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1. 发明授权

US06622095B2 Apparatus for determining concentrations of hemoglobins 有权
公开(公告)号：US06622095B2
公开(公告)日：2003-09-16
申请号：US10075623
申请日：2002-02-15
申请人： Naoki Kobayashi , Takashi Usuda , Michio Kanemoto , Yoshiaki Takamura , Teiji Ukawa
发明人： Naoki Kobayashi , Takashi Usuda , Michio Kanemoto , Yoshiaki Takamura , Teiji Ukawa
IPC分类号： A61B500
CPC分类号： A61B5/14551
摘要： An apparatus for determining concentrations of hemoglobins includes a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region, light receiving device for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue, attenuation ratio processing device for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving device, the variations are caused by a pulsation of blood and concentration ratio processing device for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing device.

2. 发明授权

US06415236B1 Apparatus for determining concentrations of hemoglobins 有权
公开(公告)号：US06415236B1
公开(公告)日：2002-07-02
申请号：US09725865
申请日：2000-11-30
申请人： Naoki Kobayashi , Michio Kanemoto , Takashi Usuda , Teiji Ukawa
发明人： Naoki Kobayashi , Michio Kanemoto , Takashi Usuda , Teiji Ukawa
IPC分类号： A61B500
摘要： An apparatus for determining concentrations of hemoglobins additionally uses a light source 3 which emits light of a third wavelength in an orangy red wavelength region of 590 to 660 nm. The apparatus includes light receiving means 6 for receiving lights that are emitted by the light sources and transmitted through or reflected by a living tissue, attenuation ratio processing means 15 for processing attenuation ratios &PHgr; on the wavelengths based on variations of signals associated with the wavelengths output from the light receiving means, which variations are caused by a pulsation of blood, and concentration ratio processing means 16 for processing concentration ratios of at least oxyhemoglobin, deoxyhemoglobin and carboxyhemoglobin based on the output signals from the attenuation ratio processing means. The apparatus thus constructed can properly measure carboxyhemoglobin COHb, and present its concentration display and an alarm display in a simple manner, which is clinically effective.

3. 发明授权

US07257433B2 Apparatus for measuring concentration of light-absorbing substance in blood 有权
标题翻译：用于测量血液中吸光物质浓度的装置
公开(公告)号：US07257433B2
公开(公告)日：2007-08-14
申请号：US10768680
申请日：2004-02-02
申请人： Yoshiaki Takamura , Naoki Kobayashi , Sunao Takeda , Takashi Usuda
发明人： Yoshiaki Takamura , Naoki Kobayashi , Sunao Takeda , Takashi Usuda
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , G01N2021/3144
摘要： An apparatus for measuring a concentration of a light-absorbing substance in blood is disclosed. A light emitter emits light beams to irradiate a living tissue, each of the light beams being associated with one wavelength which is absorbed by the blood. A first instrument measures first intensities of the light beams, which are to be incident on the living tissue. A second instrument measures second intensities of the light beams, which are transmitted through the living tissue. A first calculator calculates an attenuation variation ratio, which is a ratio of attenuation variations of the respective light beams due to variation of a volume of the blood caused by pulsation, based on the second intensities of the light beams. A second calculator calculates the concentration based on the first intensities, the second intensities, and the attenuation variation ratio.
摘要翻译：公开了一种用于测量血液中光吸收物质浓度的装置。光发射器发射光束以照射活组织，每个光束与由血液吸收的一个波长相关联。第一个仪器测量将要入射到活体组织上的光束的第一强度。第二种仪器测量透过活组织的光束的第二强度。第一计算器基于光束的第二强度计算衰减变化比，其是由于由脉动引起的血液的体积的变化引起的各个光束的衰减变化的比率。第二计算器基于第一强度，第二强度和衰减变化率来计算浓度。

4. 发明申请

US20050049469A1 Pulse oximeter 有权
标题翻译：脉搏血氧仪
公开(公告)号：US20050049469A1
公开(公告)日：2005-03-03
申请号：US10927016
申请日：2004-08-27
申请人： Takuo Aoyagi , Masayoshi Fuse , Naoki Kobayashi , Teiji Ukawa
发明人： Takuo Aoyagi , Masayoshi Fuse , Naoki Kobayashi , Teiji Ukawa
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.
摘要翻译：在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。第二计算器根据五个衰减变化计算出至少四个衰减变化率。每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

5. 发明授权

US07206621B2 Pulse oximeter 有权
标题翻译：脉搏血氧仪
公开(公告)号：US07206621B2
公开(公告)日：2007-04-17
申请号：US10927016
申请日：2004-08-27
申请人： Takuo Aoyagi , Masayoshi Fuse , Naoki Kobayashi , Teiji Ukawa
发明人： Takuo Aoyagi , Masayoshi Fuse , Naoki Kobayashi , Teiji Ukawa
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.
摘要翻译：在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。第二计算器根据五个衰减变化计算出至少四个衰减变化率。每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

6. 发明授权

US5766125A Apparatus for determining the concentration of light-absorbing materials in blood 失效
标题翻译：用于测定血液中吸光材料浓度的装置
公开(公告)号：US5766125A
公开(公告)日：1998-06-16
申请号：US429545
申请日：1995-04-27
申请人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng-tai Xie , Naoki Kobayashi , Hideaki Hirahara
发明人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng-tai Xie , Naoki Kobayashi , Hideaki Hirahara
IPC分类号： G01N21/27 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/31
CPC分类号： A61B5/14551 , G01N21/3151
摘要： Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.
摘要翻译：从发光装置发射的不同波长的光束通过活组织透射。透射光束由光电转换装置转换为电信号。脉动计算装置根据光电转换装置的输出信号，计算各波长的生物体组织的吸光度的脉动。通过使用这一点，脉动比计算装置计算吸光度值的脉动比。浓度计算装置将脉动比计算装置的输出信号设置在组织术语上具有单个未知数的公式中，其基于在各个波长的组织项之间存在预定关系的事实构成，从而计算组织术语的值和血液中光吸收材料的浓度。

7. 发明授权

US5697371A Apparatus for measuring circulating blood volume 失效
标题翻译：用于测量循环血量的装置
公开(公告)号：US5697371A
公开(公告)日：1997-12-16
申请号：US358381
申请日：1994-12-19
申请人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
发明人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
IPC分类号： A61B5/026 , A61B5/0275 , A61B5/00
CPC分类号： A61B5/0275
摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
摘要翻译：使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

8. 发明授权

US5999841A Apparatus for measuring circulating blood volume 失效
标题翻译：用于测量循环血量的装置
公开(公告)号：US5999841A
公开(公告)日：1999-12-07
申请号：US916295
申请日：1997-08-22
申请人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
发明人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
IPC分类号： A61B5/026 , A61B5/0275 , A61B6/00 , A61B5/02
CPC分类号： A61B5/0275
摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
摘要翻译：使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

9. 发明授权

US5690104A Apparatus and method for measuring oxygen saturation in blood and apparatus and method for measuring concentration of light-absorbing materials in blood 失效
标题翻译：用于测量血液中氧饱和度的装置和方法及装置及测量血液中吸光材料浓度的方法
公开(公告)号：US5690104A
公开(公告)日：1997-11-25
申请号：US661169
申请日：1996-06-10
申请人： Michio Kanemoto , Naoki Kobayashi , Takuo Aoyagi
发明人： Michio Kanemoto , Naoki Kobayashi , Takuo Aoyagi
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/6826 , A61B5/14551 , A61B5/6838 , A61B2560/0209
摘要： Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.
摘要翻译：在第一时间段内测量透过活体组织的两种不同波长的光的强度。数据处理器使用对应于在第一时间段期间测量的光强度的对数处理数据来确定第一回归线。操作者将染料注入到生物体中，并且在稍后的时间段内测量两种不同波长的光的强度。数据处理器使用对应于在稍后时间段内测量的光强度的对数处理的数据来确定第二回归线。数据处理器找到两条回归线的交点，并使用交点确定无血性水平点。然后处理器形成掺有无血型水平点数据的染料稀释曲线。

10. 发明授权

US10349842B2 Blood pressure measuring apparatus 有权
公开(公告)号：US10349842B2
公开(公告)日：2019-07-16
申请号：US13211390
申请日：2011-08-17
申请人： Takashi Usuda , Yoshiharu Kikuchi , Hideaki Hirahara , Naoki Kobayashi , Katsuyoshi Suzuki
发明人： Takashi Usuda , Yoshiharu Kikuchi , Hideaki Hirahara , Naoki Kobayashi , Katsuyoshi Suzuki
IPC分类号： A61B5/02 , A61B5/0225 , A61B5/021 , A61B5/022
摘要： A blood pressure measuring apparatus, which measures a blood pressure of a living body, includes: a cuff-pressure control unit which controls a cuff pressure of a cuff that presses a part of the living body; an oscillation signal detection unit which detects an oscillation signal from the cuff pressure; a blood pressure specification unit which specifies systolic and diastolic blood pressures as the blood pressure of the living body from the oscillation signal; and a blood pressure determination unit which determines whether systolic and diastolic blood pressures are appropriate or not. The cuff-pressure control unit controls the cuff pressure to be inflated to a first set value, the blood pressure specification unit specifies the systolic and diastolic blood pressures based on a change of an oscillation signal that is detected by the oscillation signal detection unit when the cuff pressure is inflated to the first set value, and when the blood pressure determination unit determines that both the systolic and diastolic blood pressures are appropriate, the cuff-pressure control unit ends the inflating of the cuff pressure to release the cuff pressure.

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