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1. 发明申请

WO2000058303A1 4-SUBSTITUTED QUINOLINE DERIVATIVES AS NK-3 AND/OR GABA(A) RECEPTOR LIGANDS 审中-公开
标题翻译： 4-取代的喹啉衍生物作为NK-3和/或GABA（A）受体配体
公开(公告)号：WO2000058303A1
公开(公告)日：2000-10-05
申请号：PCT/US2000/008205
申请日：2000-03-28
申请人： NEUROGEN CORPORATION , YUAN, Jun , MAYNARD, George, D. , HUTCHISON, Alan , RACHWAL, Stanislaw
发明人： YUAN, Jun , MAYNARD, George, D. , HUTCHISON, Alan , RACHWAL, Stanislaw
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D487/04 , G01N33/9426 , G01N2333/70571
摘要： The invention relates to certain novel compounds of general Formula (I) where R 1 , R 2 , R 3 , R 4 , X, Y 1 , and Y 2 are defined herein. These compounds bind with high affinity to NK-3 receptors and/or GABA A receptors. Also provided are pharmaceutical compositions comprising them, and methods of treating patients suffering from certain central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of NK-3 receptors and GABA A receptors.
摘要翻译：本发明涉及通式（I）的某些新化合物，其中R 1，R 2，R 3，R 4，X，Y 1和Y 2在本文中定义。这些化合物以高亲和力结合NK-3受体和/或GABA A受体。还提供了包含它们的药物组合物，以及用这些药物组合物治疗患有某些中枢神经系统和外周疾病或病症的患者的方法。本发明还涉及这样的化合物与一种或多种其它CNS剂组合用于增强其它CNS剂的作用的用途。本发明的化合物也可用作NK-3受体和GABA A受体定位的探针。

2. 发明申请

WO2005066137A1 2,5-DIARYL-1H-IMIDAZOLE-4-CARBOXAMIDES AS NEUROKININ-3 RECEPTOR MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES 审中-公开
标题翻译：作为治疗中枢神经系统和外周疾病的神经营养因子-3受体调节剂的2,5-DIARYL-1H-咪唑-4-羧酰胺
公开(公告)号：WO2005066137A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/041097
申请日：2004-12-07
申请人： NEUROGEN CORPORATION , MAYNARD, George , RACHWAL, Stanislaw , PRINGLE, Wallace, C. , YUAN, Jun , XIE, Linghong , XU, Yuelian , HAN, Bingsong
发明人： MAYNARD, George , RACHWAL, Stanislaw , PRINGLE, Wallace, C. , YUAN, Jun , XIE, Linghong , XU, Yuelian , HAN, Bingsong
IPC分类号： C07D233/54
CPC分类号： C07D233/90 , C07D233/64 , C07D405/04
摘要： The invention relates to compounds of general Formula I: wherein the variables are as defined herein. Also provided are pharmaceutical compositions comprising such compounds, and methods for treating patients suffering from a disorder responsive to neurokinin-3 receptor modulation. NK-3 receptor modulators provided herein are also useful as probes for the localization of NK-3 receptors.
摘要翻译：本发明涉及通式I的化合物：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，以及用于治疗患有对神经激肽-3受体调节有响应的病症的患者的方法。本文提供的NK-3受体调节剂也可用作NK-3受体定位的探针。

3. 发明申请

WO2003066634A1 SUBSTITUTED FUSED PYRAZOLECARBOXYLIC ACID ARYLAMIDES AND RELATED COMPOUNDS 审中-公开
标题翻译：取代的共聚吡咯并苯甲酸和相关化合物
公开(公告)号：WO2003066634A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/003872
申请日：2003-02-07
申请人： NEUROGEN CORPORATION , MAYNARD, George , YUAN, Jun , RACHWAL, Stanislaw
发明人： MAYNARD, George , YUAN, Jun , RACHWAL, Stanislaw
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07B2200/05 , C07D487/04
摘要： Heterocyclic compounds such as 3,4,5,6-tetrahydro-2,3,10-triaza-benzo[e]azulene-1-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinoline-9-carboxylic acid arylamides, 5,7-Dihydro-6H-pyrazolo[3,4-h]quinazoline-9-carboxylic acid arylamides, 2,4,5,6-Tetrahydro-1,2,6,7-tetraaza-as-indacene-8-carboxylic acid arylamides and related compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABA A brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABA A brain receptors and are therefore useful in the treatment of anxiety, depression, sleep and seizure disorders, overdose with benzodiazepine drugs, Alzheimer's dementia, and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Intermediates useful for the synthesis of pyrazolecarboxylic acid arylamides are also provided. Compounds of the invention are also useful as probes for the localization of GABA A receptors in tissue samples.
摘要翻译：杂环化合物如3,4,5,6-四氢-2,3,10-三氮杂 - 苯并[e]薁-1-羧酸芳基酰胺，5,7-二氢-6H-吡唑并[3,4-h] 喹啉-9-羧酸芳基酰胺，5,7-二氢-6H-吡唑并[3,4-h]喹唑啉-9-羧酸芳基酰胺，2,4,5,6-四氢-1,2,6,7- 四氮杂 - 引嗪并] -8-羧酸芳基酰胺和相关化合物。这些化合物是用于GABAA脑受体的G选择性激动剂，拮抗剂或反向激动剂或GABAA脑受体的激动剂，拮抗剂或反向激动剂的前药，因此可用于治疗焦虑，抑郁，睡眠和癫痫发作，用苯二氮卓类药物过量服用，阿尔茨海默病的痴呆，并增强记忆力。还提供药物组合物，包括包装的药物组合物。还提供了可用于合成吡唑甲酰芳基酰胺的中间体。本发明的化合物也可用作组织样品中GABA A受体定位的探针。

4. 发明申请

WO2003045315A3 CARBONYLBENZOXAZINE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 审中-公开
公开(公告)号：WO2003045315A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/037646
申请日：2002-11-25
申请人： CORTEX PHARMACEUTICALS, INC. , ROGERS, Gary, A. , ALLAN, Matthew , HARRIS, Clayton , HUANG, Jianjie , MARRS, Christopher, M. , MUELLER, Rudolf , RACHWAL, Stanislaw
发明人： ROGERS, Gary, A. , ALLAN, Matthew , HARRIS, Clayton , HUANG, Jianjie , MARRS, Christopher, M. , MUELLER, Rudolf , RACHWAL, Stanislaw
IPC分类号： C07D265/24
摘要： This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

5. 发明申请

WO2015168439A1 INORGANIC OXIDE COATED FLUORESCENT CHROMOPHORES FOR USE IN HIGHLY PHOTOSTABLE WAVELENGTH CONVERSION FILMS 审中-公开
标题翻译：用于高可光波长转换膜的无机氧化物涂层荧光染料
公开(公告)号：WO2015168439A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028579
申请日：2015-04-30
申请人： NITTO DENKO CORPORATION , HU, Yufen , RACHWAL, Stanislaw , RACHWAL, Bogumila
发明人： HU, Yufen , RACHWAL, Stanislaw , RACHWAL, Bogumila
IPC分类号： H01L31/055 , C09B57/00
CPC分类号： H01L31/055 , C09K11/02 , C09K11/06 , Y02E10/52
摘要： This disclosure relates to a wavelength conversion film. The wavelength conversion film comprises an optically transparent polymer matrix and fluorescent composite particles, wherein the fluorescent composite particles are individually between 5 nm and 1μm in diameter and are dispersed within the optically transparent polymer matrix, and wherein the fluorescent composite particles comprise an inorganic oxide matrix and a chromophore, wherein the chromophore is embedded into the inorganic oxide matrix, and wherein the chromophore converts incoming photons of a particular wavelength to a different wavelength. In some embodiments the inorganic oxide matrix comprises silica. The wavelength conversion film is useful for improving the solar harvesting efficiency of solar energy conversion devices.
摘要翻译：本公开涉及一种波长转换膜。波长转换膜包括光学透明的聚合物基质和荧光复合颗粒，其中荧光复合颗粒的直径分别在5nm和1μm之间，并且分散在光学透明的聚合物基质中，并且其中荧光复合颗粒包含无机氧化物基质和发色团，其中发色团嵌入到无机氧化物基质中，并且其中发色团将特定波长的入射光子转换成不同的波长。在一些实施方案中，无机氧化物基质包括二氧化硅。波长转换膜可用于提高太阳能转换装置的太阳能收集效率。

6. 发明申请

WO2009038752A2 3-SUBSTITUTED 1,2,3-TRIAZIN-4-ONE'S AND 3-SUBSTITUTED 1,3-PYRIMIDINONE'S FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 审中-公开
标题翻译： 3-取代的1,2,3-三嗪-4-酮和3-取代的1,3-嘧啶酮用于增强谷氨酰胺能突触反应
公开(公告)号：WO2009038752A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010877
申请日：2008-09-19
申请人： CORTEX PHARMACEUTICALS, INC. , MUELLER, Rudolf , STREET, Leslie, J. , RACHWAL, Stanislaw , ALISALA, Kashinatham
发明人： MUELLER, Rudolf , STREET, Leslie, J. , RACHWAL, Stanislaw , ALISALA, Kashinatham
IPC分类号： C07D255/04
CPC分类号： C07D487/04
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke- induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括增强负责基本和更高级行为的脑网络中的突触中的受体功能。这些参与调节呼吸的脑网络以及与记忆障碍有关的认知能力，诸如在各种痴呆症中观察到的，在不同大脑区域之间的神经元活动的不平衡中，如帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意力缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的障碍，以及呼吸障碍如过量饮酒，阿片制剂，阿片类药物，巴比妥类药物，麻醉剂或神经毒素，或者其中呼吸抑制导致形成诸如中枢性睡眠呼吸暂停，中风性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性换气不足综合征，肥胖性低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒 e，Prader-Willi综合症和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用这些化合物进行这种治疗的方法。

7. 发明申请

WO2013067288A1 MICROSTRUCTURED WAVELENGTH CONVERSION FILMS FOR ENHANCED SOLAR HARVESTING EFFICIENCY 审中-公开
标题翻译：用于增强太阳能收集效率的微结构波长转换膜
公开(公告)号：WO2013067288A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063218
申请日：2012-11-02
申请人： NITTO DENKO CORPORATION , ZHANG, Hongxi , WANG, Peng , RACHWAL, Stanislaw , JIANG, Zongcheng , YAMAMOTO, Michiharu
发明人： ZHANG, Hongxi , WANG, Peng , RACHWAL, Stanislaw , JIANG, Zongcheng , YAMAMOTO, Michiharu
IPC分类号： H01L31/0216 , C09K11/06 , C09B3/14 , H01L31/055 , H01G9/20 , H01L31/0236 , H01L33/50
CPC分类号： H01L31/02322 , C09B3/14 , C09B57/00 , C09K11/06 , C09K2211/1011 , C09K2211/1059 , G02B5/206 , H01L31/02366 , H01L31/055 , Y02E10/52
摘要： Described herein are microstructured wavelength conversion films for enhanced solar harvesting efficiency of photovoltaic devices or solar cells. The microstructured wavelength conversion film comprises a luminescent medium that is provided with a microstructured surface, where the luminescent medium and the microstructured surface can be combined into a single layer or made up of two or more separate layers. A photovoltaic module which utilizes the medium to improve the performance of photovoltaic devices or solar cells is also provided, along with a method of improving a solar cell or photovoltaic device by utilizing the microstructured wavelength conversion film.
摘要翻译：本文描述了用于提高光伏器件或太阳能电池的太阳能收获效率的微结构波长转换膜。微结构化波长转换膜包括具有微结构化表面的发光介质，其中发光介质和微结构化表面可以组合成单层或由两个或更多个单独的层组成。还提供利用该介质来提高光伏器件或太阳能电池的性能的光伏模块，以及通过利用微结构化波长转换膜改进太阳能电池或光伏器件的方法。

8. 发明申请

WO2016112200A1 THERMAL REGULATING WAVELENGTH CONVERSION FILMS INCORPORATING PHASE CHANGE MATERIALS 审中-公开
标题翻译：调节相变材料的热调节波长转换膜
公开(公告)号：WO2016112200A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012503
申请日：2016-01-07
申请人： NITTO DENKO CORPORATION , HU, Yufen , RACHWAL, Stanislaw
发明人： HU, Yufen , RACHWAL, Stanislaw
IPC分类号： C09K11/02 , C09K11/06 , A01G9/14
CPC分类号： C09K11/06 , A01G9/1438 , C09K11/02 , Y02A40/252 , Y02P60/124
摘要： This disclosure relates to a thermal regulating wavelength conversion film comprising a chromophore, an optically transparent polymer, and a phase change material. In some embodiments, the chromophore and phase change material are incorporated into the same polymer layer. In some embodiments, the chromophore and phase change material are incorporated into separate polymer layers. The thermal regulating wavelength conversion film is useful for converting incident wavelengths to more desirable wavelengths, while also absorbing and releasing heat to provide thermal regulation. The thermal regulating wavelength conversion film can be used as encapsulation for solar energy harvesting devices, a window film for building or vehicles, or may be used as a cover or roofing material for agriculture applications.
摘要翻译：本公开涉及一种包括发色团，光学透明聚合物和相变材料的热调节波长转换膜。在一些实施方案中，将发色团和相变材料并入同一聚合物层。在一些实施方案中，发色团和相变材料被并入到单独的聚合物层中。热调节波长转换膜可用于将入射波长转换为更理想的波长，同时还吸收和释放热量以提供热调节。热调节波长转换膜可以用作太阳能收集装置的封装，用于建筑物或车辆的窗膜，或者可以用作用于农业应用的覆盖物或屋顶材料。

9. 发明申请

WO2015164390A1 CHROMOPHORES FOR PHOTOCHROMIC COMPOSITIONS USEFUL FOR THREE DIMENSIONAL DISPLAY APPLICATIONS 审中-公开
标题翻译：用于三维显示应用的光致变色组合物的色素
公开(公告)号：WO2015164390A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/026897
申请日：2015-04-21
申请人： NITTO DENKO CORPORATION , GU, Tao , RACHWAL, Bogumila , SIDDIQUI, Ozair , RACHWAL, Stanislaw , KITAHARA, Isamu , SIMAVORYAN, Sergey , WANG, Peng , YAMAMOTO, Michiharu
发明人： GU, Tao , RACHWAL, Bogumila , SIDDIQUI, Ozair , RACHWAL, Stanislaw , KITAHARA, Isamu , SIMAVORYAN, Sergey , WANG, Peng , YAMAMOTO, Michiharu
IPC分类号： C08F16/00 , C08F18/08 , C08F20/00 , C08F290/06 , C09B62/008 , C09K19/00
CPC分类号： C09B62/0081 , C07C255/65 , C07D213/42 , C07D231/12 , C07D239/26 , C07D249/06 , C07D261/08 , C08K5/23 , C08L33/12 , C09B29/0003 , C09B29/0011 , C09B29/0807 , C09B62/0083 , C09B62/0086 , C09B62/0088 , C09D133/12 , C09K19/601 , G02B1/04 , G02B5/23 , G11B7/24044 , G11B7/244 , G11B7/245
摘要： Described herein are novel azo-benzene type chromophores. The chromophores are useful in photochromic compositions comprising a polymer matrix and a chromophore, wherein the chromophore is a novel azo-benzene type structure. The photochromic composition is photoresponsive upon irradiation by at least one wavelength of laser light across the visible light spectrum. Photochromic devices which comprise the novel azo-benzene type chromophore compound show significantly higher photoinduced birefringence, higher diffraction efficiency, and brighter images than devices that comprise well known azo-benzene chromophores. The photochromic composition may include a liquid crystal.
摘要翻译：本文描述的是新型偶氮苯型发色团。发色团可用于包含聚合物基质和发色团的光致变色组合物，其中发色团是新颖的偶氮 - 苯型结构。光致变色组合物在通过可见光光谱的至少一个波长的激光照射时是光响应的。包含新型偶氮 - 苯型发色团化合物的光致变色装置显示比包含公知的偶氮苯发色团的装置显着更高的光诱导双折射，更高的衍射效率和更亮的图像。光致变色组合物可以包括液晶。

10. 发明申请

WO2014197393A1 PHOTOSTABLE WAVELENGTH CONVERSION COMPOSITION 审中-公开
标题翻译：可变波长转换组合物
公开(公告)号：WO2014197393A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/040553
申请日：2014-06-02
申请人： NITTO DENKO CORPORATION , HU, Yufen , ZHANG, Hongxi , RACHWAL, Stanislaw , KITAHARA, Isamu , CAI, Jie , YAMAMOTO, Michiharu
发明人： HU, Yufen , ZHANG, Hongxi , RACHWAL, Stanislaw , KITAHARA, Isamu , CAI, Jie , YAMAMOTO, Michiharu
IPC分类号： C09K11/06 , H01L31/055
CPC分类号： C09K11/06 , A01G9/1438 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , H01L31/0481 , H01L31/055 , Y02A40/252 , Y02B10/12 , Y02E10/52 , Y02P60/124
摘要： This invention relates to compositions used for forming a photostable wavelength conversion material comprising at least one chromophore, at least one optically transparent crosslinkable polymer, and at least one crosslinking reagent. In some embodiments the composition further comprises one or more of an adhesion promoter, a stabilizer, a crosslinker, and/or an antioxidant. The composition for forming a photostable wavelength conversion material can be formed into a film or layer. The film or layer is useful as an encapsulate for solar energy devices as it provides stable enhancement of the photoelectric conversion efficiency of these devices by converting photons from one wavelength into a different more desirable wavelength that can be more efficiently utilized by the solar energy device. Simultaneously, the film or layer, when used in an encapsulation structure, also provides stable long term environmental protection to the solar energy device from oxygen and water ingress as well as protection from harmful high energy ultraviolet photons. The film or layer is also useful as a greenhouse roofing material.
摘要翻译：本发明涉及用于形成光稳定波长转换材料的组合物，其包含至少一种生色团，至少一种光学透明的可交联聚合物和至少一种交联剂。在一些实施方案中，组合物还包含一种或多种粘合促进剂，稳定剂，交联剂和/或抗氧化剂。用于形成光稳定型波长转换材料的组合物可以形成为膜或层。膜或层可用作太阳能装置的封装，因为其通过将来自一个波长的光子转换成可被太阳能装置更有效地利用的不同的更理想的波长来提供这些装置的光电转换效率的稳定增强。同时，当用于封装结构时，膜或层也可以从太阳能装置的氧气和水进入以及对有害的高能量紫外光子的保护提供稳定的长期环境保护。该膜或层也可用作温室屋面材料。

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