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1. 发明申请

WO1989003206A1 GELATIN COMPOSITION 审中-公开
标题翻译：凝胶组成
公开(公告)号：WO1989003206A1
公开(公告)日：1989-04-20
申请号：PCT/JP1988001011
申请日：1988-10-03
申请人： NITTA GELATIN INC. , TAISHO PHARMACEUTICAL CO., LTD. , TATEMATSU, Shinzo , OMATA, Kazuki , HASHIMOTO, Tatsuo , TAKAHASHI, Masato , ITO, Noriichi
发明人： NITTA GELATIN INC. , TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/48
CPC分类号： A61K9/2063 , A61K9/4825 , Y10T428/2984 , Y10T428/2989
摘要： A gelatin composition to be used for capsules of medicines or the like, as a coating or binding agent for tablets or as a wrapping material, which comprises at least gelatin and polypeptide for preventing gelatin from becoming insoluble with time without deteriorating the shape retentivity. The content of said polypeptide is 15 to 70 % based on the total weight of the polypeptide and the gelatin and said gelatin has a jelly strength of 250 Bloom or more.

2. 发明申请

WO1990007327A1 STRESS SCATTERING METHOD IN TABLETING 审中-公开
标题翻译：压应力散射方法
公开(公告)号：WO1990007327A1
公开(公告)日：1990-07-12
申请号：PCT/JP1989001323
申请日：1989-12-28
申请人： TAISHO PHARMACEUTICAL CO., LTD. , YUASA, Hiroshi , KANAYA, Yoshio , OMATA, Kazuki
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/20
CPC分类号： A61K9/2081 , A61K9/2063
摘要： This invention relates to a tableting composition containing minute gelatine balls and/or foams as stress scattering agents so as to minimize the disintegration of microcapsules or the transformation of medicine during tableting; and a stress scattering method in tableting. The use of the tableting composition according to the present invention enables tablets to be made without causing microencapsulated medicine powder, enzymes, germs or substances of a low melting point to be transformed or disintegrated.

3. 发明申请

WO1998005624A1 AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 审中-公开
标题翻译：氨基化合物和血管紧张素Ⅱ受体激动剂
公开(公告)号：WO1998005624A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002716
申请日：1997-08-05
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07C211/13
CPC分类号： C07D213/40 , C07C237/20 , C07D215/12
摘要： Amino compounds represented by general formula (1) or pharmaceutically acceptable salts thereof: (wherein X represents CH2NH or CONH; Y represents CH2NH or CONH, provided that X and Y do not represent CONH at the same time; Z represents CH=C(R )R , CH2CH(R )R or alkoxycarbonyl (wherein R and R independently represent each hydrogen or optionally substituted alkyl, aralkyl, aryl or heteroaryl); R represents hydrogen or optionally substituted lower alkyl, cycloalkyl, cycloalkyl-substituted alkyl, aralkyl or aryl; and R and R independently represent each optionally substituted lower alkyl or aralkyl); drugs composed of the amino compounds of general formula (1) or pharmaceutically acceptable salts thereof; and angiotensin receptor agonists containing the same as the active ingredient. These drugs are useful as remedies such as antagonists or agonists for various pathological states in which angiotensin IV participates, for example, accelerated renal blood flow, cerebral vasodilation, cell proliferation inhibition or hypermnesia.
摘要翻译：由通式（1）表示的氨基化合物或其药学上可接受的盐：（其中X表示CH 2 NH或CONH; Y表示CH 2 NH或CONH，条件是X和Y不同时表示CONH; Z表示CH = C R 5），CH 2 CH（R 4）R 5或烷氧基羰基（其中R 4和R 5独立地表示各个氢或任选取代的烷基，芳烷基，芳基或杂芳基）; R R 1和R 3独立地代表各个任选被取代的低级烷基或芳烷基）; R 2和R 3独立地表示任意取代的低级烷基或芳烷基。由通式（1）的氨基化合物或其药学上可接受的盐组成的药物; 和含有与活性成分相同的血管紧张素受体激动剂。这些药物可用作诸如血管紧张素IV参与的各种病理状态的拮抗剂或激动剂，例如加速肾血流量，脑血管扩张，细胞增殖抑制或高血症。

4. 发明申请

WO1997045112A1 REMEDY OR PREVENTIVE FOR HYPERLIPEMIA 审中-公开
标题翻译：补救或预防超临界
公开(公告)号：WO1997045112A1
公开(公告)日：1997-12-04
申请号：PCT/JP1996001443
申请日：1996-05-29
申请人： TAISHO PHARMACEUTICAL CO., LTD. , KITAJIMA, Hideaki , TSUNODA, Kenji , YANAGITA, Teruyoshi , MURAKAMI, Shigeru
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/185
CPC分类号： A61K31/575 , A61K2300/00
摘要： The object of the invention is to obtain a remedy or preventive for hyperlipemia which lowers the blood cholesterol and neutral fat levels and further ameliorates lipoprotein metabolism. Said remedy or preventive for hyperlipemia comprises taurine and gamma -orizanol as the active ingredients.
摘要翻译：本发明的目的是获得降低血液胆固醇和中性脂肪水平并进一步改善脂蛋白代谢的高脂血症的补救措施或预防措施。所述治疗或预防高脂血症的方法包括牛磺酸和γ-氮醇作为活性成分。

5. 发明申请

WO1997032847A1 PYRROLIDONE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO1997032847A1
公开(公告)日：1997-09-12
申请号：PCT/JP1997000627
申请日：1997-03-03
申请人： TAISHO PHARMACEUTICAL CO., LTD. , ARAI, Koshi , SATO, Masakazu
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/44
CPC分类号： C07D207/44
摘要： Pyrrolidone derivatives represented by general formula (I), wherein R represents hydrogen or C1-20 alkyl and R represents cyano or acetyl. They are effective as remedies for diseases caused by protein dephosphorylase, for example, as an antitumor agent, an immunosuppressive agent, and a diabetes remedy.
摘要翻译：由通式（I）表示的吡咯烷酮衍生物，其中R 1表示氢或C 1-20烷基，R 2表示氰基或乙酰基。它们作为由蛋白质去磷酸化酶引起的疾病的补救措施是有效的，例如作为抗肿瘤剂，免疫抑制剂和糖尿病药物。

6. 发明申请

WO1997018706A1 POISON BAIT FOR GETTING RID OF COCKROACHES 审中-公开
标题翻译：毒药索取苦味
公开(公告)号：WO1997018706A1
公开(公告)日：1997-05-29
申请号：PCT/JP1996003399
申请日：1996-11-20
申请人： TAISHO PHARMACEUTICAL CO., LTD. , HORI, Seiichi , OGINO, Kazumasa , MATSUNAGA, Shinichi , SHIMAMURA, Haruo
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A01N25/30
CPC分类号： A01N25/006
摘要： A poison bait for getting rid of cockroaches characterized by containing an insecticide and a nonionic surfactant and enhanced in the insecticidal activity and the speed of exhibiting of lethal efficacy.
摘要翻译：一种用于消除蟑螂的毒饵，其特征在于含有杀虫剂和非离子表面活性剂，并且增强了杀虫活性和显示致死功效的速度。

7. 发明申请

WO1997010264A1 CYCLIC HEXAPEPTIDE COMPOUNDS 审中-公开
标题翻译：循环下一个化合物
公开(公告)号：WO1997010264A1
公开(公告)日：1997-03-20
申请号：PCT/JP1996002570
申请日：1996-09-10
申请人： TAISHO PHARMACEUTICAL CO., LTD. , ITOKAWA, Hideji , HITOTSUYANAGI, Yukio , YAMAGISHI, Takehiro
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07K07/64
CPC分类号： C07K7/64 , A61K38/00
摘要： Object: to provide cyclic hexapeptides compounds having an excellent drug effect. Constitution: Cyclic hexapeptide compounds represented by general formula (I) or salts thereof, wherein R represents (a), wherein R and R represent each alkyl, phenyl or benzyl or (b), wherein n is an integer of from 4 to 6.
摘要翻译：目的：提供具有优异药效的环状六肽化合物。结构式：由通式（I）表示的环状六肽化合物或其盐，其中R表示（a），其中R 1和R 2表示各自的烷基，苯基或苄基或（b），其中n为整数从4到6。

8. 发明申请

WO1997009035A1 LONG-LASTING COMPOSITION FOR RECTAL ADMINISTRATION 审中-公开
标题翻译：长期管理的长效成分
公开(公告)号：WO1997009035A1
公开(公告)日：1997-03-13
申请号：PCT/JP1996002497
申请日：1996-09-04
申请人： TAISHO PHARMACEUTICAL CO., LTD. , KONDO, Osamu , FUJIMORI, Tomoko , TANAKA, Shigeo , URUSHIZAKI, Fumio
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/02
CPC分类号： A61K9/02 , A61K9/0031 , A61K45/06 , A61K47/32 , Y10S424/15 , Y10S514/966
摘要： A composition for rectal administration capable of elevating the drug concentration in the affected tissue and suitable for the treatment of hemorrhoids, etc. where a long-lasting efficacy is expected. The composition comprises an acrylic acid polymer, a vasoconstrictor and a remedy for the rectal tissue.
摘要翻译：用于直肠给药的组合物，其能够提高受影响组织中的药物浓度，并且适合于治疗痔疮等，其中期望具有长效性。组合物包含丙烯酸聚合物，血管收缩剂和用于直肠组织的补救剂。

9. 发明申请

WO1997003093A1 PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST 审中-公开
标题翻译：肽衍生物和血管紧张素受体激动剂
公开(公告)号：WO1997003093A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001836
申请日：1996-07-03
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD. , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： SAGAMI CHEMICAL RESEARCH CENTER , TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07K05/062
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/0202 , C07K5/06017 , C07K5/0804 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： Short-chain peptide derivatives represented by general formula (1) which function as an angiotensin IV receptor agonist even in a low concentration and so are useful as a remedy for various diseases wherein angiotensin IV participates.
摘要翻译：由通式（1）表示的短链肽衍生物即使在低浓度下也起到血管紧张素IV受体激动剂的作用，因此可用作血管紧张素IV参与的各种疾病的治疗方法。

10. 发明申请

WO1997003059A1 4-(SUBSTITUTED AMINOMETHYL)THIAZOLINE DERIVATIVES 审中-公开
标题翻译： 4-（取代的氨基甲酰基）噻唑啉衍生物
公开(公告)号：WO1997003059A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001923
申请日：1996-07-11
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SATO, MASAKAZU , MANAKA, Akira , TAKAHASHI, Keiko , KAWASHIMA, Yutaka , HATAYAMA, Katsuo
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07D277/56
CPC分类号： C07D277/56
摘要： Object: to provide compounds having an excellent antiplatelet aggregation effect and a good oral activity. Constitution: thiazoline derivatives represented by general formula (I) and salts thereof, wherein R represents (II) (wherein R and R represent each hydrogen, alkyl, alkoxy-carbonyl, cycloalkyl, optionally substituted phenyl or optionally substituted aralkyl), imidazolin-2-yl, etc; R represents (III) (wherein R and R represent each hydrogen, alkyl, cycloalkyl, optionally substituted phenyl or optionally substituted aralkyl), etc.; R represents hydrogen or alkyl); and R represents alkyl.
摘要翻译：目的：提供具有优异抗血小板聚集效应和良好口服活性的化合物。结构式：由通式（I）表示的噻唑啉衍生物及其盐，其中R 1表示（II）（其中R 11和R 12表示各自的氢，烷基，烷氧基 - 羰基，环烷基，任选取代的苯基或任选取代的芳烷基），咪唑啉-2-基等; R 2表示（III）（其中R 41和R 42表示各个氢，烷基，环烷基，任选取代的苯基或任选取代的芳烷基）等; R 3表示氢或烷基）; R 4表示烷基。

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