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1. 发明申请

WO2004046726A2 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 审中-公开
标题翻译：用于糖尿病快速筛选的方法和试剂盒
公开(公告)号：WO2004046726A2
公开(公告)日：2004-06-03
申请号：PCT/EP2003/012958
申请日：2003-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS, Carol, Ann , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn
发明人： MORRIS, Carol, Ann , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn
IPC分类号： G01N33/66
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译：本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间内测定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。本发明的方法通过使用本发明的试剂盒进行。试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

2. 发明申请

WO2009032122A1 CONTACT LENS PACKAGING SOLUTIONS 审中-公开
标题翻译：联系人镜头包装解决方案
公开(公告)号：WO2009032122A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010146
申请日：2008-08-27
申请人： NOVARTIS AG , MINICK, Kasey, Jon , CARNEY, Fiona, Patricia , SENTELL, Karen, Belinda , MINNO, George, Edward
发明人： MINICK, Kasey, Jon , CARNEY, Fiona, Patricia , SENTELL, Karen, Belinda , MINNO, George, Edward
IPC分类号： G02B1/04 , A61L12/08
CPC分类号： B65B25/008 , A61L12/04 , G02B1/043
摘要： An ophthalmic product, comprising a sealed and sterilized package which include a packaging solution and a soft hydrogel contact lens immersed in the packaging solution, wherein the packaging solution includes: a homopolymer or copolymer of vinylpyrrolidone, wherein the homopolymer or copolymer of vinylpyrrolidone is present in an amount sufficient to provide the packaging solution a viscosity of up to about 5.0 centipoises at 25°C; glycerin or a polyethylene glycol having an average molecular weight of about 600 or less; an α-oxo-multi-acid or salt thereof in an amount sufficient to have a reduced susceptibility to oxidation degradation of the polyethylene glycol in the packaging solution; and one or more buffering agents in an amount sufficient to provide the solution a pH of from about 6.0 to 8.0, wherein the packaging solution has an osmolality of from about 200 to about 450 mOsm/kg. The application further provides a process for making a soft contact lens capable of easing wearer's initial discomfort.
摘要翻译：一种眼科产品，包括密封和灭菌的包装，其包括浸没在包装溶液中的包装溶液和软水凝胶隐形眼镜，其中所述包装溶液包括：乙烯基吡咯烷酮的均聚物或共聚物，其中乙烯基吡咯烷酮的均聚物或共聚物存在于足以使包装溶液在25℃下的粘度高达约5.0厘泊; 甘油或平均分子量为约600以下的聚乙二醇; 一种α-氧代多酸或其盐，其量足以使包装溶液中聚乙二醇氧化降解的敏感性降低; 和一种或多种缓冲剂，其量足以提供约6.0至8.0的pH，其中所述包装溶液的重量摩尔渗透压浓度为约200至约450mOsm / kg。该应用还提供了一种制造能够减轻佩戴者初始不适的柔软隐形眼镜的方法。

3. 发明申请

WO2004080296A1 METHOD AND KITS FOR MONITORING WOMEN’S HEALTH 审中-公开
标题翻译：监测妇女健康的方法和工具
公开(公告)号：WO2004080296A1
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002529
申请日：2004-03-11
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , MORRIS, Carol, Ann
发明人： CARNEY, Fiona, Patricia , MORRIS, Carol, Ann
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/4306 , A61B10/0012 , A61B10/0045 , A61B2010/0067
摘要： The invention provides methods and kits for monitoring the status of women’s health, including HRT monitoring and determination or diagnosis of ovulation, contraception, pregnancy, menopause, polycystic ovarian disease, and female sexual dysfunction. The method comprises the steps of: (a) collecting a tear fluid from a female human; (b) determining the tear concentration of at least one hormone of relevance to female fertility, sexual differentiation of sexual dysfunction in a female human, wherein the tear concentration is diagnostics of the status of women’s health.
摘要翻译：本发明提供了监测妇女健康状况的方法和工具，包括HRT监测和排卵，避孕，怀孕，绝经，多囊卵巢疾病和女性性功能障碍的确定或诊断。该方法包括以下步骤：（a）从女性人体收集泪液; （b）确定与女性生育力相关的至少一种激素的泪液浓度，女性人类性功能障碍的性别分化，其中泪液浓度是对妇女健康状况的诊断。

4. 发明申请

WO2004080297A1 DEVICES FOR COLLECTING ANALYTES OF INTEREST IN TEARS 审中-公开
标题翻译：收集利益分析的设备
公开(公告)号：WO2004080297A1
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002543
申请日：2004-03-11
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , MORRIS, Carol, Ann , QIU, Yongxing
发明人： CARNEY, Fiona, Patricia , MORRIS, Carol, Ann , QIU, Yongxing
IPC分类号： A61B5/00
CPC分类号： A61B5/42 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/411 , A61B5/4306 , A61B10/0045 , A61B2010/0067
摘要： The present invention provides a contact lens, preferably a daily disposable contact lens, which can be used to collect one or more analytes of interest in a tear fluid, and in turn, determine the physiological state or health of an individual.
摘要翻译：本发明提供一种隐形眼镜，优选为每日一次性隐形眼镜，其可用于在泪液中收集一种或多种感兴趣的分析物，并且进而确定个体的生理状况或健康状况。

5. 发明申请

WO2004050132A2 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A2
公开(公告)日：2004-06-17
申请号：PCT/EP2003/013598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
发明人： CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供医疗装置，优选隐形眼镜，其包含含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可赋予医学以增加的表面亲水性和相对高的抗微生物活性以及低细胞毒性。本发明的抗微生物涂层对隐形眼镜的所需整体性质（例如透氧性，离子渗透性和光学性质）具有最小的不利影响。本发明的抗微生物涂层可以特别用于长效隐形眼镜。另外，本发明提供了一种用于制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

6. 发明申请

WO2003041754A1 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2003041754A1
公开(公告)日：2003-05-22
申请号：PCT/EP2002/012710
申请日：2002-11-13
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS, Carol, Ann , GABRIEL, Manal, M. , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , ASH, Marcia, Kay , CARNEY, Fiona, Patricia , MORGAN, Courtney, Flem
发明人： MORRIS, Carol, Ann , GABRIEL, Manal, M. , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , ASH, Marcia, Kay , CARNEY, Fiona, Patricia , MORGAN, Courtney, Flem
IPC分类号： A61L27/34
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和透镜材料的离子透过率。这种透镜可用作延长佩戴的隐形眼镜。此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

7. 发明申请

WO2004030544A1 METHODS AND KITS FOR ASSAYS OF ANALYTES OF INTEREST IN TEARS 审中-公开
标题翻译：用于分析利益分析的方法和工具
公开(公告)号：WO2004030544A1
公开(公告)日：2004-04-15
申请号：PCT/EP2003/010972
申请日：2003-10-02
申请人： NOVARTIS AG. , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn , MORRIS, Carol, Ann
发明人： CARNEY, Fiona, Patricia , LANE, Jennifer, Dawn , MORRIS, Carol, Ann
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B2010/0067
摘要： The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform crass-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e.g., lactoferrin, glucose, herpes simplex virus, hormones, etc.).
摘要翻译：本发明在一个方面提供了一种用于撕裂收集的条带。带材具有第一端和相对的第二端，并且优选地具有从第一端到第二端的基本均匀的粗糙部分。条带由基本上干燥状态的水凝胶材料制成。该条带的特征在于，当被泪液完全弄脏时，沿着水凝胶条具有从第一端到第二端的基本上均匀的溶胀，并且通过所述带的撕裂吸收体积与邪恶端的长度之间的相关性所述条的一部分。本发明的条带可用于测定泪液中感兴趣的分析物。本发明还提供了用于测定所关注的分析物（例如乳铁蛋白，葡萄糖，单纯疱疹病毒，激素等）的方法和试剂盒。

8. 发明申请

WO2004046726A3 METHODS AND KITS FOR ASSAYS OF RAPID SCREENING OF DIABETES 审中-公开
标题翻译：用于糖尿病快速筛选的方法和试剂盒
公开(公告)号：WO2004046726A3
公开(公告)日：2005-01-06
申请号：PCT/EP0312958
申请日：2003-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
发明人： MORRIS CAROL ANN , CARNEY FIONA PATRICIA , LANE JENNIFER DAWN
IPC分类号： A61B5/00 , C12Q1/54 , G01N33/66 , G01N33/68 , A61B10/00 , G01N33/52 , G01N33/542
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译：本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间内测定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。本发明的方法通过使用本发明的试剂盒进行。试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

9. 发明申请

WO2004050132A3 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A3
公开(公告)日：2004-10-14
申请号：PCT/EP0313598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
发明人： CARNEY FIONA PATRICIA , GABRIEL MANAL M , MORRIS CAROL ANN , LALLY JOHN MARTIN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , G02B1/04
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供一种医疗装置，优选隐形眼镜，其包括含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可以赋予医学更高的表面亲水性和相对高的抗微生物活性以及低的细胞毒性。本发明的抗微生物涂层对隐形眼镜的期望体积特性具有最小的不利影响，例如透氧性，离子渗透性和光学性质。本发明的抗微生物涂层可以在延长佩戴的隐形眼镜中发现特别的用途。此外，本发明提供了制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

10. 发明申请

WO02096477A3 DIFFUSION-CONTROLLABLE COATINGS ON MEDICAL DEVICE 审中-公开
标题翻译：扩散控制涂层在医疗设备上
公开(公告)号：WO02096477A3
公开(公告)日：2004-04-22
申请号：PCT/EP0205938
申请日：2002-05-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LALLY JOHN MARTIN , WINTERTON LYNN COOK , MORRIS CAROL ANN , QIU YONGXING , CARNEY FIONA PATRICIA , KOTOV NICOLA
发明人： LALLY JOHN MARTIN , WINTERTON LYNN COOK , MORRIS CAROL ANN , QIU YONGXING , CARNEY FIONA PATRICIA , KOTOV NICOLA
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/30 , A61L27/34 , A61L31/08 , A61L31/10 , G02B1/04
CPC分类号： A61L27/34 , A61L27/306 , A61L31/088 , A61L31/10 , G02B1/043
摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.
摘要翻译：本发明提供一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够对所述医疗装置上的扩散可控涂层施加期望的渗透性。

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