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1. 发明申请

WO2003045315A3 CARBONYLBENZOXAZINE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 审中-公开
公开(公告)号：WO2003045315A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/037646
申请日：2002-11-25
申请人： CORTEX PHARMACEUTICALS, INC. , ROGERS, Gary, A. , ALLAN, Matthew , HARRIS, Clayton , HUANG, Jianjie , MARRS, Christopher, M. , MUELLER, Rudolf , RACHWAL, Stanislaw
发明人： ROGERS, Gary, A. , ALLAN, Matthew , HARRIS, Clayton , HUANG, Jianjie , MARRS, Christopher, M. , MUELLER, Rudolf , RACHWAL, Stanislaw
IPC分类号： C07D265/24
摘要： This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

2. 发明申请

WO2004062616A2 METHOD OF TREATING COGNITIVE DECLINE DUE TO SLEEP DEPRIVATION AND STRESS 审中-公开
标题翻译：由于休眠时间和压力而处理认知失效的方法
公开(公告)号：WO2004062616A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000706
申请日：2004-01-13
申请人： CORTEX PHARMACEUTICALS, INC. , WAKE FOREST UNIVERSITY HEALTH SCIENCES , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DEADWYLER, Sam, A. , HAMPSON, Robert, E. , PORRINO, Linda, J. , ROGERS, Gary, A. , LYNCH, Gary, S.
发明人： DEADWYLER, Sam, A. , HAMPSON, Robert, E. , PORRINO, Linda, J. , ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： A61K
CPC分类号： A61K31/498 , A61K31/18 , A61K31/381 , A61K31/395 , A61K31/4015 , A61K31/454 , A61K31/536 , A61K31/5365 , A61K31/5415 , A61K31/542 , C07D498/14 , C07D498/22
摘要： This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.
摘要翻译：本发明涉及AMPA受体增强剂化合物和药物组合物用于预防和治疗由于急性或慢性睡眠剥夺而导致的认知障碍的方法，包括增强负责高级行为的脑网络突触中的受体功能。本发明的另一方面是如上所述的活性剂用于制备如上所述的病症治疗药物的用途。

3. 发明申请

WO1996038414A1 BENZOYL PIPERIDINES/PYRROLIDINES FOR ENHANCING SYNAPTIC RESPONSE 审中-公开
标题翻译：用于增强反应的苯甲酰哌啶/吡咯烷酮
公开(公告)号：WO1996038414A1
公开(公告)日：1996-12-05
申请号：PCT/US1996007607
申请日：1996-05-23
申请人： CORTEX PHARMACEUTICALS, INC.
发明人： CORTEX PHARMACEUTICALS, INC. , ROGERS, Gary, A. , NILSSON, Lena
IPC分类号： C07D211/16
CPC分类号： C07D211/16 , C07D211/14
摘要： Benzoyl piperidines and pyrrolidines and compounds of related structure (Formula I) are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depression, alcoholism and schizophrenia, and for improving memory encoding.
摘要翻译：公开了苯甲酰哌啶类和吡咯烷类和相关结构的化合物（式I）用于增强由AMPA受体介导的突触反应。由于兴奋性突触的数量或强度的缺乏或AMPA受体的数量的不足，这些化合物对于遭受神经或智力功能受损的受试者是有效的。这些化合物还可用于治疗非受损受试者，以增强感觉运动和认知任务的性能，这取决于使用AMPA受体的脑网络，改善记忆缺陷的受试者的表现，用于治疗抑郁症，酒精中毒和精神分裂症，并用于改善内存编码。

4. 发明申请

WO1997036907A1 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE 审中-公开
标题翻译：用于增强反应的苯并噻唑
公开(公告)号：WO1997036907A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005184
申请日：1997-03-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CORTEX PHARMACEUTICALS, INC
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CORTEX PHARMACEUTICALS, INC , ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： C07D498/14
CPC分类号： C07D498/04 , C07D498/14
摘要： Compounds of formula (I) in which R and R are independently selected from the group consisting of H and R O such that at least one of R and R is R O; in which R is a member selected from the group consisting of H, alkyl and halo-substituted alkyl; or R and R together form a single divalent moiety selected from the group consisting of (II), (III), (IV), (V), (VI) and (VII) are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating schizophrenia, and for improving memory encoding.
摘要翻译：其中R 1和R 2独立地选自H和R 4 O的式（I）化合物，使得R 1和R 2中的至少一个是R 1， 4> O; 其中R 4是选自H，烷基和卤素取代的烷基的成员; 或者R 1和R 2一起形成选自（II），（III），（IV），（V），（VI）和（VII）的单一二价基团，用于增强由AMPA受体介导的突触反应。由于兴奋性突触的数量或强度的缺乏或AMPA受体的数量的不足，这些化合物对于遭受神经或智力功能受损的受试者是有效的。这些化合物还可用于治疗非受损受试者，以增强感觉运动和认知任务中的表现，这取决于使用AMPA受体的脑网络，改善记忆缺陷的受试者的表现，治疗精神分裂症和改善内存编码。

5. 发明申请

WO2003102311A3 SNOW REMOVAL SYSTEM 审中-公开
公开(公告)号：WO2003102311A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/017208
申请日：2003-05-29
申请人： ROGERS, Gary, A. , BAKKEN, Dave
发明人： ROGERS, Gary, A. , BAKKEN, Dave
IPC分类号： E01H5/10
摘要： A snow removal system (100) for melting snow into water is provided. The snow removal system includes a container (110) having a storage chamber (124) adapted to store snow and a predetermined amount of water (114). The snow removal system also includes a heating assembly (104) at least partially disposed in the storage chamber and adapted to heat water stored in the storage chamber to a selected temperature. The snow removal system further includes a mixing system (106) adapted to pressurize water and discharge the pressurized water through at least one nozzle (168). The nozzle is oriented to direct the pressurized water into the storage chamber. A method of snow removal is also provided.

6. 发明授权

EP1026950B1 TREATMENT OF SCHIZOPHRENIA WITH AMPAKINES AND NEUROLEPTICS 无效
标题翻译：精神分裂症与安帕金和安定治疗
公开(公告)号：EP1026950B1
公开(公告)日：2006-02-08
申请号：EP98957382.9
申请日：1998-10-26
申请人： CORTEX PHARMACEUTICALS, INC. , The Regents of the University of California
发明人： JOHNSON, Steven, A. , ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： A01N43/46 , A01N43/58 , A01N43/40 , A01N43/38 , A01N43/36 , A61K31/535
CPC分类号： A61K45/06

7. 发明公开

EP1026950A1 TREATMENT OF SCHIZOPHRENIA WITH AMPAKINES AND NEUROLEPTICS 无效
标题翻译：精神分裂症与安帕金和安定治疗
公开(公告)号：EP1026950A1
公开(公告)日：2000-08-16
申请号：EP98957382.9
申请日：1998-10-26
申请人： CORTEX PHARMACEUTICALS, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： JOHNSON, Steven, A. , ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： A01N43/46 , A01N43/58 , A01N43/40 , A01N43/38 , A01N43/36 , A61K31/535
CPC分类号： A61K45/06
摘要： This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the invention relates to methods for the use of AMPA receptor up-modulators in conjunction with antipsychotics for the treatment of schizophrenia. Kits containing the compositions in appropriate form for administration are also provided. The figure shows that a representative Ampakine (CX516) synergistically enhances clozapine antagonism of methamphetamine-induced rearing activity.

8. 发明公开

EP0891365A1 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE 失效
标题翻译：苯并恶嗪突触对策增加
公开(公告)号：EP0891365A1
公开(公告)日：1999-01-20
申请号：EP97919965.0
申请日：1997-03-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CORTEX PHARMACEUTICALS, INC.
发明人： ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： A61K31 , A61P25 , A61P43 , C07D498
CPC分类号： C07D498/04 , C07D498/14
摘要： Compounds of formula (I) in which R?1 and R2¿ are independently selected from the group consisting of H and R4O such that at least one of R?1 and R2 is R4¿O; in which R4 is a member selected from the group consisting of H, alkyl and halo-substituted alkyl; or R?1 and R2¿ together form a single divalent moiety selected from the group consisting of (II), (III), (IV), (V), (VI) and (VII) are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating schizophrenia, and for improving memory encoding.

9. 发明公开

EP1448537A2 CARBONYLBENZOXAZINE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 审中-公开
标题翻译： CARBONYLBENZOXAZINVERBINDUNGEN加强谷氨酸突触反应的
公开(公告)号：EP1448537A2
公开(公告)日：2004-08-25
申请号：EP02789846.9
申请日：2002-11-25
申请人： CORTEX PHARMACEUTICALS, INC.
发明人： ROGERS, Gary, A. , ALLAN, Matthew , HARRIS, Clayton , HUANG, Jianjie , MARRS, Christopher, M. , MUELLER, Rudolf , RACHWAL, Stanislaw
IPC分类号： C07D265/24 , C07D491/04 , C07D498/04 , C07D513/04 , C07D515/04 , A61K31/536 , A61K31/5365 , A61P25/18
CPC分类号： C07D265/22 , C07D413/06
摘要： This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

10. 发明公开

EP1592464A2 METHOD OF TREATING COGNITIVE DECLINE DUE TO SLEEP DEPRIVATION AND STRESS 审中-公开
标题翻译：方法认知功能减退的治疗由于缺乏睡眠和压力
公开(公告)号：EP1592464A2
公开(公告)日：2005-11-09
申请号：EP04701787.6
申请日：2004-01-13
申请人： CORTEX PHARMACEUTICALS, INC. , Wake Forest University Health Sciences , The Regents of the University of California
发明人： DEADWYLER, Sam, A. , HAMPSON, Robert, E. , PORRINO, Linda, J. , ROGERS, Gary, A. , LYNCH, Gary, S.
IPC分类号： A61M1/00
CPC分类号： A61K31/498 , A61K31/18 , A61K31/381 , A61K31/395 , A61K31/4015 , A61K31/454 , A61K31/536 , A61K31/5365 , A61K31/5415 , A61K31/542 , C07D498/14 , C07D498/22
摘要： This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.

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