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1. 发明申请

WO2013088259A3 METHODS OF PURIFYING ANTIBODIES 审中-公开
标题翻译：纯化抗体的方法
公开(公告)号：WO2013088259A3
公开(公告)日：2013-11-14
申请号：PCT/IB2012003028
申请日：2012-10-19
申请人： NOVIMMUNE SA , ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： C07K16/00 , C07K16/46
CPC分类号： C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
摘要翻译：本发明提供了使用各种抗体特异性纯化介质来纯化抗体以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物以从混合物中分离出所需抗体产物的方法。本发明涉及纯化对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体，例如由单一重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个含有λ恒定结构域包括具有共同重链的不同特异性的抗体。本发明还提供了通过将完整抗体与包括游离轻链的非完整抗体分开来有效纯化完整抗体的方法。

2. 发明申请

WO2010041145A2 IL-17-MEDIATED TRANSFECTION METHODS 审中-公开
标题翻译： IL-17介导的转染方法
公开(公告)号：WO2010041145A2
公开(公告)日：2010-04-15
申请号：PCT/IB2009007235
申请日：2009-10-07
申请人： NOVIMMUNE SA , ELSON GREG , CONTIE MATHIAS , FOUQUE NICOLAS , LEGER OLIVIER , POITEVIN YVES
发明人： ELSON GREG , CONTIE MATHIAS , FOUQUE NICOLAS , LEGER OLIVIER , POITEVIN YVES
IPC分类号： C07K14/54 , C12N15/00
CPC分类号： C07K14/54
摘要： The invention comprises compositions and methods for IL-17-mediated transfection that results in superior and enhanced properties of cell survival and protein production.
摘要翻译：本发明包含用于IL-17介导的转染的组合物和方法，其导致细胞存活和蛋白质生产的优异和增强的性质。

3. 发明专利

CA2853011C METHODS OF PURIFYING ANTIBODIES 未知
公开(公告)号：CA2853011C
公开(公告)日：2022-09-06
申请号：CA2853011
申请日：2012-10-19
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： A61K39/00 , C07K16/46
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.

4. 发明专利

AU2016232349A1 Methods of purifying bispecific antibodies 未知
公开(公告)号：AU2016232349A1
公开(公告)日：2017-10-05
申请号：AU2016232349
申请日：2016-03-14
申请人： NOVIMMUNE SA
发明人： FOUQUE NICOLAS , DEPOISIER JEAN FRANÇOIS , WILSON KEITH , VAJDA JUDITH , MÜLLER EGBERT , DABRE ROMAIN
IPC分类号： C07K16/00 , C07K16/24 , C07K16/28 , C07K16/46
摘要： The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.

5. 发明专利

AU2017221794A1 Methods of Purifying Antibodies 未知
公开(公告)号：AU2017221794A1
公开(公告)日：2017-09-21
申请号：AU2017221794
申请日：2017-08-30
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： A61K39/00
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.

6. 发明专利

AU2012351751A1 Methods of purifying antibodies 未知
公开(公告)号：AU2012351751A1
公开(公告)日：2014-06-05
申请号：AU2012351751
申请日：2012-10-19
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANÇOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： A61K39/00
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.

7. 发明专利

AU2016232349B2 Methods of purifying bispecific antibodies 未知
公开(公告)号：AU2016232349B2
公开(公告)日：2022-01-20
申请号：AU2016232349
申请日：2016-03-14
申请人： NOVIMMUNE SA
发明人： FOUQUE NICOLAS , DEPOISIER JEAN FRANÇOIS , WILSON KEITH , VAJDA JUDITH , MÜLLER EGBERT , DABRE ROMAIN
IPC分类号： C07K16/00 , C07K16/24 , C07K16/28 , C07K16/46
摘要： The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.

8. 发明专利

ES2767135T3 Métodos para purificar anticuerpos 未知
公开(公告)号：ES2767135T3
公开(公告)日：2020-06-16
申请号：ES12842689
申请日：2012-10-19
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： C07K16/24 , C07K16/00 , C07K16/28 , C07K16/46
摘要： Un método para purificar un anticuerpo biespecífico que consiste en dos copias de un polipéptido de cadena pesada simple y una primera cadena ligera que comprende una región constante kappa y una segunda cadena ligera que comprende una región constante lambda, el método comprende las etapas de: (a) proporcionar una composición de anticuerpos mixtos que comprende uno o más de los anticuerpos biespecíficos que consisten en dos copias de un polipéptido de cadena pesada simple y una primera cadena ligera que comprende una región constante kappa y una segunda cadena ligera que comprende una región constante lambda (Ac biespecífico); uno o más anticuerpos monoclonales monoespecíficos que tienen dos cadenas ligeras lambda o porciones de las mismas (λ-AcM); y uno o más anticuerpos monoclonales monoespecíficos que tienen dos cadenas ligeras kappa o porciones de las mismas (κ-AcM); (b) proporcionar un medio de separación que tiene una afinidad específica por una región constante de cadena ligera kappa o una región constante de cadena ligera lambda, en donde el medio de separación se acopla a un ligando que tiene una alta especificidad y afinidad por una región constante de cadena ligera kappa o una región constante de cadena ligera lambda, y en donde el ligando es un anticuerpo monoclonal anti-lambda o un anticuerpo monoclonal anti-kappa; (c) poner en contacto los medios de separación con la composición de anticuerpos mixtos en condiciones que permitan la unión diferencial al medio de separación por el Ac biespecífico en comparación con la unión al medio de separación por las regiones constantes de cadena ligera kappa del κ-AcM o por las regiones constantes de cadena ligera lambda del λ-AcM; y (d) eluir los anticuerpos del medio de separación en condiciones que permitan el desprendimiento preferencial del Ac biespecífico en comparación con el desprendimiento de las regiones constantes de cadena ligera kappa del κ-AcM o el desprendimiento de las regiones constantes de cadena ligera lambda del λ-AcM; en donde las condiciones de unión y/o elución se seleccionan entre uno de: una variación por etapas del nivel de pH, una variación por etapas de la concentración de sal inorgánica, una variación por etapas de la concentración de un aminoácido en la composición de anticuerpos mixtos, o la inclusión de uno o más agentes desnaturalizantes.

9. 发明专利

DK2768857T3 FREMGANGSMÅDER TIL OPRENSNING AF ANTISTOFFER 未知
公开(公告)号：DK2768857T3
公开(公告)日：2020-02-03
申请号：DK12842689
申请日：2012-10-19
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： C07K16/24 , C07K16/00 , C07K16/28 , C07K16/46

10. 发明专利

AU2017221794B2 Methods of Purifying Antibodies 未知
公开(公告)号：AU2017221794B2
公开(公告)日：2019-04-18
申请号：AU2017221794
申请日：2017-08-30
申请人： NOVIMMUNE SA
发明人： ELSON GREG , FOUQUE NICOLAS , DEPOISIER JEAN-FRANCOIS , FISCHER NICOLAS , MAGISTRELLI GIOVANNI
IPC分类号： A61K39/00
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.

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