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1. 发明授权

US06622095B2 Apparatus for determining concentrations of hemoglobins 有权
公开(公告)号：US06622095B2
公开(公告)日：2003-09-16
申请号：US10075623
申请日：2002-02-15
申请人： Naoki Kobayashi , Takashi Usuda , Michio Kanemoto , Yoshiaki Takamura , Teiji Ukawa
发明人： Naoki Kobayashi , Takashi Usuda , Michio Kanemoto , Yoshiaki Takamura , Teiji Ukawa
IPC分类号： A61B500
CPC分类号： A61B5/14551
摘要： An apparatus for determining concentrations of hemoglobins includes a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region, light receiving device for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue, attenuation ratio processing device for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving device, the variations are caused by a pulsation of blood and concentration ratio processing device for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing device.

2. 发明授权

US06415236B1 Apparatus for determining concentrations of hemoglobins 有权
公开(公告)号：US06415236B1
公开(公告)日：2002-07-02
申请号：US09725865
申请日：2000-11-30
申请人： Naoki Kobayashi , Michio Kanemoto , Takashi Usuda , Teiji Ukawa
发明人： Naoki Kobayashi , Michio Kanemoto , Takashi Usuda , Teiji Ukawa
IPC分类号： A61B500
摘要： An apparatus for determining concentrations of hemoglobins additionally uses a light source 3 which emits light of a third wavelength in an orangy red wavelength region of 590 to 660 nm. The apparatus includes light receiving means 6 for receiving lights that are emitted by the light sources and transmitted through or reflected by a living tissue, attenuation ratio processing means 15 for processing attenuation ratios &PHgr; on the wavelengths based on variations of signals associated with the wavelengths output from the light receiving means, which variations are caused by a pulsation of blood, and concentration ratio processing means 16 for processing concentration ratios of at least oxyhemoglobin, deoxyhemoglobin and carboxyhemoglobin based on the output signals from the attenuation ratio processing means. The apparatus thus constructed can properly measure carboxyhemoglobin COHb, and present its concentration display and an alarm display in a simple manner, which is clinically effective.

3. 发明授权

US08548546B2 Pulse oximetry and pulse oximeter 有权
标题翻译：脉搏血氧仪和脉搏血氧饱和度计
公开(公告)号：US08548546B2
公开(公告)日：2013-10-01
申请号：US12486843
申请日：2009-06-18
申请人： Takuo Aoyagi , Michio Kanemoto , Masayoshi Fuse , Teiji Ukawa
发明人： Takuo Aoyagi , Michio Kanemoto , Masayoshi Fuse , Teiji Ukawa
IPC分类号： A61B5/00
CPC分类号： A61B5/7207 , A61B5/1455
摘要： A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.
摘要翻译：脉搏血氧测定法包括：用多个不同波长的光束照射生物体组织; 接收通过生物体组织传播或反射的光束，并将接收的光束转换成对应于不同波长的电信号; 时间分段电信号的时间序列数据; 针对电信号的每个分段时间序列数据计算每个两个电信号之间的回归线的斜率值; 根据电信号分段时间序列数据的斜率值计算SaO2; 为每个预定数量的时间段构建SaO2的直方图; 并且从直方图获得作为脉搏血氧饱和度的SpO2的模式值。

4. 发明授权

US5766125A Apparatus for determining the concentration of light-absorbing materials in blood 失效
标题翻译：用于测定血液中吸光材料浓度的装置
公开(公告)号：US5766125A
公开(公告)日：1998-06-16
申请号：US429545
申请日：1995-04-27
申请人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng-tai Xie , Naoki Kobayashi , Hideaki Hirahara
发明人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng-tai Xie , Naoki Kobayashi , Hideaki Hirahara
IPC分类号： G01N21/27 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/31
CPC分类号： A61B5/14551 , G01N21/3151
摘要： Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.
摘要翻译：从发光装置发射的不同波长的光束通过活组织透射。透射光束由光电转换装置转换为电信号。脉动计算装置根据光电转换装置的输出信号，计算各波长的生物体组织的吸光度的脉动。通过使用这一点，脉动比计算装置计算吸光度值的脉动比。浓度计算装置将脉动比计算装置的输出信号设置在组织术语上具有单个未知数的公式中，其基于在各个波长的组织项之间存在预定关系的事实构成，从而计算组织术语的值和血液中光吸收材料的浓度。

5. 发明授权

US5697371A Apparatus for measuring circulating blood volume 失效
标题翻译：用于测量循环血量的装置
公开(公告)号：US5697371A
公开(公告)日：1997-12-16
申请号：US358381
申请日：1994-12-19
申请人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
发明人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
IPC分类号： A61B5/026 , A61B5/0275 , A61B5/00
CPC分类号： A61B5/0275
摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
摘要翻译：使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

6. 发明授权

US5999841A Apparatus for measuring circulating blood volume 失效
标题翻译：用于测量循环血量的装置
公开(公告)号：US5999841A
公开(公告)日：1999-12-07
申请号：US916295
申请日：1997-08-22
申请人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
发明人： Takuo Aoyagi , Michio Kanemoto , Naoki Kobayashi
IPC分类号： A61B5/026 , A61B5/0275 , A61B6/00 , A61B5/02
CPC分类号： A61B5/0275
摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
摘要翻译：使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

7. 发明授权

US5690104A Apparatus and method for measuring oxygen saturation in blood and apparatus and method for measuring concentration of light-absorbing materials in blood 失效
标题翻译：用于测量血液中氧饱和度的装置和方法及装置及测量血液中吸光材料浓度的方法
公开(公告)号：US5690104A
公开(公告)日：1997-11-25
申请号：US661169
申请日：1996-06-10
申请人： Michio Kanemoto , Naoki Kobayashi , Takuo Aoyagi
发明人： Michio Kanemoto , Naoki Kobayashi , Takuo Aoyagi
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/6826 , A61B5/14551 , A61B5/6838 , A61B2560/0209
摘要： Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.
摘要翻译：在第一时间段内测量透过活体组织的两种不同波长的光的强度。数据处理器使用对应于在第一时间段期间测量的光强度的对数处理数据来确定第一回归线。操作者将染料注入到生物体中，并且在稍后的时间段内测量两种不同波长的光的强度。数据处理器使用对应于在稍后时间段内测量的光强度的对数处理的数据来确定第二回归线。数据处理器找到两条回归线的交点，并使用交点确定无血性水平点。然后处理器形成掺有无血型水平点数据的染料稀释曲线。

8. 发明授权

US5720284A Apparatus for measuring hemoglobin 失效
标题翻译：用于测量血红蛋白的装置
公开(公告)号：US5720284A
公开(公告)日：1998-02-24
申请号：US623862
申请日：1996-03-29
申请人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng Tai Xie
发明人： Takuo Aoyagi , Masayoshi Fuse , Michio Kanemoto , Cheng Tai Xie
IPC分类号： A61B5/00 , G01N33/72
CPC分类号： A61B5/14551 , G01N33/721 , G01N33/726
摘要： Light of various wavelengths emitted from light sources and transmitted through vital tissues is converted by light sensors and current/voltage transducers, into electric signals. The signals are converted into digital values by an A/D converter. The light source emits light of a wavelength which can be optically absorbed by water. A computer obtains a ratio of variations of the digital values for each wavelength, and calculates the values of tissue terms and the hemoglobin concentration on the basis of the ratios. In the calculation, since tissue terms of the wavelengths have mutual constant relationships, an equation which is prepared so that there exists only one unknown in the tissue terms is used.
摘要翻译：从光源发射并通过生命组织传播的各种波长的光由光传感器和电流/电压传感器转换成电信号。信号由A / D转换器转换为数字值。光源发射可被水光学吸收的波长的光。计算机获得每个波长的数字值的变化率，并且基于比率来计算组织项的值和血红蛋白浓度。在计算中，由于波长的组合项具有相互恒定的关系，所以使用准备使得在组织术语中仅存在一个未知的方程式。

9. 发明授权

US06671526B1 Probe and apparatus for determining concentration of light-absorbing materials in living tissue 有权
标题翻译：用于测定活体组织中吸光材料浓度的探针和仪器
公开(公告)号：US06671526B1
公开(公告)日：2003-12-30
申请号：US09692044
申请日：2000-10-20
申请人： Takuo Aoyagi , Masayoshi Fuse , Sunao Takeda , Cheng-tai Xie , Michio Kanemoto
发明人： Takuo Aoyagi , Masayoshi Fuse , Sunao Takeda , Cheng-tai Xie , Michio Kanemoto
IPC分类号： A61B500
CPC分类号： A61B5/0059 , A61B5/14552
摘要： A probe 1 includes a light irradiating device 2 and a light receiving device 3, which are oppositely disposed sandwiching living tissue 10. The light irradiating device 2 includes a light source 5 and a scattering plate 6 located in front of the light source 5. The light receiving device 3 includes a photo diode 8 and a light scattering portion. With such an arrangement, of the attenuation of the living tissue 10, non-absorbing attenuation is free from the wavelength. A ratio of absorbing attenuation and a thickness of a blood layer is not affected by a thickness of living tissue. Further, the absorbing attenuation is not dependent on a depth of the blood layer.
摘要翻译：探针1包括相对设置的夹持生物体组织10的光照射装置2和光接收装置3.光照射装置2包括位于光源5前方的光源5和散射板6。光接收装置3包括光电二极管8和光散射部分。通过这样的布置，对于生物体组织10的衰减，非吸收性衰减不受波长的影响。吸收衰减的比例和血液层的厚度不受生物体组织的厚度的影响。此外，吸收衰减不依赖于血液层的深度。

10. 发明授权

US06230035B1 Apparatus for determining concentrations of light-absorbing materials in living tissue 失效
标题翻译：用于测定活体组织中吸光材料浓度的装置
公开(公告)号：US06230035B1
公开(公告)日：2001-05-08
申请号：US09356521
申请日：1999-07-19
申请人： Takuo Aoyagi , Masayoshi Fuse , Chen-tai Xie , Michio Kanemoto
发明人： Takuo Aoyagi , Masayoshi Fuse , Chen-tai Xie , Michio Kanemoto
IPC分类号： A61B500
CPC分类号： A61B5/14551 , A61B5/14552
摘要： Irradiating device 3 of a pulse oximeter includes a scattering plate 6. Scattering light is projected into a living tissue. The diameter of the incident area is sufficiently large compared with that of a light receiving area or vice versa. Therefore, tissue terms in a theoretical formula of &PHgr; which represents a ratio of changes of optical densities of tissue measured with two wavelengths are not dependent on the wavelength. The digital processor 10 calculates an oxygen saturation by substituting &PHgr; measured into simultaneous equations.
摘要翻译：脉搏血氧计的照射装置3包括散射板6.散射光投射到活体组织中。与光接收区域相比，入射面积的直径足够大，反之亦然。因此，理论公式中的组织术语＆PHgr; 其表示用两个波长测量的组织的光密度变化的比率不依赖于波长。数字处理器10用“PHgr”代替氧饱和度; 测量为联立方程。

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