-07-15
申请人： Nitto Denko Corp , 日東電工株式会社 , Toa Eiyo Ltd , トーアエイヨー株式会社
发明人： MATSUOKA KENSUKE , IWAO YOSHIHIRO , HARIMA JUN , KONNO MASAKATSU , AOYANAGI KAZUHIRO , TANAKA TOMOYA , TOYODA MIKIO , AKITA YASUHIKO , MATSUI TADASHI
IPC分类号： A61F13/02
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： PROBLEM TO BE SOLVED: To provide a packaging structure of an adhesive skin patch which can be easily taken out of the packaging body.SOLUTION: The packaging structure 100a of the adhesive skin patch includes first and second laminated substrates 120, 130, and contains the adhesive skin patch. The first and second substrates 120, 130 have the first to fourth sides 121-124 and 131-134. At least one of the first and second substrates 120, 130 have the first to third openings 125-127 and 135-137. The first to third openings 125-127 (135-137) guide so as to open the inner peripheral edges 120c1, 120c2, 120c4 (130c1, 130c2, 130c4) of the sealing part 120c (130c) along them.
摘要翻译：要解决的问题：提供可以容易地从包装体中取出的粘合性皮肤贴剂的包装结构。解决方案：粘合性皮肤贴剂的包装结构100a包括第一和第二层压基底120,130，并且包含粘合性皮肤贴片。第一和第二基板120,130具有第一至第四侧面121-124和131-134。第一和第二基板120,130中的至少一个具有第一至第三开口125-127和135-137。第一至第三开口125-127（135-137）引导以沿着密封部分120c（130c）的内周边缘120c1,120c2,120c4（130c1,130c2,130c4）打开。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2008247899A Transdermal administration device for bisoprolol 有权
标题翻译：双酚A的超导管理装置
公开(公告)号：JP2008247899A
公开(公告)日：2008-10-16
申请号：JP2008057691
申请日：2008-03-07
申请人： Nitto Denko Corp , Toa Eiyo Ltd , トーアエイヨー株式会社 , 日東電工株式会社
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , IWAO YOSHIHIRO , YUASA SHUICHIRO , MATSUOKA KENSUKE
IPC分类号： A61K31/138 , A61K9/70 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： PROBLEM TO BE SOLVED: To provide a transdermal administration device which shows a relieved skin irritation at the application, particularly at the peeling, and enables the continuous administration of a therapeutically or preventively effective amount of bisoprolol to a living body. SOLUTION: The transdermal administration device 10 for bisoprolol is equipped with a supporting medium 1 and a pressure-sensitive adhesive layer 2 which is layered on one surface of the supporting medium 1 and contains bisoprolol in the pressure-sensitive adhesive layer 2. The maximum speed of releasing bisoprolol within 24 hours immediately after the application to the skin is not higher than 30 μg/cm 2 /hour, and the speed of releasing bisoprolol at the point 24 hours after the application to the skin is not higher than 10 μg/cm 2 /hour. Thus, not only the skin irritation by bisoprolol is restrained, but also the possibility of side effects such as bradycardia or dizziness by excessive antihypertension are excluded, ensuring sufficient safety. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种透皮给药装置，其在使用时特别是在剥离时显示缓解的皮肤刺激，并且能够将生物体上治疗或预防有效量的比索洛尔连续给药。
解决方案：比索洛尔的透皮给药装置10配备有支撑介质1和压敏粘合剂层2，其在层压在支撑介质1的一个表面上并在压敏粘合剂层2中含有比索洛尔。施用于皮肤后24小时内释放比索洛尔的最大速度不高于30μg/ cm 2 / SP /小时，施用后24小时释放比索洛尔的速度皮肤不高于10μg/ cm 2 / SP /小时。因此，不仅抑制了比索洛尔的皮肤刺激，而且排除了通过过度抗高血压引起的心动过缓或眩晕等副作用的可能性，确保了足够的安全性。版权所有（C）2009，JPO＆INPIT

5. 发明申请

WO2013011961A2 PACKAGING STRUCTURE FOR PATCHES 审中-公开
标题翻译：包装的包装结构
公开(公告)号：WO2013011961A2
公开(公告)日：2013-01-24
申请号：PCT/JP2012068001
申请日：2012-07-13
申请人： NITTO DENKO CORP , TOA EIYO LTD , MATSUOKA KENSUKE , IWAO YOSHIHIRO , HARIMA JUN , KONNO MASAKATSU , AOYAGI KAZUHIRO , TANAKA TOMOYA , TOYOTA MIKIO , AKITA YASUHIKO , MATSUI TADASHI
发明人： MATSUOKA KENSUKE , IWAO YOSHIHIRO , HARIMA JUN , KONNO MASAKATSU , AOYAGI KAZUHIRO , TANAKA TOMOYA , TOYOTA MIKIO , AKITA YASUHIKO , MATSUI TADASHI
IPC分类号： B65D75/62 , A61F13/02 , B65D77/30
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： The purpose of the present invention is to provide a packaging structure for patches which achieves a package body wherefrom patches can be removed easily. A packaging structure (100) for patches includes a first and a second base member (120, 130) having peripheral edge parts that are laminated together, and contains a patch. The first and second base members (120, 130) have a first, a second, a third, and a fourth edge (121-124, 131-134). At least one of the first and second base members (120, 130) has a first, a second and a third opening part (125-127, 135-137). The first, second, and third opening parts (125-127, 135-137) serve as guides to ensure opening occurs along the internal peripheral edges (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of a sealing part (120c, 130c).
摘要翻译：本发明的目的是提供一种用于贴片的包装结构，其实现了可以容易地去除贴片的包装体。用于贴片的包装结构（100）包括具有层叠在一起的周边边缘部分并且包含贴片的第一和第二基底构件（120,130）。第一和第二基座构件（120,130）具有第一，第二，第三和第四边缘（121-124,131-134）。第一和第二基座构件（120,130）中的至少一个具有第一，第二和第三开口部分（125-127,135-137）。第一，第二和第三开口部分（125-127,135-137）用作引导件，以确保沿着密封部分（120c，120c1,120c2,120c4,130c1,130c2,130c4）的内周边缘（120c1,120c2,120c4,130c1,130c2,130c4） 130℃）。

6. 发明专利

AU2008221861B2 Device for the transdermal administration of bisoprolol 未知
公开(公告)号：AU2008221861B2
公开(公告)日：2013-03-21
申请号：AU2008221861
申请日：2008-03-06
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , IWAO YOSHIHIRO , YUASA SHUICHIRO , MATSUOKA KENSUKE
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12 , A61P25/02
摘要： A device for the administration of bisoprolol having a support; and a pressure-sensitive adhesive layer containing bisoprolol which is layered on one face of the support; wherein the maximum speed of releasing bisoprolol within 24 hours immediately after the application to the skin is 30 μg/cm

7. 发明专利

CA2841456A1 PACKAGING STRUCTURE FOR PATCHES 未知
公开(公告)号：CA2841456A1
公开(公告)日：2013-01-24
申请号：CA2841456
申请日：2012-07-13
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： MATSUOKA KENSUKE , IWAO YOSHIHIRO , HARIMA JUN , KONNO MASAKATSU , AOYAGI KAZUHIRO , TANAKA TOMOYA , TOYOTA MIKIO , AKITA YASUHIKO , MATSUI TADASHI
IPC分类号： B65D75/62 , A61F13/02 , B65D77/30
摘要： The purpose of the present invention is to provide a packaging structure for patches which achieves a package body wherefrom patches can be removed easily. A packaging structure (100) for patches includes a first and a second base member (120, 130) having peripheral edge parts that are laminated together, and contains a patch. The first and second base members (120, 130) have a first, a second, a third, and a fourth edge (121-124, 131-134). At least one of the first and second base members (120, 130) has a first, a second and a third opening part (125-127, 135-137). The first, second, and third opening parts (125-127, 135-137) serve as guides to ensure opening occurs along the internal peripheral edges (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of a sealing part (120c, 130c).

8. 发明专利

CA2678424A1 PERCUTANEOUS ADMINISTRATION DEVICE OF BISOPROLOL 未知
公开(公告)号：CA2678424A1
公开(公告)日：2008-09-12
申请号：CA2678424
申请日：2008-03-06
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , YUASA SHUICHIRO , IWAO YOSHIHIRO , MATSUOKA KENSUKE
IPC分类号： A61K31/138 , A61K9/70 , A61K47/10 , A61K47/14 , A61K47/32 , A61P9/06 , A61P9/10 , A61P9/12 , A61P25/02
摘要： A device for the administration of bisoprolol having a support; and a pre ssure-sensitive adhesive layer containing bisoprolol which is layered on one face of the support; wherein the maximum speed of releasing bisoprolol with in 24 hours immediately after the application to the skin is 30 .mu.g/cm2/h or less and the speed of releasing bisoprolol at the point 24 hours after th e application to the skin is 10 .mu.g/cm2/h or less. This transdermal admini stration device shows a relived skin irritation at the application and, in p articular, at the peeling and enables the continuous administration of a the rapeutically or preventively effective amount of bisoprolol to the living bo dy.

9. 发明专利

AU2011221293A1 Adhesive patch containing bisoprolol 未知
公开(公告)号：AU2011221293A1
公开(公告)日：2012-09-13
申请号：AU2011221293
申请日：2011-02-23
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： IWAO YOSHIHIRO , MATSUOKA KENSUKE , AOYAGI KAZUHIRO , HARIMA JUN , KONNO MASAKATSU
IPC分类号： A61K31/138 , A61F13/02 , A61K9/70 , A61P9/00 , A61P9/06 , A61P9/12
摘要： Disclosed is an adhesive patch which effectively inhibits the occurrence of oozing or squeezing out of the adhesive layer component from the exposed area of the adhesive layer of the adhesive patch during storage, and also inhibits the occurrence of oozing of bisoprolol or salts of same from the adhesive layer thereby preventing reduction of drug content. A backing material, a release liner and an adhesive layer respectively, along with the entire adhesive patch, are shaped into a planar rectangle wherein the corners of the adhesive patch are formed into convex shapes on the rear surface on the backing material side. Further, the adhesive patch has a central part and edges wherein the corners of the rectangular shape of the central part can also be formed into convex shapes, and furthermore it can be provided with built-up articulated sections between two or more adjacent convex parts wherein the thickness of the adhesive patch is thinner than the thickness of the adhesive layer at each convex part. If the release liner is provided with a split at the back, the split should not traverse the convex parts.

10. 发明专利

AR065610A1 DISPOSITIVO PARA LA ADMINISTRACION PERCUTANEA DE BISOPROLOL 未知
公开(公告)号：AR065610A1
公开(公告)日：2009-06-17
申请号：ARP080100916
申请日：2008-03-06
申请人： NITTO DENKO CORP , TOA EIYO LTD
发明人： OKADA KATSUHIRO , MINAMI KUNIHIRO , IWAO YOSHIHIRO , YUASA SHUICHIRO , MATSUOKA KENSUKE
IPC分类号： A61K9/70 , A61K31/138 , A61P9/12
摘要： Dispositivo para la administracion percutánea de bisoprolol que comprende una capa de refuerzo y una capa adhesiva sensible a la presion que contiene bisoprolol, la cual está laminada sobre la superficie de la capa de refuerzo, donde el valor máximode la tasa de liberacion de bisoprolol durante un período que va desde el momento inmediatamente posterior a la aplicacion sobre la piel hasta que transcurre un lapso de 24 horas es de 30 ug/cm2/hora o menos; y donde la tasa de liberacion debisoprolol una vez transcurrido el lapso de 24 horas posteriores a la aplicacion sobre la piel es de 10 ug/cm2/hora o menos. El dispositivo para la administracion percutánea de la presente reduce la irritacion de la piel durante la aplicacion,especialmente en el momento del desprendimiento, y con el cual se puede administrar de manera constante una cantidad con eficacia terapéutica o preventiva de bisoprolol a un organismo vivo.

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