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1. 发明申请

WO2007134827A8 5-PHENYL-THIAZ0L-2-YL-UREA DERIVATIVES AND USE AS PI3 KINASE INHIBITORS 审中-公开
标题翻译： 5-PHENYL-THIAZ0L-2-YL-UREA衍生物和用作PI3激酶抑制剂
公开(公告)号：WO2007134827A8
公开(公告)日：2009-01-08
申请号：PCT/EP2007004500
申请日：2007-05-21
申请人： NOVARTIS AG , BUDD EMMA , HAYLER JUDY FOX , BRUCE IAN , LEGRAND DARREN MARK , COX BRIAN
发明人： BUDD EMMA , HAYLER JUDY FOX , BRUCE IAN , LEGRAND DARREN MARK , COX BRIAN
IPC分类号： C07D277/48 , A61K31/427 , A61P11/00 , C07D417/12
CPC分类号： C07D277/48 , C07D417/12
摘要： The present invention concerns a compound of formula Ia wherein: Ra * is hydrogen or C1-C4-alkyl; Rb* is -(C1-C4-alkylene)-Y-C1-C4-haloalkyl or -(C1-C4-alkylene)-Y-C1-C4-hydroxyalkyl; Y represents -CONH- or a five membered heteroaryl group. R2* is C1-C4-alkyl or halogen; R3* is halo, -SO2-CH3, -SO2-CF3, carboxy, -CO-NH2, -CO-di(C1-C8-alkyl)amino, or a 5- or 6- membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, that ring being optionally substituted by halo, cyano, oxo, hydroxy, carboxy, nitro, C3-C8-cycloalkyl, C1-C8-alkylcarbonyl, C1-C8-alkoxy optionally substituted by aminocarbonyl, or C1-C8-alkyl optionally substituted by hydroxy, C1- C8-alkoxy, C1- C8-alkylamino or di(C1- C8-alkyl)amino; R4* is hydrogen, halo, -SO2-CH3, nitrile, C1- C8-haloalkyl, imidazolyl, C1- C8-alkyl, -NR8*R9*, or -SO2-NR8*R9*; and R5* is hydrogen, halogen or C1- C8-alkyl; R8* and R9* are independently hydrogen, amino, C1- C8-alkylamino, di(C1- C8-alkyl)amino, or CC1- C8-alkyl optionally substituted by hydroxyl; or a pharmaceutically acceptable salt, or solvate thereof, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译：本发明涉及式Ia化合物，其中：Ra *是氢或C 1 -C 4 - 烷基; Rb *是 - （C1-C4-亚烷基）-Y-C1-C4-卤代烷基或 - （C1-C4-亚烷基）-Y-C1-C4-羟基烷基; Y表示-CONH-或五元杂芳基。 R2 *是C1-C4-烷基或卤素; R3 *是卤素，-SO2-CH3，-SO2-CF3，羧基，-CO-NH2，-CO-二（C1-C8-烷基）氨基或具有一个或多个环的5-或6-元杂环氰基，氧代，羟基，羧基，硝基，C 3 -C 8 - 环烷基，C 1 -C 8 - 烷基羰基，C 1 -C 8 - 烷氧基任选地被选自氧，氮和硫的杂原子被氨基羰基取代，或任选被羟基取代的C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，C 1 -C 8 - 烷基氨基或二（C 1 -C 8 - 烷基）氨基; R4 *是氢，卤素，-SO2-CH3，腈，C1-8-卤代烷基，咪唑基，C1-8-烷基，-NR8 * R9 *或-SO2-NR8 * R9 *; 和R5 *是氢，卤素或C 1 -C 8 - 烷基; R 8 *和R 9 *独立地为氢，氨基，C 1 -C 8 - 烷基氨基，二（C 1 -C 8 - 烷基）氨基或任选被羟基取代的C 1 -C 8烷基; 或其药学上可接受的盐或溶剂合物，用于治疗通过抑制磷脂酰肌醇3-激酶而变质的疾病的组合物和用途。

2. 发明申请

WO2005123731A3 PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS 审中-公开
标题翻译：吡咯并吡啶衍生物及其作为CRTH2拮抗剂的用途
公开(公告)号：WO2005123731A3
公开(公告)日：2006-05-04
申请号：PCT/EP2005006493
申请日：2005-06-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BALA KAMLESH , LEBLANC CATHERINE , SANDHAM DAVID ANDREW , TURNER KATHARINE LOUISE , WATSON SIMON JAMES , BROWN LYNDON NIGEL , COX BRIAN
发明人： BALA KAMLESH , LEBLANC CATHERINE , SANDHAM DAVID ANDREW , TURNER KATHARINE LOUISE , WATSON SIMON JAMES , BROWN LYNDON NIGEL , COX BRIAN
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译：根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3， R 4，R 5，R 6，Q，W，X，m，n和p如说明书中所述，方法准备他们，并用作药物。

3. 发明申请

WO2004096800A3 QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS 审中-公开
标题翻译：喹诺酮衍生物与MUCARINIC M3受体结合
公开(公告)号：WO2004096800A3
公开(公告)日：2005-01-06
申请号：PCT/EP2004004605
申请日：2004-04-30
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , COLLINGWOOD STEPHEN PAUL , COX BRIAN , BAETTIG URS , BHALAY GURDIP , DEVEREUX NICHOLAS JAMES
发明人： COLLINGWOOD STEPHEN PAUL , COX BRIAN , BAETTIG URS , BHALAY GURDIP , DEVEREUX NICHOLAS JAMES
IPC分类号： A61P11/06 , C07D453/02 , C07D519/00 , A61K31/5365
CPC分类号： C07D453/02
摘要： Compounds of formula (I), in salt or zwitterionic form wherein, wherein R , R , R , and R have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：式（I）化合物，其盐或两性离子形式，其中R 1，R 2，R 3和R 4具有说明书中所示的含义，可用于处理是由毒蕈碱M3受体介导的。还描述了含有化合物的药物组合物和制备该化合物的方法。

4. 发明申请

WO2007121920A3 PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS 审中-公开
标题翻译：用作腺苷A2A受体激动剂的嘌呤衍生物
公开(公告)号：WO2007121920A3
公开(公告)日：2008-01-10
申请号：PCT/EP2007003435
申请日：2007-04-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , FAIRHURST ROBIN ALEC , TAYLOR ROGER JOHN , COX BRIAN
发明人： FAIRHURST ROBIN ALEC , TAYLOR ROGER JOHN , COX BRIAN
IPC分类号： C07D473/16 , A61K31/52 , A61K31/7076 , A61P29/00 , C07D473/18 , C07D473/34 , C07H19/167
CPC分类号： C07D473/16 , C07D473/34
摘要： Purine derivatives of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 and R 3 are as defined herein. The compounds are useful for the treatment of a condition mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions comprising a purine derivative as active ingredient and a process for the preparation of these compounds.
摘要翻译：式（I）的嘌呤衍生物或其立体异构体或其药学上可接受的盐，其中R 1，R 2和R 3如本文所定义。该化合物可用于治疗由腺苷A2A受体的活化介导的病症，特别是炎性或阻塞性气道疾病。包含嘌呤衍生物作为活性成分的药物组合物和这些化合物的制备方法。

5. 发明申请

WO9938877A3 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES 审中-公开
标题翻译： 2-（嘌呤-9-基） - 四氢呋喃-3,4-二醇衍生物
公开(公告)号：WO9938877A3
公开(公告)日：1999-09-30
申请号：PCT/EP9900503
申请日：1999-01-29
申请人： GLAXO GROUP LTD , CHAN CHUEN , COUSINS RICHARD PETER CHARLES , COX BRIAN
发明人： CHAN CHUEN , COUSINS RICHARD PETER CHARLES , COX BRIAN
IPC分类号： A61K20060101 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P11/06 , A61P29/00 , C07D20060101 , C07H17/00 , C07H19/16 , A61K31/70
CPC分类号： C07H19/16 , C07H17/00 , Y10S514/851 , Y10S514/885 , Y10S514/925
摘要： There are provided according to the invention, novel compounds of formula (I) wherein R , R and R are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供了新的式（I）化合物，其中R 1，R 2和R 3如说明书中所述，其制备方法，含有它们的制剂及其在治疗中的用途用于治疗炎性疾病。

6. 发明申请

WO2013058889A3 BRAIDING MECHANISM AND METHODS OF USE 审中-公开
标题翻译：制动机制及使用方法
公开(公告)号：WO2013058889A3
公开(公告)日：2014-05-08
申请号：PCT/US2012054517
申请日：2012-09-10
申请人： SEQUENT MEDICAL INC , MARCHAND PHILIPPE , NOLTING JOHN , KENT DARRIN , DINH TAN , TRAN HUNG , MILBURN JAMES , THOMPSON JAMES , COX BRIAN , ROSENBLUTH ROBERT
发明人： MARCHAND PHILIPPE , NOLTING JOHN , KENT DARRIN , DINH TAN , TRAN HUNG , MILBURN JAMES , THOMPSON JAMES , COX BRIAN , ROSENBLUTH ROBERT
IPC分类号： D04C3/40
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments are described. In one embodiment, the braiding machine includes a disc with a mandrel extending from the center in a perpendicular direction and a plurality of catch mechanisms arranged circumferentially around the edge of the disc. A plurality of filaments are temporarily affixed to the mandrel, each filament extending from the mandrel toward the edge of the disc and engaging the edge of the disc at a discrete point of engagement. The plurality of catch mechanisms are attached to actuators adapted to move the catch mechanisms in a generally radial direction relative to the edge of the disc to allow the catch mechanism to engage a subset of the filaments and move the engaged filaments beyond the circumferential edge of the disc.
摘要翻译：描述了用于形成包括多根细丝的管状编织物的装置和方法。在一个实施例中，编织机包括具有在垂直方向上从中心延伸的心轴的盘和围绕盘的边缘周向布置的多个捕获机构。许多细丝临时固定在心轴上，每根细丝从心轴向盘的边缘延伸并且在离散的接合点处与盘的边缘接合。多个捕捉机构附接到致动器，其适于相对于盘的边缘在大致径向方向上移动捕获机构，以允许捕获机构接合细丝的一部分并且将所接合的细丝移动超过所述纤维的圆周边缘光盘。

7. 发明申请

WO0101970A3 NEW USES POTASSIUM CHANNEL OPENERS, SUCH AS THE TREATMENT OF EPILEPSY 审中-公开
标题翻译：新的使用钾通道开放器，如治疗EPILEPSY
公开(公告)号：WO0101970A3
公开(公告)日：2002-02-28
申请号：PCT/GB0002516
申请日：2000-06-30
申请人： GLAXO GROUP LTD , BURBIDGE STEPHEN ANTHONY , CLARE JEFFREY JOHN , COX BRIAN , DUPERE JOSEPH , HAGAN RUSSELL MICHAEL , XIE XINMIN
发明人： BURBIDGE STEPHEN ANTHONY , CLARE JEFFREY JOHN , COX BRIAN , DUPERE JOSEPH , HAGAN RUSSELL MICHAEL , XIE XINMIN
IPC分类号： A61K45/00 , A61K31/00 , A61K31/27 , A61K31/325 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： A61K31/325 , A61K31/00 , A61K31/27
摘要： The present invention relates to novel uses for retigabine and KCNQ2/3 potassium channel openers.
摘要翻译：本发明涉及瑞替加滨和KCNQ2 / 3钾通道开放剂的新用途。

8. 发明申请

WO9924449A3 ADENOSINE A1 RECEPTOR AGONISTS 审中-公开
标题翻译：腺苷A1受体激动剂
公开(公告)号：WO9924449A3
公开(公告)日：1999-08-19
申请号：PCT/EP9807021
申请日：1998-11-06
申请人： GLAXO GROUP LTD , COUSINS RICHARD PETER CHARLES , COX BRIAN , ELDRED COLIN DAVID , PENNELL ANDREW MICHAEL KENNETH
发明人： COUSINS RICHARD PETER CHARLES , COX BRIAN , ELDRED COLIN DAVID , PENNELL ANDREW MICHAEL KENNETH
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P9/00 , A61P25/00 , A61P43/00 , C07H19/16
CPC分类号： C07H19/16
摘要： A compound of formula (I) which is an agonist at the adenosine A1 receptor wherein R represents C1-3alkyl, halogen or hydrogen; R represents a fluorinated straight or branched alkyl group of 1-6 carbon atoms and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof. These compounds are agonists at the Adenosine A1 receptor.
摘要翻译：式（I）化合物，其为腺苷A1受体的激动剂，其中R 2表示C 1-3烷基，卤素或氢; R 3表示1-6个碳原子的氟化直链或支链烷基及其盐和溶剂合物，特别是其生理学上可接受的溶剂合物及其盐。这些化合物是腺苷A1受体的激动剂。

9. 发明申请

WO2007081712A3 AUDIO SPEAKER HAVING A TWEETER CAPABLE OF CONTINUOUS ROTATION 审中-公开
标题翻译：具有连续旋转的TWEE的音频扬声器
公开(公告)号：WO2007081712A3
公开(公告)日：2008-08-07
申请号：PCT/US2007000089
申请日：2007-01-04
申请人： BOSTON ACOUSTICS INC , BLACKMON LEIF , COX BRIAN , HIGGINS TIM
发明人： BLACKMON LEIF , COX BRIAN , HIGGINS TIM
IPC分类号： H04R1/02
CPC分类号： H04R1/345 , H04R1/24 , H04R9/06 , H04R2201/021 , H04R2201/025 , H04R2499/13
摘要： An audio speaker contains a tweeter capable of continuous rotation, where the audio speaker contains the tweeter and an axis mount assembly. The tweeter is removably connected to the axis mount assembly. The audio speaker also contains a first connection member capable of maintaining electrical communication with the axis mount assembly throughout continuous rotation of the axis mount assembly. The axis mount assembly contains a terminal plate connected to a bottom portion of the tweeter, where the terminal plate maintains electrical communication with the tweeter. The axis mount assembly also contains an axis mount faceplate capable of receiving the terminal plate and tweeter within an indented portion of a top portion of the axis mount faceplate. The axis mount assembly further contains an axis mount spacer and a second connection member that maintains electrical communication with the first connection member throughout continuous rotation of the axis mount assembly.
摘要翻译：音频扬声器包含能够连续旋转的高音单元，音频扬声器包含高音单元和轴安装组件。高音单元可拆卸地连接到轴安装组件。音频扬声器还包括第一连接构件，其能够在轴安装组件的连续旋转期间保持与轴安装组件的电连通。轴安装组件包括连接到高音单元的底部的端子板，其中端子板保持与高音单元的电连通。轴安装组件还包含能够在轴安装面板的顶部的凹进部分内接收端子板和高音单元的轴线安装面板。轴安装组件还包括轴安装间隔件和第二连接构件，其在轴安装组件的连续旋转期间保持与第一连接构件的电连通。

10. 发明申请

WO9733532A3 ENDOLUMINAL PROSTHESES AND THERAPIES FOR MULTIPLE-BRANCH BODY LUMEN SYSTEMS 审中-公开
标题翻译：多支血管系统的内分泌癌和治疗
公开(公告)号：WO9733532A3
公开(公告)日：1997-11-13
申请号：PCT/US9703545
申请日：1997-03-07
申请人： MEDTRONIC INC , COX BRIAN , EVANS MICHAEL A , WILL ALLAN , LENKER JAY A , FREISLINGER KIRSTEN , FOGARTY THOMAS J
发明人： COX BRIAN , EVANS MICHAEL A , WILL ALLAN , LENKER JAY A , FREISLINGER KIRSTEN , FOGARTY THOMAS J
IPC分类号： A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/95 , A61F2/958
CPC分类号： A61F2/88 , A61F2/07 , A61F2/848 , A61F2/885 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/95 , A61F2/958 , A61F2002/041 , A61F2002/044 , A61F2002/046 , A61F2002/047 , A61F2002/048 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2210/0076 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/0054 , A61F2230/0067 , A61F2250/0039
摘要： In a first aspect, the present invention provides a branching intraluminal prostheses for use in a branching body lumen system that includes a trunk lumen and first and second branch lumens. The prostheses comprises a radially expandable tubular trunk portion having a prosthetic trunk lumen, and radially expandable tubular first and second branch portions with first and second prosthetic branch lumens, respectively. A radially expandable tubular lumen separation portion provides fluid communication between the prosthetic trunk lumen and the first and second prosthetic branch lumens. Surprisingly, the expanded trunk portion is preferably more axially flexible than the lumen separation portion.

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