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1. 发明申请

US20090294051A1 OPTICAL CONTACTING ENABLED BY THIN FILM DIELECTRIC INTERFACE 审中-公开
标题翻译：薄膜电介质接口使光学接触
公开(公告)号：US20090294051A1
公开(公告)日：2009-12-03
申请号：US12432485
申请日：2009-04-29
申请人： Nick Traggis , Neil R. Claussen , Ove Lyngnes , Christopher J. Myatt
发明人： Nick Traggis , Neil R. Claussen , Ove Lyngnes , Christopher J. Myatt
IPC分类号： B32B37/02
CPC分类号： C03C27/06 , Y10T156/10
摘要： A method of assembling precision optical or optomechanical components of otherwise incompatible chemistry that provides first and second components having respective first and second polished contacting surfaces to be bonded; deposits a thin film dielectric coating at the surface of the first and or second polished surface, and contacts the coated portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structure.
摘要翻译：组装否则不相容的化学品的精密光学或光学机械部件的方法，其提供具有相应的待接合的第一和第二抛光接触表面的第一和第二部件; 在第一和/或第二抛光表面的表面沉积薄膜电介质涂层，并且在保持两个部件的对准的同时与要接合的相应的接触表面接触第一或第二部件的涂覆部分，以形成单个结构体。

2. 发明申请

US20090294017A1 OPTICAL CONTACTING ENABLED BY THIN FILM DIELECTRIC INTERFACE 审中-公开
公开(公告)号：US20090294017A1
公开(公告)日：2009-12-03
申请号：US12263806
申请日：2008-11-03
申请人： Nick Traggis , Neil R. Claussen , Ove Lyngnes , Christopher J. Myatt
发明人： Nick Traggis , Neil R. Claussen , Ove Lyngnes , Christopher J. Myatt
IPC分类号： B32B38/08 , B32B38/00
CPC分类号： C03C27/06 , C04B37/005 , C04B37/045 , C04B2237/062 , C04B2237/064 , C04B2237/066 , C04B2237/068 , C04B2237/34 , C04B2237/341 , C04B2237/343 , C04B2237/36 , C04B2237/52
摘要： A method of assembling precision optical or optomechanical components of otherwise incompatible chemistry that provides first and second components having respective first and second polished contacting surfaces to be bonded; deposits a thin film dielectric coating at the surface of the first and or second polished surface, and contacts the coated portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structure.

3. 发明申请

US20090294050A1 OPTICAL CONTACTING ENHANCED BY HYDROXIDE IONS IN A NON-AQUEOUS SOLUTION 审中-公开
标题翻译：氢氧化物离子在非水溶液中增强的光学接触
公开(公告)号：US20090294050A1
公开(公告)日：2009-12-03
申请号：US12233911
申请日：2008-09-19
申请人： Nick Traggis , Christopher J. Myatt
发明人： Nick Traggis , Christopher J. Myatt
IPC分类号： B32B37/12 , B32B37/00
CPC分类号： C03C27/06 , C04B37/001 , C04B37/005 , C04B2237/02 , C04B2237/34 , C04B2237/341 , C04B2237/343 , C04B2237/52
摘要： This invention is a method of assembling precision optical or optomechanical components that provides first and second components having respective first and second polished contacting surfaces to be bonded; generates a hydrophilic surface on at least a portion of at least one of the first or second surfaces; rinses the hydrophilic portion with water or another suitable solvent; and contacts the hydrophilic portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structure
摘要翻译：本发明是一种组装精密光学或光学机械部件的方法，其提供具有相应的第一和第二抛光接触表面的第一和第二部件将被接合; 在至少一个第一或第二表面的至少一部分上产生亲水表面; 用水或其他合适的溶剂漂洗亲水部分; 并且将第一或第二部件的亲水部分与要接合的各个接触表面接触，同时保持两个部件的对准，以形成单个结构

4. 发明申请

US20100284430A1 SYSTEMS AND METHODS FOR GENERATING HIGH REPETITION RATE ULTRA-SHORT OPTICAL PULSES 审中-公开
标题翻译：用于产生高反射率超短脉冲脉冲的系统和方法
公开(公告)号：US20100284430A1
公开(公告)日：2010-11-11
申请号：US12028459
申请日：2008-02-08
申请人： Jacob Lasri , Kurt R. Vogel , Neil R. Claussen , Christopher J. Myatt
发明人： Jacob Lasri , Kurt R. Vogel , Neil R. Claussen , Christopher J. Myatt
IPC分类号： H01S3/098
CPC分类号： H01S3/06791 , H01S3/0064 , H01S3/08004 , H01S3/1062 , H01S3/1109 , H01S3/1118 , H01S3/1305
摘要： Systems, methods, circuits and/or devices for generating high repetition rate ultra-short pulses are described. As one of many examples, an optical pulse generating laser system is described that produces mode-locked optical pulses. The laser system incorporates an optical pulse generation device that includes two optical loops coupled via a beam splitter. In addition, the optical pulse generation device includes an optical gain medium that is associated with the first optical loop, and a saturable element that is disposed in either the first optical loop or the second optical loop. The saturable element is operable to modulate a group of optical pulses propagating in at least one of the first optical loop and the second optical loop to create a group of substantially regular modulated pulses.
摘要翻译：描述了用于产生高重复率超短脉冲的系统，方法，电路和/或装置。作为许多示例之一，描述了产生锁模光脉冲的光脉冲产生激光系统。激光系统包括光脉冲发生装置，其包括通过分束器耦合的两个光环路。此外，光脉冲发生装置包括与第一光环路相关联的光学增益介质和设置在第一光环路或第二光环路中的可饱和元件。可饱和元件可操作以调制在第一光学环路和第二光学环路中的至少一个中传播的一组光脉冲，以产生一组基本上规则的调制脉冲。

5. 发明授权

US08697435B2 Integrated sample preparation and analyte detection 有权
标题翻译：综合样品制备和分析物检测
公开(公告)号：US08697435B2
公开(公告)日：2014-04-15
申请号：US12871402
申请日：2010-08-30
申请人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
发明人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
IPC分类号： C12M1/34 , G01N33/543
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/585 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
摘要翻译：用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二型颗粒，其包括对目标分析物特异性的结合部分并且能够产生信号。当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

6. 发明申请

US20120088230A1 System And Method For Cell Analysis 审中-公开
标题翻译：细胞分析系统与方法
公开(公告)号：US20120088230A1
公开(公告)日：2012-04-12
申请号：US13270973
申请日：2011-10-11
申请人： Monique Givens , Jeffrey Ives , Michael J. Lochhead , Marie J. Delaney , Kevin D. Moll , Keagan B. Rowley , Kurt R. Vogel , Christopher J. Myatt
发明人： Monique Givens , Jeffrey Ives , Michael J. Lochhead , Marie J. Delaney , Kevin D. Moll , Keagan B. Rowley , Kurt R. Vogel , Christopher J. Myatt
IPC分类号： C12Q1/70 , C12Q1/02 , C12M1/34 , G01N21/75
CPC分类号： G01N21/648 , G01N21/0303 , G01N21/7703 , G01N33/54373 , G01N2015/008 , G01N2015/1486
摘要： A system for enumeration of objects such as cells in a sample is disclosed. The system uses a low-cost cartridge and a reader instrument, based on planar waveguide imaging technology. Cells of a blood sample may be stained with fluorescence-tagged antibodies and are loaded onto the cartridge where the differentially labeled cells may be distinguished and quantified.
摘要翻译：公开了一种用于枚举样品中诸如细胞的物体的系统。该系统采用基于平面波导成像技术的低成本墨盒和读取器仪器。血液样品的细胞可以用荧光标记的抗体染色并加载到盒上，其中区分和定量差异标记的细胞。

7. 发明授权

US08586347B2 System and method for detecting multiple molecules in one assay 有权
标题翻译：在一个测定中检测多个分子的系统和方法
公开(公告)号：US08586347B2
公开(公告)日：2013-11-19
申请号：US13233794
申请日：2011-09-15
申请人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
发明人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
IPC分类号： C40B30/04 , G01N21/75 , C12Q1/68 , C12M1/00
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

8. 发明授权

US08300993B2 Waveguide with integrated lens 有权
标题翻译：波导与集成镜头
公开(公告)号：US08300993B2
公开(公告)日：2012-10-30
申请号：US12617535
申请日：2009-11-12
申请人： Kevin D. Moll , Kurt R. Vogel , Marie J. Delaney , Michael J. Lochhead , Christopher J. Myatt
发明人： Kevin D. Moll , Kurt R. Vogel , Marie J. Delaney , Michael J. Lochhead , Christopher J. Myatt
IPC分类号： G02B6/12
CPC分类号： G01N21/552 , G02B6/12004 , G02B6/4206 , G02B2006/12102
摘要： A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.
摘要翻译：可以使用包括光源，平面波导和折射体积的装置照亮样品进行分析。光源沿着传播矢量提供光。平面波导取向为使得传播矢量垂直于平面波导的法线向量并且平行于平面波导的方向平行于平面波导的法向矢量。折射体积位于平面波导附近，并且可将由光源提供的光光学耦合到平面波导。

9. 发明申请

US20120071342A1 SYSTEM AND METHOD FOR DETECTING MULTIPLE MOLECULES IN ONE ASSAY 有权
标题翻译：用于在一个测定中检测多个分子的系统和方法
公开(公告)号：US20120071342A1
公开(公告)日：2012-03-22
申请号：US13233794
申请日：2011-09-15
申请人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
发明人： Michael J. Lochhead , Jeffrey Ives , Kathryn Todorof , Charles Greef , Marie J. Delaney , Kevin D. Moll , Kurt R. Vogel , Keagan B. Rowley , Evelyn S. Woodruff , John S. Dunn , Christopher J. Myatt , Daniel T. Nieuwlandt
IPC分类号： C40B30/04 , G01N21/64 , C12Q1/70 , C12M1/34 , G01N21/75 , C40B60/12
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

10. 发明申请

US20110065209A1 Integrated Sample Preparation and Analyte Detection 有权
标题翻译：综合样品制备和分析物检测
公开(公告)号：US20110065209A1
公开(公告)日：2011-03-17
申请号：US12871402
申请日：2010-08-30
申请人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
发明人： James R. Heil , Michael J. Lochhead , Kevin D. Moll , Christopher J. Myatt
IPC分类号： G01N33/53 , G01N30/96
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/585 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
摘要翻译：用于样品制备和分析物检测的系统包括具有流体通道，波导和捕获点的盒。该系统还包括力场发生器，成像系统和流体，其包括潜在地包含目标分析物的样品，第一类型颗粒，其包括对于目标分析物特异的并且对力场有反应的结合部分，并且第二型颗粒，其包括对目标分析物特异性的结合部分并且能够产生信号。当样品含有目标分析物时，目标分析物和结合部分之间的特异性结合相互作用通过目标分析物连接第一和第二类型颗粒，以在捕捉点处形成可以捕获的多重颗粒复合物。力场允许操作颗粒和多颗粒复合物，使得来自第二类型颗粒的检测信号指示样品内的目标分析物。

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