专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009117517A3 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER 审中-公开
标题翻译：基于纳米碳和碳纳米管的DNA序列
公开(公告)号：WO2009117517A3
公开(公告)日：2010-01-07
申请号：PCT/US2009037563
申请日：2009-03-18
申请人： NUCKOLLS COLIN , TANG JINYAO , LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN , UNIV ARIZONA STATE
发明人： NUCKOLLS COLIN , TANG JINYAO , LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN
IPC分类号： C12Q1/68 , B82B3/00 , G01N33/50
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2565/631
摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.
摘要翻译：本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。碳纳米管也用作读取电路中的一个电极。碳纳米管的一端保持靠近第二电极，并且碳纳米管的每个端部用柔性系带化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个将在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

2. 发明申请

WO2009117522A3 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION SEQUENCER 审中-公开
标题翻译：基于纳米碳和碳纳米管的DNA序列和序列识别序列
公开(公告)号：WO2009117522A3
公开(公告)日：2010-04-22
申请号：PCT/US2009037570
申请日：2009-03-18
申请人： LINDSAY STUART , HE JIN , ZHANG PEIMING , REINHART KEVIN , UNIV ARIZONA
发明人： LINDSAY STUART , HE JIN , ZHANG PEIMING
IPC分类号： C12Q1/68 , B82B3/00 , G01N33/48
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

3. 发明申请

WO2008124706A2 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION 审中-公开
标题翻译：目标分子特征的装置和方法
公开(公告)号：WO2008124706A2
公开(公告)日：2008-10-16
申请号：PCT/US2008059602
申请日：2008-04-07
申请人： UNIV ARIZONA STATE , LINDSAY STUART , ZHANG PEIMING
发明人： LINDSAY STUART , ZHANG PEIMING
IPC分类号： C12M3/00
CPC分类号： G01N27/3278 , C12Q1/6869 , G01N27/028 , G01N27/3276 , G01N33/48721 , C12Q2565/631
摘要： An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may be connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes, affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
摘要翻译：用于识别易位聚合物靶分子的系统包括具有至少一个缩合物的装置，其尺寸确定为仅允许单个拷贝的分子易位。一对间隔开的感测电极与收缩部分相邻，其可以是纳米孔。第一电极连接到第一亲和元件，第二电极连接到第二亲和元件。每个亲和元件可以经由一种或多种中间化合物，例如连接分子和/或电极附着分子连接到其对应的电极。第一和第二亲和元件配置成与靶分子的第一和第二部分暂时形成氢键，因为它们经过收缩部。在易位期间，靶分子的电极，亲和元件和第一和第二部分完成电路并允许可测量的电流在第一和第二电极之间通过。该电流的随时间变化特性以及所使用的特异亲和元件允许表征靶分子。

4. 发明申请

WO2008124706A9 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION 审中-公开
标题翻译：用于目标分子表征的装置和方法
公开(公告)号：WO2008124706A9
公开(公告)日：2009-05-28
申请号：PCT/US2008059602
申请日：2008-04-07
申请人： UNIV ARIZONA STATE , LINDSAY STUART , ZHANG PEIMING
发明人： LINDSAY STUART , ZHANG PEIMING
IPC分类号： C12M1/34
CPC分类号： G01N27/3278 , C12Q1/6869 , G01N27/028 , G01N27/3276 , G01N33/48721 , C12Q2565/631
摘要： An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may be connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes, affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
摘要翻译：用于识别易位聚合物靶分子的系统包括具有至少一个收缩部的装置，所述收缩部的尺寸被设定为允许仅转移分子的单个拷贝。一对间隔开的感测电极与缩窄部分相邻，缩窄部分可以是纳米孔。第一电极连接至第一亲和元件并且第二电极连接至第二亲和元件。每个亲和元件可以经由一种或多种中间化合物（例如接头分子和/或电极附着分子）连接到其相应的电极。第一亲和元件和第二亲和元件被配置为在目标分子穿过收缩部时暂时与目标分子的第一部分和第二部分形成氢键。在易位期间，目标分子的电极，亲和元件和第一和第二部分完成电路并且允许可测量的电流在第一和第二电极之间通过。该电流的时变特性以及所采用的特定亲和元件允许表征目标分子。

5. 发明申请

WO2007139849A2 MODIFIED NUCLEIC ACID NANOARRAYS AND USES THEREFOR 审中-公开
标题翻译：改良的核酸纳豆糖及其用途
公开(公告)号：WO2007139849A2
公开(公告)日：2007-12-06
申请号：PCT/US2007012323
申请日：2007-05-23
申请人： UNIV ARIZONA STATE , CHAPUT JOHN , LINDSAY STUART , YAN HAO , ZHANG PEIMING
发明人： CHAPUT JOHN , LINDSAY STUART , YAN HAO , ZHANG PEIMING
IPC分类号： A01K67/027
CPC分类号： C12Q1/6809 , B01J19/0046 , B01J2219/00515 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C12Q1/6837 , C12Q2565/501 , C12Q2525/113 , C12Q2565/601 , C12Q2565/543 , C12Q2565/513
摘要： The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.
摘要翻译：本发明提供有限的，可寻址的和自组装的核酸平铺阵列及其使用的方法。

6. 发明专利

CA2144334A1 OLIGONUCLEOTIDES HAVING UNIVERSAL NUCLEOSIDE SPACERS 未知
公开(公告)号：CA2144334A1
公开(公告)日：1994-03-31
申请号：CA2144334
申请日：1993-09-07
申请人： BERGSTROM DONALD E , ANDREWS PHILIP C , NICHOLS RUTHANN , ZHANG PEIMING
发明人： BERGSTROM DONALD E , ANDREWS PHILIP C , NICHOLS RUTHANN , ZHANG PEIMING
IPC分类号： C12Q1/68 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24 , C07H21/00
摘要： Oligonucleotides are made having at least ten nucleosides, at least two of which are A, T, G or C and at least one is a universal nucleoside.

7. 发明公开

EP0660842A4 OLIGONUCLEOTIDES HAVING UNIVERSAL NUCLEOSIDE SPACERS. 失效
标题翻译： OLIGONUKLEOTIDE MIT UNIVERSALE NUKLEOSID-ABSTANDSHALTERN。
公开(公告)号：EP0660842A4
公开(公告)日：1996-03-27
申请号：EP93922156
申请日：1993-09-07
申请人： BERGSTROM DONALD EUGENE , ANDREWS PHILIP CHARLES , NICHOLS RUTHANN , ZHANG PEIMING
发明人： BERGSTROM DONALD EUGENE , ANDREWS PHILIP CHARLES , NICHOLS RUTHANN , ZHANG PEIMING
IPC分类号： C12Q1/68 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24 , C07H21/00 , C07H5/04 , C07H5/06 , C07H19/00 , C07H19/06
CPC分类号： C07H21/00 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Oligonucleotides are made having at least ten nucleosides, at least two of which are A, T, G or C and at least one is a universal nucleoside.
摘要翻译：具有至少10个核苷的寡核苷酸，其中至少两个选自A，T，C和G，以及至少一种核苷，其为下式通用核苷：其中：每个Rn为H， OH，F或OCH 3; Z是由O，S和CH2组成的组的成员; 并且B是具有至少两个双键的五元杂环碱基，并且还具有与其结合的吸电子基团，所述具有吸电子基团的碱基由下式表示：其中：所述具有吸电子基团的碱在X4键合到核苷的糖部分; X1，X3和X5分别是由N，O，C，S和Se组成的组的成员; X2和X4分别为N和C组成员; 并且W是由F，Cl，Br，I，O，S，OH，SH，NH2，NO2，C（O）H，C（O）NHOH，C（S）NHOH， C（NOCH 3）NH 2，OCH 3，SCH 3，SeCH 3，ONH 2，NHOCH 3，N 3，CN，C（O）NH 2，C（NOH）NH 2，CSNH 2和CO 2 H。

8. 发明申请

WO0161053A2 PROTEIN AND PEPTIDE SENSORS USING ELECTRICAL DETECTION METHODS 审中-公开
标题翻译：蛋白质和肽类传感器使用电气检测方法
公开(公告)号：WO0161053A2
公开(公告)日：2001-08-23
申请号：PCT/US0105476
申请日：2001-02-20
申请人： MOTOROLA INC , SAWYER JAYMIE ROBIN , LI CHANGMING , CHOONG VI EN , MARACAS GEORGE , ZHANG PEIMING
发明人： SAWYER JAYMIE ROBIN , LI CHANGMING , CHOONG VI-EN , MARACAS GEORGE , ZHANG PEIMING
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/5438
摘要： The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
摘要翻译：本发明提供了用于电探测分子与蛋白质或肽靶分子之间的分子相互作用的装置和方法，但不需要使用电化学或其他记录来获得可测量的信号。该方法可用于电子检测结合到阵列的限定区域的探针分子与允许与探针分子相互作用的蛋白质或肽靶分子之间的分子相互作用。

9. 发明申请

WO0143870A2 COLUMN AND ROW ADDRESSABLE HIGH DENSITY BIOCHIP ARRAY 审中-公开
标题翻译：列和可伸缩高密度BIOCHIP阵列
公开(公告)号：WO0143870A2
公开(公告)日：2001-06-21
申请号：PCT/US0034222
申请日：2000-12-14
申请人： MOTOROLA INC , SHI SONG , ZHANG PEIMING , MARACAS GEORGE
发明人： SHI SONG , ZHANG PEIMING , MARACAS GEORGE
IPC分类号： G01N33/483 , B01J19/00 , C12M1/00 , C40B20/02 , C40B40/02 , C40B50/06 , C40B60/10 , G01N27/04 , G01N27/22 , G01N27/27 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/416 , G01N27/48 , G01N33/53 , G01N33/543 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00511 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00698 , B01J2219/00704 , B01J2219/0072 , G01N27/3276 , G01N33/5438
摘要： The present invention provides a method and apparatus (9) comprising a platform for a column-and-row-addressable high-density biochip array. The apparatus (9) can be used as a high-density biochip array for electronic or electrochemical detection of molecular interactions between probe molecules bound to defined regions of the array and target molecules exposed to the array.
摘要翻译：本发明提供了一种方法和装置（9），包括用于列和行可寻址的高密度生物芯片阵列的平台。装置（9）可以用作高密度生物芯片阵列，用于电子或电化学检测结合到阵列的限定区域的探针分子和暴露于阵列的靶分子之间的分子相互作用。

10. 发明申请

WO0161053A9 PROTEIN AND PEPTIDE SENSORS USING ELECTRICAL DETECTION METHODS 审中-公开
标题翻译：蛋白质和肽类传感器使用电气检测方法
公开(公告)号：WO0161053A9
公开(公告)日：2002-10-17
申请号：PCT/US0105476
申请日：2001-02-20
申请人： MOTOROLA INC , LI CHANGMING , SAWYER JAYMIE ROBIN , CHOONG VI-EN , MARACAS GEORGE , ZHANG PEIMING
发明人： LI CHANGMING , SAWYER JAYMIE ROBIN , CHOONG VI-EN , MARACAS GEORGE , ZHANG PEIMING
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/5438
摘要： The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
摘要翻译：本发明提供了用于电探测分子与蛋白质或肽靶分子之间的分子相互作用的装置和方法，但是不需要使用电化学或其他记录来获得可测量的信号。该方法可用于电子检测结合到阵列的限定区域的探针分子与允许与探针分子相互作用的蛋白质或肽靶分子之间的分子相互作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式