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1. 发明申请

US20100256468A1 APPARATUS FOR MEASURING BIOLOGICAL LIGHT 审中-公开
标题翻译：用于测量生物光的装置
公开(公告)号：US20100256468A1
公开(公告)日：2010-10-07
申请号：US12600285
申请日：2008-02-01
申请人： Naoki Tanaka , Masashi Kiguchi , Atsushi Maki , Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi
发明人： Naoki Tanaka , Masashi Kiguchi , Atsushi Maki , Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi
IPC分类号： A61B5/1455 , G06N5/02
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/14553
摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.
摘要翻译：将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

2. 发明授权

US07353054B2 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07353054B2
公开(公告)日：2008-04-01
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病单位12.评估结果以条形图表示与各疾病组相似度的分数。

3. 发明授权

US08386192B2 Disease diagnosis support system 有权
标题翻译：疾病诊断支持系统
公开(公告)号：US08386192B2
公开(公告)日：2013-02-26
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： G01N33/48
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

4. 发明申请

US20090118602A1 Disease Diagnosis Support System 有权
标题翻译：疾病诊断支援系统
公开(公告)号：US20090118602A1
公开(公告)日：2009-05-07
申请号：US11916892
申请日：2006-06-08
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Hideo Kawaguchi , Naoki Tanaka , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/1455
CPC分类号： A61B5/145 , A61B5/14546 , A61B5/14553 , G06F19/00 , G16H50/70
摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.
摘要翻译：提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分，包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为在散点图上进行评估，叠加在散点图上。利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

5. 发明申请

US20070055118A1 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US20070055118A1
公开(公告)日：2007-03-08
申请号：US10571430
申请日：2004-09-09
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Fumio Kawaguchi , Naoki Tanaka , Hideo Kawaguchi , Masahiko Mikuni , Masato Fukuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14551 , A61B5/165
摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.
摘要翻译：提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估疾病，并且通过在存储的特征量和特征量之间的相似性的多变量分析中应用多变量分析，单位12.评估结果以条形图表示与各疾病组相似度的分数。

6. 发明授权

US07285790B2 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US07285790B2
公开(公告)日：2007-10-23
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

7. 发明授权

US07022083B2 Measurement system for living bodies 失效
标题翻译：活体测量系统
公开(公告)号：US07022083B2
公开(公告)日：2006-04-04
申请号：US10457478
申请日：2003-06-10
申请人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
发明人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/486 , A61B5/0086 , A61B5/1455
摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.
摘要翻译：在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

8. 发明授权

US08019399B2 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US08019399B2
公开(公告)日：2011-09-13
申请号：US10578725
申请日：2004-11-01
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
IPC分类号： A61B5/1455
CPC分类号： G06K9/0051 , A61B5/0261 , A61B5/4064 , A61B5/7203 , G06T5/002
摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.
摘要翻译：对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

9. 发明申请

US20070142719A1 Optical measurement apparatus for living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US20070142719A1
公开(公告)日：2007-06-21
申请号：US10578725
申请日：2004-11-01
申请人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
发明人： Shingo Kawasaki , Noriyoshi Ichikawa , Naoki Tanaka
IPC分类号： A61B5/00
CPC分类号： G06K9/0051 , A61B5/0261 , A61B5/4064 , A61B5/7203 , G06T5/002
摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.
摘要翻译：对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

10. 发明申请

US20060006343A1 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US20060006343A1
公开(公告)日：2006-01-12
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B8/06
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

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