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1. 发明申请

WO2006052841A2 GLYCOLIPIDS 审中-公开
标题翻译：糖脂
公开(公告)号：WO2006052841A2
公开(公告)日：2006-05-18
申请号：PCT/US2005040195
申请日：2005-11-03
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , WANG ZHI-GUANG
发明人： DEFREES SHAWN , WANG ZHI-GUANG
IPC分类号： A61K38/14
CPC分类号： C07H15/06 , A61K38/00 , C07H15/10
摘要： Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection is also described.
摘要翻译：描述了新的合成神经节苷脂和含有这种合成神经节苷脂的药物组合物。还描述了制备新型合成神经节苷脂化合物和组合物的方法以及它们在神经保护领域的应用。

2. 发明申请

WO2005055946A3 GLYCOPEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR 审中-公开
公开(公告)号：WO2005055946A3
公开(公告)日：2006-03-30
申请号：PCT/US2004041004
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , CLAUSEN HENRIK , ZOPF DAVID A , WANG ZHI-GUANG , BOWE CARYN
发明人： DEFREES SHAWN , CLAUSEN HENRIK , ZOPF DAVID A , WANG ZHI-GUANG , BOWE CARYN
IPC分类号： A01N43/04 , A61K20060101
CPC分类号： A61K38/193 , A61K47/60 , C07K14/535
摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
摘要翻译：本发明提供粒细胞集落刺激因子和PEG部分之间的缀合物。缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。还提供了包括缀合物的药物制剂。缀合物的制备方法也在本发明的范围内。

3. 发明申请

WO2005012484A3 ANTIBODY-TOXIN CONJUGATES 审中-公开
标题翻译：抗体毒素结合
公开(公告)号：WO2005012484A3
公开(公告)日：2007-05-24
申请号：PCT/US2004024042
申请日：2004-07-26
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , WANG ZHI-GUANG
发明人： DEFREES SHAWN , WANG ZHI-GUANG
IPC分类号： C07K16/00 , A61K47/48 , C07K16/28 , C12N20060101
CPC分类号： C07K19/00 , A61K47/60 , A61K47/6803 , A61K47/6811 , A61K47/6839 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K47/6899 , B82Y5/00 , C12N9/96
摘要： The present invention provides conjugates formed between toxins and sugars and toxins and peptide, such as antibodies. In an exemplary embodiment, a toxin-sugar construct is conjugated to an antibody through and intact glycosyl linking group.
摘要翻译：本发明提供了在毒素和糖和毒素和肽之间形成的缀合物，例如抗体。在一个示例性实施方案中，毒素 - 糖构建体通过和完整的糖基连接基团与抗体缀合。

4. 发明申请

WO2005070138A3 O-LINKED GLYCOSYLATION OF PEPTIDES 审中-公开
标题翻译：肽连接的糖蛋白
公开(公告)号：WO2005070138A3
公开(公告)日：2007-05-31
申请号：PCT/US2005000799
申请日：2005-01-10
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , ZOPF DAVID A , WANG ZHI-GUANG , CLAUSEN HENRIK
发明人： DEFREES SHAWN , ZOPF DAVID A , WANG ZHI-GUANG , CLAUSEN HENRIK
IPC分类号： C07K1/00 , A61K38/14 , A61K38/19 , C07K1/107 , C07K9/00 , C07K14/535
CPC分类号： A61K38/193 , C07K1/1077 , C07K9/00 , C07K9/001 , C07K14/535
摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.
摘要翻译：本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整的O连接的糖基残基与多肽共价连接。还提供了制备本发明的肽和方法的方法，含有肽的药物组合物和通过施用足够达到所需反应的量的本发明的肽来治疗，改善或预防哺乳动物患病的方法。

5. 发明申请

WO2004080960A3 METHODS AND COMPOSITIONS FOR THE ENZYMATIC SYNTHESIS OF GANGLIOSIDES 审中-公开
标题翻译：姜黄素的合成方法及组合物
公开(公告)号：WO2004080960A3
公开(公告)日：2005-05-06
申请号：PCT/US2004006904
申请日：2004-03-04
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , JOHNSON KARL FRANK , WANG ZHI-GUANG
发明人： DEFREES SHAWN , JOHNSON KARL FRANK , WANG ZHI-GUANG
IPC分类号： C07D20060101 , C07H15/00 , C07H15/10 , C07H15/18 , C07H15/26
CPC分类号： C07H15/00 , C07H15/10 , C07H15/18 , C07H15/26
摘要： Novel synthetic glycosphingolipids and pharmaceutical compositions containing such synthetic glycosphingolipids are described. Methods of making the novel synthetic glycosphingolipid compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.
摘要翻译：描述了含有这种合成的鞘糖脂的新型合成鞘糖脂和药物组合物。还描述了制备新型合成鞘糖脂化合物和组合物的方法及其在神经保护和癌症治疗领域中的应用。

6. 发明专利

BRPI0417342A 未知
公开(公告)号：BRPI0417342A
公开(公告)日：2007-04-17
申请号：BRPI0417342
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC
发明人： DEFREES SHAWN , CLAUSEN HENRIK , ZOPF DAVID A , BOWE CARYN , SCHWARTZ MARK , WU BINGYUAN , WANG ZHI-GUANG
IPC分类号： A01N43/04 , A61K20060101
摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

7. 发明专利

NZ542148A Methods and compositions for the enzymatic synthesis of gangliosides 未知
公开(公告)号：NZ542148A
公开(公告)日：2008-05-30
申请号：NZ54214804
申请日：2004-03-04
申请人： NEOSE TECHNOLOGIES INC
发明人： DEFREES SHAWN , JOHNSON KARL FRANK , WANG ZHI-GUANG
IPC分类号： C07D20060101 , C07H15/00 , C07H15/10 , C07H15/18 , C07H15/26 , A61K31/70 , A61P25/00
摘要： Disclosed is a compound having formula (I) wherein: Z is a member selected from O, S, C(R2)2 and NR2; X is a member selected from H, -OR3, -NR3R4, -SR3 and -CHR3R4; Y is a member selected from H, -OR7, -SR7, -NR7R8, substituted or unsubstituted alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, or heterocycloalkyl; R1 is of the formula -C(R11)=CR12R13; and the remaining substituents are as disclosed in the specification. Compounds of the formula disclosed are useful in the prevention or treatment of disorders of the nervous system.

8. 发明专利

CA2549409A1 GLYCOPEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR 未知
公开(公告)号：CA2549409A1
公开(公告)日：2005-06-23
申请号：CA2549409
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC
发明人： BOWE CARYN , DEFREES SHAWN , WANG ZHI-GUANG , ZOPF DAVID A , CLAUSEN HENRIK , WU BINGYUAN , SCHWARTZ MARC
IPC分类号： A01N43/04 , A61K20060101
摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

9. 发明专利

AU2004296855A1 Glycopegylated Granulocyte Colony Stimulating Factor 未知
公开(公告)号：AU2004296855A1
公开(公告)日：2005-06-23
申请号：AU2004296855
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC
发明人： SCHWARTZ MARC , ZOPF DAVID A , CLAUSEN HENRIK , WU BINGYUAN , WANG ZHI-GUANG , DEFREES SHAWN
IPC分类号： A01N43/04 , A61K20060101
摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

10. 发明专利

CA2518171C METHODS AND COMPOSITIONS FOR THE ENZYMATIC SYNTHESIS OF GANGLIOSIDES 未知
公开(公告)号：CA2518171C
公开(公告)日：2013-07-09
申请号：CA2518171
申请日：2004-03-04
申请人： NEOSE TECHNOLOGIES INC
发明人： DEFREES SHAWN A , JOHNSON KARL FRANK , WANG ZHI-GUANG
IPC分类号： C07H15/00 , A61P25/00 , C07D20060101 , C07H15/10 , C07H15/18 , C07H15/26
摘要： A compound having the formula (see above formula) , wherein Z is a member selected from O, S, C(R2)2 and NR2; X is a member selected from H, ¨OR3, ¨ NR3R4, ¨SR3, and -CHR3R4; R2, R3 and R4 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstitutedheteroaryl, substituted or unsubstituted heterocycloalkyl, -C(=M)R5, -C(=M)-Z-R5, -SO2R5, and -SO3; wherein M and Z are members independently selected from O, NR6 and S; Y is a member selected from H, -OR7, -SR7, -NR7R8, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocycloalkyl; wherein R5, R6, R7 and R8 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl; R11 and R12 are members independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted hetero cyclo alkyl, NR14R15, OR14, -CN and ¨C(=L)R14; wherein L is a member selected from O, S, and NR16; R13 is selected from substituted or unsubstituted heterocycloalkyl, OR17 and NR17R18; and R14 and R15 is selected from H, substituted or unsubstituted alkyl, substituted or nsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, C(O)R17, OR17 and NR17¨ 18; wherein R16, R17 and R18 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl.

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