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1. 发明授权

US06689389B2 Pharmaceutically acceptable starch 失效
标题翻译：药学上可接受的淀粉
公开(公告)号：US06689389B2
公开(公告)日：2004-02-10
申请号：US09970648
申请日：2001-10-05
申请人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
发明人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
IPC分类号： A61K950
CPC分类号： A61K9/1652 , C08B30/04 , C08B30/12 , Y10T428/2982 , Y10T428/2991
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来生产纯化的，肠胃外可给予的淀粉，以去除表面定位的蛋白质，脂质和内毒素，将淀粉溶解在水性介质中，通过剪切分解重量减少和任选地除去残留的水溶性蛋白质，优选通过阴离子交换色谱法。基于这种淀粉的纯化淀粉和微粒。

2. 发明授权

US06616948B2 Starch 失效
标题翻译：淀粉
公开(公告)号：US06616948B2
公开(公告)日：2003-09-09
申请号：US09970795
申请日：2001-10-05
申请人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
发明人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
IPC分类号： A61K950
CPC分类号： A61K9/1652 , C08B30/04 , C08B30/12 , Y10T428/2982 , Y10T428/2991
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来制备纯化的，肠胃外可施用的淀粉，以去除表面定位的蛋白质，脂质和内毒素，通过酸水解使淀粉进行分子量降低，并任选地除去残留的水溶性蛋白质。基于这种淀粉的纯化淀粉和微粒。

3. 发明授权

US07119195B2 Pharmaceutically acceptable starch 失效
公开(公告)号：US07119195B2
公开(公告)日：2006-10-10
申请号：US10627920
申请日：2003-07-28
申请人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso
发明人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso
IPC分类号： C08B31/00 , A61K31/717
CPC分类号： A61K9/1652 , C08B30/04 , C08B30/12 , Y10T428/2982 , Y10T428/2991
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography.Purified starch and microparticles based on such starch.

4. 发明申请

US20110045505A1 INTEGRATED SEPARATION AND DETECTION CARTRIDGE WITH MEANS AND METHOD FOR INCREASING SIGNAL TO NOISE RATIO 审中-公开
标题翻译：具有增加信号噪声比的方法和方法的集成分离和检测盒
公开(公告)号：US20110045505A1
公开(公告)日：2011-02-24
申请号：US12742830
申请日：2008-11-26
申请人： Peter Warthoe , Soren Mentzel , Klaus Rune Andersen , Jens Mikkelsen , Jacob Holst Madsen , Per Berdén
发明人： Peter Warthoe , Soren Mentzel , Klaus Rune Andersen , Jens Mikkelsen , Jacob Holst Madsen , Per Berdén
IPC分类号： G01N33/53 , C12M1/34 , B01L99/00
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/50273 , B01L2200/0631 , B01L2200/0647 , B01L2200/10 , B01L2300/0681 , B01L2300/0887 , B01L2300/161 , B01L2400/043 , G01N33/54326 , G01N33/54346 , G01N33/54373 , G01N33/54393
摘要： The present invention relates to a device and a method for quantitative detecting of the presence or absence of a target analyte in a liquid sample having a volume of less than 200 μl, the device comprising a reaction chamber in the form of a capillary channel, a first part comprising a sample inlet for the introduction of a sample containing an analyte, and a discharge outlet for the discharge of waste products; a second part comprising means for detection of the target analyte, and a solution inlet for introduction of washing solutions and reaction mixtures; and means for transferring an immobilized analyte from the first part to the second part of the chamber and vice versa, where the first and second parts are separated such that other liquid sample material may not enter the second part of the chamber and such that light may not be transferred from the first part of the chamber to the detector part of the second part of the chamber.
摘要翻译：本发明涉及一种用于定量检测体积小于200μl的液体样品中目标分析物的存在或不存在的装置和方法，该装置包括呈毛细通道形式的反应室，第一部分包括用于引入含有分析物的样品的样品入口和用于排出废物的排出口; 第二部分包括用于检测目标分析物的装置和用于引入洗涤溶液和反应混合物的溶液入口; 以及用于将固定的分析物从所述第一部分转移到所述室的第二部分的装置，反之亦然，其中所述第一和第二部分被分离，使得其它液体样品材料可能不会进入所述室的第二部分，不能从室的第一部分转移到室的第二部分的检测器部分。

5. 发明申请

US20100264099A1 SEPARATION DEVICE COMPRISING A PHYSICAL BARRIER 审中-公开
标题翻译：包含物理障碍物的分离装置
公开(公告)号：US20100264099A1
公开(公告)日：2010-10-21
申请号：US12742386
申请日：2007-11-26
申请人： Peter Warthoe , Per Berdén
发明人： Peter Warthoe , Per Berdén
IPC分类号： B01D35/28 , B01D37/00
CPC分类号： B01L3/502753 , B01L2300/0681 , B01L2300/16 , B01L2400/0406
摘要： The present invention relates to a device for separating a suspension into a liquid phase and a retentate phase. The device comprises a separation chamber comprising an application zone and a hydrophilic filter material. The separation chamber is connected to a first capillary channel, where the connecting junction between the separation chamber and the first capillary channel comprise a physical barrier preventing flow of residue retentate from a lower part of the chamber into the first capillary channel. The invention further relates to a method for separating a liquid sample consisting of less than 200 μl suspension, into a retentate phase comprising the suspended matter, and a liquid phase substantially free of suspended matter.
摘要翻译：本发明涉及一种用于将悬浮液分离成液相和滞留相的装置。该装置包括分离室，其包括施加区域和亲水性过滤材料。分离室连接到第一毛细通道，其中分离室和第一毛细管通道之间的连接结包括物理屏障，防止残余物滞留物从腔室的下部流入第一毛细通道。本发明还涉及将由少于200μl悬浮液组成的液体样品分离成包含悬浮物的滞留相和基本上不含悬浮物的液相的方法。

6. 发明申请

US20110008776A1 INTEGRATED SEPARATION AND DETECTION CARTRIDGE USING MAGNETIC PARTICLES WITH BIMODAL SIZE DISTRIBUTION 审中-公开
标题翻译：使用二次尺寸分布的磁性颗粒的集成分离和检测盒
公开(公告)号：US20110008776A1
公开(公告)日：2011-01-13
申请号：US12742520
申请日：2008-11-26
申请人： Peter Warthoe , Søren Mentzel , Klaus Rune Andersen , Jens Mikkelsen , Jacob Holst Madsen , Per Berdén
发明人： Peter Warthoe , Søren Mentzel , Klaus Rune Andersen , Jens Mikkelsen , Jacob Holst Madsen , Per Berdén
IPC分类号： C12Q1/68 , G01N33/573 , G01N33/53 , C12M1/40
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/50273 , B01L2200/0631 , B01L2200/0647 , B01L2200/10 , B01L2300/0681 , B01L2300/0887 , B01L2300/161 , B01L2400/043 , G01N33/54326 , G01N33/54346 , G01N33/54373 , G01N33/54393
摘要： The present invention relates to a device and a method for quantitative detecting of the presence or absence of a target analyte in a liquid sample, the device comprising a reaction chamber having a volume of less than 200 μl comprising an immobilization matrix capable of capturing the analyte, said immobilization matrix, preferably comprising a particulate magnetic material, having a size distribution that is at least bimodal.
摘要翻译：本发明涉及一种用于定量检测液体样品中目标分析物的存在或不存在的装置和方法，该装置包括体积小于200μl的反应室，其包含能够捕获分析物的固定基质，所述固定基质优选包含颗粒状磁性材料，其尺寸分布至少是双峰的。

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