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1. 发明专利

DE69332636D1 未知
公开(公告)号：DE69332636D1
公开(公告)日：2003-02-20
申请号：DE69332636
申请日：1993-12-20
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , SCHEEL-KRUEGER JORGEN , JENSEN LEIF HELTH
IPC分类号： A61K31/46 , A61P25/00 , A61P25/24 , A61P25/26 , A61P25/30 , C07D451/02

2. 发明专利

DE69332366T2 未知
公开(公告)号：DE69332366T2
公开(公告)日：2003-06-18
申请号：DE69332366
申请日：1993-12-20
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , SCHEEL-KRUEGER JOERGEN , JENSEN LEIF HELTH
IPC分类号： A61K31/435 , A61K31/46 , A61P25/00 , A61P25/24 , A61P25/26 , A61P25/30 , C07D451/02

3. 发明专利

DE69332366D1 未知
公开(公告)号：DE69332366D1
公开(公告)日：2002-11-14
申请号：DE69332366
申请日：1993-12-20
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , SCHEEL-KRUEGER JOERGEN , JENSEN LEIF HELTH
IPC分类号： A61K31/435 , A61K31/46 , A61P25/00 , A61P25/24 , A61P25/26 , A61P25/30 , C07D451/02

4. 发明专利

DE69817557T2 未知
公开(公告)号：DE69817557T2
公开(公告)日：2004-06-17
申请号：DE69817557
申请日：1998-05-12
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , WAETJEN FRANK , SCHEEL-KRUEGER JORGEN
IPC分类号： A61K31/445 , A61P3/04 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D211/28
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R3 is -CR'=NOR'' wherein R' and R'' each independently are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkylalkenyl, alkynyl, cycloalkylalkynyl, aryl or benzyl; R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; or naphthyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e. dopamine, serotonin, noradrenaline, reuptake inhibitors.

5. 发明专利

DE69817557D1 未知
公开(公告)号：DE69817557D1
公开(公告)日：2003-10-02
申请号：DE69817557
申请日：1998-05-12
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , WAETJEN FRANK , SCHEEL-KRUEGER JORGEN
IPC分类号： A61K31/445 , A61P3/04 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D211/28
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R3 is -CR'=NOR'' wherein R' and R'' each independently are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkylalkenyl, alkynyl, cycloalkylalkynyl, aryl or benzyl; R4 is phenyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; 3,4-methylenedioxyphenyl; benzyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; heteroaryl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; or naphthyl which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e. dopamine, serotonin, noradrenaline, reuptake inhibitors.

6. 发明专利

DE69705608T2 未知
公开(公告)号：DE69705608T2
公开(公告)日：2002-05-16
申请号：DE69705608
申请日：1997-02-21
申请人： NEUROSEARCH AS BALLERUP
发明人： SCHEEL-KRUEGER JOERGEN , MOLDT PETER , WAETJEN FRANK
IPC分类号： A61K31/46 , A61P25/00 , A61P25/28 , C07D451/02
摘要： The present invention relates to novel tropane-derivatives which are valuable monoamine neurotransmitter, i.e dopamine, serotonin and noradrenaline, re-uptake inhibitors and the use of the novel tropane derivatives for the treatment of disorders or diseases responsive to the inhibition of monoamine neurotransmitter re-uptake, such as Parkinson's disease, depression, obsessive compulsive disorders, panic disorders, dementia, memory deficits, attention deficit hyperactivity disorder, obesity, anxiety, eating disorders and drug addiction or misuse, including cocaine abuse.

7. 发明专利

DE69614838T2 未知
公开(公告)号：DE69614838T2
公开(公告)日：2001-12-20
申请号：DE69614838
申请日：1996-03-22
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER
IPC分类号： C07D451/02
摘要： PCT No. PCT/EP96/01277 Sec. 371 Date Nov. 4, 1997 Sec. 102(e) Date Nov. 4, 1997 PCT Filed Mar. 22, 1996 PCT Pub. No. WO96/30371 PCT Pub. Date Oct. 3, 1996The present invention discloses compounds of the formula any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.

8. 发明专利

DE69705608D1 未知
公开(公告)号：DE69705608D1
公开(公告)日：2001-08-16
申请号：DE69705608
申请日：1997-02-21
申请人： NEUROSEARCH AS BALLERUP
发明人： SCHEEL-KRUEGER JOERGEN , MOLDT PETER , WAETJEN FRANK
IPC分类号： A61K31/46 , A61P25/00 , A61P25/28 , C07D451/02
摘要： The present invention relates to novel tropane-derivatives which are valuable monoamine neurotransmitter, i.e dopamine, serotonin and noradrenaline, re-uptake inhibitors and the use of the novel tropane derivatives for the treatment of disorders or diseases responsive to the inhibition of monoamine neurotransmitter re-uptake, such as Parkinson's disease, depression, obsessive compulsive disorders, panic disorders, dementia, memory deficits, attention deficit hyperactivity disorder, obesity, anxiety, eating disorders and drug addiction or misuse, including cocaine abuse.

9. 发明专利

DE69527839T2 未知
公开(公告)号：DE69527839T2
公开(公告)日：2003-01-02
申请号：DE69527839
申请日：1995-04-12
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , WAETJEN FRANK , SCHEEL-KRUEGER JORGEN
IPC分类号： A61K31/46 , A61P3/04 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/30 , A61P43/00 , C07D451/02
摘要： PCT No. PCT/EP95/01358 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28401 PCT Pub. Date Oct. 26, 1995The present invention discloses compounds of the formula, any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharmaceutical properties as monoamine neurotransmitter, i.e dopamine, serotonin, noradrenalin, reuptake inhibitors.

10. 发明专利

DE69332636T2 未知
公开(公告)号：DE69332636T2
公开(公告)日：2003-09-11
申请号：DE69332636
申请日：1993-12-20
申请人： NEUROSEARCH AS BALLERUP
发明人： MOLDT PETER , SCHEEL-KRUEGER JORGEN , JENSEN LEIF HELTH
IPC分类号： A61K31/46 , A61P25/00 , A61P25/24 , A61P25/26 , A61P25/30 , C07D451/02

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