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1. 发明授权

US06861064B1 Encapsulation method 失效
标题翻译：封装方法
公开(公告)号：US06861064B1
公开(公告)日：2005-03-01
申请号：US09529442
申请日：1998-09-24
申请人： Timo Laakso , Mats Reslow
发明人： Timo Laakso , Mats Reslow
IPC分类号： A61K9/51 , A61K9/14 , A61K9/16 , A61K9/50 , A61K31/7064 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/04 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/43 , A61K39/00 , A61K47/34 , B01J13/00 , B01J13/02 , B01J13/18 , A01N25/28
CPC分类号： B01J13/18 , A61K9/1647 , A61K9/1694 , A61K9/5031
摘要： A novel method of encapsulating an active substance in a biodegradable polymer, which comprises: a) dissolving said biodegradable polymer in an organic solvent therefor; b1) dispersing said active substance in the organic solution obtained in step a) to provide a dispersion with the active substance as the inner phase thereof; or alternatively b2) emulsifying said active substance, dissolved in water or other aqueous solvent therefor, in the organic solution obtained in step a) to provide an emulsion with the active substance as the inner aqueous phase thereof; and c) subjecting the dispersion obtained in step b1), or alternatively the emulsion obtained in step b2), to an encapsulation operation with an aqueous polyethylene glycol solution as a continuous phase to provide micro- or nanoparticles having the active substance encapsulated therein. Sustained release particles obtainable thereby.
摘要翻译：一种将活性物质包封在生物可降解聚合物中的新方法，其包括：a）将所述生物可降解聚合物溶解在有机溶剂中; b1）将所述活性物质分散在步骤a）中获得的有机溶液中以提供活性物质作为其内相的分散体; 或者b2）将在步骤a）中获得的有机溶液中乳化所述活性物质溶于水或其它水溶剂中，以提供具有活性物质作为其内部水相的乳液; 和c）使步骤b1）中获得的分散体，或者将步骤b2）中获得的乳液进行包封操作，以聚乙二醇水溶液作为连续相，以提供其中包封活性物质的微粒或纳米颗粒。可获得的持续释放颗粒。

2. 发明授权

US06689389B2 Pharmaceutically acceptable starch 失效
标题翻译：药学上可接受的淀粉
公开(公告)号：US06689389B2
公开(公告)日：2004-02-10
申请号：US09970648
申请日：2001-10-05
申请人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
发明人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
IPC分类号： A61K950
CPC分类号： A61K9/1652 , C08B30/04 , C08B30/12 , Y10T428/2982 , Y10T428/2991
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来生产纯化的，肠胃外可给予的淀粉，以去除表面定位的蛋白质，脂质和内毒素，将淀粉溶解在水性介质中，通过剪切分解重量减少和任选地除去残留的水溶性蛋白质，优选通过阴离子交换色谱法。基于这种淀粉的纯化淀粉和微粒。

3. 发明申请

US20090325865A1 Liquid Formulations of Pegylated Growth Hormone 失效
标题翻译：聚乙二醇化生长激素的液体制剂
公开(公告)号：US20090325865A1
公开(公告)日：2009-12-31
申请号：US12063278
申请日：2006-08-30
申请人： Mats Reslow
发明人： Mats Reslow
IPC分类号： A61K38/22 , A61P19/02 , A61P19/10 , A61P9/00 , A61P11/00 , A61P15/08 , A61P3/00 , A61P1/00 , A61P25/32 , A61P25/34 , A61P25/36 , A61P25/24
CPC分类号： C07K14/61 , A61K38/27 , A61K47/60
摘要： Pharmaceutical compositions comprising pegylated growth hormone at pH 7 or below are provided.
摘要翻译：提供包含pH7或更低的聚乙二醇化生长激素的药物组合物。

4. 发明申请

US20070142325A1 Starch 审中-公开
标题翻译：淀粉
公开(公告)号：US20070142325A1
公开(公告)日：2007-06-21
申请号：US11701612
申请日：2007-02-02
申请人： Nils Gustavsson , Monica Jonsson , Per Berden , Timo Laakso , Mats Reslow
发明人： Nils Gustavsson , Monica Jonsson , Per Berden , Timo Laakso , Mats Reslow
IPC分类号： A61K31/718 , C08B31/00
CPC分类号： A61K31/718 , C08B30/04 , C08B30/14
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来制备纯化的，肠胃外可施用的淀粉，以去除表面定位的蛋白质，脂质和内毒素，通过酸水解使淀粉进行分子量降低，并任选地除去残留的水溶性蛋白质。基于这种淀粉的纯化淀粉和微粒。

5. 发明授权

US07033609B2 Microparticle preparation 失效
公开(公告)号：US07033609B2
公开(公告)日：2006-04-25
申请号：US09970792
申请日：2002-01-10
申请人： Nils Ove Gustavsson , Monica Jönsson , Timo Laakso , Mats Reslow , Sören Björn , Jörn Drustrup
发明人： Nils Ove Gustavsson , Monica Jönsson , Timo Laakso , Mats Reslow , Sören Björn , Jörn Drustrup
IPC分类号： A61F9/50 , B01J13/02 , B32B15/02
CPC分类号： A61K38/17 , A61K9/1652 , A61K38/27 , Y10T428/2982 , Y10T428/2991
摘要： A parenterally administrable, biodegradable microparticle preparation containing a biologically active substance which, during the first 24 hours after injection, exhibits a release of the active substance that is less than 25% of the total release, determined from a concentration-time curve in the form of the ratio between the area under the curve during the said first 24 hours and the total area under the curve in question

6. 发明授权

US06706288B2 Microparticles 失效
标题翻译：微粒
公开(公告)号：US06706288B2
公开(公告)日：2004-03-16
申请号：US09970793
申请日：2001-10-05
申请人： Nils Ove Gustavsson , Monica Jönsson , Timo Laakso , Mats Reslow
发明人： Nils Ove Gustavsson , Monica Jönsson , Timo Laakso , Mats Reslow
IPC分类号： A61K950
CPC分类号： A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/5031 , A61K9/5073 , A61K38/00 , B01J13/02 , B01J13/22 , Y10T428/2982 , Y10T428/2991
摘要： A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.
摘要翻译：制备肠胃外给药的微粒的方法，其中制备分子量降低的至少20重量％的纯化支链淀粉基淀粉水溶液，该溶液与生物活性物质组合，淀粉液滴的乳液形成于聚合物溶液的外相，淀粉液滴凝胶化，凝胶化淀粉颗粒干燥。释放控制壳任选也被施加到颗粒上。基本上由所述淀粉组成的微粒的氨基酸含量小于50杯，并且没有共价的化学交联。

7. 发明授权

US06616948B2 Starch 失效
标题翻译：淀粉
公开(公告)号：US06616948B2
公开(公告)日：2003-09-09
申请号：US09970795
申请日：2001-10-05
申请人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
发明人： Nils Ove Gustavsson , Monica Jönsson , Per Berdén , Timo Laakso , Mats Reslow
IPC分类号： A61K950
CPC分类号： A61K9/1652 , C08B30/04 , C08B30/12 , Y10T428/2982 , Y10T428/2991
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来制备纯化的，肠胃外可施用的淀粉，以去除表面定位的蛋白质，脂质和内毒素，通过酸水解使淀粉进行分子量降低，并任选地除去残留的水溶性蛋白质。基于这种淀粉的纯化淀粉和微粒。

8. 发明授权

US08293708B2 Liquid formulations N-terminal serine of pegylated growth hormone 失效
标题翻译：液体制剂聚乙二醇化生长激素的N-末端丝氨酸
公开(公告)号：US08293708B2
公开(公告)日：2012-10-23
申请号：US12063278
申请日：2006-08-30
申请人： Mats Reslow
发明人： Mats Reslow
IPC分类号： A61K38/27 , C07K14/61 , A61K38/00 , C07K1/107
CPC分类号： C07K14/61 , A61K38/27 , A61K47/60
摘要： Pharmaceutical compositions comprising pegylated growth hormone at pH 7 or below are provided.
摘要翻译：提供包含pH7或更低的聚乙二醇化生长激素的药物组合物。

9. 发明申请

US20120108512A1 STABLE PHARMACEUTICAL COMPOSITIONS OF PEPTIDE DERIVATIZED USING AN OXIME LINKER 审中-公开
标题翻译：使用OXIME连接器衍生的肽的稳定的药物组合物
公开(公告)号：US20120108512A1
公开(公告)日：2012-05-03
申请号：US13318865
申请日：2010-05-07
申请人： Mats Reslow
发明人： Mats Reslow
IPC分类号： A61K38/27 , A61P5/06 , C07K14/61
CPC分类号： C07K14/61 , A61K47/60
摘要： The invention relates to stable pharmaceutical compositions comprising a therapeutic peptide derivatized with a property-modifying group, wherein the property-modifying group is conjugated to the peptide by use of a linker comprising an oxime bond.
摘要翻译：本发明涉及稳定的药物组合物，其包含用性质改性基团衍生化的治疗性肽，其中通过使用包含肟键的接头将性质修饰基团与肽缀合。

10. 发明授权

US06616949B2 Process for producing microparticles 失效
公开(公告)号：US06616949B2
公开(公告)日：2003-09-09
申请号：US09970796
申请日：2001-10-05
申请人： Monica Jönsson , Timo Laakso , Mats Reslow
发明人： Monica Jönsson , Timo Laakso , Mats Reslow
IPC分类号： B01J1302
CPC分类号： A61K9/5089 , Y10T428/2985
摘要： A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an organic polymer solution, the composition obtained is mixed, after the admixture of said polymer solution, with an aqueous polymer solution, thereby forming an emulsion of droplets of first mentioned polymer as the internal phase, said droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these.

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