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1. 发明授权

US07494647B2 Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody 有权
标题翻译：针对人组织因子（TF）的人源化抗体和人源化抗体的生产过程
公开(公告)号：US07494647B2
公开(公告)日：2009-02-24
申请号：US10462062
申请日：2003-06-16
申请人： Koh Sato , Hideki Adachi , Naohiro Yabuta
发明人： Koh Sato , Hideki Adachi , Naohiro Yabuta
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： A humanized antibody against tissue factor (TF), comprising:A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the H chain FRs of a human antibody, and (2) the H chain C region of a human antibody; andB: a humanized L chain comprising (1) an L chain V region comprising the L chain CDRs of a mouse monoclonal antibody against TF and the L chain FRs of a human antibody, and (2) the L chain C region of a human antibody.After generating a humanized V region by grafting the CDRs of a mouse monoclonal antibody onto a human antibody, a humanized antibody having a higher activity is searched by replacing the FR of the above region with the corresponding FR of the human antibody having a high homology.
摘要翻译：一种抗组织因子（TF）的人源化抗体，包括：A：人源化H链，其包含（1）H链V区，其包含针对TF的小鼠单克隆抗体的H链CDR和人抗体的H链FR，以及（2）人抗体的H链C区; 和B：人源化L链，其包含（1）包含针对TF的小鼠单克隆抗体的L链CDR和人抗体的L链FR的L链V区，和（2）人的L链C区抗体。通过将小鼠单克隆抗体的CDR移植到人抗体上产生人源化V区后，通过用具有高同源性的人抗体的相应FR代替上述区域的FR来搜索具有较高活性的人源化抗体。

2. 发明授权

US06677436B1 Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody 失效
标题翻译：针对人组织因子（TF）的人源化抗体和人源化抗体的生产过程
公开(公告)号：US06677436B1
公开(公告)日：2004-01-13
申请号：US09647468
申请日：2000-09-29
申请人： Koh Sato , Hideki Adachi , Naohiro Yabuta
发明人： Koh Sato , Hideki Adachi , Naohiro Yabuta
IPC分类号： C12P2108
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to a human/mouse chimeric antibody that includes the variable region of a mouse monoclonal antibody against human tissue factor (TF) and the constant region of a human antibody. The humanized antibody contains light and heavy chain complementarity determining regions of a mouse monoclonal antibody against human TF which have been grafted onto a human antibody. The present invention also provides a therapeutic agent for disseminated intravascular coagulation (DIC) syndrome, which includes a humanized antibody against human TF as an active ingredient.
摘要翻译：本发明涉及包含针对人组织因子（TF）的小鼠单克隆抗体和人抗体恒定区的可变区的人/小鼠嵌合抗体。人源化抗体含有已经接枝到人抗体上的针对人TF的小鼠单克隆抗体的轻链和重链互补决定区。本发明还提供了用于弥散性血管内凝血（DIC）综合征的治疗剂，其包括针对人TF的人源化抗体作为活性成分。

3. 发明申请

US20050136057A1 Antibodies against human parathyroid hormone related protein 失效
标题翻译：抗甲状旁腺激素相关蛋白的抗体
公开(公告)号：US20050136057A1
公开(公告)日：2005-06-23
申请号：US11047996
申请日：2005-02-02
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C12P21/02 , A61K38/00 , A61K39/395 , C07K16/26 , C12N15/13 , C12N15/62 , C12P21/08
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

4. 发明授权

US07358355B2 Antibodies against human parathyroid hormone related protein 失效
标题翻译：抗甲状旁腺激素相关蛋白的抗体
公开(公告)号：US07358355B2
公开(公告)日：2008-04-15
申请号：US11047996
申请日：2005-02-02
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C07H21/04
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

5. 发明授权

US06903194B1 Antibody against human parathormone related peptides 失效
标题翻译：抗人类parathormone相关肽的抗体
公开(公告)号：US06903194B1
公开(公告)日：2005-06-07
申请号：US09269332
申请日：1997-09-24
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C12P21/02 , A61K38/00 , A61K39/395 , C07K16/26 , C12N15/13 , C12N15/62 , C12P21/08 , C07K1/10
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

6. 发明授权

US07842790B2 Antibodies against human parathyroid hormone related protein 失效
标题翻译：抗甲状旁腺激素相关蛋白的抗体
公开(公告)号：US07842790B2
公开(公告)日：2010-11-30
申请号：US11931429
申请日：2007-10-31
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

7. 发明授权

US06214973B1 Reshaped human antibody to human medulloblastoma cells 失效
标题翻译：人类成神经管细胞瘤细胞重构人抗体
公开(公告)号：US06214973B1
公开(公告)日：2001-04-10
申请号：US08646265
申请日：1996-09-09
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
IPC分类号： C07K1600
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译：本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。由于这种重整的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人抗体在人体中具有低水平的抗原性，因此预期可用作用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达由该抗体识别的抗原。

8. 发明授权

US07468184B2 Therapeutic agent for cachexia 失效
标题翻译：恶病质治疗剂
公开(公告)号：US07468184B2
公开(公告)日：2008-12-23
申请号：US10337981
申请日：2003-01-08
申请人： Koh Sato , Toshiaki Tsunenari , Kimie Ishii
发明人： Koh Sato , Toshiaki Tsunenari , Kimie Ishii
IPC分类号： A61K39/395
CPC分类号： C07K14/635 , A61K38/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2319/00
摘要： The invention relates to a therapeutic agent for cachexia comprising, as an active ingredient, a substance capable of inhibiting the binding between a parathyroid hormone related protein (PTHrP) and a receptor thereof.
摘要翻译：本发明涉及用于恶病质的治疗剂，其包含作为活性成分的能够抑制甲状旁腺激素相关蛋白（PTHrP）与其受体之间的结合的物质。

9. 发明授权

US07563599B2 Reshaped human antibody to human medulloblastoma cells 失效
标题翻译：人成神经管细胞瘤细胞的人源化抗体
公开(公告)号：US07563599B2
公开(公告)日：2009-07-21
申请号：US10839799
申请日：2004-05-06
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
IPC分类号： C12P21/04 , C07H21/04 , C12P21/08 , C07K16/00
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译：本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。由于这种重构的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人（人源化）抗体在人中具有低水平的抗原性，因此预期为可用作用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达被该抗体识别的抗原。

10. 发明申请

US20050249726A1 Reshaped human antibody to human medulloblastoma cells 失效
标题翻译：人成神经管细胞瘤细胞的人源化抗体
公开(公告)号：US20050249726A1
公开(公告)日：2005-11-10
申请号：US10839799
申请日：2004-05-06
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
IPC分类号： A61K38/00 , A61K39/395 , C07H21/04 , C07K16/30 , C07K16/44 , C12N5/06 , C12P21/06 , C12P21/08
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译：本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。由于这种重构的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人（人源化）抗体在人中具有低水平的抗原性，因此预期为可用作用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达被该抗体识别的抗原。

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