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1. 发明申请

US20090299462A1 ENDOVASCULAR GRAFT INCLUDING SUBSTRUCTURE FOR POSITIONING AND SEALING WITHIN VASCULATURE 审中-公开
标题翻译：包括用于在血管中定位和密封的子结构的内膜片
公开(公告)号：US20090299462A1
公开(公告)日：2009-12-03
申请号：US12470632
申请日：2009-05-22
申请人： Natalie V. Fawzi , Kimberly Barkman , Robin W. Eckert , Arnold M. Escano , Rodney H. Reinhardt , Robert A. Vincent
发明人： Natalie V. Fawzi , Kimberly Barkman , Robin W. Eckert , Arnold M. Escano , Rodney H. Reinhardt , Robert A. Vincent
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/954 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/8486 , A61F2002/9511
摘要： An endovascular graft having an improved positioning mechanism capable of positioning and securing a bifurcated graft into a bifurcated vessel described. The graft can include a sleeve affixed to graft that is used in combination with a contralateral wire loop for placement of the graft within vasculature. The graft may include a structure for post deployment positioning into the bifurcated aneurysm area. Furthermore, the endovascular graft may be configured to form a sealing pocket that expands with induced fluid pressure and prevents fluid leaks at an attachment site.
摘要翻译：具有改进的定位机构的血管内移植物，其能够将分叉的移植物定位并固定到所述的分叉血管。移植物可以包括固定到移植物上的套筒，其与对侧丝线环组合使用以将移植物放置在脉管系统内。移植物可以包括用于后部署定位到分叉动脉瘤区域中的结构。此外，血管内移植物可以构造成形成密封袋，该密封袋随着感应的流体压力而膨胀并且防止在附着部位处的流体泄漏。

2. 发明授权

US08320993B2 Subcutaneous cavity marking device 有权
标题翻译：皮下腔标记装置
公开(公告)号：US08320993B2
公开(公告)日：2012-11-27
申请号：US09805652
申请日：2001-03-13
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B5/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译：这些是皮下腔标记装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。而且，该装置包含生物可吸收或非生物可吸收标记物。该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。该方法还可以组合与所述设备一起描述的任何特征。

3. 发明授权

US08306602B2 Biopsy cavity marking device 有权
标题翻译：活检腔标记装置
公开(公告)号：US08306602B2
公开(公告)日：2012-11-06
申请号：US11241500
申请日：2005-09-30
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B19/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are site marking devices for marking a selected site within tissue of a patient. More particularly, the devices include an elongated body of gel and a metallic band disposed at least partially surrounding the body of gel. The body of gel is recognizably artificial when the marker is subject to ultrasound or x-ray imaging. Therefore, it is readily distinguishable from biological features within the tissue site.
摘要翻译：这些是用于标记患者组织内选定部位的位置标记装置。更具体地，装置包括细长的凝胶体和至少部分地围绕凝胶体的金属带。当标记物进行超声或X射线成像时，凝胶体是可识别的人造体。因此，它很容易与组织部位内的生物特征区别开来。

4. 发明授权

US08600481B2 Subcutaneous cavity marking device 有权
标题翻译：皮下腔标记装置
公开(公告)号：US08600481B2
公开(公告)日：2013-12-03
申请号：US13604158
申请日：2012-09-05
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B5/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译：这些是皮下腔标记装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。而且，该装置包含生物可吸收或非生物可吸收标记物。该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。该方法还可以组合与所述设备一起描述的任何特征。

5. 发明申请

US20120330153A1 SUBCUTANEOUS CAVITY MARKING DEVICE AND METHOD 有权
标题翻译：不饱和孔标记装置及方法
公开(公告)号：US20120330153A1
公开(公告)日：2012-12-27
申请号：US13604158
申请日：2012-09-05
申请人： D. Laksen Sirimanni , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanni , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译：这些是皮下腔标记装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。而且，该装置包含生物可吸收或非生物可吸收标记物。该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。该方法还可以组合与所述设备一起描述的任何特征。

6. 发明授权

US07668582B2 Biopsy site marker 有权
标题翻译：活检部位标记
公开(公告)号：US07668582B2
公开(公告)日：2010-02-23
申请号：US10961491
申请日：2004-10-07
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B19/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are biopsy site marking devices. More particularly, the devices include a body of gelatin and an x-ray detectable body of a specific, predetermined non-biological configuration embedded in the body of gelatin. In one embodiment, the x-ray detectable body is made from metal. In alternative embodiments, the x-ray detectable body can be made from stainless steel or metal oxides.
摘要翻译：这些是活检现场标记装置。更具体地说，这些装置包括一个明胶体和一个嵌入明胶体内的特定的预定非生物构型的x射线可检测体。在一个实施例中，X射线可检测体由金属制成。在替代实施例中，X射线可检测体可以由不锈钢或金属氧化物制成。

7. 发明授权

US09669113B1 Device and method for safe location and marking of a biopsy cavity 有权
公开(公告)号：US09669113B1
公开(公告)日：2017-06-06
申请号：US09869282
申请日：1999-12-23
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B6/00 , A61K49/00 , A61B90/00 , A61B17/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00004 , A61B2017/00539 , A61B2017/00898 , A61B2090/3912 , A61B2090/3925 , A61B2090/3962 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/0409 , A61K49/222
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

8. 发明授权

US09492570B2 Device and method for safe location and marking of a biopsy cavity 有权
标题翻译：安全定位和标记活检腔的装置和方法
公开(公告)号：US09492570B2
公开(公告)日：2016-11-15
申请号：US12777710
申请日：2010-05-11
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B6/00 , A61K49/00 , A61B17/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

9. 发明授权

US06356782B1 Subcutaneous cavity marking device and method 失效
公开(公告)号：US06356782B1
公开(公告)日：2002-03-12
申请号：US09285329
申请日：1999-04-02
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi , Gail Lebovic
IPC分类号： A61B600
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.

10. 发明授权

US6136014A Percutaneous tissue removal device 有权
标题翻译：经皮组织去除装置
公开(公告)号：US6136014A
公开(公告)日：2000-10-24
申请号：US145487
申请日：1998-09-01
申请人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi
发明人： D. Laksen Sirimanne , Douglas S. Sutton , Natalie V. Fawzi
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/28 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B17/29 , A61B17/32002 , A61B17/320068 , A61B17/32056 , A61B17/34 , A61B2017/00685 , A61B2017/00867 , A61B2017/32004 , A61B90/39
摘要： This is a device for percutaneous tissue sampling or excision. In particular, it uses a rotating cutter which produces a helically cut, discrete tissue mass that is removable through a comparatively much smaller access member. The tissue mass is easily reconstructed to its original form and orientation once taken from the body for further study.
摘要翻译：这是用于经皮组织取样或切除的装置。特别地，它使用旋转切割器，其产生可通过相对较小的进入构件移除的螺旋切割的离散组织块。组织块容易重构成其原始形式和取向，一次取自身体进一步研究。

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