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1. 发明专利

AU2006201041A1 The parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections 未知
公开(公告)号：AU2006201041A1
公开(公告)日：2006-04-06
申请号：AU2006201041
申请日：2006-03-10
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , UNIV ROCKEFELLER
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE
IPC分类号： A61K38/00

2. 发明申请

WO2004027020A2 IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLY AND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS 审中-公开
标题翻译：鉴定一株噬菌体相关的淋巴酶，以快速，特异地检测和杀灭芽孢杆菌
公开(公告)号：WO2004027020A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/015719
申请日：2003-05-19
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , FISCHETTI, Vincent, A. , SCHUCH, Raymond , NELSON, Daniel , LOOMIS, Lawrence , TRUDIL, David
发明人： FISCHETTI, Vincent, A. , SCHUCH, Raymond , NELSON, Daniel , LOOMIS, Lawrence , TRUDIL, David
IPC分类号： C12N
CPC分类号： C12N9/80 , A61K31/00 , A61K31/197 , A61K38/00 , A61K45/06 , C07K14/005 , C07K14/32 , C12N9/14 , C12N9/48 , C12N2795/10022 , C12Q1/04 , G01N33/66 , G01N2333/32 , A61K2300/00
摘要： A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
摘要翻译：公开了用于治疗炭疽芽孢杆菌感染的方法和组合物，其包括以下步骤：向感染或定植的部位施用有效量的至少一种由噬菌体遗传编码的裂解酶特异于炭疽芽孢杆菌，其中所述至少一种所述裂解酶对炭疽芽孢杆菌的细胞壁具有特异性并且能够消化所述细胞壁。裂解酶可以是嵌合或混洗的，并且也可以使用穴蛋白。披露了裂解酶γ噬菌体的序列。

3. 发明申请

WO2004000222A2 THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING PROTEINS FOR TREATING BACTERIAL DENTAL CARIES 审中-公开
标题翻译：使用细菌相关蛋白处理细菌牙科
公开(公告)号：WO2004000222A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019654
申请日：2003-06-23
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , FISCHETTI, Vincent, A. , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent, A. , LOOMIS, Lawrence
IPC分类号： A61K
CPC分类号： A23G3/44 , A23G3/366 , A23G3/368 , A61K38/162 , A61K38/46 , A61K2300/00
摘要： A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：一种用于治疗细菌性龋齿的组合物和方法，所述组合物和方法通过使用有效量的至少一种特异于溶解于引起龋齿的细菌的裂解液。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

4. 发明申请

WO1988007584A1 METHOD AND APPARATUS FOR DETECTION AND QUANTIFICATION OF BACTERIA 审中-公开
标题翻译：用于检测和定量细菌的方法和装置
公开(公告)号：WO1988007584A1
公开(公告)日：1988-10-06
申请号：PCT/US1988000852
申请日：1988-03-22
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION
发明人： NEW HORIZONS DIAGNOSTICS CORPORATION , MILLER, C., David , LOOMIS, Lawrence, J.
IPC分类号： C12Q01/66
CPC分类号： G01N21/763 , C12M41/36 , C12M41/46 , C12M47/06 , C12Q1/04 , C12Q1/66 , C12Q2304/60
摘要： The invention includes a photometer (10), a disposable test device (17) for use with the photometer (10), and a reagent system for monitoring the presence and amount of bacteria in a wide variety of samples. The photometer (10) provides a means for positioning (16) the disposable test device in proximity to a photodetector which measures the light emitted by a reaction specific to the bacterial adenosinetriphosphate (ATP) content of the sample. The disposable test device provides a method for pre-removal of reaction inhibiting constituents and non-bacterial ATP from the reaction mixture. The instrument includes an electrical circuit for generating a signal proportional to detected light and for generating an output signal representative of the presence and amount of bacteria in the sample being monitored.
摘要翻译：本发明包括光度计（10），与光度计（10）一起使用的一次性测试装置（17）和用于监测各种样品中细菌的存在和数量的试剂系统。光度计（10）提供一种用于将一次性测试装置定位（16）靠近光电检测器的装置，该光电检测器测量由特异于样品的细菌亚磷酸三磷酸（ATP）含量的反应发射的光。一次性测试装置提供了从反应混合物中预除去反应抑制成分和非细菌ATP的方法。该仪器包括用于产生与检测到的光成比例的信号的电路，并产生代表被监测样品中细菌的存在和量的输出信号。

5. 发明申请

WO2001051073A3 THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS 审中-公开
公开(公告)号：WO2001051073A3
公开(公告)日：2001-07-19
申请号：PCT/US2001/000913
申请日：2001-01-12
申请人： NEW HORIZONS DIAGNOSTICS, CORPORATION , FISCHETTI, Vincent , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent , LOOMIS, Lawrence
IPC分类号： A61K38/46
摘要： The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of a therapeutic agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of lytic enzymes, and modified lytic enzymes such as shuffled lytic enzymes, chimeric lytic enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The therapeutic agent may additionally include a holin enzyme, which may be a shuffled holin enzyme or a chimeric holin enzyme. The injection can be done intramuscularly, subcutaneously, or intravenously.

6. 发明申请

WO1988004431A1 A DEVICE AND METHOD FOR SELF CONTAINED SOLID PHASE IMMUNODIFFUSION ASSAY 审中-公开
标题翻译：一种用于自包含固体相位免疫测定的装置和方法
公开(公告)号：WO1988004431A1
公开(公告)日：1988-06-16
申请号：PCT/US1987003169
申请日：1987-12-01
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , BERNSTEIN, David
发明人： NEW HORIZONS DIAGNOSTICS CORPORATION
IPC分类号： G01N33/543
CPC分类号： G01N33/5302 , A61B10/0096 , A61B2010/0006 , A61F13/38 , B01L3/5029 , B01L3/50825 , B01L3/527 , B01L2300/044 , B01L2300/0672 , B01L2300/0681 , B01L2400/0478
摘要： A device and method for self containing solid phase immunodiffusion assay are comprised of a sample collector (15) and a pre-fabricated laminate (33) which can be used in many different forms. For example, the sample collector and laminate can be used with a tube having compartmentalized reagents. The seals can be broken through pressure on the sample collector. The sample collector is pushed through the seals, mixed with reagent, and then pushed into a ligand receptor reaction area which is part of the laminate. The tip of the sample collector contacts diffusable porous membranes or filters (25) and transfers the reactants to a capture membrane (18) wherein a ligand receptor reaction can be examined by the naked eye or otherwise.
摘要翻译：用于自体含固相免疫扩散测定的装置和方法由样品收集器（15）和可以以许多不同形式使用的预制层压板（33）组成。例如，样品收集器和层压体可以与具有间隔试剂的管一起使用。密封件可以通过样品收集器上的压力破裂。将样品收集器推过密封件，与试剂混合，然后推入作为层压体一部分的配体受体反应区域。样品收集器的尖端接触扩散的多孔膜或过滤器（25）并将反应物转移到捕获膜（18），其中可以通过肉眼或其它方式检查配体受体反应。

7. 发明申请

WO2003024410A3 COMPOSITION FOR TREATING STREPTOCOCCUS PNEUMONIAE 审中-公开
公开(公告)号：WO2003024410A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/030099
申请日：2002-09-23
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKFELLER UNIVERSITY , FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
发明人： FISCHETTI, Vincent , LOEFFLER, Jutta , NELSON, Daniel , LOOMIS, Lawrence
IPC分类号： A61K38/00
摘要： A method for the prophylactic and therapeutic treatment of Streptococcal pneumoniae infections is disclosed which comprises the treating of an individual with an effective amount of an unaltered lytic enzyme, a chimeric and/or a shuffled lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the enzyme(s). This method, and composition can be used for the treatment of upper respiratory infections, lower respiratory infections, septicemia, bacterial meningitis, and other infections involving Streptococcal pneumoniae.

8. 发明申请

WO2004064732A2 THE USE OF BACTERIAL PHAGE-ASSOCIATED LYSING PROTEINS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS IN HUMANS, ANIMALS AND FOWL 审中-公开
标题翻译：使用细菌相关蛋白来预防和治疗人体，动物和动物中的细菌感染
公开(公告)号：WO2004064732A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001077
申请日：2004-01-16
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , THE ROCKEFELLER UNIVERSITY , LOOMIS, Lawrence , FISCHETTI, Vincent, A.
发明人： LOOMIS, Lawrence , FISCHETTI, Vincent, A.
IPC分类号： A61K
CPC分类号： A61K38/47
摘要： A composition and method for treating bacterial infections by the use of an effective amount of at least one lytic specific for the bacteria causing specific. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：通过使用有效量的至少一种特异性细菌的裂解液来治疗细菌感染的组合物和方法。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

9. 发明申请

WO1998032020A1 METHOD FOR DETECTION OF CONTAMINANTS 审中-公开
标题翻译：检测污染物的方法
公开(公告)号：WO1998032020A1
公开(公告)日：1998-07-23
申请号：PCT/US1997004289
申请日：1997-03-25
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION , MILLER, C., David , LOOMIS, Lawrence
发明人： NEW HORIZONS DIAGNOSTICS CORPORATION
IPC分类号： G01N33/569
CPC分类号： C12Q1/04 , C12Q1/06 , C12Q2304/60 , G01N33/54366 , G01N33/56911 , G01N2001/028 , Y10S435/968
摘要： A method and device for determining the presence and concentration of total microbial contamination or the presence and concentration of a specific microbial species is described. The method consists of a means of collection of the microbes from an air, liquid, surface or other sample and suspending them in fluid phase (3). An aliquot of the fluid phase (3) is introduced into a disposable test device which allows filtration of the sample to concentrate the microbes and to remove extraneous substances including somatic cells, and concentration of the microbes. The total concentration of microbes is determined by adding a somatic and bacterial releasing reagent to a disposable test device (25) which comprises a membrane (26) containing the luminescent reagents luciferin and luciferase, and introducing the disposable test device (25) into a luminometer that can read the luminescence from the underside.
摘要翻译：描述了用于确定总微生物污染物的存在和浓度或特定微生物物种的存在和浓度的方法和装置。该方法包括从空气，液体，表面或其他样品中收集微生物并将其悬浮在流体相（3）中的手段。将流体相（3）的等分试样引入一次性试验装置，其允许样品过滤以浓缩微生物并除去包括体细胞的外来物质和微生物的浓缩。微生物的总浓度通过将体细菌和细菌释放试剂加入到一次性试验装置（25）中来确定，所述一次性试验装置包括含有发光试剂荧光素和荧光素酶的膜（26），并将一次性试验装置（25）引入发光计它可以从底面读取发光。

10. 发明申请

WO1989003044A1 COLLOIDAL GOLD PARTICLE CONCENTRATION IMMUNOASSAY 审中-公开
标题翻译：胶体金颗粒浓度免疫
公开(公告)号：WO1989003044A1
公开(公告)日：1989-04-06
申请号：PCT/US1988003296
申请日：1988-09-28
申请人： NEW HORIZONS DIAGNOSTICS CORPORATION
发明人： NEW HORIZONS DIAGNOSTICS CORPORATION , BERNSTEIN, David , OLSEN, Duane, A.
IPC分类号： G01N33/543
CPC分类号： G01N33/585 , Y10S435/805 , Y10S436/807
摘要： A sandwich immunoassay method is disclosed that is useful for the identification of an antigen in biological specimens. The method is comprised of a colloidal gold labeled binder specific for epitopes or receptors of a ligand, nonporous particulate solid phase which have antiligand covalently attached, and which said reagents are combined with the biological specimen or an extract of the biological specimen, and after an appropriate incubation, the said reactant mixture is contacted to a porous film having an exposed surface area of contact no greater than 30 mm2 to separate and concentrate the particle bound colloidal gold labeled binder from the unbound. The identification of an antigen is determined by the presence of color on the surface of the solid phase particles captured on the surface of the film. A competitive inhibition assay can be also used to identify the presence of a hapten or antigen, in which case the presence of the analyte is determined by the absence of color.

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