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1. 发明专利

JPH09505607A 失效
公开(公告)号：JPH09505607A
公开(公告)日：1997-06-03
申请号：JP52670095
申请日：1995-04-12
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , WATJEN FRANK , SCHEEL-KRUEGER JORGEN
IPC分类号： A61K31/46 , A61P3/04 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/30 , A61P43/00 , C07D451/02
摘要： PCT No. PCT/EP95/01358 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28401 PCT Pub. Date Oct. 26, 1995The present invention discloses compounds of the formula, any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e dopamine, serotonin, noradrenalin, reuptake inhibitors.

2. 发明申请

WO9938866A8 8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES IN LABELLED FORM AND USE OF 8-AZABICYCLO[3.2.1]OCT-2-ENE DERIVATIVES IN LABELLED AND UNLABELLED FORM 审中-公开
标题翻译： 8-亚氨基二环[3.2.1]标记形式的OCT-2-环化合物衍生物，并使用8-亚氨基半胱氨酸[3.2.1] OCT-2-环烯衍生物在标记和非限制形式
公开(公告)号：WO9938866A8
公开(公告)日：1999-10-28
申请号：PCT/DK9900044
申请日：1999-01-28
申请人： NEUROSEARCH AS , MOLDT PETER , SCHEEL KRUEGER JOERGEN , NIELSEN ELSEBET OESTERGAARD
发明人： MOLDT PETER , SCHEEL-KRUEGER JOERGEN , NIELSEN ELSEBET OESTERGAARD
IPC分类号： A61K51/00 , A61K51/04 , C07D451/02 , C07D451/06
CPC分类号： C07D451/02 , A61K51/0455 , A61K2123/00
摘要： The present invention relates to 8-azabicyclo[3.2.1]oct-2-ene derivatives in their labelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diganostic methods, in particular for in vivo receptor imaging (neuroimaging).
摘要翻译：本发明涉及其标记形式的8-氮杂双环[3.2.1]辛-2-烯衍生物。此外，本发明涉及所述衍生物在其标记或未标记形式中的用途，特别是用于体内受体成像（神经成像）。

3. 发明专利

PE20090489A1 SAL HIDROCLORURO DE (1R,2R,3S,5S)-2-METOXIMETIL-3-(3,4-DICLOROFENIL)-8-AZABICICLO[3.2.1]OCTANO 未知
公开(公告)号：PE20090489A1
公开(公告)日：2009-05-24
申请号：PE2008000400
申请日：2008-02-28
申请人： GLAXO GROUP LTD , NEUROSEARCH AS
发明人： GRINTER TREVOR JOHN , MOLDT PETER , WATJEN FRANK
IPC分类号： A61K31/46 , C07D451/02
摘要： SE REFIERE A UNA SAL HIDROCLORURO DE (1R,2R,3S,5S)-2-METOXIMETIL-3-(3,4-DICLOROFENIL)-8-AZABICICLO[3.2.1]OCTANO QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X DE POLVOS EXPRESADOS EN GRADOS 2 TETA DE 6,2; 12,5; 13,5; 15,6; 18,7; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LA FORMA CRISTALINA Y A UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION LA CUAL ES UTIL PARA EL TRATAMIENTO DE LA DEPRESION, TRASTORNOS DEL ESTADO EMOCIONAL Y TRASTORNOS DE ANSIEDAD

4. 发明专利

DE69637097D1 未知
公开(公告)号：DE69637097D1
公开(公告)日：2007-07-05
申请号：DE69637097
申请日：1996-10-11
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , SCHEEL-KRUEGER JORGEN , OLSEN GUNNAR M , NIELSEN ELSEBET STERGAARD
IPC分类号： C07D451/06 , A61K31/46 , A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D451/02
摘要： PCT No. PCT/EP96/04449 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13770 PCT Pub. Date Apr. 17, 1997A compound having the formula, or any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; and R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; or naphthyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter re-uptake inhibitors.

5. 发明专利

AT362931T 未知
公开(公告)号：AT362931T
公开(公告)日：2007-06-15
申请号：AT96934662
申请日：1996-10-11
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , SCHEEL-KRUEGER J0RGEN , OLSEN GUNNAR , NIELSEN ELSEBET
IPC分类号： C07D451/06 , A61K31/46 , A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D451/02
摘要： PCT No. PCT/EP96/04449 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13770 PCT Pub. Date Apr. 17, 1997A compound having the formula, or any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; and R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; or naphthyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter re-uptake inhibitors.

6. 发明专利

AT341542T 未知
公开(公告)号：AT341542T
公开(公告)日：2006-10-15
申请号：AT97919397
申请日：1997-04-21
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , DAHL BJARNE HUGO , DREJER JORGEN , AXELSSON OSKAR
IPC分类号： C07D401/04 , A61K31/415 , A61K31/445

7. 发明专利

AT248147T 未知
公开(公告)号：AT248147T
公开(公告)日：2003-09-15
申请号：AT98919091
申请日：1998-05-12
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , WAETJEN FRANK , SCHEEL-KRUEGER JORGEN
IPC分类号： A61K31/445 , A61P3/04 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D211/28
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R3 is -CR'=NOR'' wherein R' and R'' each independently are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkylalkenyl, alkynyl, cycloalkylalkynyl, aryl or benzyl; R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; or naphthyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e. dopamine, serotonin, noradrenaline, reuptake inhibitors.

8. 发明专利

SK283425B6 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use 未知
公开(公告)号：SK283425B6
公开(公告)日：2003-07-01
申请号：SK28798
申请日：1996-10-11
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , SCHEEL-KRUGER JORGEN , OLSEN GUNNAR M , NIELSEN ELSEBET OSTERGAARD
IPC分类号： A61K31/46 , A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D451/02 , C07D451/06
摘要： A compound having formula (I) or any of its enantiomers of any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; and R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; or naphtyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter re-uptake inhibitors.

9. 发明专利

DE69332636D1 未知
公开(公告)号：DE69332636D1
公开(公告)日：2003-02-20
申请号：DE69332636
申请日：1993-12-20
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , SCHEEL-KRUEGER JORGEN , JENSEN LEIF HELTH
IPC分类号： A61K31/46 , A61P25/00 , A61P25/24 , A61P25/26 , A61P25/30 , C07D451/02

10. 发明专利

PL183025B1 DERIVATIVES OF 2-ALDOXIN TROPHANE AS INHIBITORS OF REVERSIBLE NEUROTRANSMITTERS TRAPPING 未知
公开(公告)号：PL183025B1
公开(公告)日：2002-05-31
申请号：PL31687695
申请日：1995-04-12
申请人： NEUROSEARCH AS
发明人： MOLDT PETER , WATJEN FRANK , SCHEEL-KRUGER JORGEN
IPC分类号： A61K31/46 , A61P3/04 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/30 , A61P43/00 , C07D451/02
摘要： PCT No. PCT/EP95/01358 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28401 PCT Pub. Date Oct. 26, 1995The present invention discloses compounds of the formula, any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e dopamine, serotonin, noradrenalin, reuptake inhibitors.

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