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1. 发明授权

US09669113B1 Device and method for safe location and marking of a biopsy cavity 有权
公开(公告)号：US09669113B1
公开(公告)日：2017-06-06
申请号：US09869282
申请日：1999-12-23
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B6/00 , A61K49/00 , A61B90/00 , A61B17/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00004 , A61B2017/00539 , A61B2017/00898 , A61B2090/3912 , A61B2090/3925 , A61B2090/3962 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/0409 , A61K49/222
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

2. 发明授权

US09492570B2 Device and method for safe location and marking of a biopsy cavity 有权
标题翻译：安全定位和标记活检腔的装置和方法
公开(公告)号：US09492570B2
公开(公告)日：2016-11-15
申请号：US12777710
申请日：2010-05-11
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B6/00 , A61K49/00 , A61B17/00
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

3. 发明申请

US20100234726A1 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A BIOPSY CAVITY 有权
标题翻译：用于安全定位和标记生物密度的装置和方法
公开(公告)号：US20100234726A1
公开(公告)日：2010-09-16
申请号：US12777710
申请日：2010-05-11
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
IPC分类号： A61B5/05
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译：公开了腔和前哨淋巴结标记412装置，标记递送装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置，对患者的至少创伤和毒性。组合物和方法可用于标记活检腔，以及标记前哨淋巴结。标记方法还可以将所描述的特征与标记装置和递送装置组合。

4. 发明授权

US06371904B1 Subcutaneous cavity marking device and method 有权
标题翻译：皮下腔标记装置及方法
公开(公告)号：US06371904B1
公开(公告)日：2002-04-16
申请号：US09347185
申请日：1999-07-02
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail Lebovic , Stanley R. Conston , Peter M. Wilson
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail Lebovic , Stanley R. Conston , Peter M. Wilson
IPC分类号： A61N500
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： This is a subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译：这是皮下腔标记装置和方法。更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。而且，该装置包含生物可吸收或非生物可吸收标记物。该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。该方法还可以组合与所述设备一起描述的任何特征。

5. 发明授权

US08425473B2 Subretinal access device 失效
标题翻译：视网膜下进入装置
公开(公告)号：US08425473B2
公开(公告)日：2013-04-23
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61M25/00 , A61M31/00 , A61M1/00 , A61M5/32 , A61M35/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

6. 发明授权

US07967772B2 Injector for viscous materials 有权
标题翻译：注射器用于粘性材料
公开(公告)号：US07967772B2
公开(公告)日：2011-06-28
申请号：US10585909
申请日：2005-01-12
申请人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
发明人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
IPC分类号： A61N1/30
CPC分类号： A61M5/1456 , A61F9/0017 , A61M5/16854 , A61M5/31511 , A61M5/31586 , A61M5/486
摘要： An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.
摘要翻译：提供注射器用于将粘性物质的微量量输送到体内，例如眼睛，用于外科用途。注射器包括注射器本体，其中设置有柱塞，其联接到能够逐渐前进柱塞的正位移机构，以以恒定或预定的输送速率精确地输送材料的微量。

7. 发明授权

US07931596B2 Ultrasound interfacing device for tissue imaging 有权
标题翻译：用于组织成像的超声界面装置
公开(公告)号：US07931596B2
公开(公告)日：2011-04-26
申请号：US10521045
申请日：2003-07-14
申请人： Daniel Rachlin , Stanley R. Conston
发明人： Daniel Rachlin , Stanley R. Conston
IPC分类号： A61B5/05 , A61B8/00 , A61F9/00
CPC分类号： A61B8/10 , A61B8/4281 , A61B8/4422
摘要： A device (10) used with high frequency ultrasound provides a replaceable barrier between the ultrasound transducer and the tissues being imaged. The device (10) provides an acoustic pathway of minimal effect on the ultrasound signals, and furthermore provides for a safety barrier between a mechanical scanner and the tissues being imaged. The configuration of the device (10) allows it to function as a standoff for the ultrasound transducer to place the focus of the ultrasound beam at the desired depth of tissue for imaging. In addition, the device (10) may be sterilized and replaced as needed, providing sterile tissue contact surfaces. The device (10) has additional features, which are especially advantageous for diagnosis and surgery of the eye.
摘要翻译：与高频超声波一起使用的装置（10）在超声换能器和被成像的组织之间提供可替换的屏障。设备（10）提供对超声信号的影响最小的声学路径，并且还提供机械扫描仪和被成像的组织之间的安全屏障。设备（10）的配置允许其用作超声换能器的支架，以将超声波束的焦点放置在组织的期望深度以进行成像。此外，可以根据需要对装置（10）进行灭菌和更换，从而提供无菌的组织接触表面。装置（10）具有额外的特征，这对于眼睛的诊断和手术是特别有利的。

8. 发明申请

US20100191176A1 SUBRETINAL ACCESS DEVICE 失效
标题翻译： SUBRETINAL访问设备
公开(公告)号：US20100191176A1
公开(公告)日：2010-07-29
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F9/008 , A61B17/32 , A61F9/007 , A61B1/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

9. 发明授权

US06896659B2 Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility 失效
标题翻译：使用具有受控脆性的中空微泡超声触发药物递送的方法
公开(公告)号：US06896659B2
公开(公告)日：2005-05-24
申请号：US10028738
申请日：2001-10-22
申请人： Stanley R. Conston , Ronald Yamamoto , Thomas B. Ottoboni , E. Glenn Tickner
发明人： Stanley R. Conston , Ronald Yamamoto , Thomas B. Ottoboni , E. Glenn Tickner
IPC分类号： A61B8/00 , A61B8/14 , A61H1/00 , A61K9/00 , A61K9/50 , A61K41/00 , A61K47/48 , A61K49/22 , A61M37/00
CPC分类号： A61K9/5073 , A61B5/4839 , A61B8/481 , A61K9/0009 , A61K41/0028 , A61K47/6925 , A61K49/223 , A61M37/0092
摘要： A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.
摘要翻译：提供了一种方法，用于使用载有药剂的微泡群体将流体填充的空腔，血管或组织中的区域特异性递送治疗剂或诊断剂。人口控制脆性，其特征在于均匀的壁厚比，其定义了在群体中发生微泡破裂的超声功率的离散阈值强度值。可以通过超声监测微泡群体的位置，以确定其在施加超声波功率之前的区域处的存在以破裂成微泡。

10. 发明授权

US06224554B1 Method to measure ambient fluid pressure 失效
公开(公告)号：US06224554B1
公开(公告)日：2001-05-01
申请号：US09282514
申请日：1999-03-31
申请人： E. Glenn Tickner , Stanley R. Conston
发明人： E. Glenn Tickner , Stanley R. Conston
IPC分类号： A61B800
CPC分类号： A61B8/04 , A61B8/481
摘要： A method is provided for measuring real time ambient pressure at a region of interest in a fluid-filled body cavity by introducing into the cavity a composition of gas-containing microbubbles having a predetermined fragility threshold correlating to the rupture response of their capsules to the ambient fluid pressure and/or applied acoustic pressure. An ultrasonic signal is applied at the region of interest at a power level sufficient to destroy the microbubble population having a fragility threshold below the applied power level. The ultrasound backscatter response is detected from the population of intact and disintegrating microbubbles remaining at the region of interest and this backscatter signal is correlated to predetermined acoustic response properties to determine the ambient pressure at the region of interest.

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