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1. 发明申请

WO2010084173A1 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译：稳定的生长激素化合物
公开(公告)号：WO2010084173A1
公开(公告)日：2010-07-29
申请号：PCT/EP2010/050725
申请日：2010-01-22
申请人： NOVO NORDISK HEALTH CARE AG , OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
发明人： OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
IPC分类号： C07K14/61 , A61K38/27
CPC分类号： C07K14/61 , A61K38/00
摘要： The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
摘要翻译：本发明涉及通过引入半胱氨酸残基具有二硫键的稳定生长激素（GH）化合物，其使得化合物对蛋白水解降解具有抗性。

2. 发明申请

WO2011089250A3 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
公开(公告)号：WO2011089250A3
公开(公告)日：2011-07-28
申请号：PCT/EP2011/050909
申请日：2011-01-24
申请人： NOVO NORDISK HEALTH CARE AG , DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
发明人： DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
IPC分类号： A61K38/27 , C07K14/61 , A61K47/48 , A61P5/00
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.

3. 发明申请

WO2012010516A1 GROWTH HORMONE CONJUGATES 审中-公开
标题翻译：生长激素
公开(公告)号：WO2012010516A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062152
申请日：2011-07-15
申请人： NOVO NORDISK HEALTH CARE AG , ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
发明人： ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
IPC分类号： A61K47/48 , A61P5/06
CPC分类号： C07K14/61 , A61K47/554
摘要： The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
摘要翻译：本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变体氨基酸残基进行。生长激素多肽可以是人生长激素或生长激素变体。

4. 发明申请

WO2014139994A1 GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译：生长激素化合物
公开(公告)号：WO2014139994A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054669
申请日：2014-03-11
申请人： NOVO NORDISK HEALTH CARE AG , ZHAO, Xin , THYGESEN, Peter , JOHANSEN, Nils Langeland , NØRSKOV-LAURITSEN, Leif
发明人： ZHAO, Xin , THYGESEN, Peter , JOHANSEN, Nils Langeland , NØRSKOV-LAURITSEN, Leif
IPC分类号： C07K19/00 , C12P21/02 , C12N5/10
CPC分类号： C07K14/61 , A61K38/00 , C07K2319/30
摘要： The invention relates to growth hormone compounds with a long plasma half-life obtained by Fc linkage. An increased half-life is an advantage allowing a less frequent or low dosage administration of therapeutic. The invention further relates to methods of producing such compound including expression vectors for heterologous expression.
摘要翻译：本发明涉及通过Fc连锁获得的长血浆半衰期的生长激素化合物。增加的半衰期是允许治疗剂的较少频率或低剂量给药的优点。本发明还涉及生产包含用于异源表达的表达载体的这种化合物的方法。

5. 发明公开

EP2970506A1 GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译： WACHSTUMSHORMONVERBINDUNGEN
公开(公告)号：EP2970506A1
公开(公告)日：2016-01-20
申请号：EP14708903.1
申请日：2014-03-11
申请人： Novo Nordisk Health Care AG
发明人： ZHAO, Xin , THYGESEN, Peter , JOHANSEN, Nils Langeland , NØRSKOV-LAURITSEN, Leif
IPC分类号： C07K19/00 , C12P21/02 , C12N5/10
CPC分类号： C07K14/61 , A61K38/00 , C07K2319/30
摘要： The invention relates to growth hormone compounds with a long plasma half-life obtained by Fc linkage. An increased half-life is an advantage allowing a less frequent or low dosage administration of therapeutic. The invention further relates to methods of producing such compound including expression vectors for heterologous expression.
摘要翻译：本发明涉及通过Fc连接获得的长血浆半衰期的生长激素化合物。增加的半衰期是允许治疗剂的较少频率或低剂量给药的优点。本发明进一步涉及生产包含用于异源表达的表达载体的这种化合物的方法。

6. 发明授权

EP2389389B1 Stable growth hormone compounds 有权转让
标题翻译：稳定生长激素化合物
公开(公告)号：EP2389389B1
公开(公告)日：2015-04-15
申请号：EP10701015.9
申请日：2010-01-22
申请人： Novo Nordisk Health Care AG
发明人： OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
IPC分类号： C07K14/61 , A61K38/27
CPC分类号： C07K14/61 , A61K38/00

7. 发明公开

EP2595661A1 GROWTH HORMONE CONJUGATES 审中-公开
标题翻译：生长激素共轭物
公开(公告)号：EP2595661A1
公开(公告)日：2013-05-29
申请号：EP11731397.3
申请日：2011-07-15
申请人： Novo Nordisk Health Care AG
发明人： ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
IPC分类号： A61K47/48 , A61P5/06
CPC分类号： C07K14/61 , A61K47/554
摘要： The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
摘要翻译：本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变型氨基酸残基发生。生长激素多肽可以是wt人类生长激素或生长激素变体。

8. 发明公开

EP2525833A2 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译：稳定成长激素化合物
公开(公告)号：EP2525833A2
公开(公告)日：2012-11-28
申请号：EP11703842.2
申请日：2011-01-24
申请人： Novo Nordisk Health Care AG
发明人： DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
IPC分类号： A61K47/48 , A61K38/27 , A61P5/00 , C07K14/61
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C07K14/61
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.

9. 发明公开

EP2389389A1 STABLE GROWTH HORMONE COMPOUNDS 有权转让
标题翻译：稳定生长激素化合物
公开(公告)号：EP2389389A1
公开(公告)日：2011-11-30
申请号：EP10701015.9
申请日：2010-01-22
申请人： Novo Nordisk Health Care AG
发明人： OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
IPC分类号： C07K14/61 , A61K38/27
CPC分类号： C07K14/61 , A61K38/00
摘要： The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.

10. 发明申请

WO2004011127A1 METHOD OF PURIFYING AIR, PROCESS FOR MANUFACTURE OF FERTILIZER, APPARATUS FOR PURIFYING AIR AND BUILDING PROVIDED WITH THIS APPARATUS 审中-公开
标题翻译：净化空气的方法，肥料的制造工艺，用于净化空气的装置和用本装置提供的建筑物
公开(公告)号：WO2004011127A1
公开(公告)日：2004-02-05
申请号：PCT/DK2003/000506
申请日：2003-07-18
申请人： SCAN-AIRCLEAN APS , THYGESEN, Peter
发明人： THYGESEN, Peter
IPC分类号： B01D53/58
CPC分类号： B01D53/1418 , A01K1/0047 , B01D53/14 , B01D2257/406 , C05C3/00 , C05F3/06 , Y02A40/208 , Y02A40/76 , Y02E50/343 , Y02P20/145 , Y02P60/542
摘要： The invention relates to a method of purifying air, a process for manufacture of fertilizer and an apparatus for purifying air by scrubbing with an acid. The apparatus for purifying air contains washing liquid and comprises: at least one air cleaning unit comprising a scrubber in which the air to be purified is washed with the acid containing washing liquid, and from which the purified air and the spent washing liquid is withdrawn; and a washing liquid control unit, arranged in a distance from the air cleaning unit(s), in which the composition of the spent washing liquid withdrawn from the scrubber is readjusted, if desired, by addition of fresh water and fresh acid and withdrawal of a corresponding amount of the spent washing liquid as a product, such as a fertilizer mixture, before the optionally readjusted washing liquid is transferred to and introduced into the scrubber as acid containing washing liquid. Furthermore the invention relates to a building provided with an apparatus for purifying air.
摘要翻译：本发明涉及一种净化空气的方法，一种制造肥料的方法和一种通过用酸洗涤来净化空气的装置。用于净化空气的装置包含洗涤液体，并且包括：至少一个空气净化单元，包括洗涤器，待洗涤空气用含酸洗涤液洗涤，净化空气和废清洗液从该清洗器中取出; 以及洗涤液控制单元，其布置在与空气净化单元一定距离的位置，如果需要，通过添加淡水和鲜酸来重新调节从洗涤器中排出的废清洗液的组成，在任选地重新调整的洗涤液体转移到洗涤器中并作为含酸洗涤液体引入洗涤器之前，将相当量的作为产品的废洗涤液体，例如肥料混合物。此外，本发明涉及一种具有净化空气的装置的建筑物。

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