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1. 发明专利

JP2010227464A Radiation exposure system 有权
标题翻译：辐射曝光系统
公开(公告)号：JP2010227464A
公开(公告)日：2010-10-14
申请号：JP2009080857
申请日：2009-03-30
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： FURUKAWA TAKUJI , INABA HIROSHI , SATO SHINJI , SHIRAI TOSHIYUKI , NODA KOJI
IPC分类号： A61N5/10 , G21K5/00 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a radiation exposure system which can shorten the exposure time of radiation.
SOLUTION: An exposure position control part 44 has a radiation dose integration section 44a which integrates a radiation dose, an irradiation position change finalization signal acquisition section 44b which acquires an exposure position change finalization signal, a controlling delay determination section 44c, which determines as controlling delay when a radiation dose, which is integrated, reaches a radiation dose to be exposed in an exposure position and the exposure position change finalization signal is not acquired and determines that controlling delay is eliminated when the exposure position change finalization signal is acquired after that, and an exposure position change starting signal output part 44d which outputs an exposure position change start signal to an exposure position change device 31, when determined as controlling delay, the radiation dose integration section 44a integrates a radiation dose, in which monitoring is carried out, as a radiation dose in the following exposure position and the exposure position change starting signal output part 44d outputs an exposure position change start signal about the following exposure position when determined that controlling delay is eliminated.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可以缩短辐射的曝光时间的辐射曝光系统。
解决方案：曝光位置控制部分44具有放射剂量积分部分44a，放射剂量积分，获取曝光位置变化终止信号的照射位置变化结束信号获取部分44b，控制延迟确定部分44c，当被积分的辐射剂量达到要暴露于曝光位置的曝光剂量并且未获取曝光位置变化结束信号时确定为控制延迟，并且当获取曝光位置变化结束信号时确定控制延迟被消除之后，将曝光位置改变开始信号输出到曝光位置变更装置31的曝光位置变更开始信号输出部44d，当被确定为控制延迟时，放射线剂量积分部44a将放射剂量作为辐射剂量进行随访当确定控制延迟被消除时，曝光位置改变启动信号输出部分44d输出关于随后的曝光位置的曝光位置改变开始信号。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010220975A Particle ray irradiation apparatus 有权
标题翻译：颗粒射线辐射装置
公开(公告)号：JP2010220975A
公开(公告)日：2010-10-07
申请号：JP2009074731
申请日：2009-03-25
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： FURUKAWA TAKUJI , INABA HIROSHI , SATO SHINJI , SHIRAI TOSHIYUKI , NODA KOJI
IPC分类号： A61N5/10 , G21K5/00 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a particle ray irradiation apparatus which prevents a radiation dose-deficient region from being generated to allow formation of a precise distribution of radiation dose.
SOLUTION: The particle ray irradiation apparatus, which irradiates an irradiated object P1 with particle ray b1 sent from an accelerator 6, includes an irradiation dose monitor 3, a primary counter C1, and a secondary counter C2, wherein the irradiation dose monitor 3 determines the exposure dose of the particle ray b1 with which the irradiated object P1 is irradiated; the primary counter C1 bases on the signals of the exposure doses transmitted from the irradiation dose monitor 3 to integrate the doses of particle ray b1 to which the object P1 is exposed when the apparatus is set to irradiate the object P1 with particle ray b1; and the secondary counter C2 bases on the signals of the exposure doses to integrate the leaked doses of particle ray b1 to which the object P1 is unintentionally exposed when the apparatus is set to exempt the object P1 from being irradiated with particle ray b1.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种防止辐射剂量缺陷区域产生以允许形成辐射剂量的精确分布的粒子射线照射装置。解决方案：从加速器6发送的粒子射线b1照射被照射物体P1的粒子射线照射装置包括照射剂量监视器3，初级计数器C1和次级计数器C2，其中照射剂量监视器 3确定照射物体P1照射的粒子射线b1的曝光量; 主计数器C1基于从照射剂量监视器3发送的暴露剂量的信号，以将当设备被设置成用粒子射线b1照射物体P1时将对象P1暴露于的粒子束b1的剂量进行积分; 并且次级计数器C2基于曝光剂量的信号，以将当设备被设定为豁免对象P1被粒子射线b1照射时，对象物P1被无意地暴露的粒子射线b1的泄漏剂量进行积分。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2009045229A Method and apparatus for scanning irradiation 有权
标题翻译：扫描辐射的方法和装置
公开(公告)号：JP2009045229A
公开(公告)日：2009-03-05
申请号：JP2007214122
申请日：2007-08-20
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： KITAGAWA ATSUSHI , KANAZAWA MITSUTAKA , NODA KOJI , SATO SHINJI , SUDA MITSURU , FUJITA TAKASHI
IPC分类号： A61N5/10 , G21K5/00 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a scanning irradiation method using a three-dimensional scanning method which enables accurate irradiation based on predetermined forms and radiation dosage even if the irradiation area is moved with a repetitive change of a position caused by biological activities such as breath and pulse.
SOLUTION: The scanning irradiation method related includes the step S2 of measuring the radiation dosage, the step S3 of measuring the differential radiation dosage, and the step S4 of setting the amount of radiation dosage, and the step S3 of measuring the differential radiation dosage, and the step S4 of setting the amount of radiation dosage are repeatedly performed until the predetermined conditions are satisfied.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用三维扫描方法的扫描照射方法，其能够基于预定形式和辐射剂量进行精确照射，即使照射区域随着生物活性引起的位置的重复变化而移动如呼吸和脉搏。解决方案：相关的扫描照射方法包括测量辐射剂量的步骤S2，测量差分辐射剂量的步骤S3和设定辐射剂量的步骤S4，以及测量差分步骤S3 辐射剂量，并且重复执行设定辐射剂量的步骤S4，直到满足预定条件。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2010060523A Beam position monitor and beam position measuring method of particle beam therapy device 有权
标题翻译：粒子束处理装置的光束位置监测器和光束位置测量方法
公开(公告)号：JP2010060523A
公开(公告)日：2010-03-18
申请号：JP2008228925
申请日：2008-09-05
申请人： Natl Inst Of Radiological Sciences , Toshiba Corp , 株式会社東芝 , 独立行政法人放射線医学総合研究所
发明人： FURUKAWA TAKUJI , INABA HIROSHI , SATO SHINJI , NODA KOJI , IZEKI YASUSHI , HANAWA KATSUSHI , AMEMORI KIYOYUKI , SUETAKE NORIO
IPC分类号： G01T1/29 , A61N5/10 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a beam position monitor and a beam position measuring method for a particle beam therapy device capable of measuring beam position of particle beam with sufficient precision even if it is in the raster scanning method and attains miniaturization or cost reduction of the beam position monitor. SOLUTION: A particle beam irradiated to a test substance 10 receives signal created in a condition where no scanning is implemented from one stopping irradiation spot to next stopping irradiation spot as a timing signal to create digital signal using collected charge acquired at a timing receiving the timing signal concerned. Thus created digital signal is used to calculate the beam position of the particle beam. The main configuration includes an I/V converter 501 creating voltage signal through I/V conversion of current output depending on collected charge, an ADC circuit 503 creating digital signal through A/D conversion of the created voltage signal, an FPGA 504 calculating the beam position using created digital signal, and a radiation dosage termination signal transmitting/receiving section 505 receiving timing signal. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决的问题：提供一种用于粒子束治疗装置的束位置监测器和束位置测量方法，其能够以足够的精度测量粒子束的束位置，即使它是光栅扫描方法并且实现小型化，或者光束位置监视器的成本降低。照射到测试物质10的粒子束接收在从一个停止照射点到下一个停止照射点不进行扫描的条件下产生的信号作为定时信号，以使用在定时处采集的收集电荷来创建数字信号接收有关的定时信号。这样创建的数字信号用于计算粒子束的光束位置。主要配置包括：I / V转换器501，其根据收集的电荷产生电流输出的I / V转换产生电压信号; ADC电路503，通过所产生的电压信号的A / D转换产生数字信号;计算光束的FPGA504 使用创建的数字信号的位置，以及接收定时信号的辐射剂量终止信号发送/接收部分505。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2010032419A Exposure dose confirmation system and exposure dose confirmation method 有权
标题翻译：接触剂量确认系统和接触剂量确认方法
公开(公告)号：JP2010032419A
公开(公告)日：2010-02-12
申请号：JP2008196333
申请日：2008-07-30
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： FURUKAWA TAKUJI , SAOTOME NAOYA , INABA HIROSHI , IWATA YOSHIYUKI , SATO SHINJI , NODA KOJI
IPC分类号： G01T1/29 , A61N5/10 , G01T1/20
摘要： PROBLEM TO BE SOLVED: To provide an exposure dose confirmation system capable of confirming a dose distribution of a charged particle beam before, during or after actual exposure.
SOLUTION: The exposure dose confirmation system 1 confirms an exposure dose of a particle beam irradiation apparatus 2 which delivers the charged particle beam B to each irradiation stratum of a three-dimensional radiation field defined by a depth direction Z to an advance direction of the charged particle beam B transported from a particle accelerator, and a crosswise direction X and a longitudinal direction Y on a plane perpendicular to the advance direction, divided into a plurality of strata in the depth direction. Three-dimensional radiation field dose distribution data representing the exposure dose in the three-dimensional radiation field is generated from depth information related to a depth of the irradiation stratum, two-dimensional distribution information related to a two-dimensional distribution of the charged particle beam B, and dose information related to a dose to confirm consistency with a dose in a pre-set premeditated dose distribution.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够在实际曝光之前，期间或之后确认带电粒子束的剂量分布的曝光剂量确认系统。曝光剂量确认系统1确认粒子束照射装置2的曝光量，该粒子束照射装置2将由深度方向Z限定的三维辐射场的每个照射层的带电粒子束B输送到前进方向的从颗粒加速器输送的带电粒子束B和在与前进方向垂直的平面上的横向X和纵向方向Y被分成深度方向上的多个层。从与照射层的深度相关的深度信息生成表示三维辐射场中的曝光剂量的三维辐射场剂量分布数据，与带电粒子束的二维分布有关的二维分布信息 B和与剂量相关的剂量信息以确认与预先设定的预定剂量分布中的剂量的一致性。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2008226740A Particle accelerator, its operation method, and particle beam irradiation therapy device 有权
标题翻译：颗粒加速器，其操作方法和粒子束辐照治疗装置
公开(公告)号：JP2008226740A
公开(公告)日：2008-09-25
申请号：JP2007065941
申请日：2007-03-15
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： IWATA YOSHIYUKI , NODA KOJI , FURUKAWA TAKUJI , SATO SHINJI
IPC分类号： H05H13/04 , A61N5/10
摘要： PROBLEM TO BE SOLVED: To provide a particle accelerator capable of reducing an operation time for providing a required irradiation amount, and effective for improvement of utilization efficiency and reduction of irradiation cost of a charged particle beam; its operation method; and a particle beam irradiation therapy device equipped with the particle accelerator. SOLUTION: Multiple times of extraction cycles each executing, after an entering process of entering charged particles in to a synchrotron, an acceleration or deceleration process of accelerating or decelerating the charged particles to predetermined energy in a high-frequency acceleration cavity while revolving them on an orbit in the synchrotron, and an emission process of emitting the accelerated charged particles from the synchrotron are executed to accelerate the charged particles to energy values different from one another in the respective processes; and the charged particles accelerated to the energy values different from one another are emitted in the emission processes in the extraction cycles of the acceleration or deceleration processes. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够减少提供所需照射量的操作时间的颗粒加速器，并且有效地提高了带电粒子束的利用效率和降低照射成本; 其操作方法; 以及配备有粒子加速器的粒子束照射治疗装置。解决方案：在将带电粒子进入同步加速器的进入过程之后，执行多次提取循环，加速或减速加速或减速高频加速腔中的预定能量的加速或减速过程，同时旋转它们在同步加速器中的轨道上，并且执行从同步加速器发射加速带电粒子的发射过程，以将带电粒子加速到各个处理中彼此不同的能量值; 并且在加速或减速过程的提取循环中的发射过程中发射加速到彼此不同的能量值的带电粒子。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2008154627A Particle beam irradiation system, computer program used therefor, and computer readable storage medium 有权
标题翻译：颗粒光束辐射系统，其使用的计算机程序和计算机可读存储介质
公开(公告)号：JP2008154627A
公开(公告)日：2008-07-10
申请号：JP2006343489
申请日：2006-12-20
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： FURUKAWA TAKUJI , INABA HIROSHI , SATO SHINJI , NODA KOJI
IPC分类号： A61N5/10 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To make it possible to shorten an irradiation time, reduce temporal loads on a subject to be irradiated, and also improve the precision of irradiation.
SOLUTION: In the particle beam irradiation system 10 having an accelerator 12 for emitting a charged particle beam 2 and a radiator 20 for performing scanning irradiation of the charged particle beam emitted by the accelerator to the subject 6 to be irradiated where a cycle fluctuates many times, the system is provided with: a means for modulating beam intensity which modulates the beam intensity from the accelerator (S2) to supply an amount of beam irradiation corresponding to a size of each scanning region formed in a layer by dividing the object to be radiated in a beam axial direction; and a means for performing scanning irradiation of each amount of beam irradiation which is supplied by the charged particle beam modulated by the means for modulating the beam intensity during a gate period when a displacement amount of cycle fluctuation of the object to be radiated is within a prescribed phase (S3, S4, and S5).
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了缩短照射时间，减少被照射对象的时间负荷，并且也提高照射精度。解决方案：在具有用于发射带电粒子束2的加速器12的粒子束照射系统10和用于执行由加速器发射的带电粒子束的扫描照射到待照射的被摄体6的辐射体20中，波动多次，系统具有：用于调制光束强度的装置，其调制来自加速器（S2）的光束强度，以通过分割对象来提供对应于形成在层中的每个扫描区域的尺寸的光束照射量沿光束轴向辐射; 以及用于执行扫描照射的各种量的光束照射的装置，所述光束照射量由在待扫描物体的周期波动的位移量在栅极周期内时由用于调制光束强度的装置调制的带电粒子束提供，规定阶段（S3，S4和S5）。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2008136523A Irradiation planning method, apparatus, particle beam irradiation system and computer program for them 有权
标题翻译：辐射规划方法，装置，粒子束辐射系统及其计算机程序
公开(公告)号：JP2008136523A
公开(公告)日：2008-06-19
申请号：JP2006322939
申请日：2006-11-30
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： INABA HIROSHI , FURUKAWA TAKUJI , SATO SHINJI , NODA KOJI
IPC分类号： A61N5/10
摘要： PROBLEM TO BE SOLVED: To reduce burden of an irradiation object by reducing irradiation time while securing a flat and uniform dose distribution on a target.
SOLUTION: In a particle beam irradiation system 20, an irradiation object 6 is irradiated with a charged particle beam 2 emitted from an accelerator 22 by means of an irradiation apparatus 30. An irradiation parameter of the particle beam irradiation system is determined by an irradiation planning method. The irradiation planning method is employed to estimate irradiation error due to the particle beam irradiation system and to determine an irradiation parameter by considering the estimated irradiation error.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过减少照射时间来减轻照射对象的负担，同时确保目标上的均匀和均匀的剂量分布。解决方案：在粒子束照射系统20中，通过照射装置30对从加速器22发射的带电粒子束2照射照射物体6.粒子束照射系统的照射参数由辐射计划方法。使用照射规划方法来估计由于粒子束照射系统引起的照射误差，并且通过考虑估计的照射误差来确定照射参数。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2012239430A Gene identification method and expression analysis method in comprehensive fragment analysis 有权
标题翻译：基因识别方法和综合分析中的表达分析方法
公开(公告)号：JP2012239430A
公开(公告)日：2012-12-10
申请号：JP2011112887
申请日：2011-05-19
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所 , Maze:Kk , 株式会社メイズ
发明人： ABE MASUMI , YUNOKAWA HARUNOBU , SATO SHINJI , KONDO KAZUHIRO , HINAGATA TAKASHI
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/53 , G01N37/00
CPC分类号： C12Q1/6809 , C12Q2521/301
摘要： PROBLEM TO BE SOLVED: To provide a gene identification method and an expression analysis method that are simple and easy while holding high reliability, and a database construction method for a comprehensive fragment analysis for use in the methods.SOLUTION: The database construction method includes steps for fragmenting genomic DNA contained in a sample or cDNA obtained from a transcription product and imparting an identifiable indicator sequence to obtain a fragment DNA mixture; carrying out high-speed DNA sequencing of a portion of the fragment DNA mixture and acquiring lead sequence data on all fragment DNA contained therein; examining the presence of indicator sequence portions on all the lead sequence data and extracting the lead sequence data having the indicator sequence; carrying out clustering and assembling of the sequences using sequence similarity and sequence length parameters on all the extracted lead sequence data to form a plurality of clusters, and acquiring the number of structural sequences of the clusters, consensus sequence and consensus sequence length, and alignment information on the clusters.
摘要翻译：要解决的问题：提供简单易行且保持高可靠性的基因鉴定方法和表达分析方法，以及用于该方法的全面片段分析的数据库构建方法。解决方案：数据库构建方法包括将样本中包含的基因组DNA片段化或从转录产物获得的cDNA，并赋予可识别的指示序列以获得片段DNA混合物的步骤; 对片段DNA混合物的一部分进行高速DNA测序，并获取其中所含的所有片段DNA的引导序列数据; 检查所有引导序列数据上的指示符序列部分的存在并提取具有指示符序列的引导序列数据; 使用序列相似性和序列长度参数对所有提取的引导序列数据进行序列的聚类和组合以形成多个簇，并获取簇的结构序列数，共有序列和共有序列长度以及对齐信息在集群上。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2011212113A Particle beam irradiation system and particle beam irradiation method 有权
标题翻译：粒子束辐射系统和粒子束辐射方法
公开(公告)号：JP2011212113A
公开(公告)日：2011-10-27
申请号：JP2010081372
申请日：2010-03-31
申请人： Natl Inst Of Radiological Sciences , 独立行政法人放射線医学総合研究所
发明人： SATO SHINJI , SHIRAI TOSHIYUKI , FURUKAWA TAKUJI , NODA KOJI , MIZUSHIMA KOTA
IPC分类号： A61N5/10 , G21K5/04
摘要： PROBLEM TO BE SOLVED: To provide a particle beam irradiation system which maintains an extracted dose of charged particle beams constant.SOLUTION: In the particle beam irradiation system 1A, an accelerator control section 71 and an RF-KO (Radio Frequency-Knock Out) electrode driving device 80A for driving and controlling a synchrotron 40 drive the synchrotron 40 while stopping driving of an RF-KO electrode 45. The accelerator control section and the RF-KO electrode driving device then apply a first RF-KO signal to the RF-KO electrode 45 as RF-KO voltage, and apply the first RF-KO signal and a second RF-KO to the RF-KO electrode 45 signal as RF-KO voltage. The accelerator control section and the RF-KO electrode driving device then start feedback control of the RF-KO voltage on the basis of the dose of charged particle beams extracted from the synchrotron 40. Gain of the feedback control is continuously raised from zero to a predetermined value, and a feedback control of the RF-KO voltage is carried out while keeping the gain of the feedback control at the predetermined value.
摘要翻译：要解决的问题：提供一种维持提取剂量的带电粒子束恒定的粒子束照射系统。解决方案：在粒子束照射系统1A中，加速器控制部分71和RF-KO（射频消失）用于驱动和控制同步加速器40的电极驱动装置80A驱动同步加速器40，同时停止RF-KO电极45的驱动。加速器控制部分和RF-KO电极驱动装置然后将第一RF-KO信号施加到RF- KO电极45作为RF-KO电压，并将第一RF-KO信号和第二RF-KO施加到RF-KO电极45的信号作为RF-KO电压。加速器控制部分和RF-KO电极驱动装置然后基于从同步加速器40提取的带电粒子束的剂量开始对RF-KO电压的反馈控制。反馈控制的增益从零增加到在将反馈控制的增益保持在预定值的同时执行RF-KO电压的反馈控制。

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