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1. 发明公开

EP3219777A1 PROCESS AND PLANT FOR TRANSFORMING COMBUSTIBLE MATERIALS IN CLEAN GAS WITHOUT TARS 审中-公开
标题翻译：工艺和设备在干净气体中转换可燃材料而不用塔
公开(公告)号：EP3219777A1
公开(公告)日：2017-09-20
申请号：EP16202784.1
申请日：2016-12-07
申请人： Bordonzotti, Ivan , Antonioli, Giuseppe , Berti, Francesco
发明人： Bordonzotti, Ivan , Antonioli, Giuseppe , Berti, Francesco
IPC分类号： C10J3/30 , C10J3/66 , C10J3/00
CPC分类号： C10J3/30 , C10J3/66
摘要： Plant for transforming of combustible materials in tar-free clean gas, said plant comprising:
- a pirolysis reactor (20) suitable for being supplied on one inlet (40) by means of said combustible materials, said pirolysis reactor (20) being at least partially installed in a first chamber (30) thermally insulated and being touched in use by gases of combustion of pyrolysis gases produced by said pirolysis reactor (20), and wherein said pirolysis reactor (20) outgoing produces char ;
- a flow generation chamber (140) underlying said first chamber (30) thermally insulated and communicating with it, wherein said flow generation chamber (140) has inlet nozzles (220) supplied with pyrolysis gases produced by said pirolysis reactor (20);
- an anoxic decarburization unit (100) having first inlet means (80) supplied with said outbound char produced by said pyrolysis reactor (20) and having second inlet means, directly connected with said flow generation chamber (140); wherein in said flow generation chamber (140) takes place a stoichiometric or overstoichiometric combustion of part of said pyrolysis gases in a burner (210), wherein the resting part of said pyrolysis gases supplied with said inlet nozzles (220) is then blended with the products of said combustion thus obtaining a hot flow totally oxygen-free and wherein are completely burned the tars contained in said pyrolysis gases.
The invention comprises furthermore the associated proceeding.
摘要翻译：用于在无焦油清洁气体中转化可燃材料的设备，所述设备包括： - 适于通过所述可燃材料在一个入口（40）上供应的溶解反应器（20），所述溶解反应器（20）至少部分安装在隔热反应器（20）产生的热解气体的燃烧气体使用时保温的第一室（30）中，并且其中所述溶出反应器（20）产生焦炭; - 与所述第一室（30）隔热并与其连通的所述第一室（30）下方的流动发生室（140），其中所述流动发生室（140）具有供应有由所述溶解反应器（20）产生的热解气体的入口喷嘴（220）; - 缺氧脱碳单元（100），其具有第一入口装置（80），所述第一入口装置（80）供应有由所述热解反应器（20）产生的所述出口焦炭并具有与所述流动发生室（140）直接连接的第二入口装置; 其中在所述流动生成室（140）中发生燃烧器（210）中的所述热解气体的一部分的化学计量或超化学计量燃烧，其中与所述入口喷嘴（220）一起供应的所述热解气体的搁置部分随后与所述燃烧的产物由此获得完全无氧的热流并且其中完全燃烧包含在所述热解气体中的焦油。此外，本发明还包括相关的过程。

2. 发明申请

WO2012085668A3 COMPOUNDS 审中-公开
公开(公告)号：WO2012085668A3
公开(公告)日：2012-06-28
申请号：PCT/IB2011/003244
申请日：2011-12-23
申请人： NOVARTIS AG , COSTANTINO, Paolo , ADAMO, Roberto , ROMANO, Maria Rosaria , DANIEL, Elisa , BERTI, Francesco , CAPPELLITTI, Emilia , LAY, Luigi
发明人： COSTANTINO, Paolo , ADAMO, Roberto , ROMANO, Maria Rosaria , DANIEL, Elisa , BERTI, Francesco , CAPPELLITTI, Emilia , LAY, Luigi
IPC分类号： C07H15/04 , C07H15/18 , A61K39/08 , C08B37/00 , C08L5/00 , C12P19/04 , A61P1/12 , A61P31/04 , A61K39/40 , A61K39/44 , A61K47/48
摘要： The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.

3. 发明申请

WO2009150543A3 CONJUGATED VI SACCHARIDES 审中-公开
标题翻译：结合六味
公开(公告)号：WO2009150543A3
公开(公告)日：2010-05-06
申请号：PCT/IB2009006285
申请日：2009-06-12
申请人： NOVARTIS AG , MICOLI FRANCESCA , COSTANTINO PAOLO , BERTI FRANCESCO
发明人： MICOLI FRANCESCA , COSTANTINO PAOLO , BERTI FRANCESCO
IPC分类号： A61K47/48 , A61P43/00
CPC分类号： C07K14/195 , A61K39/0275 , A61K47/6415 , A61K47/646
摘要： Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.
摘要翻译：已经通过碳二亚胺介导的合成制备了两种Vi缀合物，其使用衍生化的CRM197（一种白喉毒素的无毒变体）和破伤风类毒素的己二酸二酰肼作为载体蛋白。

4. 发明申请

WO2009150533A2 ANALYSIS OF VI SACCHARIDES 审中-公开
标题翻译：六味子的分析
公开(公告)号：WO2009150533A2
公开(公告)日：2009-12-17
申请号：PCT/IB2009006087
申请日：2009-06-12
申请人： NOVARTIS AG , BERTI FRANCESCO , MICOLI FRANCESCA , PROIETTI DANIELA
发明人： BERTI FRANCESCO , MICOLI FRANCESCA , PROIETTI DANIELA
IPC分类号： G01N33/15
CPC分类号： G01R33/46 , G01N24/08 , G01N2333/255 , G01N2400/10 , Y10T436/143333
摘要： Salmonella typhi Vi saccharide can be assayed in two new ways. First, its proton NMR spectrum can be used, with comparison to an internal Standard permitting quantitative analysis. Second, anion exchange chromatography with amperometric detection can be used on hydrolysed saccharide.
摘要翻译：伤寒沙门氏菌Vi糖可以通过两种新方法进行测定。首先，可以使用其质子NMR谱，与允许定量分析的内部标准进行比较。第二，具有电流检测的阴离子交换层析可用于水解糖。

5. 发明申请

WO2008084411A3 MODIFIED SACCHARIDES 审中-公开
标题翻译：改良的SACCHARIDES
公开(公告)号：WO2008084411A3
公开(公告)日：2008-12-24
申请号：PCT/IB2008001116
申请日：2008-01-11
申请人： NOVARTIS AG , BARDOTTI ANGELA , BERTI FRANCESCO , COSTANTINO PAOLO
发明人： BARDOTTI ANGELA , BERTI FRANCESCO , COSTANTINO PAOLO
IPC分类号： C08B37/00 , A61K39/02 , A61K47/48
CPC分类号： C08B37/00 , A61K39/095 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , C07H13/00 , C08B37/006
摘要： Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -OX-Y (Ia) or -0-R1 (Ib) wherein X is C(O), S(O) or SO2; Y is NR1R2 or R3; R1 is C1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R2 is H or C1-6 alkyl; and R3 is C1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.
摘要翻译：在相应的天然荚膜糖的至少一个单糖单元上的羟基位置上含有封闭基团的改性荚膜糖，其中所述封闭基团为式（Ia）或（Ib）：-OX-Y（Ia）或-O-R 1（Ib）其中X为C（O），S（O）或SO 2; Y是NR1R2或R3; R1是独立地选自羟基，巯基和胺的1,2或3个基团取代的C 1-6烷基; R2是H或C1-6烷基; 且R 3为C 1-6烷基; 用阻聚基修饰荚膜糖的方法; 包含修饰的荚膜糖的糖 - 蛋白质缀合物; 制备糖 - 蛋白质缀合物的方法，包含改性荚膜糖和/或糖 - 蛋白质缀合物的药物组合物; 以及相同的方法和用途。

6. 发明申请

WO2007023386A3 ZWITTERIONIZATION OF CAPSULAR SACCHARIDES 审中-公开
标题翻译：胶囊糖蛋白的ZWT移植
公开(公告)号：WO2007023386A3
公开(公告)日：2007-07-05
申请号：PCT/IB2006002833
申请日：2006-08-24
申请人： NOVARTIS VACCINES & DIAGNOSTIC , TELFORD JOHN , BERTI FRANCESCO , WACK ANDREAS
发明人： TELFORD JOHN , BERTI FRANCESCO , WACK ANDREAS
IPC分类号： A61K39/09 , C08B37/00
CPC分类号： A61K39/092 , A61K39/095 , C08B37/006
摘要： Capsular saccharides are typically anionic. In the invention, however, cationic groups are introduced, such that the modified saccharide has a repeating unit which includes both cationic and anionic groups. These cationic and anionic groups can be balanced to give a zwitterionic repeating unit. These modifications can convert a saccharide that is normally a T-independent antigen into one that can activate T cells without requiring conjugation to a carrier. Typically, the invention modifies an anionic bacterial capsular saccharide antigen by converting a neutral group in the saccharide into a cationic group e.g. to change -NHAc to -NH 3
摘要翻译：荚膜糖通常是阴离子的。然而，在本发明中，引入阳离子基团，使得修饰的糖具有包括阳离子和阴离子基团的重复单元。这些阳离子和阴离子基团可以被平衡以产生两性离子重复单元。这些修饰可以将通常是T非依赖性抗原的糖转化为可以激活T细胞而不需要与载体缀合的糖。典型地，本发明通过将糖中的中性基团转化为阳离子基团例如改变阴离子细菌荚膜糖抗原来修饰阴离子细菌荚膜糖抗原。将-NHAc改变为-NH ₃

7. 发明申请

WO2006082530A2 CONJUGATION OF STREPTOCOCCAL CAPSULAR SACCHARIDES 审中-公开
标题翻译：结肠粘膜囊肿的结合
公开(公告)号：WO2006082530A2
公开(公告)日：2006-08-10
申请号：PCT/IB2006000756
申请日：2006-02-01
申请人： CHIRON SRL , BERTI FRANCESCO
发明人： BERTI FRANCESCO
IPC分类号： A61K47/48 , A61K39/09
CPC分类号： A61K39/385 , A61K39/09 , A61K39/092 , A61K47/48261 , A61K47/48284 , A61K47/4833 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , A61K2039/627 , A61K2039/64 , C07K14/315
摘要： Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidised sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.
摘要翻译：用于无乳链球菌荚膜糖的三种共轭方法。在第一种方法中，使用氧化唾液酸残基侧链的还原动画，但是首先将醛基胺化，然后通过接头将胺与载体偶联。在第二种方法中，将唾液酸残基和/或N-乙酰基 - 葡糖胺残基脱N-乙酰化以产生胺基，并且胺基通过接头与载体蛋白偶联。在第三种方法中，连接是通过荚膜糖中的半乳糖残基而不是唾液酸残基，这可以方便地使用半乳糖氧化酶来实现。

8. 发明申请

WO2011080595A2 POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS 审中-公开
标题翻译：多糖免疫调节蛋白与大肠杆菌载体蛋白结合
公开(公告)号：WO2011080595A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/003484
申请日：2010-12-30
申请人： NOVARTIS AG , COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
发明人： COSTANTINO, Paolo , SERINO, Laura , ROMANO, Maria, Rosaria , TONTINI, Marta , BERTI, Francesco , MICOLI, Francesca , KABANOVA, Anna
IPC分类号： A61K47/48 , A61K39/02
CPC分类号： A61K47/4833 , A61K39/0002 , A61K39/0258 , A61K39/39 , A61K47/646 , A61K2039/6068 , Y02A50/401 , Y02A50/403 , Y02A50/41 , Y02A50/478 , Y02A50/484
摘要： E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
摘要翻译：已经鉴定出大肠杆菌蛋白质可用作载体蛋白，以改善对与这种蛋白质缀合的多糖免疫原的反应。特别地，已证明AcfD前体蛋白（orf3526多肽），Flu抗原43蛋白（orf1364多肽）和含Sell重复蛋白（upec-5211多肽）是有效的。此外，这些大肠杆菌蛋白质可增强对葡聚糖，特别是葡萄糖葡萄糖的免疫应答。

9. 发明申请

WO2008084411A2 MODIFIED SACCHARIDES 审中-公开
标题翻译：改良的SACCHARIDES
公开(公告)号：WO2008084411A2
公开(公告)日：2008-07-17
申请号：PCT/IB2008/001116
申请日：2008-01-11
申请人： NOVARTIS AG , BARDOTTI, Angela , BERTI, Francesco , COSTANTINO, Paolo
发明人： BARDOTTI, Angela , BERTI, Francesco , COSTANTINO, Paolo
CPC分类号： C08B37/00 , A61K39/095 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , C07H13/00 , C08B37/006
摘要： Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -OX-Y (Ia) or -0-R 1 (Ib) wherein X is C(O), S(O) or SO 2 ; Y is NR 1 R 2 or R 3 ; R 1 is C 1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R 2 is H or C 1-6 alkyl; and R3 is C 1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.
摘要翻译：在相应的天然荚膜糖的至少一个单糖单元上的羟基位置上含有封闭基团的改性荚膜糖，其中所述封闭基团为式（Ia）或（Ib）：-OX-Y（Ia）或者-O-R 1（Ib）其中X是C（O），S（O）或SO 2; Y是NR 1，R 2或R 3; R 1是被独立地选自羟基，巯基和胺的1,2或3个基团取代的C 1-6烷基; R 2是H或C 1-6烷基; 且R 3为C 1-6烷基; 用阻聚基修饰荚膜糖的方法; 包含修饰的荚膜糖的糖 - 蛋白质缀合物; 制备糖 - 蛋白质缀合物的方法，包含改性荚膜糖和/或糖 - 蛋白质缀合物的药物组合物; 以及相同的方法和用途。

10. 发明申请

WO2013009564A1 TYROSINE LIGATION PROCESS 审中-公开
标题翻译：酪氨酸生物过程
公开(公告)号：WO2013009564A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/045549
申请日：2012-07-05
申请人： NOVARTIS AG , ADAMO, Roberto , ALLAN, Martin , BERTI, Francesco , DANIELI, Elisa , HU, Qi-Ying
发明人： ADAMO, Roberto , ALLAN, Martin , BERTI, Francesco , DANIELI, Elisa , HU, Qi-Ying
IPC分类号： A61K47/48 , A61K39/02 , A61K39/00 , A61P31/00
CPC分类号： A61K47/4833 , A61K39/385 , A61K47/51 , A61K47/54 , A61K47/549 , A61K47/593 , A61K47/62 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/505
摘要： A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide (or a protein) containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having an amino terminus end (A 1 ) and an acid terminus end (A 2 ) of the protein or polypeptide (either the amino or acid terminus end can be the at least one tyrosine unit) and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.
摘要翻译：提供了制备包含分散在氨基酸链中的n个大于或等于1的整数的n个酪氨酸单元的多肽（或蛋白质）的式（IA）或（I）的缀合物的方法，具有氨基末端（A1）和蛋白质或多肽的酸性末端（A2）（氨基酸或酸性末端可以是至少一个酪氨酸单元），并且其重均分子量等于或大于 10,000道尔顿（10kDa），其中所述缀合物包含数个m个如式（IA）或（I）所示的酪氨酸缀合物（修饰的酪氨酸残基），其中m为至少一个且小于或等于n：其中 X，Lg，L和R如本文所定义。

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