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1. 发明专利

JP2006219455A Method for separation or concentration of protein in high efficiency 有权
标题翻译：高效分离或浓缩蛋白质的方法
公开(公告)号：JP2006219455A
公开(公告)日：2006-08-24
申请号：JP2005036310
申请日：2005-02-14
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IMURA TOMOHIRO , KITAMOTO MASARU , YAGISHITA HIROSHI , NEGISHI HIDEYUKI , IKEGAMI TORU
IPC分类号： C07K1/22 , A23L1/305 , A61K39/395
摘要： PROBLEM TO BE SOLVED: To provide a low-molecular low-cost affinity ligand for various useful proteins such as antibodies and usable as a substitute for protein A and a means for easily separating or concentrating the useful proteins in high efficiency by using the affinity ligand without using a complicate multicomponent system. SOLUTION: The concentration method separates or concentrates a useful protein such as an antibody in high efficiency by an aqueous two-layer separation method using a glycolipid as an affinity ligand to quickly separate or concentrate the useful protein in high efficiency. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为各种有用的蛋白质如抗体提供低分子低成本的亲和配体，可用作蛋白质A的替代物，以及通过使用高效率容易地分离或浓缩有用的蛋白质的方法不使用复杂多组分体系的亲和配体。解决方案：浓缩方法通过使用糖脂作为亲和配体的水性双层分离方法以高效率分离或浓缩有用的蛋白质如抗体，以高效率快速分离或浓缩有用的蛋白质。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006042673A Membrane-separating/purifying system of fermented ethanol 有权
标题翻译：发酵乙醇的膜分离/净化系统
公开(公告)号：JP2006042673A
公开(公告)日：2006-02-16
申请号：JP2004227718
申请日：2004-08-04
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IKEGAMI TORU , YAGISHITA HIROSHI , SAKAKI KEIJI , NEGISHI HIDEYUKI
IPC分类号： C12P7/06 , B01D61/14 , B01D61/36 , B01D61/58 , B01D71/02 , C07C29/76 , C07C31/08
CPC分类号： Y02E50/17
摘要： PROBLEM TO BE SOLVED: To provide a system for producing directly and continuously a high concentration ethanol from dilute ethanol fermented liquid coexisted with fermentation byproducts such as an organic acid, etc., by using a pervaporization separation method by using an ethanol selective pervaporization membrane. SOLUTION: This stable concentrated ethanol liquid production system is provided by adsorption-treating the ethanol fermented liquid with an activated carbon, adjusting and maintaining the pH of the fermented liquid containing the organic acid as the byproduct of the fermentation and presenting in the fermented liquid, in the vicinity of neutral state to present the acid as a dissociated type ion by coexisting with the activated carbon and progressing the adsorption operation to markedly reduce or avoid the adsorption of the acid to the ethanol selective pervaporization separation membrane. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种直接连续生产高浓度乙醇的方法，该稀释乙醇发酵液与发酵副产物如有机酸等共存，通过使用选择性乙醇的蒸发分离方法透气膜解决方案：这种稳定的浓缩乙醇液体生产系统是通过用活性炭对乙醇发酵液进行吸附处理而提供的，调节和保持含有机酸的发酵液体的pH作为发酵的副产物，并呈现在发酵液体在中性状态附近，通过与活性炭共存而呈现离解型离子的酸，进行吸附操作，显着降低或避免了酸向乙醇选择性透气分离膜的吸附。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2005238032A Membrane separation method for fermentation ethanol 有权
标题翻译：发酵乙醇的膜分离方法
公开(公告)号：JP2005238032A
公开(公告)日：2005-09-08
申请号：JP2004048539
申请日：2004-02-24
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IKEGAMI TORU , YAGISHITA HIROSHI , KITAMOTO MASARU , NEGISHI HIDEYUKI , IMURA TOMOHIRO
IPC分类号： C12G3/10 , B01D61/36 , B01D65/08 , B01D71/02
摘要： PROBLEM TO BE SOLVED: To provide a method for directly and continuously producing a high concentration ethanol solution by a pervaporation separation method using an ethanol selective separation membrane in a method for obtaining a concentrated ethanol liquid from a diluted ethanol-containing fermentation solution.
SOLUTION: In the method, the concentrated ethanol liquid is produced from the diluted ethanol-containing fermentation solution by controlling pH within a range of 5 to neutrality and contacting it with the pervaporation separation membrane while controlling pH of the diluted ethanol-containing fermentation solution.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过使用乙醇选择性分离膜的渗透蒸发分离方法在从含稀释乙醇的发酵液中获得浓缩乙醇液体的方法中直接连续生产高浓度乙醇溶液的方法。解决方案：在该方法中，浓缩的乙醇液体通过将pH控制在5至中性的范围内，由稀释的含乙醇发酵液制备，并与渗透蒸发分离膜接触，同时控制含稀释乙醇的pH 发酵液。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2007182345A Zeolitic separation membrane 审中-公开
标题翻译： ZEOLITIC分离膜
公开(公告)号：JP2007182345A
公开(公告)日：2007-07-19
申请号：JP2006001213
申请日：2006-01-06
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： NEGISHI HIDEYUKI , YAGISHITA HIROSHI , SAKAKI KEIJI , IKEGAMI TORU
IPC分类号： C01B39/14 , B01D67/00 , B01D69/04 , B01D69/06 , B01D71/02 , C25D13/02
摘要： PROBLEM TO BE SOLVED: To provide a separation membrane prepared by forming a zeolitic membrane as thin as possible not obtainable heretofore on the surface of a porous substrate having innumerable pores or by further forming a dense zeolitic membrane on the surface of the zeolitic membrane as thin as possible not obtainable heretofore by growing a zeolite crystal thereon.
SOLUTION: This separation membrane can be obtained by electrophoretically depositing a zeolite crystal on a porous substrate to form a thin membrane thereon and forming a dense zeolitic membrane on the thin membrane by hydrothermally synthesizing synthetic gel to grow it into a zeolite crystal.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种分离膜，其通过在具有无数孔的多孔基材的表面上形成尽可能薄的沸石膜而不能获得，或者通过在沸石表面上进一步形成致密的沸石膜迄今为止，通过在其上生长沸石晶体，薄膜尽可能薄。解决方案：该分离膜可以通过在多孔基材上电泳沉积沸石晶体以在其上形成薄膜并通过水热合成合成凝胶在薄膜上形成致密的沸石膜以将其生长成沸石晶体而获得。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2007050358A Oxide thin film on porous substrate, and method for forming the same 审中-公开
标题翻译：多孔基底上的氧化物薄膜及其形成方法
公开(公告)号：JP2007050358A
公开(公告)日：2007-03-01
申请号：JP2005237849
申请日：2005-08-18
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： NEGISHI HIDEYUKI , YAGISHITA HIROSHI , OSHIMA TOKUO , HARATANI KENJI , SAKAKI KEIJI , IKEGAMI TORU
IPC分类号： B01D69/12 , B01D69/04 , B01D69/10 , B01D71/02 , C01B13/02 , C01G51/00 , C09D1/00 , C09D5/44 , C09D129/14
摘要： PROBLEM TO BE SOLVED: To provide a thin oxygen permeable film having an oxygen permeating material and capable of obtaining a practical mechanical strength.
SOLUTION: This oxide thin film is obtained by depositing oxygen separation film material powder on the surface of electrically insulated tubular porous substrate by a migration electrodeposition method, and densely forming thin film by heat treatment. The inside of the oxygen separation film electrically insulated tubular porous substrate, is separated from migration electrodeposition liquid, and is kept in a state of existence of only a dispersion medium containing no material powder. The outside of the tubular porous body is in a contact state of the oxygen separation film material powder with the migration electrodeposition liquid.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有氧渗透材料的薄氧透过膜，并且能够获得实际的机械强度。解决方案：该氧化物薄膜通过迁移电沉积法在电绝缘管状多孔基材的表面上沉积氧分离膜材料粉末并通过热处理致密地形成薄膜而获得。氧分离膜电绝缘管状多孔质基材的内部与迁移电沉积液分离，保持仅存在不含有粉末的分散介质的状态。管状多孔体的外部处于氧分离膜材料粉末与迁移电沉积液的接触状态。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2005087890A Method and apparatus for concentrating fermented alcohol aqueous solution 有权
标题翻译：用于浓缩发泡酒精水溶液的方法和装置
公开(公告)号：JP2005087890A
公开(公告)日：2005-04-07
申请号：JP2003325278
申请日：2003-09-17
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IKEGAMI TORU , YAGISHITA HIROSHI , KITAMOTO MASARU , NEGISHI HIDEYUKI , IMURA TOMOHIRO
IPC分类号： C12G3/10 , B01D53/22 , B01D61/14 , B01D61/36 , B01D69/04 , B01D69/12 , B01D71/02 , B01D71/70
CPC分类号： B01D61/362 , B01D69/12 , B01D71/028 , C12P7/06
摘要： PROBLEM TO BE SOLVED: To provide a polyfunctional multilayer structure type separation membrane for stably producing a concentrated alcohol liquid from a dilute alcohol fermented liquid at the normal temperature using an alcohol selective separation membrane, and an alcohol manufacturing method using the separation membrane.
SOLUTION: The polyfunctional multilayer structure type separation membrane is constituted so that a porous membrane having a precise filtration function is arranged outside the alcohol permselective gas separation membrane coming into direct contact with a fermented liquid and a membrane for preventing that an organic acid is brought into contact with the alcohol permselective gas separation membrane (or adsorbed by the alcohol permselective gas separation membrane) is arranged between the precise filter membrane and the alcohol permselective gas separation membrane. The concentrated alcohol liquid is stably produced by this separation membrane.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种多官能多层结构型分离膜，用于使用醇选择性分离膜在常温下从稀醇发酵液稳定地生产浓缩醇液，以及使用该分离膜的醇制造方法。解决方案：多功能多层结构型分离膜构成为具有精确过滤功能的多孔膜布置在与发酵液直接接触的醇选择性气体分离膜的外部，并且用于防止有机酸与精选过滤膜和醇选择性气体分离膜之间布置有与醇选择性气体分离膜（或被醇选择性气体分离膜吸附）接触。通过该分离膜稳定地生产浓缩的醇液。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2006028069A Method for producing liposome utilizing coacervate 有权
标题翻译：生产使用油脂的脂质体的方法
公开(公告)号：JP2006028069A
公开(公告)日：2006-02-02
申请号：JP2004207860
申请日：2004-07-14
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IMURA TOMOHIRO , KITAMOTO MASARU , YAGISHITA HIROSHI , NEGISHI HIDEYUKI , IKEGAMI TORU
IPC分类号： A61K9/127 , A61K47/36 , A61K47/44
摘要： PROBLEM TO BE SOLVED: To provide a method for producing liposome enabling substances including medicament, physiologically active substance and gene to be efficiently encapsulated, transferable into a target cell in high efficiency, and stable for a long time in the form of an aqueous solution. SOLUTION: The method for producing liposome comprises preparing it from coacervate formed by a glycolipid-based biosurfactant. The liposome thus produced is provided. A carrier comprising the liposome and to be used for transferring a medicament, physiologically active substance or gene into a biological body or cell is also provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种能够有效包封药物，生理活性物质和基因的脂质体制造物质的制造方法，能够以高效率转移到靶细胞中，长时间稳定地以水溶液。解决方案：制备脂质体的方法包括由由基于糖脂的生物表面活性剂形成的凝聚层制备。提供如此生产的脂质体。还提供了包含脂质体并用于将药物，生理活性物质或基因转移到生物体或细胞中的载体。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2005218990A Method for forming silicalite membrane and separation membrane 有权
标题翻译：用于形成硅酸盐膜和分离膜的方法
公开(公告)号：JP2005218990A
公开(公告)日：2005-08-18
申请号：JP2004030893
申请日：2004-02-06
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： NEGISHI HIDEYUKI , YAGISHITA HIROSHI , IKEGAMI TORU , KITAMOTO MASARU , IMURA TOMOHIRO , SANO YOJI , OKAMOTO MASAYOSHI
IPC分类号： B01D71/02 , B01J19/08 , C01B37/02
摘要： PROBLEM TO BE SOLVED: To provide a zeolite separation membrane which is a thin zeolite layer deposited in fine pores existing on the surface of a porous substrate.
SOLUTION: In a method for forming a fine silicalite membrane on the surface of the porous substrate, silica seed crystals are deposited on the surface of the porous substrate by applying voltage across electrodes in the presence of the porous substrate in a state of dispersing the silica seed crystals in an organic solvent or water and the silica seed crystals are grown by hydrothermally synthesizing synthetic gels obtained by adding a silica source, an alkaline source and a template on the substrate to ion exchange water to adjust them. Further, in a method for forming a fine silicalite membrane on the surface of the porous substrate, the silica seed crystals are deposited on the surface of the porous substrate by applying voltage across the porous substrate and the electrode, then the silica seed crystals are grown by hydrothermally synthesizing synthetic gels obtained by adding the silica seed crystal on the substrate, the silica source, the alkaline source, and the template to the ion exchange water to adjust them.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种沸石分离膜，其是沉积在存在于多孔基材表面上的细孔中的薄沸石层。解决方案：在多孔基材的表面上形成精细硅沸石膜的方法中，在多孔基材的存在下，通过在多孔基材的存在下施加跨过电极的电压，将二氧化硅晶种沉积在多孔基材的表面上，将二氧化硅晶种分散在有机溶剂或水中，并通过水热合成通过在基板上添加二氧化硅源，碱性源和模板而获得的合成凝胶至离子交换水来调节二氧化硅晶种。此外，在多孔基材的表面上形成微细硅质岩膜的方法中，通过在多孔基材和电极上施加电压将二氧化硅晶种沉积在多孔基材的表面上，然后将二氧化硅晶种生长通过将通过将二氧化硅晶种添加到基板上，将二氧化硅源，碱性源和模板加入到离子交换水中而获得的合成凝胶进行水热合成以进行调整。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2005087882A Polyfunctional multilayer structure type separation membrane for manufacturing highly concentrated alcohol from fermented alcohol-containing aqueous solution 有权
标题翻译：多功能多层结构型分离膜，用于制备含浓缩酒精溶液的高浓度酒精
公开(公告)号：JP2005087882A
公开(公告)日：2005-04-07
申请号：JP2003325139
申请日：2003-09-17
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： IKEGAMI TORU , YAGISHITA HIROSHI , KITAMOTO MASARU , NEGISHI HIDEYUKI , IMURA TOMOHIRO
IPC分类号： C12G3/10 , B01D53/22 , B01D61/14 , B01D61/36 , B01D69/12 , B01D71/02 , B01D71/70
CPC分类号： B01D69/10 , B01D71/70
摘要： PROBLEM TO BE SOLVED: To provide a polyfunctional multilayer structure type separation membrane for stably producing a concentrated alcohol liquid from a dilute alcohol fermented liquid at the normal temperature using an alcohol selective separation membrane, and an alcohol manufacturing method using the separation membrane.
SOLUTION: The polyfunctional multilayer structure type separation membrane is constituted so that a porous membrane having a precise filtration function is arranged outside the alcohol permselective gas separation membrane coming into direct contact with a fermented liquid and a membrane for preventing that an organic acid is brought into contact with the alcohol permselective gas separation membrane (or adsorbed by the alcohol permselective gas separation membrane) is arranged between the precise filter membrane and the alcohol permselective gas separation membrane. The concentrated alcohol liquid is stably produced by this separation membrane.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种多官能多层结构型分离膜，用于使用醇选择性分离膜在常温下从稀醇发酵液稳定地生产浓缩醇液，以及使用该分离膜的醇制造方法。解决方案：多功能多层结构型分离膜构成为具有精确过滤功能的多孔膜布置在与发酵液直接接触的醇选择性气体分离膜的外部，并且用于防止有机酸与精选过滤膜和醇选择性气体分离膜之间布置有与醇选择性气体分离膜（或被醇选择性气体分离膜吸附）接触。通过该分离膜稳定地生产浓缩的醇液。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2009028029A Production method for ethanol 有权
标题翻译：乙醇生产方法
公开(公告)号：JP2009028029A
公开(公告)日：2009-02-12
申请号：JP2008065103
申请日：2008-03-14
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： MORITA TOMOTAKE , IKEGAMI TORU , NEGISHI HIDEYUKI , NAKAYAMA SHUNICHI , KITAMOTO MASARU , SAKAKI KEIJI , YAGISHITA HIROSHI
IPC分类号： C12P7/06 , C12R1/72 , C12R1/84
CPC分类号： Y02E50/17
摘要： PROBLEM TO BE SOLVED: To provide a means for efficiently producing high-concentration ethanol, without deteriorating the performance of pervaporation membranes, when separating and condensing ethanol from a fermented liquor after ethanol fermentation by using the pervaporation membranes.
SOLUTION: The ethanol fermentation is performed on aerobic conditions by using an ethanol fermentation microorganism, which at aerobic conditions, has fully high ethanol productivity and either not produces or hardly produces performance degradation-causative agents of pervaporation membranes which are applicable to ethanol separation and condensation, especially succinic acid, and the ethanol is separated and condensed from a fermented liquor obtained as the result.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了提供一种在通过使用渗透蒸发膜在乙醇发酵后从发酵液中分离和冷凝乙醇而不劣化渗透蒸发膜的性能的有效生产高浓度乙醇的方法。解决方案：通过使用乙醇发酵微生物在需氧条件下进行乙醇发酵，其在需氧条件下具有完全高的乙醇生产率，并且不产生或几乎不产生适用于乙醇的渗透蒸发膜的性能降解致病因子分离和缩合，特别是琥珀酸，并且从获得的发酵液中分离和冷凝乙醇。版权所有（C）2009，JPO＆INPIT

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