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1. 发明申请

WO1998020115A1 SUBTILASE VARIANTS AND COMPOSITIONS 审中-公开
标题翻译：潜在变化和组成
公开(公告)号：WO1998020115A1
公开(公告)日：1998-05-14
申请号：PCT/DK1997000493
申请日：1997-10-31
申请人： NOVO NORDISK A/S , HANSEN, Peter, Kamp , VON DER OSTEN, Claus , BAUDITZ, Peter
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/54
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C12N9/54
摘要： Enzymes produced by mutating the genes for a number of subtilases at positions 167 and 170 and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in any detergent in comparison to their wild type parent enzymes.
摘要翻译：提出了通过突变多个位点167和170处的底物并在合适的宿主中表达突变的基因产生的酶。与其野生型亲本酶相比，酶在任何洗涤剂中表现出改善的洗涤性能。

2. 发明申请

WO1997028256A1 PROCESS FOR DESIZING CELLULOSIC FABRIC 审中-公开
标题翻译：流化纤维织物的方法
公开(公告)号：WO1997028256A1
公开(公告)日：1997-08-07
申请号：PCT/DK1997000041
申请日：1997-01-29
申请人： NOVO NORDISK A/S , VON DER OSTEN, Claus , BJORNVAD, Mads, Eskelund , VIND, Jesper , RASMUSSEN, Michael, Dolberg
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/00
CPC分类号： D06M16/003 , C07K2319/00 , C12N9/20 , C12N9/2414 , C12N9/2437 , C12Y302/01001 , C12Y302/01004 , D06L1/06
摘要： A process for desizing cellulose-containing fabric comprises treating the fabric with a modified enzyme (enzyme hybrid) which comprises a catalytically active amino acid sequence of an enzyme, particularly a non-cellulolytic enzyme, linked to an amino acid sequence comprising a cellulose-binding domain. A desizing composition suitable for use in the process comprises an enzyme hybrid of the type in question and a wetting agent.
摘要翻译：用于脱浆含纤维素织物的方法包括用修饰酶（酶杂合物）处理织物，该修饰酶包含与包含纤维素结合的氨基酸序列连接的酶特别是非纤维素分解酶的催化活性氨基酸序列域。适用于该方法的脱浆组合物包含所述类型的酶杂交物和润湿剂。

3. 发明申请

WO1997028243A1 PROCESS FOR REMOVAL OR BLEACHING OF SOILING OR STAINS FROM CELLULOSIC FABRIC 审中-公开
标题翻译：从细胞纤维织物去除或漂白土壤或污渍的方法
公开(公告)号：WO1997028243A1
公开(公告)日：1997-08-07
申请号：PCT/DK1997000042
申请日：1997-01-29
申请人： NOVO NORDISK A/S , VON DER OSTEN, Claus , CHERRY, Joel, R. , BJORNVAD, Mads, Eskelund , VIND, Jesper , RASMUSSEN, Michael, Dolberg
发明人： NOVO NORDISK A/S
IPC分类号： C11D03/386
CPC分类号： C12N9/0061 , C07K2319/00 , C11D3/386 , C12N9/0065 , C12N9/20 , C12N9/2417 , C12N9/2437 , C12Y302/01004
摘要： The invention relates to a process for removal or bleaching of soiling or stains present on cellulosic fabric, wherein the fabric is contacted in aqueous medium with a modified enzyme (enzyme hybrid) which comprises a catalytically active amino acid sequence of a non-cellulolytic enzyme linked to an amino acid sequence comprising a cellulose-binding domain. The invention further relates to a detergent composition comprising an enzyme hybrid of the type in question and a surfactant, and to a process for washing soiled or stained cellulosic fabric, wherein the fabric is washed in an aqueous medium to which is added such a detergent composition.
摘要翻译：本发明涉及一种去除或漂白存在于纤维素织物上的污渍或污渍的方法，其中织物在含水介质中与修饰的酶（酶杂合物）接触，所述修饰酶包含非纤维素分解酶的催化活性氨基酸序列涉及包含纤维素结合结构域的氨基酸序列。本发明还涉及包含所述类型的酶杂交物和表面活性剂的洗涤剂组合物，以及洗涤污染或染色的纤维素织物的方法，其中织物在水性介质中洗涤，向其中加入这种洗涤剂组合物。

4. 发明申请

WO1995024471A1 NOVEL ALKALINE CELLULASES 审中-公开
标题翻译：新的碱性细胞
公开(公告)号：WO1995024471A1
公开(公告)日：1995-09-14
申请号：PCT/DK1995000108
申请日：1995-03-08
申请人： NOVO NORDISK A/S , SCHÜLEIN, Martin , ROSHOLM, Peter , NIELSEN, Jack, Bech , HANSEN, Svend, Aage , VON DER OSTEN, Claus
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12N9/2437 , C11D3/386 , C11D3/38645 , D06L4/40 , D06M16/003 , D06P5/02 , D06P5/137 , D06P5/158 , D21C5/005 , D21C9/005 , D21H17/005 , D21H21/10
摘要： Cellulases selected from the group consisting of Family 7 cellulases and variants of these cellulases comprising a core and optionally a C-terminal link consisting of 10 amino acids at the most, especially cellulases having tryptophan, tyrosine or phenylalanine in position 55 relative to the sequence alignment of Figure 5 and/or cellulases having a substrate binding cleft of a depth of at least 12 ANGSTROM , exhibit enhanced enzyme activity in the alkaline pH range while exerting a moderate cellulolytic action on the cellulosic substrate and are, for example, useful in detergent compositions, especially for soil removal or colour clarification or preventing backstaining; in fabric softeners; for bio-polishing of textiles; for drainage improvement of paper pulp; for plant degradation. Cellulases from Humicola insolens, Fusarium oxysporum, Trichoderma reesei and Myceliophthora thermophile are referred to.
摘要翻译：选自由7族纤维素酶和这些纤维素酶变体组成的组的纤维素酶，其包含核心和任选的由最多10个氨基酸组成的C-末端连接物，特别是相对于序列比对在位置55具有色氨酸，酪氨酸或苯丙氨酸的纤维素酶和/或具有至少12 ANGSTROM深度的底物结合裂缝的纤维素酶在碱性pH范围内表现出增强的酶活性，同时在纤维素基质上施加中等的纤维素分解作用，并且例如可用于洗涤剂组合物，特别是去除污垢或进行颜色澄清或防止背染; 织物柔软剂; 用于纺织品的生物抛光; 用于纸浆排水改良; 用于植物降解。来自Humicola insolens，尖孢镰刀菌，里氏木霉和嗜热丝孢杆菌的纤维素酶被参考。

5. 发明申请

WO1996033267A1 CYCLOMALTODEXTRIN GLUCANOTRANSFERASE VARIANTS 审中-公开
标题翻译： CYCLOMALTODEXTRIN葡萄糖转运酶变体
公开(公告)号：WO1996033267A1
公开(公告)日：1996-10-24
申请号：PCT/DK1996000179
申请日：1996-04-22
申请人： NOVO NORDISK A/S , DIJKHUIZEN, Lubbert , DIJKSTRA, Bauke, W. , ANDERSEN, Carsten , VON DER OSTEN, Claus
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/26
CPC分类号： C12N9/1074 , C12P19/18 , C12Y204/01019
摘要： The present invention relates to variants of cyclomaltodextrin glucanotransferase. More specifically, the invention relates to a maethod of modifying the substrate binding and/or product selectivity of a precursor CGTase enzyme, and CGTase variants derived from a precursor CGTase enzyme by substitution, insertion and/or deletion of one or more amino acid residue(s), which amino acid residue(s) holds a position close to the substrate. Moreover, the invention relates to DNA constructs encoding the CGTase variants, expression vectors, host cells and methods of producing the CGTase variants of the invention.
摘要翻译：本发明涉及环糊精葡聚糖转移酶的变体。更具体地，本发明涉及通过取代，插入和/或缺失一个或多个氨基酸残基来修饰前体CGT酶的底物结合和/或产物选择性的方法和衍生自前体CGT酶的CGTase变体（ s），哪个氨基酸残基保持靠近底物的位置。此外，本发明涉及编码CGTase变体，表达载体，宿主细胞的DNA构建体和产生本发明的CGTase变体的方法。

6. 发明申请

WO1995030743A1 PROTEASE VARIANTS 审中-公开
公开(公告)号：WO1995030743A1
公开(公告)日：1995-11-16
申请号：PCT/DK1995000180
申请日：1995-05-04
申请人： NOVO NORDISK A/S , VON DER OSTEN, Claus , FREDHOLM, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/04
CPC分类号： C11D3/386 , C12N9/58
摘要： The present invention relates to novel trypsin-like protease variants with improved properties, DNA constructs coding for the expression of said variants, host cells capable of expressing the variants from the DNA constructs, as well as a method of producing the variants by cultivating said host cells. The variants may advantageously be used as constituents in detergent compositions and additives.
摘要翻译：本发明涉及具有改进性质的新型胰蛋白酶样蛋白酶变体，编码所述变体表达的DNA构建体，能够从DNA构建体表达变体的宿主细胞，以及通过培养所述宿主产生变体的方法细胞。这些变体可有利地用作洗涤剂组合物和添加剂中的组分。

7. 发明申请

WO1992019729A1 STABILIZED ENZYMES AND DETERGENT COMPOSITIONS 审中-公开
标题翻译：稳定的酶和洗涤剂组合物
公开(公告)号：WO1992019729A1
公开(公告)日：1992-11-12
申请号：PCT/DK1992000138
申请日：1992-04-30
申请人： NOVO NORDISK A/S , VON DER OSTEN, Claus , BRANNER, Sven , SVENDSEN, Allan , HEDEGÅRD, Lisbeth , ERIKSEN, Nina , EGMOND, Maarten, Robert , CASTELEIJN, Eric
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/50
CPC分类号： C12N9/54 , C11D3/386 , C12N9/00
摘要： This invention relates to enzymatic detergent compositions comprising novel stabilized proteases, in which naturally occurring amino acid residue (other than proline) has been substituted with a proline residue at one or more positions, at which position(s) the dihedral angles phi (phi) and psi (psi) constitute values within the intervals [-90 DEG
摘要翻译：本发明涉及包含新型稳定蛋白酶的酶洗涤剂组合物，其中天然存在的氨基酸残基（脯氨酸除外）已被一个或多个位置处的脯氨酸残基取代，其中二面角度phi（phi）和psi（psi）构成在[-90°

8. 发明申请

WO1992019726A1 STABILIZED ENZYMES 审中-公开
标题翻译：稳定的酶
公开(公告)号：WO1992019726A1
公开(公告)日：1992-11-12
申请号：PCT/DK1992000142
申请日：1992-05-01
申请人： NOVO NORDISK A/S , SVENDSEN, Allan , VON DER OSTEN, Claus , CLAUSEN, Ib, Groth , PATKAR, Shamkant, Anant , BORCH, Kim
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/00
CPC分类号： C11D3/38645 , C11D3/386 , C11D3/38627 , C11D3/38636 , C11D3/38654 , C12N9/00 , C12N9/20
摘要： This invention relates to novel stabilized enzymes. More specifically the invention relates to novel stabilized enzymes, in which a naturally occurring amino acid residue (other than proline) has been substituted with a proline residue at one or more positions; at which position(s) the dihedral angles phi (phi) constitute values within the interval [-90 DEG
摘要翻译：本发明涉及新的稳定化酶。更具体地，本发明涉及新的稳定化酶，其中天然存在的氨基酸残基（除脯氨酸以外）已被一个或多个位置的脯氨酸残基取代; 在哪个位置上二面角phi（phi）构成间隔[-90°

9. 发明申请

WO1996023062A1 ANIMAL FEED ADDITIVES COMPRISING XYLANASE 审中-公开
标题翻译：包含XYLANASE的动物饲料添加剂
公开(公告)号：WO1996023062A1
公开(公告)日：1996-08-01
申请号：PCT/DK1996000046
申请日：1996-01-26
申请人： NOVO NORDISK A/S , HANSEN, Peter, Kamp , WAGNER, Peter , MÜLLERTZ, Anette , KNAP, Inge, Helmer
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/24
CPC分类号： C12Y302/01032 , A23K20/189 , C12N9/248 , C12Y302/01008
摘要： The present invention relates to animal feed additives, which additives comprise a monocomponent xylanase derived from a strain of Humicola, a strain of Thermoascus, a strain of Chaetomium, a strain of Mucor, a strain of Talaromyces, a strain of Malbranchea, a strain of Myceliophthora, a strain of Thielavia, a strain of Byssochlamus, or a strain of Paecilomyces. In other aspects, the invention relates to monocomponent xylanase preparations, DNA constructs, recombinant expression vectors, host cells, and methods of producing monocomponent xylanase preparations.
摘要翻译：本发明涉及动物饲料添加剂，其添加剂包含源自Humicola菌株的单组分木聚糖酶，Thermoascus菌株，Chaetomium菌株，Mucor菌株，Talaromyces菌株，Malbranchea菌株，Malbranchea菌株丝状丝霉菌属，Thielavia菌株，Byssochlamus菌株或拟青霉菌株。在其他方面，本发明涉及单组分木聚糖酶制剂，DNA构建体，重组表达载体，宿主细胞和生产单组分木聚糖酶制剂的方法。

10. 发明公开

EP0687319A1 A PROCESS FOR PROVIDING LOCALIZED VARIATION IN THE COLOUR DENSITY OF FABRICS 失效
标题翻译：方法用于织物色彩饱和度提供本地变异
公开(公告)号：EP0687319A1
公开(公告)日：1995-12-20
申请号：EP94908295.0
申请日：1994-02-25
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S
IPC分类号： C12N9 , D06M16 , D06P1 , D06P5 , C12R1
CPC分类号： D06P1/5257 , D06P1/525 , D06P1/647 , D06P5/158
摘要： Process for providing improved localised variation in the colour density of the surface of dyed fabrics, the process comprising treating a dyed fabric with a cellulytic enzyme in an aqueous liquor comprising a di- or trivalent cation and a chelating agent in a molar ratio of 1:0.1-50.

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