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1. 发明申请

WO2008148018A3 RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL 审中-公开
公开(公告)号：WO2008148018A3
公开(公告)日：2008-12-04
申请号：PCT/US2008/064737
申请日：2008-05-23
申请人： NEW YORK BLOOD CENTER INC. , STONE, Alan , NEURATH, Alexander, Robert , STRICK, Nathan , JIANG, Shibo
发明人： STONE, Alan , NEURATH, Alexander, Robert , STRICK, Nathan , JIANG, Shibo
IPC分类号： A61K9/20 , A61K31/00
摘要： A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2- benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hydroxypropyl methylcellulose; 50 to 250 mg of glycerol and optionally 2 to 4 mg of at least one preservative which protects against microbicidal contamination and discourages the growth of yeast in the vagina. The tablet which includes CAP as the vaginal medication is vaginally administered before coitus in methods for preventing the sexual transmission of HIV- 1, HIV-2, herpesvirus, or an infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Haemophilus ducreyi or Treponema pallidum. The tablet which includes CAP as the vaginal medication is vaginally administered to prevent or treat bacterial vaginosis.

2. 发明公开

EP1030547A1 METHODS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS USING CELLULOSE ACETATE PHTHALATE OR HYDROXYPROPYL METHYLCELLULOSE PHTHALATE EXCIPIENTS 有权
标题翻译：使用纤维素乙酸邻苯二甲酸酯或羟丙基甲基纤维素邻苯二甲酸酯预防和治疗细菌感染的方法
公开(公告)号：EP1030547A1
公开(公告)日：2000-08-30
申请号：EP98956122.0
申请日：1998-10-21
申请人： New York Blood Center, Inc. , Neurath, Alexander Robert , Jiang, Shibo , Debnath, Asim Kumar , Strick, Nathan , DOW, Gordon J.
发明人： NEURATH, Alexander, Robert , JIANG, Shibo , DEBNATH, Asim, Kumar , STRICK, Nathan , DOW, Gordon, Jay
IPC分类号： A01F25/02 , A01F25/08 , A61K9/14
CPC分类号： A61K9/14 , A61K31/717
摘要： A method for decreasing the frequency of transmission of human immunodeficiency virus or herpesviruses or for preventing the transmission of or treating a sexually transmitted bacterial infection by administering to a human an anti-human immunodeficiency virus amount or an anti-herpesvirus amount or an anti-bacterial amount of cellulose acetate phthalate (CAP) or hydroxypropyl methylcellulose phthalate (HPMCP), such as in micronized form, or a combination thereof, either alone or in combination with a pharmaceutically acceptable carrier or diluent. The CAP and/or HPMCP may be employed as a suspension of micronized particles and may further contain a water miscible, non-solvent for CAP or HPMCP, such as glycerol.
摘要翻译：一种降低人类免疫缺陷病毒或疱疹病毒的传播频率或通过对人施用抗人类免疫缺陷病毒量或抗疱疹病毒量或抗菌素来预防性传播细菌感染的传播或治疗的方法单独或与药学上可接受的载体或稀释剂组合的邻苯二甲酸醋酸纤维素（CAP）或邻苯二甲酸羟丙基甲基纤维素（HPMCP）的量，例如微粉化形式，或其组合。 CAP和/或HPMCP可以用作微粉化颗粒的悬浮液，并且可以进一步含有用于CAP或HPMCP的可与水混溶的非溶剂，例如甘油。

3. 发明授权

EP1030547B1 METHODS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS USING CELLULOSE ACETATE PHTHALATE OR HYDROXYPROPYL METHYLCELLULOSE PHTHALATE EXCIPIENTS 有权
标题翻译：使用纤维素乙酸邻苯二甲酸酯或羟丙基甲基纤维素邻苯二甲酸酯预防和治疗细菌感染的方法
公开(公告)号：EP1030547B1
公开(公告)日：2004-12-15
申请号：EP98956122.0
申请日：1998-10-21
申请人： New York Blood Center, Inc. , Neurath, Alexander Robert , Jiang, Shibo , Debnath, Asim Kumar , Strick, Nathan , DOW, Gordon J.
发明人： NEURATH, Alexander, Robert , JIANG, Shibo , DEBNATH, Asim, Kumar , STRICK, Nathan , DOW, Gordon, Jay
IPC分类号： A61K9/14 , A61K31/715 , A61K31/717 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22
CPC分类号： A61K9/14 , A61K31/717

4. 发明申请

WO2007044348A2 ANTI-INFECTIVE HYGIENE PRODUCTS BASED ON CELLULOSE ACETATE PHTHALATE 审中-公开
标题翻译：基于纤维素乙酸邻苯二甲酸酯的抗感染卫生产品
公开(公告)号：WO2007044348A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/038668
申请日：2006-10-04
申请人： NEW YORK BLOOD CENTER, INC. , NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-yao
发明人： NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-yao
IPC分类号： A61K31/717 , A61F13/20
CPC分类号： A61F13/2051 , A61K31/717
摘要： Methods for maintaining a low vaginal pH, preventing the propagation of toxic shock syndrome toxin (1) production during menstruation, preventing the shedding and dissemination of a herpesvirus and treating herpes lesions comprising administering to a human a formulation comprising a pharmaceutically effective amount of an insoluble micronized form of cellulose acetate phthalate or a cellulose acetate phthalate film or a cellulose acetate phthalate porous sponge. Also a method of treating Candida albicans infection comprising.administering to a human female a pharmaceutically effective amount of a composition comprising micronized cellulose acetate phthalate and miconazole nitrate.
摘要翻译：用于维持低阴道pH值，防止月经期间中毒性休克综合征毒素（1）产生的增加，防止疱疹病毒脱落和散播以及治疗疱疹病变的方法，所述方法包括向人施用制剂其包含药学有效量的不溶性微粉化形式的邻苯二甲酸乙酸纤维素或邻苯二甲酸乙酸纤维素膜或邻苯二甲酸乙酸纤维素多孔海绵。还一种治疗白色念珠菌感染的方法，包括给予人类女性一种药用有效量的包含微粉化醋酸邻苯二甲酸纤维素和硝酸咪康唑的组合物。

5. 发明申请

WO2006033971A3 STARCH-POMEGRANATE JUICE COOMPLEX AS AN HIV ENTRY INHIBITOR AND TOPICAL MICROBICIDE 审中-公开
公开(公告)号：WO2006033971A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/032979
申请日：2005-09-15
申请人： NEW YORK BLOOD CENTER, INC. , NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-Yao
发明人： NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-Yao
IPC分类号： A01N65/00
摘要： A complex comprising a starch and an active antiHIV-1 or anti-HIV-2 ingredient of pomegranate juice that is adsorbed on the starch when the starch is in a water insoluble form. The complex inhibits HIV-1 or HIV-2 infection and blocks the binding of HIV-1 or HIV-2 to the CD4 receptor and the CCR5 and CXCR4 coreceptors. The complex is used in a method of preventing HIV-1 or HIV-2 infection comprising administering to a mucous membrane of a human a pharmaceutically effective anti-HIV-1 or anti-HIV-2 amount of the complex.

6. 发明申请

WO2005034854A2 WATER DISPERSIBLE FILM 审中-公开
标题翻译：水分散膜
公开(公告)号：WO2005034854A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/028178
申请日：2004-08-30
申请人： NEW YORK BLOOD CENTER, INC. , NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-Yao
发明人： NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-Yao
IPC分类号： A61K
CPC分类号： A61K31/716 , A61K9/0034 , A61K9/7007
摘要： A soft, pliable cellulose acetate phthalate (CAP) - hydroxypropyl cellulose (HPC) composite film is provided which is generated by casting from organic solvent mixtures containing ethanol. The film rapidly reduces the infectivity of several sexually transmitted disease pathogens, including the human immunodeficiency virus (HIV-1), herpesvirus (HSV), non-viral sexually transmitted disease pathogens (such as Neisseria gonorrhoeae, Haemophilus ducreyi, Chlamydia trachomatis and Treponema pallidum) and bacteria associated with bacterial vaginosis (BV). The film is converted into a gel/cream and thus does not have to be removed following application and use. In addition to being a topical microbicide, the film can be employed for the mucosal delivery of pharmaceuticals other than cellulose acetate phthalate.
摘要翻译：提供柔软易弯曲的邻苯二甲酸醋酸纤维素（CAP） - 羟丙基纤维素（HPC）复合膜，其由含乙醇的有机溶剂混合物浇铸而成。该膜快速降低了几种性传播疾病病原体的传染性，包括人类免疫缺陷病毒（HIV-1），疱疹病毒（HSV），非病毒性传播疾病病原体（如淋病奈瑟菌，杜克雷嗜血杆菌，沙眼衣原体和梅毒螺旋体）和与细菌性阴道病相关的细菌（BV）。该膜被转换成凝胶/乳膏，因此在应用和使用后不必除去。除了是一种局部用杀微生物剂之外，该膜还可用于除醋酸邻苯二甲酸纤维素之外的药物的粘膜输送。

7. 发明申请

WO2003075788A2 BIODEGRADABLE MICROBICIDAL VAGINAL BARRIER DEVICE 审中-公开
标题翻译：生物可降解微生物屏障装置
公开(公告)号：WO2003075788A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/003961
申请日：2003-02-11
申请人： NEW YORK BLOOD CENTER, INC.
发明人： NEURATH, Alexander, Robert , STRICK, Nathan
IPC分类号： A61F
CPC分类号： A61K9/0036 , A61F13/15252 , A61F13/202 , A61F13/2022 , A61F13/2051 , A61F13/2074 , A61F13/2082 , A61F13/8405 , A61F2013/8414 , A61K9/122
摘要： An intravaginal bio-erodible microbicidal barrier device. The device comprises (a) at least one micronized compound selected from the group consisting of cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, and (b) at least one pectin, such as an apple pectin, and optionally at least one water soluble or water dispersible cellulose compound selected from the group consisting of hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxyethylethylcellulose and hydroxypropylethylcellulose. The device is prepared by a combination of foaming, freezing and freeze-drying processes.
摘要翻译：阴道内生物侵蚀性杀菌屏障装置。该装置包括至少一种选自乙酸邻苯二甲酸纤维素和羟丙基甲基纤维素邻苯二甲酸酯的微粉化化合物，以及b至少一种果胶，例如苹果果胶，以及任选的至少一种水溶性或水分散性纤维素化合物，其选自羟丙基甲基纤维素，甲基纤维素，羟乙基纤维素，羟丙基纤维素，羟乙基甲基纤维素，羟乙基乙基纤维素和羟丙基乙基纤维素组成的组。该设备通过发泡，冷冻和冷冻干燥过程的组合来制备。

8. 发明申请

WO2003075788A3 BIODEGRADABLE MICROBICIDAL VAGINAL BARRIER DEVICE 审中-公开
公开(公告)号：WO2003075788A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/003961
申请日：2003-02-11
申请人： NEW YORK BLOOD CENTER, INC.
发明人： NEURATH, Alexander, Robert , STRICK, Nathan
IPC分类号： A61F13/02
摘要： An intravaginal bio-erodible microbicidal barrier device. The device comprises (a) at least one micronized compound selected from the group consisting of cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, and (b) at least one pectin, such as an apple pectin, and optionally at least one water soluble or water dispersible cellulose compound selected from the group consisting of hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxyethylethylcellulose and hydroxypropylethylcellulose. The device is prepared by a combination of foaming, freezing and freeze-drying processes.

9. 发明公开

EP1931291A2 ANTI-INFECTIVE HYGIENE PRODUCTS BASED ON CELLULOSE ACETATE PHTHALATE 审中-公开
标题翻译： ANTI传染性HYGIENEARTIKEL基于邻苯二甲酸醋酸纤维素
公开(公告)号：EP1931291A2
公开(公告)日：2008-06-18
申请号：EP06825405.1
申请日：2006-10-04
申请人： New York Blood Center, Inc.
发明人： NEURATH, Alexander, Robert , STRICK, Nathan , LI, Yun-Yao
IPC分类号： A61F13/02 , A61F13/20
CPC分类号： A61F13/2051 , A61K31/717
摘要： Methods for maintaining a low vaginal pH, preventing the propagation of toxic shock syndrome toxin (1) production during menstruation, preventing the shedding and dissemination of a herpesvirus and treating herpes lesions comprising administering to a human a formulation comprising a pharmaceutically effective amount of an insoluble micronized form of cellulose acetate phthalate or a cellulose acetate phthalate film or a cellulose acetate phthalate porous sponge. Also a method of treating Candida albicans infection comprising.administering to a human female a pharmaceutically effective amount of a composition comprising micronized cellulose acetate phthalate and miconazole nitrate.

10. 发明公开

EP2146698A2 RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL 审中-公开
标题翻译：快速分散的阴道分泌片提供了一种生物凝胶
公开(公告)号：EP2146698A2
公开(公告)日：2010-01-27
申请号：EP08756218.7
申请日：2008-05-23
申请人： New York Blood Center, Inc.
发明人： STONE, Alan , NEURATH, Alexander, Robert , STRICK, Nathan , JIANG, Shibo
IPC分类号： A61K9/20 , A61K31/00
CPC分类号： A61K9/0034 , A61K9/2018 , A61K31/00
摘要： A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2- benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hydroxypropyl methylcellulose; 50 to 250 mg of glycerol and optionally 2 to 4 mg of at least one preservative which protects against microbicidal contamination and discourages the growth of yeast in the vagina. The tablet which includes CAP as the vaginal medication is vaginally administered before coitus in methods for preventing the sexual transmission of HIV- 1, HIV-2, herpesvirus, or an infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Haemophilus ducreyi or Treponema pallidum. The tablet which includes CAP as the vaginal medication is vaginally administered to prevent or treat bacterial vaginosis.
摘要翻译：一种用于插入阴道的片剂，包括0.01-500mg阴道药物，如杀微生物剂，如1,2-苯二甲酸乙酸纤维素（CAP）; 100至500毫克甘露糖醇粉末; 50至300mg的惰性微晶纤维素; 10至80mg的羟丙基甲基纤维素; 50至250mg的甘油和任选的2至4mg的至少一种防腐剂，其防止微生物污染并阻止阴道中酵母的生长。包含CAP作为阴道用药的片剂在性交前用于预防HIV-1，HIV-2，疱疹病毒的性传播或由淋病奈瑟氏球菌，沙眼衣原体，阴道毛滴虫，杜克氏嗜血杆菌或梅毒螺旋体引起的感染的方法中阴道给药梅毒螺旋体。将包含CAP作为阴道用药的片剂阴道给药以预防或治疗细菌性阴道病。

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