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1. 发明申请

WO2003024410A3 COMPOSITION FOR TREATING STREPTOCOCCUS PNEUMONIAE 审中-公开
公开(公告)号：WO2003024410A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/030099
申请日：2002-09-23
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKFELLER UNIVERSITY , FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
IPC分类号： A61K38/00
摘要： A method for the prophylactic and therapeutic treatment of Streptococcal pneumoniae infections is disclosed which comprises the treating of an individual with an effective amount of an unaltered lytic enzyme, a chimeric and/or a shuffled lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the enzyme(s). This method, and composition can be used for the treatment of upper respiratory infections, lower respiratory infections, septicemia, bacterial meningitis, and other infections involving Streptococcal pneumoniae.

2. 发明申请

WO2004027020A2 IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLY AND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS 审中-公开
标题翻译：鉴定一株噬菌体相关的淋巴酶，以快速，特异地检测和杀灭芽孢杆菌
公开(公告)号：WO2004027020A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/015719
申请日：2003-05-19
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , FISCHETTI, Vincent, A. , SCHUCH, Raymond , NELSON, Daniel , LOOMIS, Lawrence , TRUDIL, David
发明人： FISCHETTI, Vincent, A. , SCHUCH, Raymond , NELSON, Daniel , LOOMIS, Lawrence , TRUDIL, David
IPC分类号： C12N
CPC分类号： C12N9/80 , A61K31/00 , A61K31/197 , A61K38/00 , A61K45/06 , C07K14/005 , C07K14/32 , C12N9/14 , C12N9/48 , C12N2795/10022 , C12Q1/04 , G01N33/66 , G01N2333/32 , A61K2300/00
摘要： A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
摘要翻译：公开了用于治疗炭疽芽孢杆菌感染的方法和组合物，其包括以下步骤：向感染或定植的部位施用有效量的至少一种由噬菌体遗传编码的裂解酶特异于炭疽芽孢杆菌，其中所述至少一种所述裂解酶对炭疽芽孢杆菌的细胞壁具有特异性并且能够消化所述细胞壁。裂解酶可以是嵌合或混洗的，并且也可以使用穴蛋白。披露了裂解酶γ噬菌体的序列。

3. 发明申请

WO2003024410A2 THE USE OF BACTERIAL SHUFFLED AND CHIMERIC PHAGE ASSOCIATED LYTIC ENZYMES FOR THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF COLONIZATION AND INFECTIONS CAUSED BY STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：细菌消化和细胞毒素相关LYTIC酶的使用用于由结核分枝杆菌引起的结肠和感染的预防和治疗治疗
公开(公告)号：WO2003024410A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/030099
申请日：2002-09-23
申请人： NEW HORIZONS DIAGNOSTICS, INC. , FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
IPC分类号： A61K
CPC分类号： A61K38/47 , C11D3/0078 , C11D3/386 , C12N9/503 , C12Y302/01017
摘要： A method for the prophylactic and therapeutic treatment of Streptococcal pneumoniae infections is disclosed which comprises the treating of an individual with an effective amount of an unaltered lytic enzyme, a chimeric and/or a shuffled lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the enzyme(s). This method, and composition can be used for the treatment of upper respiratory infections, lower respiratory infections, septicemia, bacterial meningitis, and other infections involving Streptococcal pneumoniae.
摘要翻译：公开了一种用于预防和治疗肺炎链球菌感染的方法，其包括用有效量的未改变的溶解酶，对于感染细菌特异性的嵌合和/或混洗溶解酶组合物治疗个体，以及载体用于递送酶。该方法和组合物可用于治疗上呼吸道感染，下呼吸道感染，败血症，细菌性脑膜炎和其他涉及肺炎链球菌感染。

4. 发明申请

WO2001051073A3 THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS 审中-公开
公开(公告)号：WO2001051073A3
公开(公告)日：2001-07-19
申请号：PCT/US2001/000913
申请日：2001-01-12
申请人： NEW HORIZONS DIAGNOSTICS, CORPORATION , FISCHETTI, Vincent , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent , LOOMIS, Lawrence
IPC分类号： A61K38/46
摘要： The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of a therapeutic agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of lytic enzymes, and modified lytic enzymes such as shuffled lytic enzymes, chimeric lytic enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The therapeutic agent may additionally include a holin enzyme, which may be a shuffled holin enzyme or a chimeric holin enzyme. The injection can be done intramuscularly, subcutaneously, or intravenously.

5. 发明申请

WO2004064732A2 THE USE OF BACTERIAL PHAGE-ASSOCIATED LYSING PROTEINS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS IN HUMANS, ANIMALS AND FOWL 审中-公开
标题翻译：使用细菌相关蛋白来预防和治疗人体，动物和动物中的细菌感染
公开(公告)号：WO2004064732A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001077
申请日：2004-01-16
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , LOOMIS, Lawrence , FISCHETTI, Vincent, A.
发明人： LOOMIS, Lawrence , FISCHETTI, Vincent, A.
IPC分类号： A61K
CPC分类号： A61K38/47
摘要： A composition and method for treating bacterial infections by the use of an effective amount of at least one lytic specific for the bacteria causing specific. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：通过使用有效量的至少一种特异性细菌的裂解液来治疗细菌感染的组合物和方法。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

6. 发明申请

WO2004000222A2 THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING PROTEINS FOR TREATING BACTERIAL DENTAL CARIES 审中-公开
标题翻译：使用细菌相关蛋白处理细菌牙科
公开(公告)号：WO2004000222A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019654
申请日：2003-06-23
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , FISCHETTI, Vincent, A. , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent, A. , LOOMIS, Lawrence
IPC分类号： A61K
CPC分类号： A23G3/44 , A23G3/366 , A23G3/368 , A61K38/162 , A61K38/46 , A61K2300/00
摘要： A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：一种用于治疗细菌性龋齿的组合物和方法，所述组合物和方法通过使用有效量的至少一种特异于溶解于引起龋齿的细菌的裂解液。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

7. 发明申请

WO2002102405A1 THE USE OF BACTERIAL PHAGE ASSOCIATED LYTIC ENZYMES TO PREVENT FOOD POISONING 审中-公开
标题翻译：使用细菌相关的LYTIC ENZYMES预防食物毒素
公开(公告)号：WO2002102405A1
公开(公告)日：2002-12-27
申请号：PCT/US2001/042886
申请日：2001-11-01
申请人： NEW HORIZONS DIAGNOSTICS INC. , FISCHETTI, Vincent , LOOMIS, Lawrence , TRUDIL, David
发明人： FISCHETTI, Vincent , LOOMIS, Lawrence , TRUDIL, David
IPC分类号： A61K38/43
CPC分类号： A23B7/155 , A23B4/22 , A23B5/16 , A23K20/189 , A23K30/00 , A23L3/3463 , A23L3/3571
摘要： The present invention discloses a method and composition for the treatment of bacterial contamination of food by the use of a phage associated lysing enzyme, preferably blended with an appropriate carrier. The method for treating food stuffs comprises treating the food stuffs with an anti-infection agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for the bacteria.. Additionally, chimeric lytic enzymes shuffled lytic enzymes, and holin proteins, either alone or in combination, may be used to treat or prevent bacterial contamination of foodstuffs. The lytic enzyme can be used for the treatment or prevention of various strains of Staphylococcus, Streptococcus, Listeria, Salmonella, E. coli, Campylobacter, Pseudomonas, Brucella, other bacteria, and an,Y combination thereof. Feed for livestock, poultry and beef in slaughterhouses, canned and bottled goods, salad bars, and eggs are just some of the food items that can be treated with at least one lytic enzyme to reduce the risk of food contamination by bacteria.
摘要翻译：本发明公开了一种通过使用噬菌体相关的裂解酶处理食物细菌污染的方法和组合物，优选与合适的载体共混。用于处理食物的方法包括用抗感染剂处理食物，所述抗感染剂包含有效量的由细菌特异性感染的细菌产生的至少一种裂解酶。另外，嵌合裂解酶洗涤裂解酶，和单独或组合的蛋白质可用于治疗或预防食品的细菌污染。溶解酶可用于治疗或预防葡萄球菌，链球菌，利斯特氏菌，沙门氏菌，大肠杆菌，弯曲杆菌，假单胞菌，布鲁杆菌，其他细菌及其Y组合的各种菌株。在屠宰场，罐装和瓶装食品，沙拉吧和鸡蛋中饲养牲畜，家禽和牛肉只是一些可以用至少一种溶解酶处理的食物，以减少细菌食物污染的风险。

8. 发明申请

WO2005077046A2 A COMPOSITION AND METHOD OF TREATING MASTITIS 审中-公开
标题翻译：一种处理主体的组成和方法
公开(公告)号：WO2005077046A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004048
申请日：2005-02-10
申请人： NEW HORIZONS DIAGNOSTICS, INC. , ROCKEFELLER UNIVERSITY , LOOMIS, Lawrence , FISCHETTI, Vincent
发明人： LOOMIS, Lawrence , FISCHETTI, Vincent
IPC分类号： A61K38/54
CPC分类号： A61K38/47 , C12Y302/01017
摘要： A composition and method for treating mastitis by the use of an effective amount of at least one lytic specific for the bacteria causing the disease. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：一种用于通过使用有效量的至少一种对引起该疾病的细菌特异性的裂解液来治疗乳腺炎的组合物和方法。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

9. 发明授权

EP0901631B1 METHOD FOR DETECTION OF CONTAMINANTS 失效
标题翻译：检测方法的污染物的
公开(公告)号：EP0901631B1
公开(公告)日：2004-08-25
申请号：EP97916812.7
申请日：1997-03-25
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION
发明人： MILLER, C., David , LOOMIS, Lawrence
IPC分类号： G01N33/569
CPC分类号： C12Q1/04 , C12Q1/06 , C12Q2304/60 , G01N33/54366 , G01N33/56911 , G01N2001/028 , Y10S435/968
摘要： A method and device for determining the presence and concentration of total microbial contamination or the presence and concentration of a specific microbial species is described. The method consists of a means of collection of the microbes from an air, liquid, surface or other sample and suspending them in fluid phase (3). An aliquot of the fluid phase (3) is introduced into a disposable test device which allows filtration of the sample to concentrate the microbes and to remove extraneous substances including somatic cells, and concentration of the microbes. The total concentration of microbes is determined by adding a somatic and bacterial releasing reagent to a disposable test device (25) which comprises a membrane (26) containing the luminescent reagents luciferin and luciferase, and introducing the disposable test device (25) into a luminometer that can read the luminescence from the underside.

10. 发明公开

EP1246641A2 THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS 有权
标题翻译：噬菌体相关裂解酶对于治疗治疗细菌感染
公开(公告)号：EP1246641A2
公开(公告)日：2002-10-09
申请号：EP01901984.3
申请日：2001-01-12
申请人： New Horizons Diagnostics, Corporation
发明人： FISCHETTI, Vincent , LOOMIS, Lawrence
IPC分类号： A61K38/46
CPC分类号： A61K38/46 , A61K38/162 , Y02A50/406 , Y02A50/481 , A61K2300/00
摘要： The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, holin enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.

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