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1. 发明申请

WO2004080960A3 METHODS AND COMPOSITIONS FOR THE ENZYMATIC SYNTHESIS OF GANGLIOSIDES 审中-公开
标题翻译：姜黄素的合成方法及组合物
公开(公告)号：WO2004080960A3
公开(公告)日：2005-05-06
申请号：PCT/US2004006904
申请日：2004-03-04
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , JOHNSON KARL FRANK , WANG ZHI-GUANG
发明人： DEFREES SHAWN , JOHNSON KARL FRANK , WANG ZHI-GUANG
IPC分类号： C07D20060101 , C07H15/00 , C07H15/10 , C07H15/18 , C07H15/26
CPC分类号： C07H15/00 , C07H15/10 , C07H15/18 , C07H15/26
摘要： Novel synthetic glycosphingolipids and pharmaceutical compositions containing such synthetic glycosphingolipids are described. Methods of making the novel synthetic glycosphingolipid compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.
摘要翻译：描述了含有这种合成的鞘糖脂的新型合成鞘糖脂和药物组合物。还描述了制备新型合成鞘糖脂化合物和组合物的方法及其在神经保护和癌症治疗领域中的应用。

2. 发明申请

WO2006052841A2 GLYCOLIPIDS 审中-公开
标题翻译：糖脂
公开(公告)号：WO2006052841A2
公开(公告)日：2006-05-18
申请号：PCT/US2005040195
申请日：2005-11-03
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , WANG ZHI-GUANG
发明人： DEFREES SHAWN , WANG ZHI-GUANG
IPC分类号： A61K38/14
CPC分类号： C07H15/06 , A61K38/00 , C07H15/10
摘要： Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection is also described.
摘要翻译：描述了新的合成神经节苷脂和含有这种合成神经节苷脂的药物组合物。还描述了制备新型合成神经节苷脂化合物和组合物的方法以及它们在神经保护领域的应用。

3. 发明申请

WO2005055946A3 GLYCOPEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR 审中-公开
公开(公告)号：WO2005055946A3
公开(公告)日：2006-03-30
申请号：PCT/US2004041004
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , CLAUSEN HENRIK , ZOPF DAVID A , WANG ZHI-GUANG , BOWE CARYN
发明人： DEFREES SHAWN , CLAUSEN HENRIK , ZOPF DAVID A , WANG ZHI-GUANG , BOWE CARYN
IPC分类号： A01N43/04 , A61K20060101
CPC分类号： A61K38/193 , A61K47/60 , C07K14/535
摘要： The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
摘要翻译：本发明提供粒细胞集落刺激因子和PEG部分之间的缀合物。缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。还提供了包括缀合物的药物制剂。缀合物的制备方法也在本发明的范围内。

4. 发明申请

WO2005070138A3 O-LINKED GLYCOSYLATION OF PEPTIDES 审中-公开
标题翻译：肽连接的糖蛋白
公开(公告)号：WO2005070138A3
公开(公告)日：2007-05-31
申请号：PCT/US2005000799
申请日：2005-01-10
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , ZOPF DAVID A , WANG ZHI-GUANG , CLAUSEN HENRIK
发明人： DEFREES SHAWN , ZOPF DAVID A , WANG ZHI-GUANG , CLAUSEN HENRIK
IPC分类号： C07K1/00 , A61K38/14 , A61K38/19 , C07K1/107 , C07K9/00 , C07K14/535
CPC分类号： A61K38/193 , C07K1/1077 , C07K9/00 , C07K9/001 , C07K14/535
摘要： The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.
摘要翻译：本发明提供了包含在野生型肽中不存在的O-连接的糖基化位点的多肽。本发明的多肽包括糖缀合物，其中诸如水溶性聚合物的物质，生物分子的治疗剂通过完整的O连接的糖基残基与多肽共价连接。还提供了制备本发明的肽和方法的方法，含有肽的药物组合物和通过施用足够达到所需反应的量的本发明的肽来治疗，改善或预防哺乳动物患病的方法。

5. 发明申请

WO03017949A3 NOVEL SYNTHETIC GANGLIOSIDE DERIVATIVES AND COMPOSITIONS THEREOF 审中-公开
标题翻译：新型合成神经鞘糖苷衍生物及其组合物
公开(公告)号：WO03017949A3
公开(公告)日：2003-12-04
申请号：PCT/US0227935
申请日：2002-08-29
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , WANG ZHI GUANG
发明人： DEFREES SHAWN , WANG ZHI GUANG
IPC分类号： C12P19/00 , A61K31/70 , A61K31/7034 , A61K31/7056 , A61K31/706 , A61K31/739 , A61P9/10 , A61P17/02 , A61P25/00 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , C07H3/06 , C07H15/00 , C07H15/04 , C07H15/18 , C07H15/26 , C07H17/02 , C12P19/28 , C12P7/64 , C12P19/04 , C12P19/12 , C12P19/26 , C12P19/44
CPC分类号： C12P19/28 , C07H3/06 , C07H17/02
摘要： Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.
摘要翻译：描述了新的合成神经节苷脂和含有这种合成神经节苷脂的药物组合物。还描述了制备新的合成神经节苷脂化合物和组合物的方法以及它们在神经保护和癌症治疗领域的用途。

6. 发明申请

WO2005012484A3 ANTIBODY-TOXIN CONJUGATES 审中-公开
标题翻译：抗体毒素结合
公开(公告)号：WO2005012484A3
公开(公告)日：2007-05-24
申请号：PCT/US2004024042
申请日：2004-07-26
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , WANG ZHI-GUANG
发明人： DEFREES SHAWN , WANG ZHI-GUANG
IPC分类号： C07K16/00 , A61K47/48 , C07K16/28 , C12N20060101
CPC分类号： C07K19/00 , A61K47/60 , A61K47/6803 , A61K47/6811 , A61K47/6839 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K47/6899 , B82Y5/00 , C12N9/96
摘要： The present invention provides conjugates formed between toxins and sugars and toxins and peptide, such as antibodies. In an exemplary embodiment, a toxin-sugar construct is conjugated to an antibody through and intact glycosyl linking group.
摘要翻译：本发明提供了在毒素和糖和毒素和肽之间形成的缀合物，例如抗体。在一个示例性实施方案中，毒素 - 糖构建体通过和完整的糖基连接基团与抗体缀合。

7. 发明申请

WO2008151258A3 O-LINKED GLYCOSYLATION USING N-ACETYLGLUCOSAMINYL TRANSFERASES 审中-公开
标题翻译：使用N-乙酰氨基葡萄糖转移的O-连接的糖蛋白
公开(公告)号：WO2008151258A3
公开(公告)日：2009-02-12
申请号：PCT/US2008065825
申请日：2008-06-04
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN
发明人： DEFREES SHAWN
IPC分类号： C12N9/10 , C12Q1/48
CPC分类号： C07K14/51 , A61K47/60 , C07K14/535 , C07K14/56 , C07K14/61 , C07K2319/00
摘要： The present invention provides covalent conjugates between a polypeptide and a modifying group, such as a water-soluble polymer (e.g., PEG). The amino acid sequence of the polypeptide includes one or more O-linked glycosylation sequence, each being a substrate for a GIcNAc transferase. The modifying group is covalently linked to the polypeptide via a glycosyl-linking group interposed between and covalently linked to both the polypeptide and the modifying group. In one embodiment, a glucosamine linking group is directly attached to an amino acid residue of the O-linked glycosylation sequence. The invention further provides methods of making polypeptide conjugates. The present invention also provides non-naturally ocurring polypeptides that include at leats one O-linked linked glycosylation sequence of the invention, wherein each glycosylation sequence is a substrate for a GIcNAc transferase. The invention further provides pharmaceutical compositions that include a polypeptide conjugate of the invention.
摘要翻译：本发明提供多肽和修饰基团之间的共价缀合物，例如水溶性聚合物（例如PEG）。多肽的氨基酸序列包括一个或多个O-连接的糖基化序列，各自为GlcNAc转移酶的底物。修饰基团通过插入在多肽和修饰基团之间并且共价连接的糖基连接基团与多肽共价连接。在一个实施方案中，葡糖胺连接基团直接连接到O-连接的糖基化序列的氨基酸残基。本发明进一步提供了制备多肽缀合物的方法。本发明还提供了非天然的多肽，其包括在本发明的一个O-连接的糖基化序列中，其中每个糖基化序列是GlcNAc转移酶的底物。本发明进一步提供包含本发明的多肽缀合物的药物组合物。

8. 发明申请

WO2007056191A3 NUCLEOTIDE SUGAR PURIFICATION USING MEMBRANES 审中-公开
标题翻译：使用膜的核糖体净化
公开(公告)号：WO2007056191A3
公开(公告)日：2007-10-25
申请号：PCT/US2006043048
申请日：2006-11-03
申请人： NEOSE TECHNOLOGIES INC , FELO MICHAEL , DEFREES SHAWN
发明人： FELO MICHAEL , DEFREES SHAWN
IPC分类号： C12N9/10 , C12N9/12 , C12P19/00 , C12P19/18
CPC分类号： C12P19/305 , C07H19/06 , Y02P20/582
摘要： The invention provides methods of removing contaminants from a mixture of a desired product and contaminants by pH adjustments and molecular weight cut-offs. The contaminants include phosphate groups, magnesium sulfate, sodium pyruvate and tetrasodium pyrophosphate groups. The desired product includes nucleotide sugars, glycolipids, LnNT, sialyl lactose, and salts.
摘要翻译：本发明提供了通过pH调节和分子量截留从所需产物和污染物的混合物中除去污染物的方法。污染物包括磷酸盐基团，硫酸镁，丙酮酸钠和焦磷酸四钠基团。所需产物包括核苷酸糖，糖脂，LnNT，唾液酸乳糖和盐。

9. 发明申请

WO2005118798A3 MUTANT ENDOGLYCOCERAMIDASES WITH ENHANCED SYNTHETIC ACTIVITY 审中-公开
标题翻译：具有增强合成活性的突变内毒素
公开(公告)号：WO2005118798A3
公开(公告)日：2007-05-10
申请号：PCT/US2005019451
申请日：2005-06-01
申请人： NEOSE TECHNOLOGIES INC , UNIV BRITISH COLUMBIA UNIVERSI , JOHNSON KARL F , DEFREES SHAWN , WITHERS STEPHEN , VAUGHAN MARK
发明人： JOHNSON KARL F , DEFREES SHAWN , WITHERS STEPHEN , VAUGHAN MARK
IPC分类号： C12N9/24 , C12N9/00 , C12N9/14 , C12N9/16 , C12N9/20
CPC分类号： C12P19/26 , C12N9/2402 , C12Y302/01123
摘要： The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme.
摘要翻译：本发明涉及其水解活性已经显着降低或消除的新型神经酰胺糖内切酶，使得该酶可用于从单糖或寡糖和神经酰胺合成糖脂。更具体地，神经酰胺糖内切酶是天然存在的神经酰胺糖内切酶的突变形式，优选地包含酶的活性位点或亲核位点内的突变，更优选地包含活性位点或亲核位点内的Glu残基的取代突变。还公开了产生突变型神经酰胺糖内切酶的方法和使用该突变酶酶促合成糖脂的方法。

10. 发明申请

WO2005055950A3 GLYCOPEGYLATED FACTOR IX 审中-公开
标题翻译：糖蛋白因子九
公开(公告)号：WO2005055950A3
公开(公告)日：2005-10-20
申请号：PCT/US2004041070
申请日：2004-12-03
申请人： NEOSE TECHNOLOGIES INC , DEFREES SHAWN , BAYER ROBERT J , BOWE CARYN , PANNEERSELVAM KRISHNASAMY
发明人： DEFREES SHAWN , BAYER ROBERT J , BOWE CARYN , PANNEERSELVAM KRISHNASAMY
IPC分类号： A61K20060101 , A61K31/00 , C07K1/00
CPC分类号： C12N9/644 , A61K47/60 , C12Y304/21022
摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译：本发明提供因子IX和PEG部分之间的缀合物。缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。通过糖基转移酶的作用由糖基化肽形成缀合物。糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

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