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1. 发明申请

WO2009117517A3 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER 审中-公开
标题翻译：基于纳米碳和碳纳米管的DNA序列
公开(公告)号：WO2009117517A3
公开(公告)日：2010-01-07
申请号：PCT/US2009037563
申请日：2009-03-18
申请人： NUCKOLLS COLIN , TANG JINYAO , LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN , UNIV ARIZONA STATE
发明人： NUCKOLLS COLIN , TANG JINYAO , LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN
IPC分类号： C12Q1/68 , B82B3/00 , G01N33/50
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2565/631
摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.
摘要翻译：本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。碳纳米管也用作读取电路中的一个电极。碳纳米管的一端保持靠近第二电极，并且碳纳米管的每个端部用柔性系带化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个将在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

2. 发明申请

WO2009117522A3 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION SEQUENCER 审中-公开
标题翻译：基于纳米碳和碳纳米管的DNA序列和序列识别序列
公开(公告)号：WO2009117522A3
公开(公告)日：2010-04-22
申请号：PCT/US2009037570
申请日：2009-03-18
申请人： LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN , UNIV ARIZONA
发明人： LINDSAY STUART , HE JIN , ZHANG PEIMING
IPC分类号： C12Q1/68 , B82B3/00 , G01N33/48
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

3. 发明公开

EP3188035A4 INFORMATION TRANSMISSION METHOD, CLIENT AND SERVER 审中-公开
标题翻译： INFORMATIONSBERTRAGUNGSVERFAHREN，客户UND服务器
公开(公告)号：EP3188035A4
公开(公告)日：2017-07-26
申请号：EP14903050
申请日：2014-09-29
申请人： HUAWEI TECH CO LTD , HE JIN
发明人： HE JIN
IPC分类号： G06F17/30
CPC分类号： H04L67/42 , G06F17/30716 , G06F17/30905 , H04L51/32
摘要： Embodiments of the present invention provide an information transfer method, a client, and a server, and relate to the field of Internet technologies. The information transfer method includes: receiving, by a client, N pieces of information and N pieces of corresponding identification information sent by a server according to a data obtaining request; obtaining, by the client, attribute information of at least two pieces of information in the N pieces of information, where the attribute information includes at least one of the following attributes of the at least two pieces of information: content separability or location adjustability; generating, by the client, to-be-posted information according to the attribute information of the at least two pieces of information and an operation instruction of a user for the at least two pieces of information; and determining, by the client, identification information corresponding to the to-be-posted information and second indication information corresponding to the to-be-posted information, and sending the server the identification information and the second indication information corresponding to the to-be-posted information. The embodiments of the present invention reduce information utilization randomness, protect lawful rights of an information publisher, and enhance user experience of the information publisher.
摘要翻译：本发明实施例提供了一种信息传递方法，客户端和服务器，涉及互联网技术领域。该信息传递方法包括：客户端根据数据获取请求接收服务器发送的N条信息和N条对应的标识信息; 所述客户端获取所述N条信息中至少两条信息的属性信息，所述属性信息包括所述至少两条信息中的至少一个属性：内容可分离性或位置可调性; 所述客户端根据所述至少两条信息的属性信息和用户对所述至少两条信息的操作指令，生成待发布信息; 所述客户端确定所述待发布信息对应的标识信息和所述待发布信息对应的第二指示信息，并向所述服务器发送所述标识信息和所述待发布信息对应的第二指示信息发布信息。本发明实施例降低了信息利用随机性，保护了信息发布者的合法权利，增强了信息发布者的用户体验。

4. 发明专利

IL195328A Antibodies binding to anionic phospholipids and aminophospholipids and their use in the preparation of pharmaceutical compositions for treating viral infections 未知
公开(公告)号：IL195328A
公开(公告)日：2014-12-31
申请号：IL19532808
申请日：2008-11-17
申请人： UNIV TEXAS , THORPE PHILIP E , SOARES MELINA M , HE JIN
发明人： THORPE PHILIP E , SOARES MELINA M , HE JIN
IPC分类号： A61K45/00 , A61K39/395 , A61P3/04 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/10 , A61P15/08 , A61P17/00 , A61P17/10 , A61P19/02 , A61P19/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/18 , C07K16/28 , C07K16/44
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

5. 发明专利

IL223908A Substantially cell-impermeant phosphatidylethanolamine-binding peptides, pharmaceutical compositions comprising them and their uses in treating viral infections and cancer 未知
公开(公告)号：IL223908A
公开(公告)日：2015-07-30
申请号：IL22390812
申请日：2012-12-26
申请人： UNIV TEXAS , THORPE PHILIP E , SOARES M MELINA , HE JIN
发明人： THORPE PHILIP E , SOARES M MELINA , HE JIN
IPC分类号： A61K20060101 , A61K39/395 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/10 , A61P15/08 , A61P17/00 , A61P17/10 , A61P19/02 , A61P19/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/18 , C07K16/28 , C07K16/44
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

6. 发明申请

WO2004006847A3 SELECTED ANTIBODIES AND DURAMYCIN PEPTIDES BINDING TO ANIONIC PHOSPHOLIPIDS AND AMINOPHOSPHOLIPIDS AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER 审中-公开
标题翻译：选择的抗体和DURAMYCIN蛋白结合至阴离子磷脂和氨基磷脂，以及它们在治疗病毒感染和癌症中的应用
公开(公告)号：WO2004006847A3
公开(公告)日：2005-04-07
申请号：PCT/US0321925
申请日：2003-07-15
申请人： UNIV TEXAS , THORPE PHILIP E , SOARES MELINA M , HUANG XIANMING , HE JIN , RAN SOPHIA
发明人： THORPE PHILIP E , SOARES MELINA M , HUANG XIANMING , HE JIN , RAN SOPHIA
IPC分类号： A61K45/00 , A61K39/395 , A61P3/04 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/10 , A61P15/08 , A61P17/00 , A61P17/10 , A61P19/02 , A61P19/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/18 , C07K16/28 , C07K16/44 , C07K16/00
CPC分类号： A61K39/395 , A61K39/39558 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K2039/505 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
摘要翻译：公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

7. 发明申请

WO2004065549A3 SMALL INTERFERENCE RNA GENE THERAPY 审中-公开
标题翻译：小干扰RNA基因治疗
公开(公告)号：WO2004065549A3
公开(公告)日：2005-03-24
申请号：PCT/US2004001320
申请日：2004-01-15
申请人： UNIV FLORIDA , CHANG LUNG-JI , HE JIN
发明人： CHANG LUNG-JI , HE JIN
IPC分类号： A61K48/00 , C12N15/11 , C12N15/113 , C07H21/04 , C12N15/63
CPC分类号： C12N15/1135 , A61K48/00 , C12N15/111 , C12N15/1132 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/027
摘要： Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.
摘要翻译：通过向细胞中导入编码针对该基因特异的siRNA的慢病毒载体，在细胞中抑制基因表达。编码针对癌症相关基因的siRNA的慢病毒载体抑制基因的表达，并在导入癌细胞后导致细胞死亡。在将HIV基因特异性siRNA的慢病毒载体导入细胞后，HIV感染细胞中的病毒复制被抑制。

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