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1. 发明申请

WO0045878A3 COMPRESSED AIR INHALER FOR PULMONARY APPLICATION OF LIPOSOMAL POWDER AEROSOLS AND POWDER AEROSOLS SUITABLE THEREFOR 审中-公开
标题翻译： DRUCKLUFTINHALATOR肺应用脂质体粉末涂料，适合的粉末气溶胶
公开(公告)号：WO0045878A3
公开(公告)日：2000-09-28
申请号：PCT/DE0000337
申请日：2000-02-03
申请人： MAX DELBRUECK CENTRUM , FRAUNHOFER GES FORSCHUNG , DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61M11/001 , A61M11/06 , A61M15/0086 , B05B7/0012 , B05B7/066
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.
摘要翻译：本发明涉及一种用于承载无负载或脂质体粉末气雾剂的活性剂的肺部给药的Druckluftinhalator。本发明的目的是提供一种吸入器，用于处理与特定药物携带脂质体的肺部给药而无需用力呼吸动作成为可能与活性剂可以以期望的作用位点足够量带来不活性剂逸出，在该Druckluftinhalator为脂质体粉末气雾剂，对于其中药物携带脂质体分散在水中含有液体充电（19）用雾化器喷嘴的水性脂质体分散液的容器（20）的肺应用（1实现）和（与干燥单元17）是连接到所述脂质体的喷雾干燥雾化室，其输出端（18）作为吹口相邻接，其中，所述喷嘴（1）分开的进料（14，包括16个）用于将压缩空气和该脂质体分散体，包括（图1）。本发明还涉及一种新的粉末气雾剂，其中包括脂质体或纳米颗粒。

2. 发明专利

AU3416400A Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor 未知
公开(公告)号：AU3416400A
公开(公告)日：2000-08-25
申请号：AU3416400
申请日：2000-02-03
申请人： MAX DELBRUECK CENTRUM , FRAUNHOFER GES FORSCHUNG
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LODDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.

3. 发明专利

DE10004860A1 Pressurized air inhaler for administering drug-containing liposomal powder aerosol for treatment of respiratory disease, has nebulization chamber for drying aqueous liposome suspension 未知
公开(公告)号：DE10004860A1
公开(公告)日：2000-10-05
申请号：DE10004860
申请日：2000-02-03
申请人： MAX DELBRUECK CENTRUM , FRAUNHOFER GES FORSCHUNG
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
摘要： A pressurized air inhaler for pulmonary administration of a liposomal powder aerosol comprises: (i) a container for aqueous liposome suspension, linked via a liquid dosing device with an atomizing nozzle and with a drying unit (e.g. nebulization chamber) for spray drying the liposomes; (ii) a mouthpiece outlet; and (iii) separate lines for supplying pressurized air and liposome dispersion to the atomizing nozzle. Independent claims are included for the following: (a) a powder aerosol consisting of liposomes and/or nanoparticles, which is free of moisture and cryoprotective agents and comprises spherical, amorphous or crystalline particles of size 0.5-10 mu m or is prepared by pressurized air nebulization of liposomes and/or a nanoparticle dispersion via a 2-component nozzle at a nebulization pressure of 1-5 bars and a dispersion concentration of 0.2-1%; (b) liposomal powder aerosols comprising: (1) phospholipids, cholesterol, natural or artificial pulmonary surfactant or cationic amphiphiles and active agent; (2) large multilamellar vesicles (MLV) or small unilamellar vesicles (SUV) as liposomes; (3) hydrogenated soya phosphatidyl choline and cholesterol in molar ratio 1 : 0.25, plus SUV's prepared by ultrasonication or MLV's prepared by homogenization; (4) hydrogenated soya phosphatidyl choline, cholesterol and polyethylene glycol in molar ratio 1 : 1 : 0.1, plus SUV's prepared by ultrasonication or MLV's prepared by shaking a lipid film; (5) phosphatidyl choline and cholesterol in molar ratio 1 : 0.5 charged with 5,6-carboxyfluorescein, plus SUV's prepared by ultrasonication; or (6) DAC-Chol and DOPE in weight ratio 2 : 3 (optionally complexed with protamine sulfate or poly-L-lysine); and (c) nanoparticulate powder aerosols, consisting exclusively of active agent crystals of polymer particles charged with active agent.

4. 发明专利

HU0105445A2 COMPRESSED AIR INHALER FOR PULMONARY APPLICATION OF LIPOSOMAL POWDER AEROSOLS AND POWDER AEROSOLS SUITABLE THEREFOR 未知
公开(公告)号：HU0105445A2
公开(公告)日：2002-06-29
申请号：HU0105445
申请日：2000-02-03
申请人： FRAUNHOFER GES FORSCHUNG , MAX DELBRUECK CENTRUM
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LOEDDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.

5. 发明专利

SK10942001A3 COMPRESSED AIR INHALER FOR PULMONARY APPLICATION OF LIPOSOMAL POWDER AEROSOLS AND POWDER AEROSOLS SUITABLE THEREFOR 未知
公开(公告)号：SK10942001A3
公开(公告)日：2002-05-09
申请号：SK10942001
申请日：2000-02-03
申请人： MAX DELBRUECK CENTRUM , FRAUNHOFER GES FORSCHUNG
发明人： DIEDERICHS JULIA EVA , KOCH WOLFGANG , LODDING HUBERT , RESZKA REGINA , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.

6. 发明专利

CA2361807A1 COMPRESSED AIR INHALER FOR PULMONARY APPLICATION OF LIPOSOMAL POWDER AEROSOLS AND POWDER AEROSOLS SUITABLE THEREFOR 未知
公开(公告)号：CA2361807A1
公开(公告)日：2000-08-10
申请号：CA2361807
申请日：2000-02-03
申请人： FRAUNHOFER GES FORSCHUNG , MAX DELBRUECK CENTRUM
发明人： RESZKA REGINA , KOCH WOLFGANG , DIEDERICHS JULIA EVA , LODDING HUBERT , WINDT HORST
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51 , A61K9/72 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L9/12 , A61M11/02 , A61M11/06 , A61M15/00 , A61P11/00 , B05B7/00 , B05B7/06
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of whi ch the pulmonary application of especially liposomes that carry active agents i s possible without forced breathing manoeuvres and by means of which the activ e agent can be transferred to the desired place of action in a sufficient amou nt without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying un it can be an atomising chamber for spray drying the liposomes. An outlet (18) a nd a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and t he dispersion of the liposomes (fig.1). The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.

7. 发明申请

WO2006105980A8 DEVICE FOR DOSING AND DRY NEBULIZATION 审中-公开
标题翻译：用于剂量和干燥性能的装置
公开(公告)号：WO2006105980A8
公开(公告)日：2008-01-10
申请号：PCT/EP2006003172
申请日：2006-04-07
申请人： NYCOMED GMBH , EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
发明人： EISTETTER KLAUS , WURST WILHELM , POHLMANN GERHARD , WINDT HORST , NOLTE OLIVER , KOCH WOLFGANG
IPC分类号： A61M11/06 , A61M15/00 , A61M16/20 , B05B7/14 , B05B11/06
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material (12) chosen from the group comprising anti- infective agents and immunomodulators, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve (16) for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir (10) open only towards the nebulization channel, which contains the nebulizable material (12), is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation (22) takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.
摘要翻译：本发明涉及一种用于定量和干燥可雾化材料（12）雾化的装置（1），该装置选自包含抗感染剂和免疫调节剂的组，包括雾化通道（3），其具有第一附接件和第二附件以及经由阀（16）连接到第一附接件的压缩载气源，用于将载气压力脉冲发送到雾化通道中。该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅包含可雾化材料（12）的朝向雾化通道打开的储存器（10）连接到喷雾通道，它相对于环境是气密的，并且当阀关闭时，在雾化通道和储存器中进行压力补偿（22）。本发明还涉及通过这种装置对这种可喷雾材料进行计量和干燥雾化的方法。

8. 发明专利

ES2740964T3 Dispositivo y sistema para el suministro de un aerosol a un paciente en soporte ventilatorio 未知
公开(公告)号：ES2740964T3
公开(公告)日：2020-02-07
申请号：ES11741221
申请日：2011-08-08
申请人： FRAUNHOFER GES FORSCHUNG
发明人： IWATSCHENKO PETER , POHLMANN GERHARD , RAHMEL DANIELA , TAUT FRIEDEMANN , DE MUYNCK CHRISTIAN , KOCH WOLFGANG , WINDT HORST
IPC分类号： A61M16/14 , A61M11/00 , A61M16/06 , A61M16/10 , A61M16/12 , A61M16/16
摘要： Dispositivo configurado para conectar las vías respiratorias de un paciente con soporte de ventilación con una fuente de gas respirable y una fuente de aerosol, comprendiendo dicho dispositivo un componente (10) de contacto adaptado para colocarse en contacto con las vías respiratorias, en el que el componente (10) de contacto es una cánula nasal, comprendiendo el componente (10) de contacto: dos tubos (18, 20) que comprenden cada uno un primer lumen (18a, 20a) correspondiente a través de la cual se pueden administrar gas respiratorio y aerosol a las vías respiratorias del paciente; un segundo lumen (24) que está en conexión de fluido con los primeros lúmenes (18a, 20a) de los dos tubos (18, 20) y que tiene un eje (24c) longitudinal que se extiende en un ángulo de 90° ± 15° a los ejes (18c, 20c) longitudinales de los primeros lúmenes (18a, 20a); y un puerto (28) a través del cual se puede introducir aerosol en dicho segundo lumen (24) y disponerse de manera tal que el aerosol y un gas respirable se puedan mezclar en el segundo lumen (24), configurándose el puerto de tal manera que, en uso, el aerosol se inyecta en el segundo lumen (24) en una dirección de flujo de aerosol, en el que la dirección de flujo del aerosol es en un ángulo de 90° ± 15° con respecto a los ejes longitudinales de los dos tubos (18, 20); en el que el componente (10) de contacto está conectado de manera desconectable a un soporte de componente (12) de contacto del dispositivo, dicho soporte de componente (12) de contacto que comprende un tercer lumen (12a), el tercer lumen (12a) que se puede conectar a través de un tubo (14) a un dispositivo para generar un flujo de gas respirable, en el que el segundo lumen (24) está situado próximo a, y está en conexión de fluido con dicho tercer lumen (12a).

9. 发明专利

DE19500726C2 未知
公开(公告)号：DE19500726C2
公开(公告)日：1998-07-02
申请号：DE19500726
申请日：1995-01-12
申请人： FRAUNHOFER GES FORSCHUNG
发明人： WINDT HORST , OENNING GUENTHER , OTT WOLFGANG
IPC分类号： A61M15/00 , G01F11/24 , B01F15/04 , B01F3/06

10. 发明专利

AT139131T 未知
公开(公告)号：AT139131T
公开(公告)日：1996-06-15
申请号：AT92113852
申请日：1992-08-14
申请人： SOLVAY DEUTSCHLAND , FRAUNHOFER GES FORSCHUNG
发明人： LOEDDING HUBERT , WINDT HORST , KOCH WOLFGANG , KLINGEBIEL RANDOLF , WHITE RICHARD DR
IPC分类号： A61M11/00 , A61M15/00

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