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1. 发明申请

WO2006105980A8 DEVICE FOR DOSING AND DRY NEBULIZATION 审中-公开
标题翻译：用于剂量和干燥性能的装置
公开(公告)号：WO2006105980A8
公开(公告)日：2008-01-10
申请号：PCT/EP2006003172
申请日：2006-04-07
申请人： NYCOMED GMBH , EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
发明人： EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material (12) chosen from the group comprising anti- infective agents and immunomodulators, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve (16) for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir (10) open only towards the nebulization channel, which contains the nebulizable material (12), is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation (22) takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.
摘要翻译：本发明涉及一种用于定量和干燥可雾化材料（12）雾化的装置（1），该装置选自包含抗感染剂和免疫调节剂的组，包括雾化通道（3），其具有第一附接件和第二附件以及经由阀（16）连接到第一附接件的压缩载气源，用于将载气压力脉冲发送到雾化通道中。该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅包含可雾化材料（12）的朝向雾化通道打开的储存器（10）连接到喷雾通道，它相对于环境是气密的，并且当阀关闭时，在雾化通道和储存器中进行压力补偿（22）。本发明还涉及通过这种装置对这种可喷雾材料进行计量和干燥雾化的方法。

2. 发明申请

WO0045878A3 COMPRESSED AIR INHALER FOR PULMONARY APPLICATION OF LIPOSOMAL POWDER AEROSOLS AND POWDER AEROSOLS SUITABLE THEREFOR 审中-公开
标题翻译： DRUCKLUFTINHALATOR肺应用脂质体粉末涂料，适合的粉末气溶胶
公开(公告)号：WO0045878A3
公开(公告)日：2000-09-28
申请号：PCT/DE0000337
申请日：2000-02-03
申请人： MAX DELBRUECK CENTRUM , FRAUNHOFER GES FORSCHUNG , DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61M11/001 , A61M11/06 , A61M15/0086 , B05B7/0012 , B05B7/066
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.
摘要翻译：本发明涉及一种用于承载无负载或脂质体粉末气雾剂的活性剂的肺部给药的Druckluftinhalator。本发明的目的是提供一种吸入器，用于处理与特定药物携带脂质体的肺部给药而无需用力呼吸动作成为可能与活性剂可以以期望的作用位点足够量带来不活性剂逸出，在该Druckluftinhalator为脂质体粉末气雾剂，对于其中药物携带脂质体分散在水中含有液体充电（19）用雾化器喷嘴的水性脂质体分散液的容器（20）的肺应用（1实现）和（与干燥单元17）是连接到所述脂质体的喷雾干燥雾化室，其输出端（18）作为吹口相邻接，其中，所述喷嘴（1）分开的进料（14，包括16个）用于将压缩空气和该脂质体分散体，包括（图1）。本发明还涉及一种新的粉末气雾剂，其中包括脂质体或纳米颗粒。

3. 发明专利

BRPI0609536A2 未知
公开(公告)号：BRPI0609536A2
公开(公告)日：2010-04-13
申请号：BRPI0609536
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： EISTETTER KLAUS , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG , WURST WILHELM
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： The invention relates to a device 1 for dosing and dry nebulization of nebulizable material 12 chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel 3, which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir 10 open only towards the nebulization channel, which contains the nebulizable material 12, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

4. 发明专利

EA013024B1 УСТРОЙСТВО ДОЗИРОВАНИЯ И СУХОГО РАСПЫЛЕНИЯ 未知
公开(公告)号：EA013024B1
公开(公告)日：2010-02-26
申请号：EA200702147
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M13/00 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： Визобретенииописаноустройство (1) дозированияи сухогораспыленияматериала (12), выбранногоизгруппы, вкоторуювходятантиинфекционныесредстваи имунномодуляторы, содержащеераспылительныйканал (3), имеющийпервыйприсоединительныйузели второйприсоединительныйузел, иисточниксжатогогаза-носителя, соединенныйс первымприсоединительнымузломчерезклапан (16) дляподачиимпульсадавлениягаза-носителяв распылительныйканал. Устройствоотличаетсятем, чтомеждупервымприсоединительнымузломи вторымприсоединительнымузлом, надраспылительнымканаломрасположеноткрытыйтольков негорезервуар (10), содержащийраспыляемыйматериал (12) иимеющийгерметичноеотносительноокружающейсредысоединениес распылительнымканалом, причемкогдаклапанзакрыт, происходиткомпенсация (22) давленияв распылительномканалеи резервуаре. Визобретениитакжепредложенспособдозированияи сухогораспылениятакогораспыляемогоматериалапосредствомпредложенногоустройства.

5. 发明专利

MX2007012228A DISPOSITIVO PARA DOSIFICAR Y PARA NEBULIZACION EN SECO. 未知
公开(公告)号：MX2007012228A
公开(公告)日：2007-12-10
申请号：MX2007012228
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： La invencion se refiere a un dispositivo (1) para dosificar y para la nebulizacion en seco de material nebulizable (12), que comprende un canal de nebulizacion (3) que tiene una primera pieza de conexion y una segunda pieza de conexion; y una fuente de gas portador comprimido, conectada a la primera pieza de conexion por medio de una valvula (16), con el proposito de enviar un pulso de presion de gas portador hacia el canal de nebulizacion. El dispositivo esta caracterizado porque, entre la primera pieza de conexion y la segunda pieza de conexion, y encima del canal de nebulizacion, un deposito (10) abierto unicamente hacia el canal de nebulizacion y usado para recibir el material nebulizable, esta conectado al canal de nebulizacion de manera que sea hermetico al gas con respecto al medio ambiente; y porque, cuando se cierra la valvula se lleva a cabo una compensacion de presion (22) en el canal de nebulizacion y en el deposito. La invencion se refiere al uso de este dispositivo para la administracion inhalada de una preparacion farmaceutica en polvo y a un metodo para dosificar y para la nebulizacion en seco de material nebulizable por medio de ese dispositivo.

6. 发明专利

BRPI1016186A2 aparelhos aperfeiçoados para o tratamento por aerossol de grandes volumes de pó seco 未知
公开(公告)号：BRPI1016186A2
公开(公告)日：2016-07-05
申请号：BRPI1016186
申请日：2010-04-22
申请人： NYCOMED GMBH
发明人： POHLMANN GERHARD , WINDT HORST , KIST MICHEL , IWATSCHENKO PETER , KOCH WOLFGANG
IPC分类号： A61M11/02 , A61M11/06 , A61M15/00

7. 发明专利

NZ561878A Device for dosing and dry nebulization 未知
公开(公告)号：NZ561878A
公开(公告)日：2011-04-29
申请号：NZ56187806
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： A device 1 for dosing and dry nebulization of nebulizable material 12, comprising a nebulization channel 3 which has a first attachment piece 18 and a second attachment piece 6/7, and a source of compressed carrier gas connected to the first attachment piece 18 via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel 3. Between the first attachment piece 18 and second attachment piece 6/7 and above the nebulization channel 3 is a reservoir 10 open only towards the nebulization channel 3 which contains the nebulizable material 12. The reservoir 10 is connected to the nebulizaton channel 3 such that it is gas-tight with respect to the environment. When the valve 16 is closed a pressure compensation takes place in the nebulization channel 3 and in the reservoir 10.

8. 发明专利

NZ561877A Device for dosing and dry nebulization 未知
公开(公告)号：NZ561877A
公开(公告)日：2011-04-29
申请号：NZ56187706
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： The use of a nebulizer for the dosing and dry nebulisation of nebulizable material 12 chosen from the group comprising anti- infective agents and immunomodulators, where the nebulizer comprises a nebulisation channel 3 with a first attachment piece 18 and a second attachment piece 6/7, a source of compressed carrier gas connected to the first attachment piece 18 via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulisation channel 3, and a nebulizable material reservoir 10 placed between the first attachment piece 13 and second attachment piece and open only towards the nebulisation channel 3. The reservoir 10 is connected to the nebulisation channel 3 such that it is gas-tight with respect to the environment. When the valve 16 is closed gas flows back to the nebulisation channel 3 and reservoir 10 to compensate for the pressure change.

9. 发明专利

UA103921C2 УСТРОЙСТВО ДЛЯ ДОЗИРОВАНИЯ И АЭРОЗОЛИЗАЦИИ АЭРОЗОЛИЗИРОВАННОГО МАТЕРИАЛА И СИСТЕМА ДЛЯ ДОЗИРОВАНИЯ И СУХОГО РАСПЫЛЕНИЯ РАСПЫЛЯЕМОГО МАТЕРИАЛА (ВАРИАНТЫ) 未知
公开(公告)号：UA103921C2
公开(公告)日：2013-12-10
申请号：UAA201113392
申请日：2010-04-22
申请人： NYCOMED GMBH
发明人： IWATSCHENKO PETER , POHLMANN GERHARD , WINDT HORST , KOCH WOLFGANG , KIST MICHEL
IPC分类号： A61M15/00 , A61M11/02 , A61M11/06
摘要： Изобретениеотноситсяк устройствудлядозированияи аэрозолизацииаэрозолизированногоматериала. Предложенноев изобретенииустройствосодержиткорпусс каналомаэрозолизации, которыйимеетдистальнуюсоединительнуючасть, котораясоединяетсяс источникомгаза-носителя, котороеподаетимпульсыдавленияв каналаэрозолизации, проксимальнуюсоединительнуючастьдлявыводааэрозолизированногоматериалаи резервуардляразмещенияаэрозолизированногоматериала. Резервуаримеетстенки, герметическисоединенс корпусоми соединяетсяс каналомаэрозолизации. Поменьшеймере, частьстенокустройствапредставляетсобойсамовозбуждающиесямембраны, которыеприводятсяв колебательноедвижениеимпульсамидавления.

10. 发明专利

BRPI0608674A2 未知
公开(公告)号：BRPI0608674A2
公开(公告)日：2010-01-19
申请号：BRPI0608674
申请日：2006-04-07
申请人： NYCOMED GMBH
发明人： POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
摘要： The invention relates to a device 1 for dosing and dry nebulization of nebulizable material 12 chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel 3, which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir 10 open only towards the nebulization channel, which contains the nebulizable material 12, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

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