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1. 发明申请

WO2004048472A3 STABILIZATION OF POLY(OXYALKYLENE) CONTINING POLYMERIC MATERIALS 审中-公开
标题翻译：聚（氧亚烷基）连续聚合物材料的稳定化
公开(公告)号：WO2004048472A3
公开(公告)日：2004-07-15
申请号：PCT/EP0313320
申请日：2003-11-26
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14 , C08K5/09 , A61L27/00 , A61L31/00 , C08K5/00
CPC分类号： C08L75/14 , A61L27/18 , C08G18/5024 , C08G18/6685 , C08G18/71 , C08G2120/00 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/175 , C08L71/02 , C08L2203/02 , C08L2666/04
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.
摘要翻译：本发明提供了用于生产由稳定的含聚（氧化烯）的聚合物材料制成的医疗装置，优选为眼科装置，更优选为隐形眼镜的方法。本发明的方法包括以下步骤：在模具中固化组合物，所述组合物包含（a）具有至少一个聚（氧化烯）单元的预聚物，（b）其量为生物相容性有机多酸或其生物相容性盐的量足以改善由该组合物制备的含聚（氧化烯）的聚合物，（c）任选的光引发剂或热引发剂，和（d）任选的一种或多种乙烯基单体的稳定性，以形成不易受氧化降解; 并从模具中取出医疗装置。

2. 发明申请

WO2005025843A3 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2005025843A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004010135
申请日：2004-09-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , TENA MIREILLE
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , TENA MIREILLE
IPC分类号： B29C35/08 , B29D11/00
CPC分类号： B29D11/0099 , B29C35/0894 , B29C2035/0827 , B29C2035/0833 , B29D11/00057 , B29D11/00125 , B29L2011/0041
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.
摘要翻译：本发明涉及一种用于制造具有相对高的边缘质量并且在再现期望的透镜设计时具有相对高的精度和保真度的隐形眼镜的方法和流体组合物。本发明的方法包括：模具，其具有具有第一模制表面的第一模具半部和具有第二模制表面的第二模具半部，其中第一和第二半模构造成彼此接收，使得形成空腔在限定待制造的隐形眼镜的相对的两个表面的第一和第二模制表面之间; 光化辐射的空间限制，以限定要产生的隐形眼镜的边缘; 以及在包含透镜形成材料的流体组合物中添加自由基清除剂，以减少由光化学的空间限制之外和周围的流体组合物的扩散，散射和/或反射入射光化辐射引起的交联/聚合辐射。

3. 发明申请

WO2005054325A3 CROSSLINKABLE POLYUREA PREPOLYMERS 审中-公开
标题翻译：可交联聚氨酯预处理剂
公开(公告)号：WO2005054325A3
公开(公告)日：2005-11-24
申请号：PCT/EP2004013352
申请日：2004-11-24
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , DEVLIN BRIAN GERRARD , TENA MIREILLE
发明人： DEVLIN BRIAN GERRARD , TENA MIREILLE
IPC分类号： C08G18/50 , C08G18/66 , C08G18/79 , C08L75/16 , C08G18/67 , G02B1/04
CPC分类号： C08G18/5024 , C08G18/6685 , C08G18/792 , C08L75/16
摘要： The present invention provides a water-soluble crosslinkable polyurea prepolymer. The crosslinkable polyurea prepolymer of the invention is prepared by reacting an amine- or isocyanate-capped polyurea with a multifunctional compound having at least one one ethylenically unsaturated group and a functional group coreactive with the capping amine or isocyanate groups of the amine- or isocyanate-capped polyurea. The amine- or isocyanatecapped polyurea is a copolymerization production of: (a) at least one poly(oxyalkylene) diamine, (b) optionally at least one organic dior poly-amine, (c) optionally at least one diisocyanate, and (d) at least one polyisocyanate. The crosslinkable polyurea prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a medical device, preferably an ophthalmic device, more preferably a contact lens.
摘要翻译：本发明提供水溶性交联性聚脲预聚物。本发明的可交联聚脲预聚物是通过使胺或异氰酸酯封端的聚脲与具有至少一个烯属不饱和基团的官能化合物和与胺或异氰酸酯封端的聚脲的封端胺或异氰酸酯 - 封端聚脲。胺或异氰酸酯封端的聚脲是：（a）至少一种聚（氧化烯）二胺，（b）任选的至少一种有机二聚胺，（c）任选至少一种二异氰酸酯，和（d）至少一种多异氰酸酯。本发明的可交联聚脲预聚物可用于经济地生产具有所需物理性能的耐久，高弹性软性隐形眼镜的隐形眼镜。此外，本发明提供了制造医疗装置，优选眼科装置，更优选隐形眼镜的方法。

4. 发明专利

NO20052917L 未知
公开(公告)号：NO20052917L
公开(公告)日：2005-06-15
申请号：NO20052917
申请日：2005-06-15
申请人： NOVARTIS AG
发明人： MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE , DEVLIN BRIAN GERRARD
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

5. 发明专利

NO20052917A 未知
公开(公告)号：NO20052917A
公开(公告)日：2005-06-15
申请号：NO20052917
申请日：2005-06-15
申请人： NOVARTIS AG
发明人： MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE , DEVLIN BRIAN GERRARD
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14
CPC分类号： C08L75/14 , A61L27/18 , C08G18/5024 , C08G18/6685 , C08G18/71 , C08G2120/00 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/175 , C08L71/02 , C08L2203/02 , C08L2666/04

6. 发明专利

DE602006021189D1 VERFAHREN ZUR HERSTELLUNG VON KONTAKTLINSEN 未知
公开(公告)号：DE602006021189D1
公开(公告)日：2011-05-19
申请号：DE602006021189
申请日：2006-08-10
申请人： NOVARTIS AG
发明人： WANG GUIGUI , SMITH DAWN , VOGT JUERGEN , LALLY JOHN MARTIN , DEVLIN BRIAN GERRARD
IPC分类号： G02B1/04

7. 发明专利

DE602006015171D1 KONTINUIERLICHES VERFAHREN ZUR HERSTELLUNG VON POLYMERMATERIALIEN 未知
公开(公告)号：DE602006015171D1
公开(公告)日：2010-08-12
申请号：DE602006015171
申请日：2006-03-02
申请人： NOVARTIS AG
发明人： DEVLIN BRIAN GERRARD , HOLLAND TROY VERNON , SMITH DAWN ALISON , AZZAWI ALEXANDER
IPC分类号： C08F2/01 , B01J19/00 , C08F2/04 , C08F2/46

8. 发明专利

DE60321955D1 未知
公开(公告)号：DE60321955D1
公开(公告)日：2008-08-14
申请号：DE60321955
申请日：2003-11-26
申请人： NOVARTIS AG
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO NORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
IPC分类号： C08K5/09 , A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

9. 发明专利

BR0316478A 未知
公开(公告)号：BR0316478A
公开(公告)日：2005-10-11
申请号：BR0316478
申请日：2003-11-26
申请人： NOVARTIS AG
发明人： DEVLIN BRIAN GERRARD , MEDINA ARTURO BORBERTO , SENTELL KAREN BELINDA , PERREAULT STEPHEN RAYMOND , TENA MIREILLE
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14 , C08K5/09 , A61L27/00 , C08K5/00 , A61L31/00
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)-containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

10. 发明专利

CA2503529A1 STABILIZATION OF POLY(OXYALKYLENE) CONTINING POLYMERIC MATERIALS 未知
公开(公告)号：CA2503529A1
公开(公告)日：2004-06-10
申请号：CA2503529
申请日：2003-11-26
申请人： NOVARTIS AG
发明人： TENA MIREILLE , MEDINA ARTURO NORBERTO , PERREAULT STEPHEN RAYMOND , SENTELL KAREN BELINDA , DEVLIN BRIAN GERRARD
IPC分类号： A61L27/18 , C08G18/50 , C08G18/66 , C08G18/71 , C08K3/32 , C08K5/092 , C08K5/098 , C08K5/17 , C08L71/02 , C08L75/14 , C08K5/09 , C08K5/00 , A61L27/00 , A61L31/00
摘要： The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprisin g (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

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