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1. 发明申请

WO2006138118A3 ANTI-VIRAL COMPOSITIONS COMPRISING HETEROCYCLIC SUBSTITUTED PHENYL FURANS AND RELATED COMPOUNDS 审中-公开
公开(公告)号：WO2006138118A3
公开(公告)日：2006-12-28
申请号：PCT/US2006/021993
申请日：2006-06-06
申请人： NEW YORK BLOOD CENTER , JIANG, Shibo , DEBNATH, Asim, Kumar , LU, Hong
发明人： JIANG, Shibo , DEBNATH, Asim, Kumar , LU, Hong
IPC分类号： A61K31/53 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/4439 , A61K31/427
摘要： A group of compounds that inhibit HIV replication by blocking HIV entry was identified. One representative compound, designated NB-206, and its analogs inhibited HIV replication (p24 production) with IC50 values at nanomolar levels. It was proved that NB-206 and its analogs are HIV entry inhibitors by targeting the HIV gp41 since: 1) they inhibited HIV-mediated cell fusion; 2) they inhibited HIV replication only when they were added to the cells less than one hour after virus addition; 3) they blocked the formation of the gp41 core that is detected by sandwich enzyme linked immunosorbent assay (ELISA) using a conformation- specific MAb NC-I; and 4) they inhibited the formation of the gp41 six-helix bundle revealed by fluorescence native-polyacrylamide gel electrophoresis (FN-PAGE) . These results suggested that NB-206 and its analogs may interact with the hydrophobic cavity and block the formation of the fusion- active gp41 coiled coil domain, resulting in inhibition of HIV-I mediated membrane fusion and virus entry.

2. 发明公开

EP1030547A1 METHODS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS USING CELLULOSE ACETATE PHTHALATE OR HYDROXYPROPYL METHYLCELLULOSE PHTHALATE EXCIPIENTS 有权
标题翻译：使用纤维素乙酸邻苯二甲酸酯或羟丙基甲基纤维素邻苯二甲酸酯预防和治疗细菌感染的方法
公开(公告)号：EP1030547A1
公开(公告)日：2000-08-30
申请号：EP98956122.0
申请日：1998-10-21
申请人： New York Blood Center, Inc. , Neurath, Alexander Robert , Jiang, Shibo , Debnath, Asim Kumar , Strick, Nathan , DOW, Gordon J.
发明人： NEURATH, Alexander, Robert , JIANG, Shibo , DEBNATH, Asim, Kumar , STRICK, Nathan , DOW, Gordon, Jay
IPC分类号： A01F25/02 , A01F25/08 , A61K9/14
CPC分类号： A61K9/14 , A61K31/717
摘要： A method for decreasing the frequency of transmission of human immunodeficiency virus or herpesviruses or for preventing the transmission of or treating a sexually transmitted bacterial infection by administering to a human an anti-human immunodeficiency virus amount or an anti-herpesvirus amount or an anti-bacterial amount of cellulose acetate phthalate (CAP) or hydroxypropyl methylcellulose phthalate (HPMCP), such as in micronized form, or a combination thereof, either alone or in combination with a pharmaceutically acceptable carrier or diluent. The CAP and/or HPMCP may be employed as a suspension of micronized particles and may further contain a water miscible, non-solvent for CAP or HPMCP, such as glycerol.
摘要翻译：一种降低人类免疫缺陷病毒或疱疹病毒的传播频率或通过对人施用抗人类免疫缺陷病毒量或抗疱疹病毒量或抗菌素来预防性传播细菌感染的传播或治疗的方法单独或与药学上可接受的载体或稀释剂组合的邻苯二甲酸醋酸纤维素（CAP）或邻苯二甲酸羟丙基甲基纤维素（HPMCP）的量，例如微粉化形式，或其组合。 CAP和/或HPMCP可以用作微粉化颗粒的悬浮液，并且可以进一步含有用于CAP或HPMCP的可与水混溶的非溶剂，例如甘油。

3. 发明授权

EP1030547B1 METHODS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS USING CELLULOSE ACETATE PHTHALATE OR HYDROXYPROPYL METHYLCELLULOSE PHTHALATE EXCIPIENTS 有权
标题翻译：使用纤维素乙酸邻苯二甲酸酯或羟丙基甲基纤维素邻苯二甲酸酯预防和治疗细菌感染的方法
公开(公告)号：EP1030547B1
公开(公告)日：2004-12-15
申请号：EP98956122.0
申请日：1998-10-21
申请人： New York Blood Center, Inc. , Neurath, Alexander Robert , Jiang, Shibo , Debnath, Asim Kumar , Strick, Nathan , DOW, Gordon J.
发明人： NEURATH, Alexander, Robert , JIANG, Shibo , DEBNATH, Asim, Kumar , STRICK, Nathan , DOW, Gordon, Jay
IPC分类号： A61K9/14 , A61K31/715 , A61K31/717 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22
CPC分类号： A61K9/14 , A61K31/717

4. 发明申请

WO2004047730A3 COMPOUNDS FOR INHIBITION OF HIV INFECTION BY BLOCKING HIV ENTRY 审中-公开
公开(公告)号：WO2004047730A3
公开(公告)日：2004-06-10
申请号：PCT/US2003/036359
申请日：2003-11-12
申请人： NEW YORK BLOOD CENTER , JIANG, Shibo , DEBNATH, Asim, Kumar
发明人： JIANG, Shibo , DEBNATH, Asim, Kumar
IPC分类号： C07D207/30
摘要： Compounds that inhibit HIV replication by blocking HIV entry was identified.

5. 发明申请

WO2008148018A3 RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL 审中-公开
公开(公告)号：WO2008148018A3
公开(公告)日：2008-12-04
申请号：PCT/US2008/064737
申请日：2008-05-23
申请人： NEW YORK BLOOD CENTER INC. , STONE, Alan , NEURATH, Alexander, Robert , STRICK, Nathan , JIANG, Shibo
发明人： STONE, Alan , NEURATH, Alexander, Robert , STRICK, Nathan , JIANG, Shibo
IPC分类号： A61K9/20 , A61K31/00
摘要： A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2- benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hydroxypropyl methylcellulose; 50 to 250 mg of glycerol and optionally 2 to 4 mg of at least one preservative which protects against microbicidal contamination and discourages the growth of yeast in the vagina. The tablet which includes CAP as the vaginal medication is vaginally administered before coitus in methods for preventing the sexual transmission of HIV- 1, HIV-2, herpesvirus, or an infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Haemophilus ducreyi or Treponema pallidum. The tablet which includes CAP as the vaginal medication is vaginally administered to prevent or treat bacterial vaginosis.

6. 发明申请

WO2006086561A3 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME-ASSOCIATED CORONAVIRUS 审中-公开
公开(公告)号：WO2006086561A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/004599
申请日：2006-02-08
申请人： NEW YORK BLOOD CENTER , JIANG, Shibo , HE, Yuxian
发明人： JIANG, Shibo , HE, Yuxian
IPC分类号： A61K39/00 , A61K39/395 , A61K39/42 , A61K39/215
摘要： The present invention provides an isolated antibody capable of binding to the receptor- binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host cells. These mAbs or substances can be used: 1) as passive-immunizing agents for prevention of SARS-CoV infection; 2) as biological reagents for diagnosis of SARS-CoV infection; 3) as immunotherapeutics for early treatment of SARS-CoV infection; and 4) as probes for studying the immunogenicity, antigenicity, structure, and function of the SARS- CoV S protein.

7. 发明申请

WO2005120565A2 SARS VACCINES AND METHODS TO PRODUCE HIGHLY POTENT ANTIBODIES 审中-公开
标题翻译： SARS疫苗和生产高度抗体的方法
公开(公告)号：WO2005120565A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019266
申请日：2005-06-01
申请人： NEW YORK BLOOD CENTER , JIANG, Shibo , HE, Yuxian , LIU, Shuwen
发明人： JIANG, Shibo , HE, Yuxian , LIU, Shuwen
IPC分类号： A61K39/215
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/30 , C12N2770/20022
摘要： This invention provides a vaccine comprising an effective amount of an isolated polypeptide or recombinant protein containing the sequence of the receptor-binding domain in the SARS associated coronavirus spike protein or a functional fragment thereof, or a nucleic acid molecule comprising the sequence of a fragment which encodes the sequence of the receptor-binding domain in the Severe Acute Respiratory Syndrome associated coronavirus spike protein or a functional fragment thereof. This invention provides a composition for increasing the immunogenicity of an antigen comprising an effective amount of an antigen and an IgG Fc domain, its functional fragment, or a substance containing an IgG Fc domain or its functional fragment. The antigen and the IgG Fc may be linked or unlinked. Finally, this invention also provides method for using any of the above compositions for immunization.
摘要翻译：本发明提供一种疫苗，其包含有效量的分离的多肽或重组蛋白，其含有SARS相关冠状病毒穗状蛋白或其功能片段中受体结合结构域的序列，或包含该片段的序列的核酸分子编码重症急性呼吸综合征相关冠状病毒穗蛋白或其功能片段中受体结合结构域的序列。本发明提供用于增加抗原的免疫原性的组合物，其包含有效量的抗原和IgG Fc结构域，其功能片段或含有IgG Fc结构域或其功能片段的物质。抗原和IgG Fc可以连接或未连接。最后，本发明还提供了使用任何上述组合物进行免疫的方法。

8. 发明申请

WO2012054745A1 INFLUENZA HEMAGGLUTININ-SPECIFIC MONOCLONAL ANTIBODIES FOR PREVENTING AND TREATING INFLUENZA VIRUS INFECTION 审中-公开
标题翻译：用于预防和治疗流感病毒感染的流感嗜血球蛋白特异性单克隆抗体
公开(公告)号：WO2012054745A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057127
申请日：2011-10-20
申请人： NEW YORK BLOOD CENTER, INC. , JIANG, Shibo , DU, Lanying , ZHOU, Yusen
发明人： JIANG, Shibo , DU, Lanying , ZHOU, Yusen
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76
摘要： Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-1 15 of the HA1 domain of H5N1 influenza virus hemagglutinin.
摘要翻译：本文公开了具有交叉中和活性和针对流感病毒发散污染物的交叉保护作用的中和抗体，其对于与H5N1流感病毒的HA1结构域的氨基酸+ 72-115具有至少90％同源性的表位是特异性的血凝素。

9. 发明申请

WO2010019717A2 COMBINATION THERAPY OF HIV FUSION/ENTRY INHIBITORS TARGETING GP41 审中-公开
标题翻译：靶向GP41的HIV融合/入侵抑制剂的组合治疗
公开(公告)号：WO2010019717A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053619
申请日：2009-08-12
申请人： NEW YORK BLOOD CENTER , JIANG, Shibo , PAN, Chungen
发明人： JIANG, Shibo , PAN, Chungen
IPC分类号： C07K14/16 , A61K39/21 , A61K38/16
CPC分类号： A61K38/08 , A61K38/16 , C07K14/005 , C12N2740/16122 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions for the prophylactic and therapeutic treatment of HIV comprising combinations of HIV fusion/entry inhibitors with different target sites in HIV gp41 or different mechanisms of action. Also disclosed are methods of treating HIV infection by administering such compositions.
摘要翻译：本文提供了用于预防和治疗HIV的药物组合物，其包含HIV融合/进入抑制剂与HIV gp41中不同靶位点或不同作用机制的组合。还公开了通过施用这种组合物来治疗HIV感染的方法。

10. 发明申请

WO2011140092A1 BIFUNCTIONAL MOLECULES FOR INACTIVATING HIV AND BLOCKING HIV 审中-公开
标题翻译：用于免疫HIV和阻断HIV的双功能分子
公开(公告)号：WO2011140092A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035007
申请日：2011-05-03
申请人： NEW YORK BLOOD CENTER, INC. , JIANG, Shibo , PAN, Chungen , LU, Lu
发明人： JIANG, Shibo , PAN, Chungen , LU, Lu
IPC分类号： A61K38/16 , C07K14/16
CPC分类号： C07K14/005 , A61K38/162 , C07K14/70514 , C07K2319/32 , C12N2740/16122
摘要： Disclosed herein are bifunctional molecules which inactivate human immunodeficiency virus (HIV) even before the virus attacks the target cell and inhibits HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV. Further disclosed are methods for prophylaxis against HIV and treatment of HIV infection.
摘要翻译：本文公开了甚至在病毒攻击靶细胞并抑制HIV进入靶细胞之前使人免疫缺陷病毒（HIV）失活的双功能分子。还公开了用于治疗感染艾滋病毒的患者的新型抗HIV治疗剂。进一步公开的是用于预防HIV和治疗HIV感染的方法。

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