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1. 发明申请

WO2008116132A3 SILICONE-CONTAINING PREPOLYMERS WITH HYDROPHILIC POLYMERIC CHAINS 审中-公开
标题翻译：含硅氧烷聚合物的含硅酮的预聚物
公开(公告)号：WO2008116132A3
公开(公告)日：2008-12-11
申请号：PCT/US2008057775
申请日：2008-03-21
申请人： NOVARTIS AG , ZHOU JIAN S , CHANG FRANK , MEDINA ARTURO NORBERTO , SCOTT ROBERT
发明人： ZHOU JIAN S , CHANG FRANK , MEDINA ARTURO NORBERTO , SCOTT ROBERT
IPC分类号： G02B1/04 , A61L27/26 , C08F283/12 , C08G77/06
CPC分类号： C08F283/12 , C08L51/085 , C08L2666/02
摘要： The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
摘要翻译：本发明提供了一类含有悬浮亲水聚合物链的含硅氧烷预聚物。这种含硅氧烷的预聚物能够进行光化交联以形成具有亲水表面的硅氧烷水凝胶材料，而无需后固化表面处理。本发明还涉及由这种含硅氧烷的预聚物制成的硅酮水凝胶隐形眼镜以及制备硅酮水凝胶隐形眼镜的方法。

2. 发明申请

WO2008008752A3 ACTINICALLY CROSSLINKABLE COPOLYMERS FOR MANUFACTURING CONTACT LENSES 审中-公开
标题翻译：用于制造接触镜片的交联共聚物
公开(公告)号：WO2008008752A3
公开(公告)日：2008-02-28
申请号：PCT/US2007073119
申请日：2007-07-10
申请人： NOVARTIS AG , CHANG FRANK , MEDINA ARTURO NORBERTO
发明人： CHANG FRANK , MEDINA ARTURO NORBERTO
IPC分类号： C08F2/46 , C08F8/00 , C08F220/00 , C08G77/442 , G02B1/04 , G02C7/04
CPC分类号： C07C231/12 , C07C67/00 , C08F8/00 , C08F220/06 , C08F220/26 , C08F220/56 , C08F230/08 , C08F2220/286 , C08F2800/20 , C08F2810/20 , C08F2810/30 , C08G77/442 , C08J3/075 , C08J3/28 , C08J2433/04 , C08J2483/04 , G02B1/043 , C08L51/085 , C08F290/068 , C08F285/00
摘要： The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.
摘要翻译：本发明涉及可通过（a）共聚选自N，N-二甲基丙烯酰胺（DMA），丙烯酸2-羟基乙酯（HEA），甲基丙烯酸缩水甘油酯（GMA））的至少两种不同亲水性单体的新型可交联共聚物，，N-乙烯基吡咯烷酮（NVP），丙烯酸（AA）和C 1 -C 4 -C 4 - 烷氧基聚乙二醇（甲基）丙烯酸酯，其重均分子量为在具有官能团的链转移剂的存在下，至少一种包含两个或更多个烯键式不饱和双键的交联剂; 和（b）使所得共聚物的一种或多种官能团与具有烯属不饱和基团的有机化合物反应。

3. 发明申请

WO2004048472A3 STABILIZATION OF POLY(OXYALKYLENE) CONTINING POLYMERIC MATERIALS 审中-公开
标题翻译：聚（氧亚烷基）连续聚合物材料的稳定化
公开(公告)号：WO2004048472A3
公开(公告)日：2004-07-15
申请号：PCT/EP0313320
申请日：2003-11-26
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14 , C08K5/09 , A61L27/00 , A61L31/00 , C08K5/00
CPC分类号： C08L75/14 , A61L27/18 , C08G18/5024 , C08G18/6685 , C08G18/71 , C08G2120/00 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/175 , C08L71/02 , C08L2203/02 , C08L2666/04
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.
摘要翻译：本发明提供了用于生产由稳定的含聚（氧化烯）的聚合物材料制成的医疗装置，优选为眼科装置，更优选为隐形眼镜的方法。本发明的方法包括以下步骤：在模具中固化组合物，所述组合物包含（a）具有至少一个聚（氧化烯）单元的预聚物，（b）其量为生物相容性有机多酸或其生物相容性盐的量足以改善由该组合物制备的含聚（氧化烯）的聚合物，（c）任选的光引发剂或热引发剂，和（d）任选的一种或多种乙烯基单体的稳定性，以形成不易受氧化降解; 并从模具中取出医疗装置。

4. 发明申请

WO2005025843A3 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2005025843A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004010135
申请日：2004-09-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , TENA MIREILLE
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , TENA MIREILLE
IPC分类号： B29C35/08 , B29D11/00
CPC分类号： B29D11/0099 , B29C35/0894 , B29C2035/0827 , B29C2035/0833 , B29D11/00057 , B29D11/00125 , B29L2011/0041
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.
摘要翻译：本发明涉及一种用于制造具有相对高的边缘质量并且在再现期望的透镜设计时具有相对高的精度和保真度的隐形眼镜的方法和流体组合物。本发明的方法包括：模具，其具有具有第一模制表面的第一模具半部和具有第二模制表面的第二模具半部，其中第一和第二半模构造成彼此接收，使得形成空腔在限定待制造的隐形眼镜的相对的两个表面的第一和第二模制表面之间; 光化辐射的空间限制，以限定要产生的隐形眼镜的边缘; 以及在包含透镜形成材料的流体组合物中添加自由基清除剂，以减少由光化学的空间限制之外和周围的流体组合物的扩散，散射和/或反射入射光化辐射引起的交联/聚合辐射。

5. 发明专利

PL2092376T3 Wytwarzanie urządzeń okulistycznych na bazie fotoindukowanej polimeryzacji stopniowej 未知
公开(公告)号：PL2092376T3
公开(公告)日：2013-03-29
申请号：PL07855080
申请日：2007-12-12
申请人： NOVARTIS AG
发明人： MEDINA ARTURO NORBERTO , SMITH DAWN A , SCOTT ROBERT
IPC分类号： G02B1/04

6. 发明专利

BRPI0714430A2 未知
公开(公告)号：BRPI0714430A2
公开(公告)日：2013-03-12
申请号：BRPI0714430
申请日：2007-07-10
申请人： NOVARTIS AG
发明人： CHANG FRANK , MEDINA ARTURO NORBERTO
IPC分类号： C08F2/46 , C08F8/00 , C08F220/00 , C08G77/442 , G02B1/04 , G02C7/04
摘要： The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

7. 发明专利

PT2092376E PRODUÇÃO DE DISPOSITIVOS OFTÁLMICOS BASEADOS EM POLIMERIZAÇÃO COM PASSO DE CRESCIMENTO FOTO-INDUZIDO 未知
公开(公告)号：PT2092376E
公开(公告)日：2012-12-19
申请号：PT07855080
申请日：2007-12-12
申请人： NOVARTIS AG
发明人： MEDINA ARTURO NORBERTO , SMITH DAWN A , SCOTT ROBERT
IPC分类号： G02B1/04

8. 发明专利

CA2808462A1 WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF 未知
公开(公告)号：CA2808462A1
公开(公告)日：2012-04-12
申请号：CA2808462
申请日：2011-10-05
申请人： NOVARTIS AG
发明人： HUANG JINYU , CHANG FRANK , SCOTT ROBERT , MEDINA ARTURO NORBERTO , SHANKERNARAYANAN MANIVAKKAM J , KUYU SELMA , SMITH DAWN ALISON , WU DAQING
IPC分类号： C08G77/42 , C08G77/20 , C08G77/442 , C08L83/10 , G02B1/04
摘要： The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

9. 发明专利

DK2038310T3 Aktinisk tværbindelige copolymerer til fremstilling af kontaktlinser 未知
公开(公告)号：DK2038310T3
公开(公告)日：2010-09-27
申请号：DK07812745
申请日：2007-07-10
申请人： NOVARTIS AG
发明人： CHANG FRANK , MEDINA ARTURO NORBERTO
IPC分类号： C08F2/46 , C08F8/00 , C08F220/00 , C08G77/442 , G02B1/04 , G02C7/04

10. 发明专利

DE602007007082D1 AKTINISCH VERNETZBARE COPOLYMERE ZUR HERSTELLUNG VON KONTAKTLINSEN 未知
公开(公告)号：DE602007007082D1
公开(公告)日：2010-07-22
申请号：DE602007007082
申请日：2007-07-10
申请人： NOVARTIS AG
发明人： CHANG FRANK , MEDINA ARTURO NORBERTO
IPC分类号： C08F2/46 , C08F8/00 , C08F220/00 , C08G77/442 , G02B1/04 , G02C7/04

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