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    • 3. 发明授权
    • Spotting pin
    • 点针
    • US06835352B2
    • 2004-12-28
    • US10434214
    • 2003-05-09
    • Seiichiro ItoMitsuhiro Tachibana
    • Seiichiro ItoMitsuhiro Tachibana
    • B01L302
    • B01L3/0244B01L3/0248B01L3/0262B01L2200/0605B01L2400/025B01L2400/0406Y10T436/2575
    • A spotting pin 10 capable of spotting equal amounts of a solution in a sequential manner comprises a first member 11 having a solution holding portion 13 formed at the tip thereof for holding a predetermined amount of solution, and a second member 12 having a solution supply portion 14 for holding the solution by a capillary action, the second member adapted to slide along the first member. As the solution supply portion 14 is brought into contact with the solution holding portion 13, the solution enters the solution holding portion 13 from the solution supply portion 14 by a capillary action. As the solution supply portion 14 and the solution holding portion 13 are separated from each other, a predetermined amount of the solution can be carried in the solution holding portion 13. Then, as the solution holding portion 13 is brought into contact with a water-absorbing support 21, a spot 22 of a predetermined amount of the solution can be formed thereon.
    • 能够顺序地分配等量溶液的点针10包括:第一构件11,其具有形成在其顶端处的用于保持预定量溶液的溶液保持部分13;以及第二构件12,其具有溶液供应部分 14,用于通过毛细作用保持溶液,第二构件适于沿着第一构件滑动。 当溶液供应部分14与溶液保持部分13接触时,溶液通过毛细作用从溶液供应部分14进入溶液保留部分13。 当溶液供应部分14和溶液保持部分13彼此分离时,可以在溶液保留部分13中承载预定量的溶液。然后,当溶液保持部分13与水溶液保持部分13接触时, 吸收支撑件21,可以在其上形成预定量的溶液的点22。
    • 4. 发明授权
    • Biochip reader and labeling reagent
    • 生物芯片阅读器和贴标试剂
    • US06787349B1
    • 2004-09-07
    • US09889747
    • 2001-07-19
    • Kenji YamamotoMitsuhiro TachibanaKatsuya Mizuno
    • Kenji YamamotoMitsuhiro TachibanaKatsuya Mizuno
    • C12M100
    • G01N33/543B01J2219/00536Y10T436/13
    • The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage (3) for mounting a biochip (6) and scanning the biochip (6) in a two-dimensional manner, a controller (4) for the X-Y stage, a magnetic sensor (1) for reading the magnetic field strength, an ohmmeter (2), and a computer (5) for signal processing. As a result, a high-performance, inexpensive biochip reader can be provided without using an expensive laser or an expensive optical system, by employing a magnetic sensor and a disk driving mechanism generally used in a hard disk drive and the like.
    • 与荧光方法相比,本发明提供了一种用于读取生物芯片的高灵敏度,便宜的生物芯片读取器。 生物芯片读取器设置有用于安装生物芯片(6)并以二维方式扫描生物芯片(6)的XY台(3),用于XY台的控制器(4),用于 读取磁场强度,欧姆表(2)和用于信号处理的计算机(5)。 结果,通过采用通常用于硬盘驱动器等中的磁传感器和盘驱动机构,可以提供高性能,廉价的生物芯片读取器,而不需要使用昂贵的激光器或昂贵的光学系统。