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1. 发明申请

WO2007087318A2 DETERGENT COMPOSITIONS 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：WO2007087318A2
公开(公告)日：2007-08-02
申请号：PCT/US2007001802
申请日：2007-01-22
申请人： PROCTER & GAMBLE , SOUTER PHILIP FRANK , BURDIS JOHN ALLEN , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , VIND JESPER , YAVER DEBBIE , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , BJORNVAD MADS ESCHELUND , HANSEN PETER KAMP , LAMSA MICHAEL
发明人： SOUTER PHILIP FRANK , BURDIS JOHN ALLEN , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , VIND JESPER , YAVER DEBBIE , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , BJORNVAD MADS ESCHELUND , HANSEN PETER KAMP , LAMSA MICHAEL
IPC分类号： C07K14/43
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to detergent compositions comprising a detergent ingredient and a lipase variant with reduced potential for odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明涉及洗涤剂组合物，其包含洗涤剂成分和通过在母体脂肪酶中鉴定的一个或多个区域中引入突变而获得的具有降低的气味生成潜力的脂肪酶变体。

2. 发明申请

WO2007087508A8 LIPASE VARIANTS 审中-公开
标题翻译：脂肪变种
公开(公告)号：WO2007087508A8
公开(公告)日：2009-07-30
申请号：PCT/US2007060841
申请日：2007-01-22
申请人： NOVOZYMES AS , NOVOZYMES INC , VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
发明人： VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

3. 发明申请

WO2007087508A3 LIPASE VARIANTS 审中-公开
标题翻译：脂肪变种
公开(公告)号：WO2007087508A3
公开(公告)日：2008-01-24
申请号：PCT/US2007060841
申请日：2007-01-22
申请人： NOVOZYMES AS , NOVOZYMES NORTH AMERICA INC , VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
发明人： VIND JESPER , KNOTZEL JURGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP , GE HAIYAN , LAMSA MICHAEL
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

4. 发明申请

WO2009107091A3 DETERGENT COMPOSITION COMPRISING LIPASE 审中-公开
标题翻译：包含脂酶的洗涤剂组合物
公开(公告)号：WO2009107091A3
公开(公告)日：2009-12-10
申请号：PCT/IB2009050786
申请日：2009-02-26
申请人： PROCTER & GAMBLE , SOUTER PHILIP FRANK , LANT NEIL JOSEPH , HAYNES THERESA CLARE , VIND JESPER , KNOETZEL JUERGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP
发明人： SOUTER PHILIP FRANK , LANT NEIL JOSEPH , HAYNES THERESA CLARE , VIND JESPER , KNOETZEL JUERGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HONGER , YAVER DEBBIE , BJORNVAD MADS ESKELUND , HANSEN PETER KAMP
IPC分类号： C12N9/20 , C11D3/386
CPC分类号： C12N9/20 , C11D3/38627
摘要： This invention relates to compositions comprising certain lipase enzymes and processes for making and using such compositions, including the use of such compositions to clean and/or treat a situs.
摘要翻译：本发明涉及包含某些脂肪酶的组合物以及制备和使用该组合物的方法，包括使用这种组合物来清洁和/或治疗部位。

5. 发明申请

WO2008079685A3 LIPASE VARIANTS FOR PHARMACEUTICAL USE 审中-公开
标题翻译：用于药物使用的脂肪酶变体
公开(公告)号：WO2008079685A3
公开(公告)日：2008-11-06
申请号：PCT/US2007087168
申请日：2007-12-12
申请人： NOVOZYMES AS , NOVOZYMES INC , SOLVAY PHARM GMBH , SVENDSEN ALLAN , SKJOET MICHAEL , YAVER DEBBIE , CHRISTENSEN LARS LEHMANN HYLLING , LARSEN SIGNE ESKILDSEN , LUNDIN NINA , LAMSA MICHAEL , GREGORY PETER COLIN
发明人： SVENDSEN ALLAN , SKJOET MICHAEL , YAVER DEBBIE , CHRISTENSEN LARS LEHMANN HYLLING , LARSEN SIGNE ESKILDSEN , LUNDIN NINA , LAMSA MICHAEL , GREGORY PETER COLIN
IPC分类号： C12N9/20 , A61K38/46 , A61K38/54
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , C12N9/20
摘要： The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, an are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.
摘要翻译：与包含SEQ ID NO：2的氨基酸1-269的疏棉状嗜热丝孢菌（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。医学适应症的实例是：消化性疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。本发明的脂肪酶具有例如体外改善的消化性能，在中性范围的pH下改善的活性，在低pH下的稳定性改善，对蛋白酶降解稳定，和/或在存在下稳定胃蛋白酶和胆汁盐。本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新型变体。

6. 发明申请

WO2012074818A3 COMPOSITIONS AND METHODS FOR 3-HYDROXYPROPIONIC ACID PRODUCTION 审中-公开
标题翻译： 3-羟基丙酸生产的组合物和方法
公开(公告)号：WO2012074818A3
公开(公告)日：2012-09-27
申请号：PCT/US2011061717
申请日：2011-11-21
申请人： NOVOZYMES INC , JESSEN HOLLY , RUSH BRIAN , HURYTA JEANETTE , MASTEL BETH , BERRY ALAN , YAVER DEBBIE , CATLETT MICHAEL , BARNHARDT MICHELLE
发明人： JESSEN HOLLY , RUSH BRIAN , HURYTA JEANETTE , MASTEL BETH , BERRY ALAN , YAVER DEBBIE , CATLETT MICHAEL , BARNHARDT MICHELLE
IPC分类号： C12N1/18 , C12P7/42 , C12P7/52
CPC分类号： C12N15/52 , C12N1/18 , C12N9/0006 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/81 , C12N15/815 , C12P7/42 , C12Y101/01059 , C12Y206/01001 , C12Y206/01018 , C12Y206/01019 , C12Y401/01031
摘要： The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP.
摘要翻译：本申请公开了包含活性3-HP发酵途径的遗传修饰酵母细胞，以及使用这些细胞产生3-HP。

7. 发明专利

AU2015269381A1 Enzyme compositions and uses thereof 未知
公开(公告)号：AU2015269381A1
公开(公告)日：2016-11-24
申请号：AU2015269381
申请日：2015-06-04
申请人： YAVER DEBBIE , MOYER DONNA , NOVOZYMES AS
发明人： SHASKY JEFFREY , YAVER DEBBIE , MOYER DONNA
IPC分类号： C12P19/02 , C12N9/24
摘要： The present invention relates to enzyme compositions and processes of producing and using the compositions for the saccharification of lignocellulosic material.

8. 发明申请

WO2012075151A2 PROMOTERS FOR EXPRESSING GENES IN A FUNGAL CELL 审中-公开
公开(公告)号：WO2012075151A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062663
申请日：2011-11-30
申请人： NOVOZYMES INC , CATLETT MICHAEL , YAVER DEBBIE
发明人： CATLETT MICHAEL , YAVER DEBBIE
IPC分类号： C12N15/80
CPC分类号： C12N15/815 , C12N15/80 , C12P21/00 , C12P21/06
摘要： The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.

9. 发明申请

WO2008008967A2 METHODS FOR INCREASING EXPRESSION OF GENES IN A FUNGAL CELL 审中-公开
标题翻译：提高真核细胞中基因表达的方法
公开(公告)号：WO2008008967A2
公开(公告)日：2008-01-17
申请号：PCT/US2007073486
申请日：2007-07-13
申请人： NOVOZYMES INC , NOVOZYMES AS , YAVER DEBBIE , CHERRY BARBARA , BJOERNVAD MADS ESKELUND
发明人： YAVER DEBBIE , CHERRY BARBARA , BJOERNVAD MADS ESKELUND
CPC分类号： C12N15/81 , C07K14/395
摘要： The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide comprising a nucleic acid sequence encoding the polypeptide operably linked to a copper-inducible promoter sequence comprising a copper-responsive upstream activation sequence activated by a copper-dependent trans-acting transcription factor and a second polynucleotide comprising one or more (several) additional copper-responsive upstream activation sequences operably linked upstream to the promoter sequence, wherein the promoter sequence is foreign to the nucleic acid sequence encoding the polypeptide and the copper-responsive upstream activation sequences are responsible for copper-induced transcription of the promoter sequence, and a third polynucleotide comprising at least one copy of a gene encoding the copper-dependent trans-acting transcription factor; and (b) isolating the polypeptide from the cultivation medium.
摘要翻译：本发明涉及用于产生多肽的方法，其包括：（a）在有助于产生所述多肽的培养基中培养真菌宿主细胞，其中所述真菌宿主细胞包含第一多核苷酸，所述第一多核苷酸包含操作性编码所述多肽的核酸序列与铜诱导型启动子序列连接，所述启动子序列包含铜依赖性反式作用转录因子激活的铜响应上游激活序列和第二多核苷酸，所述第二多核苷酸包含一个或多个（几个）额外的铜响应上游激活序列，启动子序列，其中所述启动子序列对编码所述多肽的核酸序列是外源的并且所述铜响应上游激活序列负责所述启动子序列的铜诱导的转录，和第三多核苷酸，其包含编码所述多肽的基因的至少一个拷贝铜依赖的反式转录转录 n因素; 和（b）从培养基中分离多肽。

10. 发明申请

WO2013028912A3 METHODS FOR PRODUCING MULTIPLE RECOMBINANT POLYPEPTIDES IN A FILAMENTOUS FUNGAL HOST CELL 审中-公开
标题翻译：在真菌真菌宿主细胞中产生多种重组多肽的方法
公开(公告)号：WO2013028912A3
公开(公告)日：2013-06-06
申请号：PCT/US2012052143
申请日：2012-08-23
申请人： NOVOZYMES INC , YAVER DEBBIE , JIN QIMING
发明人： YAVER DEBBIE , JIN QIMING
IPC分类号： C12N15/80
CPC分类号： C12N9/2437 , C12N9/2402 , C12N15/80 , C12N15/87 , C12Y302/01091 , C12Y302/0115
摘要： The present invention relates to methods for constructing a filamentous fungal strain for production of multiple recombinant polypeptides having biological activity. The present invention also relates to methods for producing multiple recombinant polypeptides having biological activity in a filamentous fungal strain. The present invention also relates to filamentous fungal strains expressing multiple recombinant polypeptides having biological activity.
摘要翻译：本发明涉及构建用于生产具有生物活性的多重重组多肽的丝状真菌菌株的方法。本发明还涉及在丝状真菌菌株中生产具有生物活性的多重重组多肽的方法。本发明还涉及表达具有生物活性的多种重组多肽的丝状真菌菌株。

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