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1. 发明申请

WO2004050132A3 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A3
公开(公告)日：2004-10-14
申请号：PCT/EP0313598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
发明人： CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , G02B1/04
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可以赋予医学更高的表面亲水性和相对高的抗微生物活性以及低的细胞毒性。本发明的抗微生物涂层对隐形眼镜的期望体积特性具有最小的不利影响，例如透氧性，离子渗透性和光学性质。本发明的抗微生物涂层可以在延长佩戴的隐形眼镜中发现特别的用途。此外，本发明提供了制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

2. 发明申请

WO02096477A3 DIFFUSION-CONTROLLABLE COATINGS ON MEDICAL DEVICE 审中-公开
标题翻译：扩散控制涂层在医疗设备上
公开(公告)号：WO02096477A3
公开(公告)日：2004-04-22
申请号：PCT/EP0205938
申请日：2002-05-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LALLY JOHN MARTIN , WINTERTON LYNN COOK , MORRIS CAROL ANN , QIU YONGXING , CARNEY FIONA PATRICIA , KOTOV NICOLA
发明人： LALLY JOHN MARTIN , WINTERTON LYNN COOK , MORRIS CAROL ANN , QIU YONGXING , CARNEY FIONA PATRICIA , KOTOV NICOLA
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/30 , A61L27/34 , A61L31/08 , A61L31/10 , G02B1/04
CPC分类号： A61L27/34 , A61L27/306 , A61L31/088 , A61L31/10 , G02B1/043
摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.
摘要翻译：本发明提供一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够对所述医疗装置上的扩散可控涂层施加期望的渗透性。

3. 发明申请

WO2004046726A3 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 审中-公开
标题翻译：用于糖尿病快速筛选的方法和试剂盒
公开(公告)号：WO2004046726A3
公开(公告)日：2005-01-06
申请号：PCT/EP0312958
申请日：2003-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
发明人： MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
IPC分类号： A61B5/00 , C12Q1/54 , G01N33/66 , G01N33/68 , A61B10/00 , G01N33/52 , G01N33/542
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译：本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间内测定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。本发明的方法通过使用本发明的试剂盒进行。试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

4. 发明专利

AT348640T 未知
公开(公告)号：AT348640T
公开(公告)日：2007-01-15
申请号：AT03795870
申请日：2003-12-02
申请人： NOVARTIS PHARMA GMBH
发明人： CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , G02B1/04
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.

5. 发明专利

AU2002344189A1 Diffusion-controllable coatings on medical device 未知
公开(公告)号：AU2002344189A1
公开(公告)日：2002-12-09
申请号：AU2002344189
申请日：2002-05-29
申请人： NOVARTIS PHARMA GMBH
发明人： LALLY JOHN MARTIN , QIU YONGXING , KOTOV NICOLA , WINTERTON LYNN COOK , MORRIS CAROL ANN , CARNEY FIONA PATRICIA
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/30 , A61L27/34 , A61L31/08 , A61L31/10 , G02B1/04
摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

6. 发明专利

DE602004022793D1 未知
公开(公告)号：DE602004022793D1
公开(公告)日：2009-10-08
申请号：DE602004022793
申请日：2004-03-11
申请人： NOVARTIS AG
发明人： CARNEY FIONA PATRICIA , MORRIS CAROL ANN , QIU YONGXING
IPC分类号： A61B5/00 , A61B10/00 , A61F9/00 , G02B1/04

7. 发明专利

AU2003298164A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 未知
公开(公告)号：AU2003298164A1
公开(公告)日：2004-06-23
申请号：AU2003298164
申请日：2003-12-02
申请人： NOVARTIS AG
发明人： GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN , CARNEY FIONA PATRICIA
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.

8. 发明专利

CA2460027A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 未知
公开(公告)号：CA2460027A1
公开(公告)日：2003-05-22
申请号：CA2460027
申请日：2002-11-13
申请人： NOVARTIS AG
发明人： WINTERTON LYNN COOK , MORRIS CAROL ANN , GABRIEL MANAL M , LALLY JOHN MARTIN , MORGAN COURTNEY FLEM , ASH MARCIA KAY , QIU YONGXING , CARNEY FIONA PATRICIA
IPC分类号： G02C7/04 , A61F2/16 , A61F9/00 , A61K31/785 , A61K45/00 , A61L27/00 , A61L27/34 , A61L31/10 , A61L33/16 , A61P31/00 , G02B1/04
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear conta ct lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

9. 发明专利

AU2003293704A1 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 未知
公开(公告)号：AU2003293704A1
公开(公告)日：2004-06-15
申请号：AU2003293704
申请日：2003-11-19
申请人： NOVARTIS AG
发明人： MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
IPC分类号： A61B5/00 , C12Q1/54 , G01N33/66 , G01N33/68
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

10. 发明专利

AU2003268912A1 METHODS AND KITS FOR ASSAYS OF ANALYTES OF INTEREST IN TEARS 未知
公开(公告)号：AU2003268912A1
公开(公告)日：2004-04-23
申请号：AU2003268912
申请日：2003-10-02
申请人： NOVARTIS AG
发明人： LANE JENNIFER DAWN , MORRIS CAROL ANN , CARNEY FIONA PATRICIA
IPC分类号： A61B10/00
摘要： The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform cross-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e.g., lactoferrin, glucose, herpes simplex virus, hormones, etc.).

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