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1. 发明申请

WO2005090357A1 TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS 审中-公开
标题翻译：三聚苯并噻唑化合物作为抗真菌剂
公开(公告)号：WO2005090357A1
公开(公告)日：2005-09-29
申请号：PCT/JP2005/006004
申请日：2005-03-23
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , OHRAI, Kazuhiko , SHIGETA, Yukihiko , UESUGI, Osamu , OKADA, Takumi , MATSUDA, Tomoyuki
发明人： OHRAI, Kazuhiko , SHIGETA, Yukihiko , UESUGI, Osamu , OKADA, Takumi , MATSUDA, Tomoyuki
IPC分类号： C07D491/04
CPC分类号： C07D513/04 , C07D491/04 , C07D515/04
摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R 1 and R 2 are independently of each other hydrogen atom, C 1-6 alkyl group or C 6-14 aryl group, R 3 is hydrogen atom or C 1-6 alkylcarbonyloxy group, or together with R 4 forms a bond, R 4 is hydrogen atom, or together with R 3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR 7 R 8 , NR 9 , O, S, SO or SO 2 , R 5 is hydrogen atom or C 1-6 alkyl group, R 6 is hydrogen atom, C 1-6 alkyl group, C 3-8 cycloalkyl group, C 3-8 cycloalkenyl group, amino group, C 1-6 alkylamino group, di-C 1-6 alkylamino group, C 6-14 arylamino group, C 2-9 heteroarylamino group, C 6-14 aryl group, C 2-9 heteroaryl group or C 2-9 heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
摘要翻译：本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R 1和R 2彼此独立地为氢原子，C 1-6烷基或C 6-14芳基，R 3是氢原子或C 1-6烷基羰基氧基，或与R 4一起形成键，R 4是氢原子，或与R 3一起形成键，m是0-4的整数，n为0〜4的整数，V为单键，CR 7 R 8，NR 9，O，S，SO或SO 2，R 5为氢原子或C 1-6烷基 R 6是氢原子，C 1-6烷基，C 3-8环烷基，C 3-8环烯基，氨基，C 1-6烷基氨基，二-C 1-6烷基氨基，C 6-14芳基氨基，C 2-9杂芳基氨基，C 6 -14芳基，C2-9杂芳基或C2-9杂环基，A是与苯环稠合的5-，6-或7-元环，作为环的构成原子，可以含有氧原子，氮原子或硫原子单独或其组合的1至3的数量环中的不饱和键是1,2或3，包括待稠合的苯环的不饱和键，构成环的碳原子可以是羰基或硫代羰基。这些化合物可用作抗心律不齐剂。

2. 发明授权

EP2921489B1 2-PYRIDONE COMPOUND 有权
标题翻译： 2-吡啶酮化合物
公开(公告)号：EP2921489B1
公开(公告)日：2017-09-06
申请号：EP13855534.7
申请日：2013-11-12
申请人： Nissan Chemical Industries, Ltd.
发明人： KURODA, Shoichi , IMAI, Yudai , KAWAGUCHI, Takanori , FUSEGI, Keiko , BOHNO, Masahiro , ASANUMA, Hajime , CHONAN, Tomomichi , SATO, Nagaaki , MONMA, Souichi , SASAKO, Shigetada , MIZUTANI, Marie , ITOH, Shin , OKADA, Takumi , OTA, Hirofumi , ISHIYAMA, Seishi
IPC分类号： C07D401/06 , A61K31/4439 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/02 , A61P43/00
CPC分类号： C07D401/06 , A61K31/4439

3. 发明公开

EP2123654A1 PYRAZOLOPYRIMIDINE COMPOUND 审中-公开
标题翻译： PYRAZOLOPYRIMIDINVERBINDUNG
公开(公告)号：EP2123654A1
公开(公告)日：2009-11-25
申请号：EP07860481.6
申请日：2007-12-28
申请人： Taisho Pharmaceutical Co. Ltd. , Nissan Chemical Industries, Ltd.
发明人： YAGI, Makoto , UMEMIYA, Hiroki , ASANUMA, Hajime , OKA, Yusuke , NISHIKAWA, Rie , HAYASHI, Keishi , OKADA, Takumi , SHIMIZU, Takanori , SASAKO, Shigetada
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/55 , A61K31/553 , A61P19/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Disclosed is a novel compound having Syk and/or Abl inhibitory activities, which is useful for prevention/treatment of allergic diseases, autoimmune diseases, arthritides and cancers. Specifically disclosed is a pyrazolopyrimidine compound represented by the formula [I] or [III] below, a tautomer thereof, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvent of any of them.
摘要翻译：公开了具有Syk和/或Abl抑制活性的新化合物，其可用于预防/治疗过敏性疾病，自身免疫性疾病，关节炎和癌症。具体公开的是由下式[I]或[III]表示的吡唑并嘧啶化合物，其互变异构体，其立体异构体，其药学上可接受的盐或其任何一种的溶剂。

4. 发明公开

EP2921489A1 2-PYRIDONE COMPOUND 有权
标题翻译： 2-吡啶酮VERBINDUNG
公开(公告)号：EP2921489A1
公开(公告)日：2015-09-23
申请号：EP13855534.7
申请日：2013-11-12
申请人： Taisho Pharmaceutical Co., Ltd. , Nissan Chemical Industries, Ltd.
发明人： KURODA, Shoichi , IMAI, Yudai , KAWAGUCHI, Takanori , FUSEGI, Keiko , BOHNO, Masahiro , ASANUMA, Hajime , CHONAN, Tomomichi , SATO, Nagaaki , MONMA, Souichi , SASAKO, Shigetada , MIZUTANI, Marie , ITOH, Shin , OKADA, Takumi , OTA, Hirofumi , ISHIYAMA, Seishi
IPC分类号： C07D401/06 , A61K31/4439 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/02 , A61P43/00
CPC分类号： C07D401/06 , A61K31/4439
摘要： This 2-pyridone compound represented by formula [1] or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or said tautomer, or a solvate of said compound or the like has a superior GK-activating effect and is useful as a pharmaceutical.
摘要翻译：由式[1]表示的2-吡啶酮化合物或所述化合物的互变异构体或所述化合物或所述互变异构体的药学上可接受的盐，或所述化合物等的溶剂合物具有优异的GK-活化作用，可用作制药。

5. 发明公开

EP2157090A1 PYRAZINAMIDE COMPOUND 审中-公开
标题翻译：吡嗪酰胺化合物
公开(公告)号：EP2157090A1
公开(公告)日：2010-02-24
申请号：EP08765775.5
申请日：2008-06-20
申请人： Taisho Pharmaceutical Co. Ltd. , Nissan Chemical Industries, Ltd.
发明人： UMEMIYA, Hiroki , WATATANI, Kengo , KAWAGUCHI, Takanori , KAWABE, Kenichi , OKADA, Takumi , SASAKO, Shigetada , SAITO, Noriko
IPC分类号： C07D403/12 , A61K31/497 , A61K31/501 , A61P3/04 , A61P3/10 , A61P43/00 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Disclosed is a pyrazinamide compound represented by the formula (1), a tautomer, stereoisomer or pharmaceutically acceptable salt thereof, or a solvate of the compound or the tautomer, stereoisomer or pharmaceutically acceptable salt thereof, which has an excellent GK-activating activity and is therefore useful as a medicinal agent. (1) wherein R 1 represents a hydrogen atom, a C 1-8 alkyl group, a C 3-8 cycloalkyl group, a C 2-9 heterocyclyl group, a phenyl group, a C 1-9 heteroaryl group, a C 7-14 arylalkyl group or the like; R 2 represents a C 1-8 alkyl group, a C 2-9 heterocyclyl group, a phenyl group, a C 1-9 heteroaryl group or the like; Ar represents a monocyclic or fused polycyclic C 1-9 heteroaryl group represented by the formula (2) or a C 2-9 heterocyclyl group represented by formula (2); Y represents -S-, -O-or -NH-; and Z represents -S-, -O- or -CH 2 -.
摘要翻译：本发明公开了式（1）代表的吡嗪酰胺化合物，其互变异构体，立体异构体或药学上可接受的盐，或其化合物或其互变异构体，立体异构体或药学上可接受的盐的溶剂合物，其具有优异的GK活化活性，因此可用作药剂。（1）其中R1代表氢原子，C1-8烷基，C3-8环烷基，C2-9杂环基，苯基，C1-9杂芳基，C7-14芳烷基或喜欢; R2代表C1-8烷基，C2-9杂环基，苯基，C1-9杂芳基等; Ar表示由式（2）表示的单环或稠合多环C1-9杂芳基或由式（2）表示的C2-9杂环基; Y代表-S - ， - O-或-NH-; Z表示-S - ， - O-或-CH 2 - 。

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