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1. 发明申请

WO2004091707A3 AEROSOLIZATION APPARATUS WITH CAPSULE PUNCTURE ALIGNMENT GUIDE 审中-公开
标题翻译：胶囊矫正装置与胶囊针刺对准指南
公开(公告)号：WO2004091707A3
公开(公告)日：2005-03-31
申请号：PCT/US2004011234
申请日：2004-04-09
申请人： NEKTAR THERAPEUTICS , DUNKLEY MICHAEL JOHN , TUCKWELL JONATHAN DAVID , VERNON-HARCOURT EDWARD WILLIAM , GLUSKER MARK J , PABOOJIAN STEVE
发明人： DUNKLEY MICHAEL JOHN , TUCKWELL JONATHAN DAVID , VERNON-HARCOURT EDWARD WILLIAM , GLUSKER MARK J , PABOOJIAN STEVE
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： An aerosolization apparatus (100) comprises a housing (105) defining a chamber (110) having one or more air inlets (115) . The chamber is sized to receive a capsule (125) which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism (130) within the housing. The puncturing mechanism comprises an alignment guide (132) and a puncture member (135), wherein the alignment guide comprises a surface (133) adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions (300). An end section (140) is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.
摘要翻译：雾化装置（100）包括限定具有一个或多个空气入口（115）的腔室（110）的壳体（105）。该腔室的大小适于接收含有可雾化药物制剂的胶囊（125）。雾化装置还包括在壳体内的穿刺机构（130）。穿刺机构包括对准引导件（132）和穿刺构件（135），其中对准引导件包括适于在穿刺构件前进到胶囊中以接触胶囊的表面（133），以在胶囊中形成开口。表面的至少一部分相对于胶囊的纵向轴线倾斜。或者或另外，表面可以包括一个或多个突起（300）。端部（140）与壳体相关联。端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。对准引导件允许胶囊的更一致的穿刺和装置的更长的使用寿命。

2. 发明专利

JP2006312086A System and method for forming aerosol of medical agent 有权
标题翻译：用于形成医药用神经药物的系统和方法
公开(公告)号：JP2006312086A
公开(公告)日：2006-11-16
申请号：JP2006227120
申请日：2006-08-23
申请人： Nektar Therapeutics , ネクターセラピューティクス
发明人： SCHULER CARLOS , PABOOJIAN STEVE , TUTTLE DERRICK J , SMITH ADRIAN E , RASMUSSEN DENNIS R , BAKSHI ANEESH , CLARK ANDREW , WARD BRIAN R S , ALSTON WILLIAM W JR , NASON KEVIN S
IPC分类号： A61M15/00 , A61M16/20
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide a system and method for forming aerosol of medical agent. SOLUTION: In this method, breathing air is prevented from flowing into lungs when it is inhaled. Next, breathing air is suddenly let to flow into the lungs. Then, the flow of the breathing air is usable for extracting medical agent from a receiver, and putting the medical agent into the flow of the breathing air so as to form aerosol. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于形成药剂气溶胶的系统和方法。
解决方案：在这种方法中，吸入时防止呼吸空气流入肺部。接下来，呼吸空气突然流入肺部。然后，呼吸空气的流动可用于从接收器中提取药剂，并将医药置于呼吸空气流中，形成气溶胶。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2009136688A Flow resistance modulated aerosolized active agent delivery 审中-公开
标题翻译：流动电阻调节的活性剂递送
公开(公告)号：JP2009136688A
公开(公告)日：2009-06-25
申请号：JP2009002017
申请日：2009-01-07
申请人： Nektar Therapeutics , ネクターセラピューティックス
发明人： ANDREW CLARKE , SCHULER CARLOS , PABOOJIAN STEVE
IPC分类号： A61K9/12 , A61M15/00 , A61M11/00 , A61M16/00
CPC分类号： A61M15/00 , A61M2016/0021 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide methods and devices for delivering an active agent formulation to the lung of a human patient, in which the active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant, and the active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.
SOLUTION: The device 104 for delivering an active agent formulation to the lung of a human patient comprises a flow resistance modulator that modulates resistance to the flow of the aerosolized active agent formulation to produce an initial target flow rate of the aerosolized active agent formulation in a manner that is independent of patient instruction and flow rate monitoring 106.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供将活性剂制剂递送到人类患者的肺中的方法和装置，其中活性剂制剂可以是干粉形式，其可以是雾化的，或者可以是与推进剂混合，并且活性剂制剂以低吸入流速在初始时期递送给患者以提高活性剂的生物利用度。解决方案：用于将活性剂制剂输送到人类患者的肺的装置104包括流阻阻抗调节剂，其调节对雾化活性剂制剂的流动的阻力以产生雾化活性剂的初始目标流速以不同于患者指导和流量监测106的方式进行制定。版权所有（C）2009年，JPO＆INPIT

4. 发明专利

SK287044B6 Devices for delivering an active agent formulation to the lungs of a human patient 未知
公开(公告)号：SK287044B6
公开(公告)日：2009-10-07
申请号：SK4772001
申请日：1999-10-07
申请人： NEKTAR THERAPEUTICS
发明人： CLARK ANDREW , SCHULER CARLOS , PABOOJIAN STEVE
IPC分类号： A61K9/12 , A61M15/00 , A61K9/00 , A61M11/00 , A61M16/00
摘要： Devices for delivering an active agent formulation to the lungs of a human patient comprising a flow resistance modulator (100) adapted to change the flow resistance during delivery over one inhalation of an aerosolized active agent to the lungs of a human patient from a first flow resistance during an initial time period to a second flow resistance following the initial time period wherein the second flow resistance being less than the first flow resistance.

5. 发明专利

DE60032173T2 未知
公开(公告)号：DE60032173T2
公开(公告)日：2007-09-27
申请号：DE60032173
申请日：2000-12-15
申请人： NEKTAR THERAPEUTICS
发明人： PABOOJIAN STEVE , SCHULER CARLOS , CLARK ANDREW
IPC分类号： A61M13/00 , A61M15/00 , B05B7/14 , B05B11/06 , B65D75/36
摘要： An apparatus (134) for aerosolizing a powdered medicament, comprising: a housing (136) having a holder (138) that is adapted to receive a receptacle (140) having a cavity that holds a powder; a piercing mechanism that is adapted to pierce a hole in a bottom end of the receptacle (140); a vent forming mechanism for forming multiple vents (126) in a top end of the receptacle (140); and an extraction tube (144) that is adapted to be placed into the cavity so as to be spaced above the bottom end of the receptacle (140) and to be aligned with the hole in the bottom end.

6. 发明专利

PT1237608E RECEPTÁCULOS PARA FACILITAR EXTRACÇÃO DE PÓS 未知
公开(公告)号：PT1237608E
公开(公告)日：2007-02-28
申请号：PT00989270
申请日：2000-12-15
申请人： NEKTAR THERAPEUTICS
发明人： PABOOJIAN STEVE , SCHULER CARLOS , CLARK ANDREW
IPC分类号： A61M13/00 , A61M15/00 , B05B7/14 , B05B11/06 , B65D75/36

7. 发明专利

DK1181069T3 未知
公开(公告)号：DK1181069T3
公开(公告)日：2006-10-09
申请号：DK00936239
申请日：2000-05-24
申请人： NEKTAR THERAPEUTICS
发明人： SCHULER CARLOS , PABOOJIAN STEVE , TUTTLE DERRICK , BAKSHI ANEESH K
IPC分类号： A61M11/02 , A61M15/00 , A61M11/04 , A61M11/06 , B05B7/00
摘要： The invention provides exemplary methods and apparatus for aerosolizing a pharmaceutical formulation contained within a receptacle. In one method, a metered amount of a pressurized gas is provided, with the pressurized gas previously being in equilibrium with a liquid. The metered gas is released to create a high pressure gas stream. The high pressure gas stream is flowed through an aerosolization mechanism to extract the pharmaceutical formulation from the receptacle and to disperse the pharmaceutical formulation within the gas stream to form an aerosol.

8. 发明专利

MY125534A SYSTEMS AND METHODS FOR AEROSOLIZING PHARMACEUTICAL FORMULATIONS 未知
公开(公告)号：MY125534A
公开(公告)日：2006-08-30
申请号：MYPI20002769
申请日：2000-06-20
申请人： NEKTAR THERAPEUTICS
发明人： SCHULER CARLOS , NASON KEVIN S , PABOOJIAN STEVE , TUTTLE DERRICK J , SMITH ADRIAN E , RASMUSSEN DENNIS R , BAKSHI ANEESH , CLARK ANDREW , WARD BRIAN R S , ALSTON WILLIAM A JR
IPC分类号： A61M15/00 , A61M16/20
摘要： SYSTEMS AND METHODS ARE PROVIDED FOR AEROSOLIZING A PHARMACEUTICAL FORMULATION. ACCORDING TO ONE METHOD, RESPIRATORY GASES ARE PREVENTED FROM FLOWING TO THE LUNGS WHEN ATTEMPTING TO INHALE. THEN, RESPIRATORY GASES ARE ABRUPTLY PERMITTED TO FLOW TO THE LUNGS. THE FLOW OF RESPIRATORY GASES MAY THEN BE USED TO EXTRACT A PHARMACEUTICAL FORMULATION FROM A RECEPTACLE AND TO PLACE THE PHARMACEUTICAL FORMULATION WITHIN THE FLOW OF RESPIRATORY GASES TO FORM AN AEROSOL.(FIGURE 5)

9. 发明专利

HU225057B1 FLOW RESISTANCE MODULATED AEROSOLIZED ACTIVE AGENT DELIVERY 未知
公开(公告)号：HU225057B1
公开(公告)日：2006-05-29
申请号：HU0103805
申请日：1999-10-07
申请人： NEKTAR THERAPEUTICS
发明人： CLARK ANDREW , SCHULER CARLOS , PABOOJIAN STEVE
IPC分类号： A61K9/12 , A61M15/00 , A61M11/00 , A61M16/00
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

10. 发明专利

DK1119384T3 未知
公开(公告)号：DK1119384T3
公开(公告)日：2005-09-19
申请号：DK99970333
申请日：1999-10-07
申请人： NEKTAR THERAPEUTICS
发明人： PABOOJIAN STEVE , CLARK ANDREW , SCHULER CARLOS
IPC分类号： A61K9/12 , A61M11/00 , A61M15/00 , A61M16/00
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

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