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    • 1. 发明申请
    • TUNING BIOLOGICAL SYSTEM PROPERTIES FOR OPTIMIZED TREATMENT EFFICACY
    • 调节生物系统性能优化治疗效果
    • US20160263150A1
    • 2016-09-15
    • US15067010
    • 2016-03-10
    • Nadia C. LaraAndrew R. BarronStuart CorrSteven Curley
    • Nadia C. LaraAndrew R. BarronStuart CorrSteven Curley
    • A61K33/00
    • A61K33/44A61K9/14A61K33/10A61K33/24
    • Various embodiments of the present disclosure pertain to methods of optimizing a treatment efficacy of a biological system by tuning a property of the biological system through the addition of an optimizing agent to the biological system. The tuning can include: (a) determining a property parameter of the biological system; (b) selecting an optimizing agent to be added to the biological system based on the determined property parameter; and (c) adding the optimizing agent to the biological system. The optimizing agent can include a kosmotropic material. The biological system can include a tissue, such as a tumor. The methods of the present disclosure can be utilized to enhance the efficacy of various treatments, such as the heat treatment of a biological system exposed to a radiofrequency field. The methods of the present disclosure can also include a step of treating the biological system.
    • 本公开的各种实施方案涉及通过通过向生物系统添加优化剂来调节生物系统的性质来优化生物系统的治疗功效的方法。 调整可以包括:(a)确定生物系统的属性参数; (b)基于所确定的属性参数选择要添加到所述生物系统的优化剂; 和(c)将优化剂加入到生物系统中。 优化剂可以包括一种感光性材料。 生物系统可以包括诸如肿瘤的组织。 本公开的方法可以用于增强各种治疗的功效,例如暴露于射频场的生物系统的热处理。 本公开的方法还可以包括处理生物系统的步骤。