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1. 发明申请

WO2008148845A3 METHOD OF PREPARING A DOUGH-BASED PRODUCT 审中-公开
标题翻译：制备基于产品的方法
公开(公告)号：WO2008148845A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008056999
申请日：2008-06-05
申请人： NOVOZYMES AS , BEIER LARS , FRIIS ESBEN PETER , LUNDQVIST HENRIK , HANSEN PETER KAMP , SPENDLER TINA
发明人： BEIER LARS , FRIIS ESBEN PETER , LUNDQVIST HENRIK , HANSEN PETER KAMP , SPENDLER TINA
IPC分类号： C12N9/28 , A21D8/04 , C12N15/56
CPC分类号： C12N9/2417 , A21D8/042 , C07K2299/00
摘要： Dough with a high sucrose content (such as cake dough) tends to inhibit the activity of an anti-staling amylase such as Novamyl®, making it less effective to prevent the staling of dough-based products with high sucrose content such as cakes. A good anti-staling effect in cakes can be achieved by using a carefully selected anti-staling amylase with certain properties. Analysis of a 3D structure of Novamyl® shows that sucrose may inhibit by binding in the active site. Sucrose docks into the active site of Novamyl® differently from the substrate or inhibitor in published models 1QHO and 1QHP. This finding is used to design sucrose-tolerant variants.
摘要翻译：具有高蔗糖含量的面团（如蛋糕面团）倾向于抑制抗淀粉酶如Novamyl®的活性，因此防止用蔗糖含量高的面团产品（如蛋糕）变形的效果较差。通过使用精心挑选的具有某些性质的抗陈化淀粉酶，可以实现蛋糕中良好的抗陈化效果。对Novamyl®的3D结构的分析显示，蔗糖可以通过在活性位点中的结合来抑制。蔗糖在已出版的模型1QHO和1QHP中基本停留在与基质或抑制剂不同的Novamyl®活性位点。该发现用于设计耐受蔗糖的变体。

2. 发明申请

WO2007087508A8 LIPASE VARIANTS 审中-公开
标题翻译：脂肪变种
公开(公告)号：WO2007087508A8
公开(公告)日：2009-07-30
申请号：PCT/US2007060841
申请日：2007-01-22
申请人： NOVOZYMES AS , NOVOZYMES INC , VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
发明人： VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

3. 发明申请

WO2011082425A3 ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译： ALPHA-AMYLASE变体和编码它们的多核苷酸
公开(公告)号：WO2011082425A3
公开(公告)日：2011-09-29
申请号：PCT/US2011020128
申请日：2011-01-04
申请人： NOVOZYMES AS , NOVOZYMES NORTH AMERICA INC , ANDERSEN CARSTEN , DEINHAMMER RANDALL , POULSEN THOMAS AGERSTEN , TOSCANO MIGUEL DUARTE , HANSEN PETER KAMP , FRIIS-MADSEN HENRIK , VIKSOE-NIELSEN ANDERS , LARSEN SIGNE E , CHRISTENSEN LARS LEHMANN HYLLING
发明人： ANDERSEN CARSTEN , DEINHAMMER RANDALL , POULSEN THOMAS AGERSTEN , TOSCANO MIGUEL DUARTE , HANSEN PETER KAMP , FRIIS-MADSEN HENRIK , VIKSOE-NIELSEN ANDERS , LARSEN SIGNE E , CHRISTENSEN LARS LEHMANN HYLLING
IPC分类号： C12N9/28
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38681 , C12N9/2414 , C12N15/8257 , C12P7/06 , C12P7/14 , C12P19/02 , C12P19/04 , C12P19/14 , C12P2203/00 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.
摘要翻译：本发明涉及母体α-淀粉酶的变体。本发明还涉及编码变体的多核苷酸和包含多核苷酸的核酸构建体，载体和宿主细胞，以及使用变体酶的方法。

4. 发明申请

WO02072876A3 SCREENING METHOD FOR THE SELECTION OF PEPTIDES OR PROTEINS COMPRISING DISCRETE DIMENSION ASSAYS, GENE MUTATION AND APPLICATION ASSAYS 审中-公开
标题翻译：选择包含离散尺寸测定的蛋白质或蛋白质的筛选方法，基因突变和应用测定
公开(公告)号：WO02072876A3
公开(公告)日：2002-12-12
申请号：PCT/DK0200160
申请日：2002-03-12
申请人： NOVOZYMES AS , KJAERULF SOEREN , LAMSA MICHAEL , THISTED THOMAS , HANSEN PETER KAMP , PEDERSEN HENRIK , FRISNER HENRIK
发明人： KJAERULF SOEREN , LAMSA MICHAEL , THISTED THOMAS , HANSEN PETER KAMP , PEDERSEN HENRIK , FRISNER HENRIK
IPC分类号： C12N15/10 , C12N15/09
CPC分类号： C12N15/1058
摘要： The present invention relates to a screening method for identifying actives (peptides or proteins) with improved performance comprising: (1) screening a library of actives encoded by nucleotide sequences in at least two different discrete dimension assays employing selected parameters and selecting the actives exhibiting improved properties in the discrete dimension assays, (2) collecting nucleotide sequences encoding the selected actives, (3) mutating collected nucleotide sequences, (4) screening actives encoded by the mutated nucleotide sequences in an application assay and selecting actives, which exhibit improved performance.
摘要翻译：本发明涉及用于鉴定具有改进性能的活性物质（肽或蛋白质）的筛选方法，其包括：（1）使用选择的参数在至少两个不同离散维度测定中筛选由核苷酸序列编码的活性物质文库，并选择显示改进的活性物质离子维度测定中的性质，（2）收集编码所选活性物质的核苷酸序列，（3）突变收集的核苷酸序列，（4）在应用测定中筛选由突变的核苷酸序列编码的活性物，并选择表现出改善的性能的活性物质。

5. 发明申请

WO2007087508A3 LIPASE VARIANTS 审中-公开
标题翻译：脂肪变种
公开(公告)号：WO2007087508A3
公开(公告)日：2008-01-24
申请号：PCT/US2007060841
申请日：2007-01-22
申请人： NOVOZYMES AS , NOVOZYMES NORTH AMERICA INC , VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
发明人： VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

6. 发明申请

WO2009107091A3 DETERGENT COMPOSITION COMPRISING LIPASE 审中-公开
标题翻译：包含脂酶的洗涤剂组合物
公开(公告)号：WO2009107091A3
公开(公告)日：2009-12-10
申请号：PCT/IB2009050786
申请日：2009-02-26
申请人： PROCTER & GAMBLE , SOUTER PHILIP FRANK , LANT NEIL JOSEPH , HAYNES THERESA CLARE , VIND JESPER , KNOETZEL JUERGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP
发明人： SOUTER PHILIP FRANK , LANT NEIL JOSEPH , HAYNES THERESA CLARE , VIND JESPER , KNOETZEL JUERGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP
IPC分类号： C12N9/20 , C11D3/386
CPC分类号： C12N9/20 , C11D3/38627
摘要： This invention relates to compositions comprising certain lipase enzymes and processes for making and using such compositions, including the use of such compositions to clean and/or treat a situs.
摘要翻译：本发明涉及包含某些脂肪酶的组合物以及制备和使用该组合物的方法，包括使用这种组合物来清洁和/或治疗部位。

7. 发明申请

WO2007087318A2 DETERGENT COMPOSITIONS 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：WO2007087318A2
公开(公告)日：2007-08-02
申请号：PCT/US2007001802
申请日：2007-01-22
申请人： PROCTER & GAMBLE , SOUTER PHILIP FRANK , BURDIS JOHN ALLEN , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , VIND JESPER , YAVER DEBBIE , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , BJORNVAD MADS ESCHELUND , HANSEN PETER KAMP , LAMSA MICHAEL
发明人： SOUTER PHILIP FRANK , BURDIS JOHN ALLEN , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , VIND JESPER , YAVER DEBBIE , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , BJORNVAD MADS ESCHELUND , HANSEN PETER KAMP , LAMSA MICHAEL
IPC分类号： C07K14/43
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to detergent compositions comprising a detergent ingredient and a lipase variant with reduced potential for odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明涉及洗涤剂组合物，其包含洗涤剂成分和通过在母体脂肪酶中鉴定的一个或多个区域中引入突变而获得的具有降低的气味生成潜力的脂肪酶变体。

8. 发明申请

WO2004041979A3 SUBTILASE VARIANTS 审中-公开
标题翻译：补充变量
公开(公告)号：WO2004041979A3
公开(公告)日：2004-09-10
申请号：PCT/DK0300756
申请日：2003-11-05
申请人： NOVOZYMES AS
发明人： DRAGBORG HENRIETTE , HANSEN PETER KAMP , BJOERNVAD MADS ESKELUND , NOERREGAARD-MADSEN MADS , MIKKELSEN MIKAEL
IPC分类号： C11D3/386 , C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , Y02P20/582
摘要： The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The subtilase variant has a modification in at least one of the positions 62, 68, 97, 98, 99, 106, 131, 170, 245 and/or 252 in combination with one or more modifications in other positions (159 specified positions), or one or more modification in position 68 (no combination). Further claimed are 56 subtilase variants not linked to the variants specified above.
摘要翻译：本发明涉及在一种或多种性质中显示相对于亲本脱羧酶的改变的新型脱羧酶变体，包括：洗涤性能，热稳定性，储存稳定性或催化活性。本发明的变体适用于例如，清洁剂或洗涤剂组合物，例如衣物洗涤剂组合物和洗碟组合物，包括自动洗碗组合物。所述脱羧酶变体在位置62,68,97,98,99,106,131,170,245和/或252中的至少一个中具有与其它位置（159个指定位置）中的一个或多个修饰相结合的修饰，或位置68中的一个或多个修改（无组合）。进一步要求保护的是56个与上述变体无关的脱羧酶变体。

9. 发明申请

WO2016001450A3 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：补充变体和编码其的多核苷酸
公开(公告)号：WO2016001450A3
公开(公告)日：2016-04-14
申请号：PCT/EP2015065376
申请日：2015-07-06
申请人： NOVOZYMES AS
发明人： RASMUSSEN FRANK WINTHER , HANSEN PETER KAMP , CHRISTENSEN LARS LEHMANN HYLLING
IPC分类号： C12N9/54 , C11D3/386 , C12N9/64
CPC分类号： C12N9/54 , C11D3/386 , C12N9/52 , C12Y304/21062
摘要： The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
摘要翻译：本发明涉及显示出增加的稳定性，优选标准或改进的洗涤性能的新型脱羧酶变体。本发明的变体适用于例如，清洁剂或洗涤剂组合物，例如衣物洗涤剂组合物和洗碟组合物，包括自动洗碗组合物。本发明还涉及编码变体，表达载体，宿主细胞的分离的DNA序列，以及用于生产和使用本发明的变体的方法。

10. 发明公开

EP2893009A4 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF 审中-公开
标题翻译： GLYCOAMYLASEVARIANTEN确保两CODING多核苷酸及其用途
公开(公告)号：EP2893009A4
公开(公告)日：2016-03-02
申请号：EP13834830
申请日：2013-09-06
申请人： NOVOZYMES AS
发明人： CRAIG JOYCE , VIND JESPER , FRIIS ESBEN PETER , POULSEN THOMAS AGERSTEN , SKJØT MICHAEL , HANSEN PETER KAMP , RASMUSSEN FRANK WINTHER , KROGSGAARD STEEN , COWARD-KELLY GUILLERMO , AYABE KEIICHI
IPC分类号： C12N9/34 , C12N15/56
CPC分类号： C12N9/2428 , C12N9/242 , C12N15/52 , C12P7/10 , C12P19/02 , C12P19/24 , Y02E50/16
摘要： The present invention relates to variants of a parent glucoamylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the glucoamylase variants.

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