专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007080197A3 IMMOBILISED ENZYMES 审中-公开
标题翻译：固定化酶
公开(公告)号：WO2007080197A3
公开(公告)日：2007-10-11
申请号：PCT/EP2007050402
申请日：2007-01-16
申请人： NOVOZYMES AS , SVENDSEN ALLAN , SKJOT MICHAEL , BRASK JESPER , VIND JESPER , PATKAR SHAMKANT ANANT , MARIA LEONARDO DE
发明人： SVENDSEN ALLAN , SKJOT MICHAEL , BRASK JESPER , VIND JESPER , PATKAR SHAMKANT ANANT , DE MARIA LEONARDO
IPC分类号： C07K17/00 , C07K1/04 , C07K17/06 , C12N11/00
CPC分类号： C12N11/06 , C07K2299/00 , C12N9/00 , C12N9/20 , C12N9/52
摘要： The invention relate to variant enzymes having one or more mutations with respect to the wild type of said variant enzyme, wherein said mutations selectively spatially orientating the active region of the variant enzyme towards the substrate when covalently immobilised.
摘要翻译：本发明涉及相对于所述变体酶的野生型具有一个或多个突变的变体酶，其中所述突变在共价固定时选择性地将变体酶的活性区朝向底物空间取向。

2. 发明申请

WO2008065060A3 LIPOLYTIC ENZYME VARIANTS 审中-公开
公开(公告)号：WO2008065060A3
公开(公告)日：2009-01-08
申请号：PCT/EP2007062783
申请日：2007-11-26
申请人： NOVOZYMES AS , MARIA LEONARDO DE , BRASK JESPER , SKJOET MICHAEL , PATKAR SHAMKANT ANANT , BORCH KIM , SVENDSEN ALLAN
发明人： DE MARIA LEONARDO , BRASK JESPER , SKJOET MICHAEL , PATKAR SHAMKANT ANANT , BORCH KIM , SVENDSEN ALLAN
IPC分类号： C12N9/20 , C12P7/40
CPC分类号： C12N9/20 , C12P7/40 , C12P7/62 , C12P7/6418 , C12Y301/01003
摘要： Molecular dynamics (MD) simulation on the three-dimensional structure of Candida anrtarctica lipase B revealed two hitherto unknown lids with a marked mobility, and this discovery was used to design lipolytic enzyme variants with increased lipolytic enzyme activity.
摘要翻译：针对念珠菌脂肪酶B的三维结构的分子动力学（MD）模拟显示两个具有明显迁移率的未知盖，并且该发现用于设计具有增加的脂肪分解酶活性的脂肪分解酶变体。

3. 发明申请

WO2006084470A2 ENZYMATIC ENANTIOSELECTIVE ESTER OR AMIDE HYDROLYSIS OR SYNTHESIS 审中-公开
标题翻译：酶活性选择性酯或酰胺水解或合成
公开(公告)号：WO2006084470A2
公开(公告)日：2006-08-17
申请号：PCT/DK2006000076
申请日：2006-02-10
申请人： NOVOZYMES AS , SVENDSEN ALLAN , VIND JESPER , BRASK JESPER , MARIA LEONARDO DE
发明人： SVENDSEN ALLAN , VIND JESPER , BRASK JESPER , DE MARIA LEONARDO
IPC分类号： C12N9/20 , C12P7/02 , C12P7/40 , C12P7/62 , C12P13/00 , C12P13/02 , C12P41/00
CPC分类号： C12N9/20 , C07K2299/00 , C12P7/02 , C12P7/40 , C12P7/62 , C12P13/02 , C12P41/004 , C12P41/007
摘要： The enantioselectivity of fungal lipolytic enzymes can be altered by substituting a suitably selected amino acid residue. The residue to be substituted is selected from its location in the 3D structure of the enzyme and an ester substrate (or a substrate analogue). A residue in the lid may be selected if it is located close to the acid part or close to the alcohol part of an ester substrate. A residue outside the lid region may be selected if it is located close to the active site or close to the substrate.
摘要翻译：真菌脂肪分解酶的对映体选择性可以通过替代适当选择的氨基酸残基来改变。待取代的残基选自其酶的位置和酯底物（或底物类似物）的3D结构。如果位于靠近酸性部分或靠近酯基材的醇部分的位置，则可以选择盖子中的残余物。如果位于靠近活性部位或靠近基底的位置，则可以选择盖子外部的残余物。

4. 发明申请

WO2004056988A3 GALACTANASE VARIANTS 审中-公开
标题翻译：糖皮质激素变体
公开(公告)号：WO2004056988A3
公开(公告)日：2004-08-12
申请号：PCT/DK0300851
申请日：2003-12-11
申请人： NOVOZYMES AS , MARIA LEONARDO DE , SVENDSEN ALLAN , BORCHERT TORBEN VEDEL , CHRISTENSEN LARS LEHMANN HYLLI , LARSEN SINE , RYTTERSGAARD CARSTEN
发明人： DE MARIA LEONARDO , SVENDSEN ALLAN , BORCHERT TORBEN VEDEL , CHRISTENSEN LARS LEHMANN HYLLI , LARSEN SINE , RYTTERSGAARD CARSTEN
IPC分类号： C12N9/38
CPC分类号： C12N9/2468 , C12Y302/01089
摘要： Variants of Glycoside hydrolase family 53 galactanases having an ateration in at least one position out of a large number of positions. The variants may be used in the dairy industry, for preparation of galacto-oligo-saccharides or for hydrolysis of lactose, and may be derived from strains of Yersinia, Aspergillus, Humicola, Meripilus, Myceliophthora, Thermomyces, Bacillus, Bifidobacterium, Cellvibrio, Clostridium, Pseudomonas, Thermotoga, or Xanthomonas.
摘要翻译：糖苷水解酶家族的53个半乳聚糖酶在大量位置上具有至少一个位置的位置。这些变体可以用于乳制品工业，用于制备低聚半乳糖或用于水解乳糖，并且可以衍生自耶尔森氏菌，曲霉属，腐质霉属，Meripilus，Myceliophthora，Thermomyces，Bacillus，Bifidobacterium，Cellvibrio，Clostridium ，假单胞菌属，热氧化酵母或黄单胞菌属。

5. 发明申请

WO2009127702A2 LACCASE VARIANTS 审中-公开
公开(公告)号：WO2009127702A2
公开(公告)日：2009-10-22
申请号：PCT/EP2009054554
申请日：2009-04-16
申请人： NOVOZYMES AS , OESTERGAARD LARS HENRIK , MARIA LEONARDO DE , TOSCANO MIGUEL DUARTE
发明人： OESTERGAARD LARS HENRIK , DE MARIA LEONARDO , TOSCANO MIGUEL DUARTE
IPC分类号： C12N9/02
CPC分类号： D21H21/32 , C11D3/38636 , C11D3/38681 , C12N9/0061 , C12Y110/03002 , D21H11/00 , D21H17/005
摘要： The present invention relates to variants of a parent laccase. The present invention also relates to polynucleotides encoding the variant laccasesand to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.
摘要翻译：本发明涉及母漆酶的变体。本发明还涉及编码变体lacCases的多核苷酸和包含多核苷酸的核酸构建体，载体和宿主细胞的多核苷酸，以及使用该变体酶的方法。

6. 发明申请

WO2011117396A3 THERMOSTABLE PHYTASE VARIANTS 审中-公开
标题翻译：热稳定的植物酶变体
公开(公告)号：WO2011117396A3
公开(公告)日：2011-11-24
申请号：PCT/EP2011054639
申请日：2011-03-25
申请人： NOVOZYMES AS , SKOV LARS KOBBEROEE , MARIA LEONARDO DE , MATSUI TOMOKO
发明人： SKOV LARS KOBBEROEE , DE MARIA LEONARDO , MATSUI TOMOKO
IPC分类号： C12N9/16 , A01H5/00 , C12N15/55 , C12N15/82
CPC分类号： C12N9/96 , A23K10/16 , A23L33/195 , A61K38/46 , C12N9/16 , C12N15/8243 , C12P7/00 , C12P7/14 , C12P21/00 , C12Y301/03008 , C12Y301/03026 , C12Y301/03072
摘要： The present invention relates to a method for producing phytase variants which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least two additional disulfide bonds as compared to this phytase. These phytase variants have modified, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to the variants produced, DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及产生与来自布氏柠檬酸杆菌的肌醇六磷酸酶具有至少74％同一性并且与该植酸酶相比包含至少两个另外的二硫键的肌醇六磷酸酶变体的方法。这些肌醇六磷酸酶变体具有修饰的，优选改进的性质，如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及所产生的变体，编码这些肌醇六磷酸酶的DNA，它们的生产方法以及它们的用途，例如，在动物饲料和动物饲料添加剂中。

7. 发明申请

WO2004072279A2 PROTEASES 审中-公开
标题翻译：蛋白酶
公开(公告)号：WO2004072279A2
公开(公告)日：2004-08-26
申请号：PCT/DK2004000091
申请日：2004-02-09
申请人： NOVOZYMES AS , PONTOPPIDAN KATRINE , WU WENPING , LAN TANG , LIU YE , MARIA LEONARDO DE
发明人： PONTOPPIDAN KATRINE , WU WENPING , LAN TANG , LIU YE , DE MARIA LEONARDO
IPC分类号： C12N9/52 , C12N9/58 , C12N15/57 , A23J3/34 , C12N9/64
CPC分类号： C12N9/52 , A01K2217/05 , C12N9/58 , C12N2310/111
摘要： The invention relates to a sub-class of novel proteases with distinct differences of expected structural relevance to known proteases of Metarhizium and Nocardiopsis. The sub-class encompasses proteases derived from Gliocladium, Periconia, Curvularia, and Brachysporiella. The invention also relates to DNA encoding such proteases, the expression thereof in a host cell, including animal and plant cells, as well as to the use thereof, e.g. in animal feed and in detergents. The invention furthermore relates to the use in animal feed of proteases of at least 55% identity to the protease derived from Brachysporiella. The Metarhizium protease is an The invention relates to a sub-class of novel proteases with distinct differences of expected structural relevance to known proteases of Metarhizium and Nocardiopsis. The sub-class encompasses proteases derived from Gliocladium, Periconia, Curvularia, and Brachysporiella. The invention also relates to DNA encoding such proteases, the expression thereof in a host cell, including animal and plant cells, as well as to the use thereof, e.g. in animal feed and in detergents. The invention furthermore relates to the use in animal feed of proteases of at least 55% identity to the protease derived from Brachysporiella. The Metarhizium protease is an example of such proteases.
摘要翻译：本发明涉及具有与已知的绿僵菌和拟诺卡氏菌蛋白酶的预期结构相关性明显不同的新型蛋白酶的亚类。亚类包括来源于粘帚霉（Gliocladium），Periconia，弯孢属（Curvularia）和短柄螺属（Brachysporiella）的蛋白酶。本发明还涉及编码这种蛋白酶的DNA，其在包括动物和植物细胞的宿主细胞中的表达，以及其用途，例如，在动物饲料和洗涤剂中。本发明还涉及在动物饲料中与来源于短柄螺属的蛋白酶具有至少55％同一性的蛋白酶的用途。 Metarhizium蛋白酶是一种新型蛋白酶的亚类，与已知的绿僵菌和拟诺卡氏菌蛋白酶的预期结构相关性有明显差异。亚类包括来源于粘帚霉（Gliocladium），Periconia，弯孢属（Curvularia）和短柄螺属（Brachysporiella）的蛋白酶。本发明还涉及编码这种蛋白酶的DNA，其在包括动物和植物细胞的宿主细胞中的表达，以及其用途，例如，在动物饲料和洗涤剂中。本发明还涉及在动物饲料中与来源于短柄螺属的蛋白酶具有至少55％同一性的蛋白酶的用途。 Metarhizium蛋白酶是这类蛋白酶的一个例子。

8. 发明申请

WO2015079064A2 PEROXYGENASE VARIANTS 审中-公开
标题翻译：过氧化物歧化酶
公开(公告)号：WO2015079064A2
公开(公告)日：2015-06-04
申请号：PCT/EP2014076107
申请日：2014-12-01
申请人： NOVOZYMES AS
发明人： VIND JESPER , OESTERGAARD LARS HENRIK , DE MARIA LEONARDO , KALUM LISBETH , AMOURGI ELENI
IPC分类号： C12N9/08
CPC分类号： C12N9/0065 , C12P7/02 , C12P7/24 , C12P7/26 , C12P7/6409 , C12Y111/02001
摘要： The present invention relates to peroxygenasevariants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及过氧化酶变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

9. 发明申请

WO2013178808A2 POLYPEPTIDES HAVING ORGANOPHOSPHOROUS HYDROLASE ACTIVITY 审中-公开
标题翻译：具有有机磷酸酯活性的多肽
公开(公告)号：WO2013178808A2
公开(公告)日：2013-12-05
申请号：PCT/EP2013061314
申请日：2013-05-31
申请人： NOVOZYMES AS
发明人： HANSEN BJARNE GRAM , DANIELSEN STEFFEN , SKOV LARS KOBBEROEE , DE MARIA LEONARDO , RANNES JULIE BILLE
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A62D3/02 , A62D3/30 , A62D2101/02 , A62D2101/04 , A62D2101/26 , C12Y301/08002
摘要： The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有有机磷水解酶活性的分离的多肽和编码多肽的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

10. 发明申请

WO2010034835A3 HAFNIA PHYTASE VARIANTS 审中-公开
公开(公告)号：WO2010034835A3
公开(公告)日：2010-06-24
申请号：PCT/EP2009062539
申请日：2009-09-28
申请人： NOVOZYMES AS
发明人： LASSEN SOEREN FLENSTED , SKOV LARS KOBBEROEE , DE MARIA LEONARDO , FRIIS ESBEN PETER , MATSUI TOMOKO , NOERGAARD ALLAN , VIND JESPER
IPC分类号： C12N9/16 , A23K1/165
CPC分类号： C12N9/16 , A23K20/189 , A23K50/30 , A23K50/75 , Y02E50/17
摘要： The present invention relates to phytases having at least 76% identity to a phytase derived from Hafnia alvei and comprises at least one modification in the amino acid sequence thereof. These phytase variants have modified, preferably improved, properties, such as, reduced protease sensitiliby, preferably they exhibit improved properties in respect of thermal performance, such as heat-stability (temperature stability, thermostability), steam stability, pelleting stability and/or temperature profile; and/or protease stability, in particular pepsin stability, pH profile, specific activity, substrate specificity, performance in animal feed(such as an improved release and/or degradation of phytate), susceptibility to glycation, and/or glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of thei r production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及与衍生自哈夫单胞菌属植物的植酸酶具有至少76％同一性的植酸酶，并且包含其氨基酸序列中的至少一个修饰。这些植酸酶变体具有修饰的，优选改进的性质，例如降低的蛋白酶敏感性，优选它们在热性能方面具有改进的性能，例如热稳定性（温度稳定性，热稳定性），蒸汽稳定性，造粒稳定性和/或温度简介; 和/或蛋白酶稳定性，特别是胃蛋白酶稳定性，pH曲线，比活性，底物特异性，动物饲料中的性能（如植酸盐的改善的释放和/或降解），对糖基化的敏感性和/或糖基化模式。本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式