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1. 发明申请

WO1997045112A1 REMEDY OR PREVENTIVE FOR HYPERLIPEMIA 审中-公开
标题翻译：补救或预防超临界
公开(公告)号：WO1997045112A1
公开(公告)日：1997-12-04
申请号：PCT/JP1996001443
申请日：1996-05-29
申请人： TAISHO PHARMACEUTICAL CO., LTD. , KITAJIMA, Hideaki , TSUNODA, Kenji , YANAGITA, Teruyoshi , MURAKAMI, Shigeru
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/185
CPC分类号： A61K31/575 , A61K2300/00
摘要： The object of the invention is to obtain a remedy or preventive for hyperlipemia which lowers the blood cholesterol and neutral fat levels and further ameliorates lipoprotein metabolism. Said remedy or preventive for hyperlipemia comprises taurine and gamma -orizanol as the active ingredients.
摘要翻译：本发明的目的是获得降低血液胆固醇和中性脂肪水平并进一步改善脂蛋白代谢的高脂血症的补救措施或预防措施。所述治疗或预防高脂血症的方法包括牛磺酸和γ-氮醇作为活性成分。

2. 发明申请

WO1996022102A1 REMEDY FOR DERMATITIS 审中-公开
标题翻译：补救措施
公开(公告)号：WO1996022102A1
公开(公告)日：1996-07-25
申请号：PCT/JP1996000064
申请日：1996-01-18
申请人： TAISHO PHARMACEUTICAL CO., LTD. , YONEDA, Akiko , KITAJIMA, Hideaki , TSUNODA, Kenji , HASEGAWA, Kazuo , ISHI, Takako
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K33/30
CPC分类号： A61K33/30 , A61K31/215 , A61K31/19 , A61K31/20 , A61K2300/00
摘要： A remedy for dermatitis comprising one or more compounds selected from the group consisting of (A) zinc compounds and (B) polyvalent unsaturated fatty acids and esters thereof and being highly efficacious against intestinal acrodermatitis and dermatitis seborrhoica showing similar skin symptoms, psoriasis vulgaris, bullous diseases, pruritus cutaneous or symptoms accompanying zinc deficiency caused by trauma, burn or frostbite.
摘要翻译：包含一种或多种选自（A）锌化合物和（B）多价不饱和脂肪酸及其酯的化合物的化合物的皮炎补救剂，并且对于显示类似皮肤症状的牛皮癣和皮脂疮皮病，牛皮癣，大疱疾病，皮肤瘙痒或伴有由创伤，烧伤或冻伤引起的锌缺乏症状。

3. 发明申请

WO1997024134A1 A PHARMACEUTICAL COMPOSITION COMPRISING PLANT WORMS AND MUIRAPUAMA 审中-公开
标题翻译：包含植物物种和MUIRAPUAMA的药物组合物
公开(公告)号：WO1997024134A1
公开(公告)日：1997-07-10
申请号：PCT/JP1996003733
申请日：1996-12-20
申请人： TAISHO PHARMACEUTICAL CO., LTD. , HANAWA, Masaaki , KITAJIMA, Hideaki , TSUNODA, Kenji
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K35/78
CPC分类号： A61K36/185 , A61K2300/00
摘要： A composition comprising plant worms and muirapuama is very effective for relieving physical and mental fatigue and ameliorating weakened constitution without any side effect, even administered for a long time.
摘要翻译：包括植物蠕虫和米拉普拉马的组合物对于减轻身体和精神疲劳以及改善弱化的体质而没有任何副作用是非常有效的，甚至长时间施用。

4. 发明申请

WO1996019211A1 LIPOSOME EYE DROPS 审中-公开
公开(公告)号：WO1996019211A1
公开(公告)日：1996-06-27
申请号：PCT/JP1995002599
申请日：1995-12-19
申请人： TAISHO PHARMACEUTICAL CO., LTD. , KATO, Muneyoshi , OHTSUKI, Tomohiro , EGAMI, Fuminobu , TSUNODA, Kenji
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/185
CPC分类号： A61K45/06 , A61K9/0048 , A61K9/127 , A61K31/185 , A61K33/14 , A61K2300/00
摘要： [Object] To provide eye drops excellent in the effect of mitigating or curing symptoms caused by dry eye. [Constitution] Liposome eye drops comprising taurine, glucose and inorganic salts.
摘要翻译： [目的]提供眼睛滴液对于减轻或治愈由干眼症引起的症状的效果。 [结构]含有牛磺酸，葡萄糖和无机盐的脂质体滴眼液。

5. 发明申请

WO1998005342A1 LIQUID PREPARATION COMPRISING IRON COMPOUND 审中-公开
标题翻译：包含铁化合物的液体制剂
公开(公告)号：WO1998005342A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002717
申请日：1997-08-05
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SAKATA, Yasuko , TSUNODA, Kenji , NAKANO, Hiroshi
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K33/26
CPC分类号： A61K9/0095 , A61K33/26 , A61K2300/00
摘要： A liquid preparation comprising an iron component, an eugenol-containing component and at least one salt selected from among L-amino acid salts and gluconic acid salts. This liquid preparation is suppressed in the thermal change with time inherent in liquid preparations for internal use comprising iron compounds, is excellent in long-term stability of quality, and exhibits good feelings in administration.
摘要翻译：一种液体制剂，其包含铁组分，含有丁子香酚的组分和至少一种选自L-氨基酸盐和葡萄糖酸盐的盐。该液体制剂在含有铁化合物的内用液体制剂的固有时间的温度下被抑制，在长期的质量稳定性方面是优异的，并且在施用中表现出良好的感觉。

6. 发明申请

WO1997000072A1 ANTI-INFLAMMATORY/ANALGETIC COMPOSITION 审中-公开
标题翻译：抗炎/毒理组合物
公开(公告)号：WO1997000072A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001614
申请日：1996-06-13
申请人： TAISHO PHARMACEUTICAL CO., LTD. , OKUDAIRA, Ichiro , TSUNODA, Kenji
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/42
CPC分类号： A61K31/42 , A61K31/19 , A61K31/165 , A61K2300/00
摘要： An anti-inflammatory/analgetic composition which comprises as the active ingredients (a) oxaprozin and (b) ibuprofen or acetaminophen. Compared with cases wherein either (a) oxaprozin or (b) ibuprofen or acetaminophen is employed alone, the composition has an enhanced analgetic effect and is efficacious against respiratory system diseases such as cold syndrome, which makes it usable as a remedy for cold.
摘要翻译：一种抗炎/止痛组合物，其包含作为活性成分（a）奥沙普秦和（b）布洛芬或对乙酰氨基酚。与单独使用（a）奥沙普秦或（b）布洛芬或对乙酰氨基酚的情况相比，该组合物具有增强的止痛效果，并且对抗呼吸系统疾病如冷综合征是有效的，其使其可用作感冒的补救剂。

7. 发明申请

WO1997041832A1 SUSPENSION OF SPARINGLY WATER-SOLUBLE ACIDIC DRUG 审中-公开
标题翻译：悬浮性水溶性酸性药物
公开(公告)号：WO1997041832A1
公开(公告)日：1997-11-13
申请号：PCT/JP1997001496
申请日：1997-05-01
申请人： TAISHO PHARMACEUTICAL CO., LTD. , NAITO, Mayumi , NAKANO, Hiroshi , HASEGAWA, Kazuo , NAKAJIMA, Toshiaki , OKUDAIRA, Ichiro , TSUNODA, Kenji
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/107
CPC分类号： A61K9/0095
摘要： A suspension of a sparingly water-soluble acidic drug especially, a nonsteroidal anti-inflammatory analgetic agent, which is stable for a prolonged period of time and is highly dissolvable; and a process for simply and easily producing the suspension. This suspension has a pH value of 2 to 5 and comprises a sparingly water-soluble acidic drug whose average particle size ranges from 1 to 15 mu m, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water, optionally, together with an inorganic powder having an average particle size of 1 to 15 mu m. This process is characterized by carrying out pulverization and dispersion of sparingly water-soluble acid drug, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water by means of a pulverizer comprising a main shaft adapted to rotate in a casing and a plurality of layshafts adapted to revolve in relationship interlocked with the rotation of the main shaft, each of the layshafts being fitted with a multiplicity of annular grinding media.
摘要翻译：一种微溶水性酸性药物，特别是非甾体类消炎镇痛药的悬浮液，它是长时间稳定且高度可溶的; 以及简单且容易地制造悬浮液的方法。该悬浮液的pH值为2〜5，包含平均粒径为1〜15μm的微溶水性酸性药物，聚甘油脂肪酸酯，水溶性多元醇和水，以及平均粒径为1〜15μm的无机粉末。该方法的特征在于通过粉碎机进行微水溶性酸性药物，聚甘油脂肪酸酯，水溶性多元醇和水的粉碎和分散，该粉碎机包括适于在壳体中旋转的主轴和多个的副轴适于以与主轴的旋转互锁的关系旋转，每个副轴装配有多个环形研磨介质。

8. 发明申请

WO1996021622A1 SMALL-CLUSTER WATER 审中-公开
标题翻译：小聚集水
公开(公告)号：WO1996021622A1
公开(公告)日：1996-07-18
申请号：PCT/JP1996000018
申请日：1996-01-10
申请人： TAISHO PHARMACEUTICAL CO., LTD. , TSUNODA, Kenji , OSADA, Kazumi
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C02F01/68
CPC分类号： C02F1/005 , C02F1/68
摘要： The cluster water having a potassium ion concentration of 100 ppm or more and containing potassium ions, magnesium ions and calcium ions in a weight ratio of potassium ions : magnesium ions : calcium ions of 1 : 0.3 - 4.5 : 0.5 - 8.5 has small clusters on the average, which are retained stably for a very long period of time at ordinary temperature.
摘要翻译：钾离子浓度为100ppm以上并且含有钾离子：镁离子：钙离子为1:0.3-4.5:0.5-8.5的重量比的钾离子，镁离子和钙离子的簇水具有小簇平均值在常温下稳定保持很长时间。

9. 发明申请

WO1998005624A1 AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 审中-公开
标题翻译：氨基化合物和血管紧张素Ⅱ受体激动剂
公开(公告)号：WO1998005624A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002716
申请日：1997-08-05
申请人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER , KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi , TOMISAWA, Kazuyuki
发明人： TAISHO PHARMACEUTICAL CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07C211/13
CPC分类号： C07D213/40 , C07C237/20 , C07D215/12
摘要： Amino compounds represented by general formula (1) or pharmaceutically acceptable salts thereof: (wherein X represents CH2NH or CONH; Y represents CH2NH or CONH, provided that X and Y do not represent CONH at the same time; Z represents CH=C(R )R , CH2CH(R )R or alkoxycarbonyl (wherein R and R independently represent each hydrogen or optionally substituted alkyl, aralkyl, aryl or heteroaryl); R represents hydrogen or optionally substituted lower alkyl, cycloalkyl, cycloalkyl-substituted alkyl, aralkyl or aryl; and R and R independently represent each optionally substituted lower alkyl or aralkyl); drugs composed of the amino compounds of general formula (1) or pharmaceutically acceptable salts thereof; and angiotensin receptor agonists containing the same as the active ingredient. These drugs are useful as remedies such as antagonists or agonists for various pathological states in which angiotensin IV participates, for example, accelerated renal blood flow, cerebral vasodilation, cell proliferation inhibition or hypermnesia.
摘要翻译：由通式（1）表示的氨基化合物或其药学上可接受的盐：（其中X表示CH 2 NH或CONH; Y表示CH 2 NH或CONH，条件是X和Y不同时表示CONH; Z表示CH = C R 5），CH 2 CH（R 4）R 5或烷氧基羰基（其中R 4和R 5独立地表示各个氢或任选取代的烷基，芳烷基，芳基或杂芳基）; R R 1和R 3独立地代表各个任选被取代的低级烷基或芳烷基）; R 2和R 3独立地表示任意取代的低级烷基或芳烷基。由通式（1）的氨基化合物或其药学上可接受的盐组成的药物; 和含有与活性成分相同的血管紧张素受体激动剂。这些药物可用作诸如血管紧张素IV参与的各种病理状态的拮抗剂或激动剂，例如加速肾血流量，脑血管扩张，细胞增殖抑制或高血症。

10. 发明申请

WO1997032847A1 PYRROLIDONE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO1997032847A1
公开(公告)日：1997-09-12
申请号：PCT/JP1997000627
申请日：1997-03-03
申请人： TAISHO PHARMACEUTICAL CO., LTD. , ARAI, Koshi , SATO, Masakazu
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/44
CPC分类号： C07D207/44
摘要： Pyrrolidone derivatives represented by general formula (I), wherein R represents hydrogen or C1-20 alkyl and R represents cyano or acetyl. They are effective as remedies for diseases caused by protein dephosphorylase, for example, as an antitumor agent, an immunosuppressive agent, and a diabetes remedy.
摘要翻译：由通式（I）表示的吡咯烷酮衍生物，其中R 1表示氢或C 1-20烷基，R 2表示氰基或乙酰基。它们作为由蛋白质去磷酸化酶引起的疾病的补救措施是有效的，例如作为抗肿瘤剂，免疫抑制剂和糖尿病药物。

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