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1. 发明授权

US07732133B2 Screening methods for biologically active ligands 失效
标题翻译：生物活性配体的筛选方法
公开(公告)号：US07732133B2
公开(公告)日：2010-06-08
申请号：US10333103
申请日：2001-07-17
申请人： Naohiro Yabuta , Hideki Adachi , Yasushi Shimonaka , Kunihiro Hattori
发明人： Naohiro Yabuta , Hideki Adachi , Yasushi Shimonaka , Kunihiro Hattori
IPC分类号： G01Q1/68 , G01Q33/53 , G01N33/566 , C12P21/04 , C12N15/00
CPC分类号： G01N33/566 , G01N2500/00
摘要： In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method wherein a common detection marker is utilized for separately detecting the presence or absence of each of the biological activities. The present inventors discovered that a compound having at least one of two or more distinct biological activities can be efficiently and conveniently detected by simultaneously assaying at least one test sample or more by the above-mentioned method. Furthermore, for a test sample that proved to be positive by the detection method, they found that it is possible to efficiently and conveniently screen for a test sample having an objective specific biological activity by combining with a method wherein an individual activity of a test sample can be detected to specify the biological activity.
摘要翻译：在存在两个目标生物活性的情况下，目的是分离具有至少一种生物活性的化合物时，本发明人开发了一种测定方法，其中使用常见的检测标记来分别检测每种化合物的存在或不存在生物活动。本发明人发现通过上述方法同时测定至少一种测试样品，可有效地方便地检测具有两种或更多种不同生物活性中至少一种的化合物。此外，对于通过检测方法证实为阳性的测试样品，他们发现可以通过结合其中测试样品的单独活性的方法有效和方便地筛选具有客观特异性生物活性的测试样品可以检测到指定生物活性。

2. 发明申请

US20100333220A1 HUMAN TISSUE FACTOR-PRODUCING KNOCK-IN NON-HUMAN ANIMAL 失效
标题翻译：人体组织因子生产非人类动物
公开(公告)号：US20100333220A1
公开(公告)日：2010-12-30
申请号：US12461453
申请日：2009-08-12
申请人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
发明人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
IPC分类号： C12P21/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N2800/30
摘要： A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.
摘要翻译：所述动物具有编码人TF的cDNA已被插入非人动物基因组的翻译起始密码子的上游的基因组，所述非人动物产生人组织因子（TF），而基本上不产生非人动物组织因子 TF基因。

3. 发明授权

US08067665B2 Methods of using human tissue factor-producing knock-in mice 失效
标题翻译：使用人组织因子产生敲入小鼠的方法
公开(公告)号：US08067665B2
公开(公告)日：2011-11-29
申请号：US12461453
申请日：2009-08-12
申请人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
发明人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
IPC分类号： C12P21/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N2800/30
摘要： A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.
摘要翻译：所述动物具有编码人TF的cDNA已被插入非人动物基因组的翻译起始密码子的上游的基因组，所述非人动物产生人组织因子（TF），而基本上不产生非人动物组织因子 TF基因。

4. 发明授权

US07592502B2 Knock-in non-human animal producing human tissue factor 失效
标题翻译：敲入非人类动物产生人体组织因子
公开(公告)号：US07592502B2
公开(公告)日：2009-09-22
申请号：US10478058
申请日：2002-05-17
申请人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
发明人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
IPC分类号： A01K67/027 , C12N15/00 , C12N15/87 , C12N5/00 , C12N5/02
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N2800/30
摘要： A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.
摘要翻译：所述动物具有编码人TF的cDNA已被插入非人动物基因组的翻译起始密码子的上游的基因组，所述非人动物产生人组织因子（TF），而基本上不产生非人动物组织因子 TF基因。

5. 发明授权

US07494647B2 Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody 有权
标题翻译：针对人组织因子（TF）的人源化抗体和人源化抗体的生产过程
公开(公告)号：US07494647B2
公开(公告)日：2009-02-24
申请号：US10462062
申请日：2003-06-16
申请人： Koh Sato , Hideki Adachi , Naohiro Yabuta
发明人： Koh Sato , Hideki Adachi , Naohiro Yabuta
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： A humanized antibody against tissue factor (TF), comprising:A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the H chain FRs of a human antibody, and (2) the H chain C region of a human antibody; andB: a humanized L chain comprising (1) an L chain V region comprising the L chain CDRs of a mouse monoclonal antibody against TF and the L chain FRs of a human antibody, and (2) the L chain C region of a human antibody.After generating a humanized V region by grafting the CDRs of a mouse monoclonal antibody onto a human antibody, a humanized antibody having a higher activity is searched by replacing the FR of the above region with the corresponding FR of the human antibody having a high homology.
摘要翻译：一种抗组织因子（TF）的人源化抗体，包括：A：人源化H链，其包含（1）H链V区，其包含针对TF的小鼠单克隆抗体的H链CDR和人抗体的H链FR，以及（2）人抗体的H链C区; 和B：人源化L链，其包含（1）包含针对TF的小鼠单克隆抗体的L链CDR和人抗体的L链FR的L链V区，和（2）人的L链C区抗体。通过将小鼠单克隆抗体的CDR移植到人抗体上产生人源化V区后，通过用具有高同源性的人抗体的相应FR代替上述区域的FR来搜索具有较高活性的人源化抗体。

6. 发明授权

US06677436B1 Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody 失效
标题翻译：针对人组织因子（TF）的人源化抗体和人源化抗体的生产过程
公开(公告)号：US06677436B1
公开(公告)日：2004-01-13
申请号：US09647468
申请日：2000-09-29
申请人： Koh Sato , Hideki Adachi , Naohiro Yabuta
发明人： Koh Sato , Hideki Adachi , Naohiro Yabuta
IPC分类号： C12P2108
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to a human/mouse chimeric antibody that includes the variable region of a mouse monoclonal antibody against human tissue factor (TF) and the constant region of a human antibody. The humanized antibody contains light and heavy chain complementarity determining regions of a mouse monoclonal antibody against human TF which have been grafted onto a human antibody. The present invention also provides a therapeutic agent for disseminated intravascular coagulation (DIC) syndrome, which includes a humanized antibody against human TF as an active ingredient.
摘要翻译：本发明涉及包含针对人组织因子（TF）的小鼠单克隆抗体和人抗体恒定区的可变区的人/小鼠嵌合抗体。人源化抗体含有已经接枝到人抗体上的针对人TF的小鼠单克隆抗体的轻链和重链互补决定区。本发明还提供了用于弥散性血管内凝血（DIC）综合征的治疗剂，其包括针对人TF的人源化抗体作为活性成分。

7. 发明申请

US20060102289A1 Substrate processing apparatus, substrate processing method, substrate position correcting apparatus, and substrate position correcting method 失效
标题翻译：基板处理装置，基板处理方法，基板位置校正装置和基板位置校正方法
公开(公告)号：US20060102289A1
公开(公告)日：2006-05-18
申请号：US11270338
申请日：2005-10-28
申请人： Eiji Fukatsu , Hiroyuki Yashiki , Hideki Adachi , Katsuhiko Miya
发明人： Eiji Fukatsu , Hiroyuki Yashiki , Hideki Adachi , Katsuhiko Miya
IPC分类号： C23F1/00 , H01L21/306
CPC分类号： H01L21/67259 , H01L21/67051 , H01L21/68 , Y10S414/136
摘要： A substrate W rotates about the center of rotations A0 of a spin base 3, while supported by plural support pins 5 in such a manner that the substrate W can freely slide and while held owing to the force of friction which develops between the bottom surface of the substrate W and the support pins 5. After a detection sensor 74 detects, while the substrate W rotates, an edge surface position (eccentric position) of the edge surface of the substrate which is the farthest from the center of rotations A0, a press block 71 pushes this edge surface position to a preset position P1 which is away along the horizontal direction from the center of rotations A0 by a distance which is determined in accordance with the radius of the substrate W. This aligns the eccentric position to the preset position P1 and positions the center W0 of the substrate within a predetermined range from the center of rotations A0.
摘要翻译：基板W围绕旋转基座3的旋转中心A 0旋转，同时由多个支撑销5支撑，使得基板W能够自由滑动并且由于摩擦力在底面的基板W和支撑销5。在检测传感器74检测到基板W旋转之后，离开旋转中心A 0的基板的边缘表面的边缘表面位置（偏心位置）时，压块71将该边缘表面位置推到预设位置P 1，其从旋转中心A 0沿水平方向离开根据基板W的半径确定的距离。将偏心位置对准预设位置P 1并将中心位置 W 0从旋转中心A 0的预定范围内。

8. 发明申请

US20050150450A1 Thin film forming apparatus, film supplier, film cassette, transport mechanism and transport method 有权
公开(公告)号：US20050150450A1
公开(公告)日：2005-07-14
申请号：US11052599
申请日：2005-02-07
申请人： Hideki Adachi
发明人： Hideki Adachi
IPC分类号： H01L21/285 , B32B38/18 , H01L21/00 , H01L21/283 , H01L21/31 , H01L21/677 , H01L21/687 , H01L21/768 , B05C11/02 , B05C13/00
CPC分类号： B32B38/18 , B32B38/164 , B32B2037/243 , B32B2038/1891 , B32B2457/14 , B32B2457/20 , H01L21/6715 , H01L21/67167 , H01L21/6719 , H01L21/67207 , H01L21/67248 , H01L21/67742 , H01L21/68707 , Y10S414/141 , Y10T156/17 , Y10T156/1705 , Y10T156/1744
摘要： A center robot is fixed approximately in a central portion of a process part. A coating unit, a drying unit, a transfer unit, a peeling unit, a film supplying unit and a reversing unit are arranged around the center robot. The center robot comprises a hand-for-substrate and a hand-for-film which are allowed to directly access the respective units. Within a process part, the center robot transports a sheet film and/or a substrate between the coating unit, the drying unit, the transfer unit and the film supplying unit, and a thin film is formed on the substrate using the sheet film.

9. 发明授权

US6064915A Equipment control apparatus 失效
标题翻译：设备控制装置
公开(公告)号：US6064915A
公开(公告)日：2000-05-16
申请号：US797891
申请日：1997-02-10
申请人： Tokuharu Kaneko , Masanori Miyata , Hideki Adachi , Shinichi Nakamura , Naoyuki Ohki , Satoshi Kuroyanagi , Hiroshi Ozaki , Hisatsugu Tahara , Satoshi Kaneko , Taisei Fukada , Mitsuharu Takizawa
发明人： Tokuharu Kaneko , Masanori Miyata , Hideki Adachi , Shinichi Nakamura , Naoyuki Ohki , Satoshi Kuroyanagi , Hiroshi Ozaki , Hisatsugu Tahara , Satoshi Kaneko , Taisei Fukada , Mitsuharu Takizawa
IPC分类号： G03G15/00 , G05B15/00
CPC分类号： G03G15/5091 , G03G2215/00109
摘要： An equipment control apparatus in a system having an input unit for entering data on the conditions of equipment from the equipment, a communication unit for communicating with the apparatus located at a distance, and a control unit for exerting control in such a way as to transmit the data to the apparatus located at a distance through the steps of interrupting communication once on receiving a call from the apparatus requesting the data and then calling the apparatus located at a distance via the communication unit.
摘要翻译：一种系统中的设备控制装置，具有用于从设备输入设备状态的输入单元的输入单元，用于与远程位置的设备进行通信的通信单元和用于以发送方式进行控制的控制单元通过在从请求数据的装置接收到呼叫并随后通过通信单元呼叫位于一定距离的设备的情况下通过中断一次通信的步骤将数据传送到设备。

10. 发明授权

US5699167A Image forming apparatus which outputs a color image by separating color image information into at least two color components 失效
标题翻译：图像形成装置，其通过将彩色图像信息分离成至少两个颜色分量来输出彩色图像
公开(公告)号：US5699167A
公开(公告)日：1997-12-16
申请号：US315299
申请日：1994-09-29
申请人： Tetsuya Nozaki , Hideki Adachi , Yoshiyuki Suzuki , Kazuhiko Hirooka , Hiroyuki Ichikawa , Masahito Yamamoto
发明人： Tetsuya Nozaki , Hideki Adachi , Yoshiyuki Suzuki , Kazuhiko Hirooka , Hiroyuki Ichikawa , Masahito Yamamoto
IPC分类号： G06T1/00 , H04N1/46 , H04N1/52 , H04N1/60 , H04N1/40 , G03F3/08
CPC分类号： H04N1/52
摘要： An image forming apparatus discriminates a color of an inputted color image for each pixel and generates a first color component and a second color component. The apparatus compares values of the first and the second color components, and selects and outputs the color component having a larger value. Meanwhile a color component which is not selected is diffused to neighboring pixels. When pixels neighboring a pixel of interest in a predetermined area are filled with one color component, the other color component is selected and outputted regardless of the values of the first and second color components.
摘要翻译：图像形成装置识别每个像素的输入彩色图像的颜色，并生成第一颜色分量和第二颜色分量。该装置比较第一和第二颜色分量的值，并选择和输出具有较大值的颜色分量。同时，未选择的颜色分量被扩散到相邻像素。当与一个颜色分量填充预定区域中感兴趣的像素相邻的像素时，与第一和第二颜色分量的值无关地选择和输出另一个颜色分量。

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