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1. 发明申请

WO2012006488A3 OPHTHALMIC LENS MOLDS WITH LOW LEVELS OF UV LIGHT TRANSMITTANCE, OPHTHALMIC LENSES MOLDED THEREIN, AND RELATED METHODS 审中-公开
标题翻译：具有紫外光透射低水平的眼镜镜片，模制的眼镜及相关方法
公开(公告)号：WO2012006488A3
公开(公告)日：2012-03-29
申请号：PCT/US2011043288
申请日：2011-07-08
申请人： NORRIS LEE DARREN , BIALEK EDYTA S , ALMOND SARAH L , MORSLEY DAVID ROBERT , SIDDIQUI SHAHAB A K M , ROGERS RICHARD C , BRUCE IAN , SHEADER BENJAMIN S
发明人： NORRIS LEE DARREN , BIALEK EDYTA S , ALMOND SARAH L , MORSLEY DAVID ROBERT , SIDDIQUI SHAHAB A K M , ROGERS RICHARD C , BRUCE IAN , SHEADER BENJAMIN S
IPC分类号： B29D11/00 , G02C7/00
CPC分类号： B29D11/00442 , B29D11/00 , B29D11/00038 , B29D11/00057 , B29D11/00067 , B29D11/00115 , B29D11/0048 , G02B1/043
摘要： Ophthalmic lens molds made from one or more thermoplastic polymer having a low level of UV light transmittance (UV %T) ophthalmic lenses including silicone hydrogel contact lenses molded using these thermoplastic polymer having low UV %T, and methods of manufacturing ophthalmic lenses by cast molding a polymerizable composition in mold members formed of these thermoplastic polymers having low UV %T and curing the polymerizable composition using UV light are described.
摘要翻译：由一种或多种具有低水平的UV光透射率（UV％T）眼用透镜制成的眼用透镜模具，包括使用具有低UV％T的这些热塑性聚合物成型的硅酮水凝胶隐形眼镜，以及通过流延成型制造眼科镜片的方法描述了由这些具有低UV％T的热塑性聚合物形成的模制件中的可聚合组合物，并且使用紫外光固化可聚合组合物。

2. 发明申请

WO2012006485A3 POLAR THERMOPLASTIC OPTHALMIC LENS MOLDS, OPTHALMIC LENSES MOLDED THEREIN, AND RELATED METHODS 审中-公开
标题翻译：极性热塑性眼镜片模具，其中成型的眼用透镜及相关方法
公开(公告)号：WO2012006485A3
公开(公告)日：2012-03-29
申请号：PCT/US2011043283
申请日：2011-07-08
申请人： NORRIS LEE DARREN , BIALEK EDYTA S , ALMOND SARAH L , MORSLEY DAVID ROBERT , SIDDIQUI A K M SHAHAB , ROGERS RICHARD C , BRUCE IAN , SHEADER BENJAMIN S
发明人： NORRIS LEE DARREN , BIALEK EDYTA S , ALMOND SARAH L , MORSLEY DAVID ROBERT , SIDDIQUI A K M SHAHAB , ROGERS RICHARD C , BRUCE IAN , SHEADER BENJAMIN S
IPC分类号： B29D11/00 , G02C7/02
CPC分类号： B29D11/00442 , B29D11/00 , B29D11/00038 , B29D11/00057 , B29D11/00067 , B29D11/00115 , B29D11/0048 , G02B1/043
摘要： Ophthalmic lens molds made from one or more thermoplastic polymers with average polarities from about 1% to about 7%, ophthalmic lenses including silicone hydrogel contact lenses molded using these less polar thermoplastic polymers, and related methods are described. When the molds are used to cast mold silicone hydrogel contact lenses, the resulting polymerized lens bodies have ophthalmically acceptably wettable surfaces.
摘要翻译：描述了由一种或多种平均极性为约1％至约7％的热塑性聚合物制成的眼科镜片模具，包括使用这些极性较低的热塑性聚合物模塑的硅酮水凝胶隐形眼镜的眼科镜片以及相关方法。当模具用于铸塑模具硅酮水凝胶隐形眼镜时，所得到的聚合镜片主体具有眼睛可接受的可润湿表面。

3. 发明申请

WO2007021597A3 SYSTEMS AND METHODS FOR PRODUCING SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：用于生产硅胶水凝胶接触镜的系统和方法
公开(公告)号：WO2007021597A3
公开(公告)日：2009-05-07
申请号：PCT/US2006030498
申请日：2006-08-07
申请人： COOPERVISION INC , GOODENOUGH NEIL G , DEAN GREGG A , DARNTON SARAH E , ROGERS RICHARD C , BRAME PHILIP A , BLYTH GEOFFREY A , ALMOND SARAH L , BRUCE IAN , COLDREY PETE , SNELL JAMIE
发明人： GOODENOUGH NEIL G , DEAN GREGG A , DARNTON SARAH E , ROGERS RICHARD C , BRAME PHILIP A , BLYTH GEOFFREY A , ALMOND SARAH L , BRUCE IAN , COLDREY PETE , SNELL JAMIE
IPC分类号： G02C7/04
CPC分类号： B29D11/0024 , B29C2035/0827 , B29C2043/5046 , B29D11/0048 , B29L2011/0016 , G02B1/043
摘要： Systems and methods for producing silicone hydrogel contact lenses are described. Certain of the present systems include a contact lens mold forming station, a station for filling a contact lens mold section with a lens precursor composition and for placing a second mold section on the filled mold section to form a contact lens mold assembly, a curing station for forming a contact lens, a mold assembly separation station, and an extraction/hydration station. Certain of the present methods include forming a plurality of mold sections, placing a lens precursor composition on a surface of a first mold section, placing a second mold section on the first mold section, polymerizing the lens precursor composition, separating the first and second mold sections, removing the silicone hydrogel contact lens from one of the mold sections, extracting extractable components from the contact lens, and hydrating the contact lens.
摘要翻译：描述了制备硅酮水凝胶隐形眼镜的系统和方法。本发明的一些系统包括隐形眼镜模具成型站，用于将具有透镜前体组合物的隐形眼镜模具部分填充并将第二模具部分放置在填充的模具部分上以形成隐形眼镜模具组件的固定站用于形成隐形眼镜，模具组件分离站和提取/水化站。本发明的一些方法包括形成多个模具部分，将透镜前体组合物放置在第一模具部分的表面上，将第二模具部分放置在第一模具部分上，使透镜前体组合物聚合，将第一和第二模具从一个模具部分去除硅酮水凝胶隐形眼镜，从隐形眼镜中提取可提取组分，并使隐形眼镜保湿。

4. 发明申请

WO2008000421A3 THIAZOLYL UREA DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 审中-公开
标题翻译：三唑衍生物作为磷酸胆碱3-激酶抑制剂
公开(公告)号：WO2008000421A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007005599
申请日：2007-06-25
申请人： NOVARTIS AG , BRUCE IAN , WEITZ SCHMIDT GABRIELE
发明人： BRUCE IAN , WEITZ SCHMIDT GABRIELE
IPC分类号： C07D401/14 , A61K31/4439 , A61P37/00 , C07D417/14
CPC分类号： C07D401/14 , C07D417/14
摘要： The present invention concerns a compound of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, wherein the groups Ri- Rs are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中R 1 -R基团在说明书中定义为化合物在治疗通过抑制作用而变酸化的疾病的组合物和用途磷脂酰肌醇3-激酶。

5. 发明申请

WO2009013348A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2009013348A2
公开(公告)日：2009-01-29
申请号：PCT/EP2008059748
申请日：2008-07-24
申请人： NOVARTIS AG , BRUCE IAN , DUNSTAN ANDREW , HUNT THOMAS ANTHONY , HOWSHAM CATHERINE
发明人： BRUCE IAN , DUNSTAN ANDREW , HUNT THOMAS ANTHONY , HOWSHAM CATHERINE
IPC分类号： C07D239/34 , A61K31/506 , A61P35/00 , C07D239/42 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D419/12
CPC分类号： C07D239/34 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar', A and B are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式（I）化合物或其盐，合适的其药学上可接受的盐或溶剂合物，其中R 1，R 2，Ar'，A和B基团在说明书中定义为组合物和用途通过抑制磷脂酰肌醇3-激酶治疗疾病的化合物。

6. 发明申请

WO2005021519A3 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES 审中-公开
标题翻译： 5-苯基-4-甲基 - 噻唑-2-基胺衍生物作为磷酸胆碱酯酶3激酶（PI3）的抑制剂用于治疗炎症性气道疾病
公开(公告)号：WO2005021519A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004009586
申请日：2004-08-27
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BLOOMFIELD GRAHAM CHARLES , BRUCE IAN , HAYLER JUDY FOX , LEBLANC CATHERINE , LE GRAND DARREN MARK , MCCARTHY CLIVE
发明人： BLOOMFIELD GRAHAM CHARLES , BRUCE IAN , HAYLER JUDY FOX , LEBLANC CATHERINE , LE GRAND DARREN MARK , MCCARTHY CLIVE
IPC分类号： C07D277/48 , C07D417/12 , C07D451/04 , C07D471/04 , A61K31/427 , A61P11/06 , C07C275/26
CPC分类号： C07D451/04 , C07D277/48 , C07D417/12 , C07D471/04
摘要： Compounds of Formula (I) in free or salt form, wherein R , R , R , R , R and R have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase such as inflammatory airway diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：游离或盐形式的式（I）化合物，其中R a，R b，R 2，R 3，R 4和R 5具有如说明书中所示的含义可用于治疗由磷脂酰肌醇3-激酶介导的病症，例如炎性气道疾病。还描述了含有化合物的药物组合物和制备该化合物的方法。

7. 发明申请

WO2009115517A3 PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K 审中-公开
标题翻译：吡啶和吡啶作为PI3K的抑制剂
公开(公告)号：WO2009115517A3
公开(公告)日：2010-01-07
申请号：PCT/EP2009053136
申请日：2009-03-17
申请人： NOVARTIS AG , BRUCE IAN , BUDD EMMA , EDWARDS LEE , HOWSHAM CATHERINE
发明人： BRUCE IAN , BUDD EMMA , EDWARDS LEE , HOWSHAM CATHERINE
IPC分类号： C07D213/73 , A61K31/4427 , A61K31/4965 , A61K31/497 , A61P37/06 , A61P37/08 , C07D241/20 , C07D401/06 , C07D401/14
CPC分类号： C07D401/06 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar', A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.
摘要翻译：本发明涉及式（I）化合物或其盐，其合适的药学上可接受的盐或溶剂合物，其中R 1，R 2，Ar'，A和Y基团在说明书中定义为组合物和用途化合物治疗炎症和过敏症状。

8. 发明申请

WO2007134827A8 5-PHENYL-THIAZ0L-2-YL-UREA DERIVATIVES AND USE AS PI3 KINASE INHIBITORS 审中-公开
标题翻译： 5-PHENYL-THIAZ0L-2-YL-UREA衍生物和用作PI3激酶抑制剂
公开(公告)号：WO2007134827A8
公开(公告)日：2009-01-08
申请号：PCT/EP2007004500
申请日：2007-05-21
申请人： NOVARTIS AG , BUDD EMMA , HAYLER JUDY FOX , BRUCE IAN , LEGRAND DARREN MARK , COX BRIAN
发明人： BUDD EMMA , HAYLER JUDY FOX , BRUCE IAN , LEGRAND DARREN MARK , COX BRIAN
IPC分类号： C07D277/48 , A61K31/427 , A61P11/00 , C07D417/12
CPC分类号： C07D277/48 , C07D417/12
摘要： The present invention concerns a compound of formula Ia wherein: Ra * is hydrogen or C1-C4-alkyl; Rb* is -(C1-C4-alkylene)-Y-C1-C4-haloalkyl or -(C1-C4-alkylene)-Y-C1-C4-hydroxyalkyl; Y represents -CONH- or a five membered heteroaryl group. R2* is C1-C4-alkyl or halogen; R3* is halo, -SO2-CH3, -SO2-CF3, carboxy, -CO-NH2, -CO-di(C1-C8-alkyl)amino, or a 5- or 6- membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by halo, cyano, oxo, hydroxy, carboxy, nitro, C3-C8-cycloalkyl, C1-C8-alkylcarbonyl, C1-C8-alkoxy optionally substituted by aminocarbonyl, or C1-C8-alkyl optionally substituted by hydroxy, C1- C8-alkoxy, C1- C8-alkylamino or di(C1- C8-alkyl)amino; R4* is hydrogen, halo, -SO2-CH3, nitrile, C1- C8-haloalkyl, imidazolyl, C1- C8-alkyl, -NR8*R9*, or -SO2-NR8*R9*; and R5* is hydrogen, halogen or C1- C8-alkyl; R8* and R9* are independently hydrogen, amino, C1- C8-alkylamino, di(C1- C8-alkyl)amino, or CC1- C8-alkyl optionally substituted by hydroxyl; or a pharmaceutically acceptable salt, or solvate thereof, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式Ia化合物，其中：Ra *是氢或C 1 -C 4 - 烷基; Rb *是 - （C1-C4-亚烷基）-Y-C1-C4-卤代烷基或 - （C1-C4-亚烷基）-Y-C1-C4-羟基烷基; Y表示-CONH-或五元杂芳基。 R2 *是C1-C4-烷基或卤素; R3 *是卤素，-SO2-CH3，-SO2-CF3，羧基，-CO-NH2，-CO-二（C1-C8-烷基）氨基或具有一个或多个环的5-或6-元杂环氰基，氧代，羟基，羧基，硝基，C 3 -C 8 - 环烷基，C 1 -C 8 - 烷基羰基，C 1 -C 8 - 烷氧基任选地被选自氧，氮和硫的杂原子被氨基羰基取代，或任选被羟基取代的C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，C 1 -C 8 - 烷基氨基或二（C 1 -C 8 - 烷基）氨基; R4 *是氢，卤素，-SO2-CH3，腈，C1-8-卤代烷基，咪唑基，C1-8-烷基，-NR8 * R9 *或-SO2-NR8 * R9 *; 和R5 *是氢，卤素或C 1 -C 8 - 烷基; R 8 *和R 9 *独立地为氢，氨基，C 1 -C 8 - 烷基氨基，二（C 1 -C 8 - 烷基）氨基或任选被羟基取代的C 1 -C 8烷基; 或其药学上可接受的盐或溶剂合物，用于治疗通过抑制磷脂酰肌醇3-激酶而变质的疾病的组合物和用途。

9. 发明申请

WO2008062321A2 METHODS AND SYSTEMS FOR FORMING OPHTHALMIC LENS MOLD ASSEMBLIES 审中-公开
标题翻译：形成眼镜镜模组装的方法和系统
公开(公告)号：WO2008062321A2
公开(公告)日：2008-05-29
申请号：PCT/IB2007004339
申请日：2007-05-30
申请人： COOPERVISION INT HOLDING CO LP , BRUCE IAN , BAILEY STUART , OAG ROB , SAUNDERS STEPHEN
发明人： BRUCE IAN , BAILEY STUART , OAG ROB , SAUNDERS STEPHEN
IPC分类号： G06F19/00
CPC分类号： B29D11/005 , B29C33/202 , B29L2011/0041 , Y10S425/808
摘要： Methods and systems are provided for making an ophthalmic lens. The present methods and systems are effecting in coupling two mold sections together at two or more discrete regions. Embodiments of the methods and systems form a bore that extends completely through one of the mold sections and only partially through the other mold section. During formation of the bore, the mold material in proximity to the bore being formed becomes molten and diffuses from the bore. A portion of the molten mold material is provided at a contact point between the two mold sections and when the molten material cools, the material forms a spot weld between the mold sections. By forming multiple hollow spot welds in a mold assembly, the two mold sections can be securely coupled to each other during the manufacture of an ophthalmic lens, such as a silicone hydrogel contact lens.
摘要翻译：提供了用于制造眼科镜片的方法和系统。目前的方法和系统正在两个或更多个离散区域将两个模具部分联接在一起。方法和系统的实施例形成了一个完全穿过其中一个模具部分并且仅部分地穿过另一个模具部分的孔。在孔的形成期间，靠近所形成的孔的模具材料变得熔化并且从孔扩散。熔融模具材料的一部分设置在两个模具部分之间的接触点处，并且当熔融材料冷却时，该材料在模具部分之间形成点焊。通过在模具组件中形成多个中空点焊，在制造眼用透镜（例如硅酮水凝胶隐形眼镜）期间，两个模具部分可以彼此牢固地联接。

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