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1. 发明申请

WO2010022764A1 A METHOD OF REDUCING THE ENZYMATIC DIGESTION RATES OF STARCH GRANULES IN FOOD AND FOOD PRODUCTS PRODUCED THEREFROM 审中-公开
标题翻译：食品中生产淀粉颗粒的酶消化率的方法
公开(公告)号：WO2010022764A1
公开(公告)日：2010-03-04
申请号：PCT/EP2008/061103
申请日：2008-08-26
申请人： NESTEC S.A. , FOO, Check Woo , KASAPIS, Stefan , KOH, Lee Wah , JIANG, Bin
发明人： FOO, Check Woo , KASAPIS, Stefan , KOH, Lee Wah , JIANG, Bin
IPC分类号： A21D2/18 , A21D13/00 , A23L1/0532 , A23L1/16 , A23P1/08
CPC分类号： A23L1/0532 , A23L7/109 , A23L7/113 , A23L29/256 , A23V2002/00 , A23V2200/328 , A23V2200/224 , A23V2250/1578 , A23V2250/50 , A23V2250/5026
摘要： The present invention describes a method of reducing the enzymatic digestion rates of starch granules in food, particularly rice-based food. The method is carried out by encapsulating the starch granules with a reaction compound formed by the chemical reaction of at least a crosslinkable polysaccharide that has been pre-mixed with the ingredients for food production, and at least a crosslinking agent. The invention also relates to a process of preparing food products by incorporating the method of the present invention and food products produced by the present method.
摘要翻译：本发明描述了一种降低食品中淀粉颗粒的酶消化速率的方法，特别是基于米的食品。该方法通过将淀粉颗粒与通过与预先用于食品生产的成分进行预混合的至少可交联多糖的化学反应形成的反应化合物和至少一种交联剂进行包封来进行。本发明还涉及通过掺入本发明的方法和通过本方法生产的食品来制备食品的方法。

2. 发明申请

WO2012125886A1 PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途
公开(公告)号：WO2012125886A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029334
申请日：2012-03-16
申请人： BRISTOL-MYERS SQUIBB COMPANY , WROBLESKI, Stephen T. , BROWN, Gregory D. , DOWEYKO, Lidia M. , DUAN, Jingwu , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , LU, Zhonghui , SPERGEL, Steven, H. , TOKARSKI, John S. , WU, Hong , YANG, Bingwei Vera
发明人： WROBLESKI, Stephen T. , BROWN, Gregory D. , DOWEYKO, Lidia M. , DUAN, Jingwu , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , LU, Zhonghui , SPERGEL, Steven, H. , TOKARSKI, John S. , WU, Hong , YANG, Bingwei Vera
IPC分类号： A61K31/5025 , A61P37/00 , A61P29/00 , A61P17/00 , A61P19/00 , C07D519/00 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐。式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

3. 发明申请

WO2012125893A1 PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：吡咯烷酮JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途
公开(公告)号：WO2012125893A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029366
申请日：2012-03-16
申请人： BRISTOL-MYERS SQUIBB COMPANY , WROBLESKI, Stephen T. , DAS, Jagabandhu , DUAN, Jingwu , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , LU, Zhonghui , PITTS, William J. , SPERGEL, Steven H. , WU, Hong , YANG, Bingwei Vera
发明人： WROBLESKI, Stephen T. , DAS, Jagabandhu , DUAN, Jingwu , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , LU, Zhonghui , PITTS, William J. , SPERGEL, Steven H. , WU, Hong , YANG, Bingwei Vera
IPC分类号： C07D487/04 , A61K31/5025 , A61P37/00 , A61P29/00 , A61P17/00 , A61P19/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。

4. 发明申请

WO2012125887A1 PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途
公开(公告)号：WO2012125887A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029337
申请日：2012-03-16
申请人： BRISTOL-MYERS SQUIBB COMPANY , WROBLESKI, Stephen T. , JAGABANDHU, Das , DOWEYKO, Lidia M. , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , SPERGEL, Steven H. , TOKARSKI, John S. , WU, Hong , YANG, Bingwei Vera
发明人： WROBLESKI, Stephen T. , JAGABANDHU, Das , DOWEYKO, Lidia M. , GUO, Junqing , HYNES, John , JIANG, Bin , KEMPSON, James , LIN, Shuqun , SPERGEL, Steven H. , TOKARSKI, John S. , WU, Hong , YANG, Bingwei Vera
IPC分类号： A61K31/5025 , A61P37/00 , A61P29/00 , A61P17/00 , A61P19/00 , C07D487/04 , C07F9/11
CPC分类号： C07D487/04 , C07F9/6561
摘要： Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐。式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

5. 发明申请

WO2008021926A2 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-κB活性及其用途
公开(公告)号：WO2008021926A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/075543
申请日：2007-08-09
申请人： BRISTOL-MYERS SQUIBB COMPANY , WEINSTEIN, David, S. , GONG, Hua , DUAN, Jingwu , DHAR, T.G. Murali , YANG, Bingwei Vera , CHEN, Ping , JIANG, Bin
发明人： WEINSTEIN, David, S. , GONG, Hua , DUAN, Jingwu , DHAR, T.G. Murali , YANG, Bingwei Vera , CHEN, Ping , JIANG, Bin
CPC分类号： C07D417/12 , C07D277/46 , C07D405/12 , C07D417/14 , C07D491/04
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-KB activity, including inflammatory and immune diseases, having the structure of formula (I), an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8- membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R 5 , R 6 , R 7 , and R 8 ; J 1 , J 2 , and J3 are at each occurrence the same or different and are independently -A 1 QA 2 -; Q is a bond, O, S, S(O), or S(O)2; A 1 and A 2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C 1 - 3 alkylene, C 2 -4alkenylene, and substituted C 2 - 4 alkenylene, provided that A 1 and A 2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R 1 to R 11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
摘要翻译：提供了新的非甾体化合物，其可用于治疗与式（I）结构的糖皮质激素受体，AP-1和/或NF-κB活性（包括炎症和免疫疾病）的调节相关的疾病，对映异构体，非对映体或其互变异构体，或其前药酯或其药学上可接受的盐，其中：Z是杂环或杂芳基; A是5-至8-元碳环或5-至8-元杂环; B是环烷基，环烯基，芳基，杂环或杂芳基环，其中每个环与相邻原子上的A环稠合，并且任选地被一至四个相同或不同的基团取代，并且独立地选自R 1， R 5，R 6，R 7和R 8; J 1，J 2和J 3在每次出现时相同或不同，并且独立地为-A 1 N 2 QA 2， SUB> - ; Q是键，O，S，S（O）或S（O）2; A 1和A 2各自相同或不同，并且在每次出现时独立地选自键，C 1-3亚烷基，取代的C 1 H 3，

6. 发明申请

WO2018116134A1 METHODS, APPARATUS AND COMPUTER PROGRAM FOR AUTOMATICALLY DERIVING SMALL-SCALE MAPS 审中-公开
公开(公告)号：WO2018116134A1
公开(公告)日：2018-06-28
申请号：PCT/IB2017/058073
申请日：2017-12-18
申请人： JIANG, Bin
发明人： JIANG, Bin
IPC分类号： G01C21/36 , G09B29/10
CPC分类号： G09B29/106 , G01C21/367 , G09B29/003
摘要： One or more small-scale maps are generated automatically and directly from a single large-scale map or database. A subset of geographic features to be represented in the small-scale map is selected based on the scaling law. The geographic features in the subset are determined based on topological connectivity, size, bend size or point density characterizing the geographic features, so the subset includes the larger or more connected or with higher density among the geographic features.

7. 发明申请

WO2013086356A1 METHOD AND APPARATUS FOR POWER SWITCHING 审中-公开
标题翻译：电源开关的方法和装置
公开(公告)号：WO2013086356A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068494
申请日：2012-12-07
申请人： MARVELL WORLD TRADE, LTD. , SUTARDJA, Pantas , SIGUENZA, Oscar , JIANG, Bin , CHAO, Hsien-Chih , TRIVEDI, Devang
发明人： SUTARDJA, Pantas , SIGUENZA, Oscar , JIANG, Bin , CHAO, Hsien-Chih , TRIVEDI, Devang
IPC分类号： H03K19/00 , G06F1/32
CPC分类号： H02J7/0052 , G06F1/263 , G06F1/266 , G06F1/3287 , H03K19/0013 , H03K19/0016 , Y02D10/171
摘要： Aspects of the disclosure provide a circuit. The circuit includes a switch and a switch controller. The switch is between a first node that receives a first power supply and a second node, and is controlled to couple/decouple the second node with the first node to switch on/off a second power supply at the second node. The switch controller is configured to generate a switch control signal to control a charging current flowing through the switch to switch on the second power supply.
摘要翻译：本公开的方面提供电路。该电路包括开关和开关控制器。交换机在接收第一电源和第二节点的第一节点之间，并且被控制以使第二节点与第一节点耦合/解耦，以在第二节点处接通/断开第二电源。开关控制器被配置为产生开关控制信号以控制流过开关的充电电流以接通第二电源。

8. 发明申请

WO2011019780A1 AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF 审中-公开
标题翻译： AZAINDAZOLES作为BTK激酶调节剂及其用途
公开(公告)号：WO2011019780A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045109
申请日：2010-08-11
申请人： BRISTOL-MYERS SQUIBB COMPANY , DUAN, Jingwu , JIANG, Bin , LU, Zhonghui
发明人： DUAN, Jingwu , JIANG, Bin , LU, Zhonghui
IPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A 1 , A 2 , A 3 , R 4 , are as defined herein.
摘要翻译：具有式（I）的化合物及其对映异构体和非对映体药学上可接受的盐，（I）可用作激酶调节剂，包括Btk调节，其中A1，A2，A3，R4如本文所定义。

9. 发明申请

WO2009100171A1 FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译：葡萄糖激素受体，AP-1和/或NF-κB活性的融合异源调节剂及其用途
公开(公告)号：WO2009100171A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033134
申请日：2009-02-05
申请人： BRISTOL-MYERS SQUIBB COMPANY , DUAN, Jingwu , WEINSTEIN, David, S. , JIANG, Bin
发明人： DUAN, Jingwu , WEINSTEIN, David, S. , JIANG, Bin
IPC分类号： C07D491/04 , A61P3/00 , A61P29/00 , A61P37/00 , A61K31/436 , C07D491/147
CPC分类号： C07D491/147
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; • A is a S- to 8- membered carbocyclic ring or a S- to 8-membered heterocyclic ring; B 1 and B 2 rings are pyridyl rings, wherein the B 1 and B 2 rings are each fused to the A ring and the B 1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R 1 , R 2 , and R 4 , and the B 2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R 5 , R 7 , and R 3 J 1 , J 2 , and J 3 are at each occurrence the same or different and are independently - A 1 QA 2 -; Q is a bond, O, S, S(O), or S(O) 2 ; A 1 and A 2 are the same or different and are at each occurrence independently selected from a bond, C 1 - 3 alkylene, substituted C 1-3 alkylene, C 2-4 alkenylene, and substituted C 2-4 alkenylene, provided that A 1 and A 2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R 1 to R 11 are as defined herein....
摘要翻译：提供了新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性（包括代谢和炎症和免疫疾病或病症）相关的疾病或障碍，其具有以下结构：式（I）：其对映异构体，非对映异构体或其衍生物或其前药酯或其药学上可接受的盐，其中：Z是杂环基或杂芳基; A为S-至8-元碳环或S至8-元杂环; B1和B2环是吡啶环，其中B1和B2环各自与A环稠合，B1环任选被一至三个相同或不同并且独立地选自R 1，R 2和R 4的基团取代并且B2环任选地被一至三个相同或不同并且独立地选自R 5，R 7和R 3的基团取代，J 1，J 2和J 3在每次出现时相同或不同，并且独立地为-AlQA2- ; Q是键，O，S，S（O）或S（O）2; A1和A2相同或不同，并且在每次出现时独立地选自键，C1-3亚烷基，取代的C1-3亚烷基，C2-4亚烯基和取代的C2-4亚烯基，条件是A1和A2被选择为该环A为5-至8-元碳环或杂环; R1至R11如本文所定义。

10. 发明申请

WO2007073503A2 INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译：葡萄糖激素受体，AP-1和/或NF-κB活性的调节因子及其用途
公开(公告)号：WO2007073503A2
公开(公告)日：2007-06-28
申请号：PCT/US2006/049075
申请日：2006-12-21
申请人： BRISTOL-MYERS SQUIBB COMPANY , DUAN, Jingwu , JIANG, Bin
发明人： DUAN, Jingwu , JIANG, Bin
CPC分类号： C07D285/135 , C07D233/76 , C07D249/12 , C07D277/46 , C07D285/08
摘要： Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): [INSERT CHEMICAL STRUCTURE HERE] (I) or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is -A1QA2-; Q is a bond, -C(=O)-, -OC(O)-, -C(=O)NR5-, -SOp-, -SOpNR5-, -C(O)O-, - NR5C(O)-, -OC(O)NR5-, -NR5C(O)O-, - S(O)pNR5C(O)-, -C(O)NR5S(O)p- - NR5S(O)p-, or -NR5C(=O)NR6-. Y is selected from hydrogen, C1-6alkyl, OR16, substituted C1-6alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A1 and A2 are independently selected from a bond, C1-3alkylene, or C1-3alkenylene, and R1 - R11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.
摘要翻译：提供了新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的肥胖症，糖尿病，炎症和免疫疾病，：[INSERT CHEMICAL STRUCTURE HERE]（I）或其对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为-A1QA2-; Q是键，-C（= O） - ， - OC（O） - ， - C（= O）NR5-，-SOp-，-SOpNR5-，-C（O）O-，-NR5C（O） - （O）NR 5 - ， - NR 5 C（O）O-，-S（O）pNR 5 C（O） - ， - C（O）NR 5 S（O） NR 5 C（= O）NR 6 - 。 Y选自氢，C 1-6烷基，OR 16，取代的C 1-6烷基，环烷基，芳基，杂环和杂芳基。 A1和A2独立地选自键，C1-3亚烷基或C1-3亚烯基，并且R1-R11在本文中定义。还提供了治疗包含所述化合物的肥胖症，糖尿病和炎性或免疫相关疾病的药物组合物，组合和方法。

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