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1. 发明申请

WO2011080595A3 POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS 审中-公开
标题翻译：多糖免疫调节蛋白与大肠杆菌载体蛋白结合
公开(公告)号：WO2011080595A3
公开(公告)日：2012-07-26
申请号：PCT/IB2010003484
申请日：2010-12-30
申请人： NOVARTIS AG , COSTANTINO PAOLO , SERINO LAURA , ROMANO MARIA ROSARIA , TONTINI MARTA , BERTI FRANCESCO , MICOLI FRANCESCA , KABANOVA ANNA
发明人： COSTANTINO PAOLO , SERINO LAURA , ROMANO MARIA ROSARIA , TONTINI MARTA , BERTI FRANCESCO , MICOLI FRANCESCA , KABANOVA ANNA
IPC分类号： A61K47/48 , A61K39/02
CPC分类号： A61K47/4833 , A61K39/0002 , A61K39/0258 , A61K39/39 , A61K47/646 , A61K2039/6068
摘要： E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
摘要翻译：已经鉴定出大肠杆菌蛋白质可用作载体蛋白，以改善对与这种蛋白质缀合的多糖免疫原的反应。特别地，已证明AcfD前体蛋白（orf3526多肽），Flu抗原43蛋白（orf1364多肽）和含Sell重复蛋白（upec-5211多肽）是有效的。此外，这些大肠杆菌蛋白质可增强对葡聚糖，特别是葡萄糖葡萄糖的免疫应答。

2. 发明申请

WO2013038385A2 ESCHERICHIA COLI VACCINE COMBINATION 审中-公开
标题翻译： ESCHERICHIA COLI疫苗组合
公开(公告)号：WO2013038385A2
公开(公告)日：2013-03-21
申请号：PCT/IB2012054825
申请日：2012-09-14
申请人： NOVARTIS AG , SERINO LAURA , PIZZA MARIAGRAZIA
发明人： SERINO LAURA , PIZZA MARIAGRAZIA
IPC分类号： C07K14/245 , A61K39/108 , A61P31/04
CPC分类号： A61K39/0258 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/55544 , A61K2039/70 , C07K14/245
摘要： The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.
摘要翻译：本发明提供了免疫原性组合物，其包含（i）具有SEQ ID NO：2所示氨基酸序列的细菌Ig样结构域蛋白片段（orf405B）或与其具有至少80％相似性的蛋白，和（ii））具有SEQ ID NO：8所示氨基酸序列的推定脂蛋白（orf3526）或与其具有至少80％相似性的蛋白质。

3. 发明申请

WO2008020330A3 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI 审中-公开
标题翻译：来自UROPATHOGENIC ESCHERICHIA COLI的免疫原
公开(公告)号：WO2008020330A3
公开(公告)日：2009-03-19
申请号：PCT/IB2007003306
申请日：2007-08-15
申请人： NOVARTIS AG , SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , HACKER JOERG , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
发明人： SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , HACKER JOERG , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
IPC分类号： C07K14/245 , A61K39/00
CPC分类号： A61K39/0258
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译：本文公开了可以包含在对致病性大肠杆菌菌株特异性的免疫原性组合物中的各种多肽。这些多肽具有让其免疫系统可接近的细胞位置。编码多肽的基因最初被鉴定为存在于致病菌株536中，但不存在于非致病菌株中。

4. 发明申请

WO2011004263A9 CONSERVED ESCHERICHIA COLI IMMUNOGENS 审中-公开
公开(公告)号：WO2011004263A9
公开(公告)日：2011-07-28
申请号：PCT/IB2010001962
申请日：2010-07-07
申请人： NOVARTIS AG , SERINO LAURA , FONTANA MARIA RITA , MORIEL DANILO GOMES
发明人： SERINO LAURA , FONTANA MARIA RITA , MORIEL DANILO GOMES
IPC分类号： C07K14/435
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258
摘要： Homologs of the E. coli proteins orf353, bacterial lg-like domain (group 1) protein (orf405), flu antigen 43 (orfl 364), NodT-family outer-membrane-factor-lipoprotein efflux transporter (orfl 767), gspK (orf3515), gspJ (orf3516), toriB-dependent siderophore receptor (orO597), fibrial protein (orf3613), upec-948, upec- 1232. A chain precursor of the type- 1 fimbria! protein (upec- 1875), yapH homolog (upec-2820), hemolysin A (recp-3768), and Sel l repeat-containing protein (upec-521 1 ) from several pathogenic strains of E. coli have been identified with regions within the proteins that are conserved across all E. coli. Fragments corresponding to the conserved regions, especially immunogenic fragments such a linear B-epitopes, are provided. In addition, variants of the bacterial lg-l ike domain (group 1 ) protein (orf405), yapH homolog (upec2820) and two different fragments of hemolysin A (recp3768) are provided herein that have increased solubility as compared to the native protein where the variants still raise a substantially similar immune response in a subject as the corresponding native protein.

5. 发明申请

WO2009104092A3 ESCHERICHIA COLI IMMUNOGENS WITH IMPROVED SOLUBILITY 审中-公开
标题翻译：具有改善溶解性的ESCHERICHIA COLI IMMUNOGENS
公开(公告)号：WO2009104092A3
公开(公告)日：2010-02-25
申请号：PCT/IB2009000440
申请日：2009-02-23
申请人： NOVARTIS AG , SERINO LAURA , PIZZA MARIAGRAZIA , GOMES MORIEL DANILO , FONTANA MARIA RITA
发明人： SERINO LAURA , PIZZA MARIAGRAZIA , GOMES MORIEL DANILO , FONTANA MARIA RITA
IPC分类号： C07K14/245 , A61K39/02 , C12N15/31
CPC分类号： A61K39/0258 , C07K14/245
摘要： Variants of the pathogenic E. coli 'AcfD precursor' have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.
摘要翻译：与天然AcfD蛋白质相比，与天然AcfD蛋白质在主体中产生基本上相似的免疫应答的天然AcfD蛋白质相比，鉴定出致病性大肠杆菌“AcfD前体”的变体具有增加的溶解度。

6. 发明申请

WO2011004263A3 CONSERVED ESCHERICHIA COLI IMMUNOGENS 审中-公开
标题翻译：保留ESCHERICHIA COLI IMMUNOGENS
公开(公告)号：WO2011004263A3
公开(公告)日：2011-09-29
申请号：PCT/IB2010001962
申请日：2010-07-07
申请人： NOVARTIS AG , SERINO LAURA , FONTANA MARIA RITA , MORIEL DANILO GOMES
发明人： SERINO LAURA , FONTANA MARIA RITA , MORIEL DANILO GOMES
IPC分类号： C07K14/245 , A61K39/02
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258
摘要： Homologs of the E. coli proteins orf353, bacterial lg-like domain (group 1) protein (orf405), flu antigen 43 (orfl 364), NodT-family outer-membrane-factor-lipoprotein efflux transporter (orfl 767), gspK (orf3515), gspJ (orf3516), toriB-dependent siderophore receptor (orO597), fibrial protein (orf3613), upec-948, upec- 1232. A chain precursor of the type- 1 fimbria! protein (upec- 1875), yapH homolog (upec-2820), hemolysin A (recp-3768), and Sel l repeat-containing protein (upec-521 1 ) from several pathogenic strains of E. coli have been identified with regions within the proteins that are conserved across all E. coli. Fragments corresponding to the conserved regions, especially immunogenic fragments such a linear B-epitopes, are provided. In addition, variants of the bacterial lg-l ike domain (group 1 ) protein (orf405), yapH homolog (upec2820) and two different fragments of hemolysin A (recp3768) are provided herein that have increased solubility as compared to the native protein where the variants still raise a substantially similar immune response in a subject as the corresponding native protein.
摘要翻译：大肠杆菌蛋白orf353，细菌Ig样结构域（组1）蛋白（orf405），流感抗原43（orf1364），NodT家族外膜因子脂蛋白流出转运蛋白（orf1 767），gspK（ orf3515），gspJ（orf3516），toriB依赖性铁载体受体（or597），纤维蛋白（orf3613），upec-948，upec-1232。已经鉴定了来自几种大肠杆菌致病菌株的蛋白质（upec-1875），yapH同源物（upec-2820），溶血素A（recp-3768）和含有Sel1重复序列的蛋白质（upec-5211）在所有大肠杆菌中保守的蛋白质。提供了对应于保守区的片段，特别是免疫原性片段，例如线性B表位。此外，本文提供了与天然蛋白质相比具有增加的溶解度的细菌Ig-1结构域（组1）蛋白质（orf405），yapH同源物（upec2820）和两种不同的溶血素A片段（recp3768）的变体，其中变体仍然在对象中产生与对应的天然蛋白质基本相似的免疫应答。

7. 发明申请

WO2008020330A9 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI 审中-公开
标题翻译：来自UROPATHOGENIC ESCHERICHIA COLI的免疫原
公开(公告)号：WO2008020330A9
公开(公告)日：2008-10-23
申请号：PCT/IB2007003306
申请日：2007-08-15
申请人： NOVARTIS AG , SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , HACKER JOERG , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
发明人： SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , HACKER JOERG , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
IPC分类号： C07K14/245 , A61K39/00
CPC分类号： A61K39/0258
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译：本文公开了可以包含在对致病性大肠杆菌菌株特异性的免疫原性组合物中的各种多肽。这些多肽具有让其免疫系统可接近的细胞位置。编码多肽的基因最初被鉴定为存在于致病菌株536中，但不存在于非致病菌株中。

8. 发明申请

WO2008020330A8 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI 审中-公开
标题翻译：来自UROPATHOGENIC ESCHERICHIA COLI的免疫原
公开(公告)号：WO2008020330A8
公开(公告)日：2008-06-05
申请号：PCT/IB2007003306
申请日：2007-08-15
申请人： NOVARTIS AG , NOVARTIS VACCINES & DIAGNOSTIC , SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
发明人： SCORZA FRANCESCO BERLANDA , MORIEL DANILO GOMES , PIZZA MARIAGRAZIA , SERINO LAURA , FONTANA MARIA RITA
CPC分类号： A61K39/0258
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译：本文公开了可包含在对致病性大肠杆菌菌株特异的免疫原性组合物中的各种多肽。多肽具有使其可被免疫系统接近的细胞位置。编码多肽的基因最初被鉴定为存在于尿路致病性菌株536中，但不存在于非致病性菌株中。

9. 发明申请

WO2006091517A2 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI 审中-公开
标题翻译：来自UROPATHOGENIC ESCHERICHIA COLI的免疫原
公开(公告)号：WO2006091517A2
公开(公告)日：2006-08-31
申请号：PCT/US2006005912
申请日：2006-02-17
申请人： CHIRON CORP , PIZZA MARIAGRAZIA , SERINO LAURA , BERLANDA SCORZA FRANCESCO , MASIGNANI VEGA
发明人： PIZZA MARIAGRAZIA , SERINO LAURA , BERLANDA SCORZA FRANCESCO , MASIGNANI VEGA
CPC分类号： C07K14/245 , A61K38/00
摘要： Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains but are absent from non-pathogenic strains, and their encoded proteins have cellular locations which render them accessible to the immune system.
摘要翻译：本文公开了可以包含在对病原性大肠杆菌菌株特异性的免疫原性组合物中的各种基因。这些基因来自尿毒性致病菌株，但不存在于非致病菌株中，并且它们编码的蛋白质具有使其免疫系统可接近的细胞位置。

10. 发明申请

WO2006089264A2 PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI 审中-公开
标题翻译：来自MENINGITIS / SEPSIS相关的ESCHERICHIA COLI的蛋白质和核酸
公开(公告)号：WO2006089264A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005913
申请日：2006-02-17
申请人： CHIRON CORP , INST GENOMIC RESEARCH , BERLANDA SCORZA FRANCESCO , PIZZA MARIAGRAZIA , SERINO LAURA , MASIGNANI VEGA , TETTELIN HERVE
发明人： BERLANDA SCORZA FRANCESCO , PIZZA MARIAGRAZIA , SERINO LAURA , MASIGNANI VEGA , TETTELIN HERVE
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
摘要： Disclosed herein are various open reading frames from a strain of E.coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
摘要翻译：本文公开了来自负责新生儿脑膜炎（MNEC）的大肠杆菌菌株的各种开放阅读框，以及对于制备用于免疫MNEC感染的组合物特别有意义的这些的一部分。

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